| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.242823 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.111781 |
| INHBA | inhibin, beta A | 0.0781376 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0751959 |
| RPL4 | ribosomal protein L4 | 0.070057 |
| COL1A1 | collagen, type I, alpha 1 | 0.0625798 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0605677 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.059944 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0570549 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0561783 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0526702 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.052501 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0508724 |
| HLA-B | major histocompatibility complex, class I, B | 0.0495433 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.048592 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0479253 |
| STC1 | stanniocalcin 1 | 0.0466648 |
| CDH13 | cadherin 13 | 0.0462123 |
| CD109 | CD109 molecule | 0.045979 |
| GOLGA4 | golgin A4 | 0.0459538 |
| RBM39 | RNA binding motif protein 39 | 0.0426491 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0426318 |
| CALR | calreticulin | 0.0424368 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0408152 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0406602 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0405885 |
| OGA | O-GlcNAcase | 0.03989 |
| HLA-A | major histocompatibility complex, class I, A | 0.0366349 |
| CAVIN1 | caveolae associated protein 1 | 0.0352968 |
| PCBP3 | poly(rC) binding protein 3 | 0.0346609 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.034622 |
| PGK1 | phosphoglycerate kinase 1 | 0.0330436 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0324301 |
| MMP12 | matrix metallopeptidase 12 | 0.0323977 |
| COL1A2 | collagen, type I, alpha 2 | 0.0322456 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0321836 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0315557 |
| INSIG2 | insulin induced gene 2 | 0.0307752 |
| AHNAK | AHNAK nucleoprotein | 0.0305556 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0299673 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0294683 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.029014 |
| CADM1 | cell adhesion molecule 1 | 0.0286931 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0286678 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0286249 |
| TPM4 | tropomyosin 4 | 0.0286242 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0279746 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0277928 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0274675 |
| GNAS | GNAS complex locus | 0.0273532 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0273159 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0270321 |
| MEF2A | myocyte enhancer factor 2A | 0.0268598 |
| TMEM51 | transmembrane protein 51 | 0.0265668 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0262769 |
| HDLBP | high density lipoprotein binding protein | 0.0256388 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0253751 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0245943 |
| S100A6 | S100 calcium binding protein A6 | 0.0244228 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0234441 |
| FAM20C | family with sequence similarity 20, member C | 0.0233953 |
| RND3 | Rho family GTPase 3 | 0.0232774 |
| H1-0 | H1.0 linker histone | 0.0232363 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0231095 |
| FNIP1 | folliculin interacting protein 1 | 0.0228577 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0227409 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0226492 |
| HLA-C | major histocompatibility complex, class I, C | 0.0226443 |
| SYNDIG1 | synapse differentiation inducing 1 | 0.0224636 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0224191 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | 0.0223749 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0223173 |
| ATP13A3 | ATPase type 13A3 | 0.0220931 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.021871 |
| FMNL2 | formin-like 2 | 0.0218457 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0218139 |
| SDC4 | syndecan 4 | 0.0218042 |
| LOXL2 | lysyl oxidase-like 2 | 0.0217456 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0217159 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0214586 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.021431 |
| FAM13A | family with sequence similarity 13, member A | 0.0213985 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.021088 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0209739 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0209185 |
| CA12 | carbonic anhydrase XII | 0.0208027 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0207794 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0206517 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0206437 |
| ARF1 | ADP-ribosylation factor 1 | 0.0205734 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0202063 |
| TBX3 | T-box 3 | 0.0202042 |
| DNER | delta/notch-like EGF repeat containing | 0.0201843 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0201376 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0201365 |
| RLF | rearranged L-myc fusion | 0.0195105 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.019173 |
| MMP2 | matrix metallopeptidase 2 | 0.0191441 |
| CEP95 | centrosomal protein 95kDa | 0.0191244 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.01891 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.232437 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.224486 |
| NDRG1 | N-myc downstream regulated 1 | -0.144978 |
| POTEF | POTE ankyrin domain family, member F | -0.130225 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126944 |
| CD44 | CD44 molecule (Indian blood group) | -0.0953145 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0947108 |
| EGR1 | early growth response 1 | -0.0842622 |
| VEGFA | vascular endothelial growth factor A | -0.0814681 |
| MSN | moesin | -0.0775376 |
| MT2A | metallothionein 2A | -0.0672667 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.066965 |
| PKM | pyruvate kinase, muscle | -0.0623039 |
| TGM2 | transglutaminase 2 | -0.0556388 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0529901 |
| FHIT | fragile histidine triad | -0.0499738 |
| NRP1 | neuropilin 1 | -0.0460287 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0438771 |
| ASPH | aspartate beta-hydroxylase | -0.0427995 |
| ATXN1 | ataxin 1 | -0.042044 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0415508 |
| PTK2 | protein tyrosine kinase 2 | -0.0414766 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0394723 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.039331 |
| SVIL | supervillin | -0.0392022 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0390823 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0377122 |
| ATM | ATM serine/threonine kinase | -0.0374648 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0371469 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0358605 |
| FOSL1 | FOS-like antigen 1 | -0.0357431 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0354953 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0342374 |
| COL5A1 | collagen, type V, alpha 1 | -0.0341188 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0339806 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0331889 |
| ITGAV | integrin, alpha V | -0.0331574 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0330639 |
| MCL1 | myeloid cell leukemia 1 | -0.0312448 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0310961 |
| THBS1 | thrombospondin 1 | -0.0310654 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0308505 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0307543 |
| DSTN | destrin (actin depolymerizing factor) | -0.0306677 |
| VMP1 | vacuole membrane protein 1 | -0.0306444 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0304853 |
| ZNF644 | zinc finger protein 644 | -0.0301097 |
| USP34 | ubiquitin specific peptidase 34 | -0.0299804 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0295461 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0294393 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0292709 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0290646 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0290439 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0288823 |
| TPM1 | tropomyosin 1 (alpha) | -0.0286184 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0283869 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0282295 |
| UTRN | utrophin | -0.028148 |
| ACTN1 | actinin, alpha 1 | -0.0275678 |
| RUNX1 | runt-related transcription factor 1 | -0.0274309 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0274103 |
| EXOC6B | exocyst complex component 6B | -0.0273792 |
| CCNL1 | cyclin L1 | -0.0273248 |
| CLIC4 | chloride intracellular channel 4 | -0.0270804 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0270096 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0266801 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.0263375 |
| AGRN | agrin | -0.0262402 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0261229 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0261221 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0259982 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0255657 |
| BBX | bobby sox homolog (Drosophila) | -0.0254545 |
| MED13L | mediator complex subunit 13-like | -0.0252079 |
| SFPQ | splicing factor proline/glutamine-rich | -0.024708 |
| NAV1 | neuron navigator 1 | -0.0245729 |
| BRD2 | bromodomain containing 2 | -0.0242668 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0242568 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | -0.0240741 |
| RPL19 | ribosomal protein L19 | -0.0239084 |
| SHISA5 | shisa family member 5 | -0.0236933 |
| NAV2 | neuron navigator 2 | -0.0236728 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0235386 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0234538 |
| MX1 | MX dynamin-like GTPase 1 | -0.023327 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0233154 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0230017 |
| TNS3 | tensin 3 | -0.0228492 |
| INTS6 | integrator complex subunit 6 | -0.0228374 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0227612 |
| AFAP1 | actin filament associated protein 1 | -0.0225612 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0224929 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0222412 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0221637 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0219196 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0218129 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.021682 |
| SSH1 | slingshot protein phosphatase 1 | -0.0216709 |
| FRMD4A | FERM domain containing 4A | -0.0214956 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0214609 |
