Dorzolamide (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.147397
CALCA calcitonin-related polypeptide alpha 0.106186
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0897109
ENO1 enolase 1, (alpha) 0.085741
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.085423
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0731127
PEG10 paternally expressed 10 0.0723861
CENPF centromere protein F, 350/400kDa 0.0701972
RPL4 ribosomal protein L4 0.0618409
RPS6 ribosomal protein S6 0.0552897
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0545389
RPS3 ribosomal protein S3 0.0531099
FTL ferritin, light polypeptide 0.0525477
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0498242
RPL26 ribosomal protein L26 0.0489689
RPS8 ribosomal protein S8 0.0460271
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.044926
MT2A metallothionein 2A 0.0438448
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0424833
VGF VGF nerve growth factor inducible 0.0416898
RPS21 ribosomal protein S21 0.0406804
TMSB4X thymosin beta 4, X-linked 0.0391805
KPNB1 karyopherin (importin) beta 1 0.0390822
NIPSNAP2 nipsnap homolog 2 0.0387043
RPLP1 ribosomal protein, large, P1 0.0385174
S100A9 S100 calcium binding protein A9 0.0377847
RPL11 ribosomal protein L11 0.0376994
ATP5F1E ATP synthase F1 subunit epsilon 0.0373347
IFI6 interferon, alpha-inducible protein 6 0.0366246
RPL8 ribosomal protein L8 0.0361299
SET SET nuclear proto-oncogene 0.0353693
CCDC88A coiled-coil domain containing 88A 0.0350196
SINHCAF SIN3-HDAC complex associated factor 0.0346319
MKI67 marker of proliferation Ki-67 0.0340148
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0340012
RPS12 ribosomal protein S12 0.0338484
RTN4 reticulon 4 0.033766
EIF1 eukaryotic translation initiation factor 1 0.0330907
B2M beta-2-microglobulin 0.0330175
SASH1 SAM and SH3 domain containing 1 0.0329581
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0329062
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0327775
RPL23 ribosomal protein L23 0.0322651
DSTN destrin (actin depolymerizing factor) 0.0319135
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0308307
MIS18BP1 MIS18 binding protein 1 0.0305073
STMN1 stathmin 1 0.0303263
RPL7 ribosomal protein L7 0.0302213
RPL5 ribosomal protein L5 0.0301751
RPL37A ribosomal protein L37a 0.0300459
RPS19 ribosomal protein S19 0.0300256
RPS27A ribosomal protein S27a 0.0294545
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0292106
RPL30 ribosomal protein L30 0.0287812
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0285685
RPS16 ribosomal protein S16 0.0285154
RPL35 ribosomal protein L35 0.0283229
EIF4A1 eukaryotic translation initiation factor 4A1 0.0276631
RPS17 ribosomal protein S17 0.0275569
TUBB4B tubulin, beta 4B class IVb 0.0275465
RPS25 ribosomal protein S25 0.0272162
RPL37 ribosomal protein L37 0.0271962
ATP5F1B ATP synthase F1 subunit beta 0.0271112
MAP1B microtubule-associated protein 1B 0.0269828
RAD21 RAD21 homolog (S. pombe) 0.0269332
RPLP0 ribosomal protein, large, P0 0.0268658
CPE carboxypeptidase E 0.0268408
LDHA lactate dehydrogenase A 0.0267438
RPL12 ribosomal protein L12 0.0267355
RSRC2 arginine/serine-rich coiled-coil 2 0.0267098
FOXC1 forkhead box C1 0.0266988
PA2G4 proliferation-associated 2G4, 38kDa 0.0266937
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0265579
PKM pyruvate kinase, muscle 0.0264102
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0263477
YBX1 Y box binding protein 1 0.0260035
RPL19 ribosomal protein L19 0.0255098
SMC1A structural maintenance of chromosomes 1A 0.0254781
LOC112694756 uncharaterized LOC112694756 0.0253894
KTN1 kinectin 1 (kinesin receptor) 0.0253646
MATR3 matrin 3 0.0252505
PGK1 phosphoglycerate kinase 1 0.025209
RPL7A ribosomal protein L7a 0.0252035
TPX2 TPX2, microtubule-associated 0.0250385
ACTG1 actin gamma 1 0.0249533
EEF2 eukaryotic translation elongation factor 2 0.0248803
STC1 stanniocalcin 1 0.0248491
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0246854
HMGB2 high mobility group box 2 0.0246348
TXNRD1 thioredoxin reductase 1 0.0244841
RPS5 ribosomal protein S5 0.0244087
RACK1 receptor for activated C kinase 1 0.0244048
RPS2 ribosomal protein S2 0.0243558
RPL32 ribosomal protein L32 0.0242609
RPL31 ribosomal protein L31 0.0242051
HLA-A major histocompatibility complex, class I, A 0.024161
RBM25 RNA binding motif protein 25 0.0238397
XPO1 exportin 1 0.0234474
HMGN2 high mobility group nucleosomal binding domain 2 0.023148
ASCL1 achaete-scute family bHLH transcription factor 1 0.0229386

decreased expression

Symbol Name Standardized Value
GPC6 glypican 6 -0.143775
NALF1 NALCN channel auxiliary factor 1 -0.143419
NRG1 neuregulin 1 -0.123622
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.111162
RORA RAR-related orphan receptor A -0.0821348
SMYD3 SET and MYND domain containing 3 -0.0804447
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0783747
MCL1 myeloid cell leukemia 1 -0.0714065
SNTG1 syntrophin, gamma 1 -0.0685874
MCTP1 multiple C2 domains, transmembrane 1 -0.0683068
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0665135
PDE10A phosphodiesterase 10A -0.0642247
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0642043
RIMS2 regulating synaptic membrane exocytosis 2 -0.0580292
DTNA dystrobrevin, alpha -0.0578112
EXT1 exostosin glycosyltransferase 1 -0.0569859
ESRRG estrogen-related receptor gamma -0.0554649
PTCHD4 patched domain containing 4 -0.0549806
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0548697
GMDS GDP-mannose 4,6-dehydratase -0.0533935
EFNA5 ephrin-A5 -0.0520243
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0488508
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0486515
TSHZ2 teashirt zinc finger homeobox 2 -0.0476359
GRB10 growth factor receptor-bound protein 10 -0.0472352
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0464257
EPHA6 EPH receptor A6 -0.0446792
GPC5 glypican 5 -0.0435103
STXBP5 syntaxin binding protein 5 (tomosyn) -0.042443
KLHL29 kelch-like family member 29 -0.042363
CNTNAP2 contactin associated protein-like 2 -0.0421377
NBEA neurobeachin -0.0421253
SDK1 sidekick cell adhesion molecule 1 -0.0413187
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0410982
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0409918
TRIO trio Rho guanine nucleotide exchange factor -0.0408898
SETX senataxin -0.0397624
NCKAP5 NCK-associated protein 5 -0.039427
ST18 suppression of tumorigenicity 18, zinc finger -0.0393628
ADGRL3 adhesion G protein-coupled receptor L3 -0.038871
KIF26B kinesin family member 26B -0.0386934
ASPH aspartate beta-hydroxylase -0.038605
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0385096
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0385043
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0366655
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0361811
DENND1A DENN/MADD domain containing 1A -0.0357798
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0355137
CADM1 cell adhesion molecule 1 -0.0346673
NDRG1 N-myc downstream regulated 1 -0.0344756
PCBP3 poly(rC) binding protein 3 -0.0335103
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0327609
TBC1D22A TBC1 domain family, member 22A -0.0327354
ZFHX3 zinc finger homeobox 3 -0.0325746
NELL1 NEL-like 1 (chicken) -0.0323292
ANKRD36C ankyrin repeat domain 36C -0.0322355
SCFD2 sec1 family domain containing 2 -0.0321832
ZSWIM6 zinc finger, SWIM-type containing 6 -0.031546
ZBTB20 zinc finger and BTB domain containing 20 -0.0314168
GOLGB1 golgin B1 -0.0299197
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0296638
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0292915
SNAP25 synaptosomal-associated protein, 25kDa -0.0290971
MYT1L myelin transcription factor 1-like -0.0289619
LSAMP limbic system-associated membrane protein -0.0288767
AUTS2 autism susceptibility candidate 2 -0.0284676
RPH3AL rabphilin 3A-like (without C2 domains) -0.0282399
ASIC2 acid sensing (proton gated) ion channel 2 -0.0282321
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.028173
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0276519
DOCK5 dedicator of cytokinesis 5 -0.0276355
BACE2 beta-site APP-cleaving enzyme 2 -0.0274718
CDK13 cyclin-dependent kinase 13 -0.0273
BCL2 B-cell CLL/lymphoma 2 -0.0270821
ZNF804A zinc finger protein 804A -0.0269131
HOMER1 homer scaffolding protein 1 -0.026653
FGF14 fibroblast growth factor 14 -0.0266104
PDE4B phosphodiesterase 4B, cAMP-specific -0.0264411
MSI2 musashi RNA-binding protein 2 -0.0258993
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0256799
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0255258
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0252709
IQSEC1 IQ motif and Sec7 domain 1 -0.0250398
ANKRD17 ankyrin repeat domain 17 -0.0249659
FNDC3B fibronectin type III domain containing 3B -0.0248862
LIMCH1 LIM and calponin homology domains 1 -0.0246819
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0245816
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0243687
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0240327
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0240125
RNF213 ring finger protein 213 -0.0239422
CTBP2 C-terminal binding protein 2 -0.0236686
CNKSR3 CNKSR family member 3 -0.0236222
ANKH ANKH inorganic pyrophosphate transport regulator -0.0235895
INTS6 integrator complex subunit 6 -0.0234075
APP amyloid beta (A4) precursor protein -0.0232594
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0231454
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0230041
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0229338
TUSC3 tumor suppressor candidate 3 -0.0228261