| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.190428 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.151527 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.131028 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0826153 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0809845 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0738146 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0632461 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0629848 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0619491 |
| RPL4 | ribosomal protein L4 | 0.0608653 |
| SPAG9 | sperm associated antigen 9 | 0.0570579 |
| ENO1 | enolase 1, (alpha) | 0.0510416 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0491676 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0455729 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0453881 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0436244 |
| PRELID2 | PRELI domain containing 2 | 0.0426637 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.041721 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0403174 |
| TPM3 | tropomyosin 3 | 0.0391604 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0375789 |
| OGA | O-GlcNAcase | 0.0375375 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0372962 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0366317 |
| CANX | calnexin | 0.0366034 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0363893 |
| ANLN | anillin, actin binding protein | 0.0360332 |
| GOLGA4 | golgin A4 | 0.0353869 |
| SQSTM1 | sequestosome 1 | 0.0350435 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0349163 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0338523 |
| MKI67 | marker of proliferation Ki-67 | 0.0337408 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0335587 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0323915 |
| NGLY1 | N-glycanase 1 | 0.0309691 |
| ANGPTL4 | angiopoietin-like 4 | 0.0306822 |
| SET | SET nuclear proto-oncogene | 0.0298572 |
| CENPF | centromere protein F, 350/400kDa | 0.0297752 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0295986 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0293962 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0283277 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0276511 |
| MT1X | metallothionein 1X | 0.027643 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0273495 |
| CALR | calreticulin | 0.0272054 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0272035 |
| NAV2 | neuron navigator 2 | 0.0268982 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0267498 |
| SEPTIN9 | septin 9 | 0.0263804 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0262104 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0259501 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0257695 |
| SNX14 | sorting nexin 14 | 0.0249233 |
| RPL14 | ribosomal protein L14 | 0.0247905 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0246896 |
| CDC27 | cell division cycle 27 | 0.0245187 |
| RRBP1 | ribosome binding protein 1 | 0.0239572 |
| RBM39 | RNA binding motif protein 39 | 0.0239131 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0236856 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0236631 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.023533 |
| RPS2 | ribosomal protein S2 | 0.0232899 |
| POM121 | POM121 transmembrane nucleoporin | 0.0232311 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0229828 |
| SGO2 | shugoshin 2 | 0.0227989 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0227346 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0226838 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0223477 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0222238 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0221948 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0221528 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.0220745 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0219417 |
| TPX2 | TPX2, microtubule-associated | 0.0218405 |
| MSI2 | musashi RNA-binding protein 2 | 0.0217132 |
| ZNF292 | zinc finger protein 292 | 0.0213888 |
| HMGB2 | high mobility group box 2 | 0.0213232 |
| MMP12 | matrix metallopeptidase 12 | 0.0212419 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0210493 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0208775 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0207688 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0205167 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0204319 |
| MYO1B | myosin IB | 0.0203659 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.020355 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0201008 |
| TPI1 | triosephosphate isomerase 1 | 0.020079 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.019996 |
| CDK19 | cyclin-dependent kinase 19 | 0.0198807 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.019731 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0195508 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0195498 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.0191527 |
| TXNRD1 | thioredoxin reductase 1 | 0.0189677 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0188326 |
| TUBB6 | tubulin, beta 6 class V | 0.0188195 |
| ASPH | aspartate beta-hydroxylase | 0.0187273 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0186531 |
| SEPTIN10 | septin 10 | 0.0185024 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0184475 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.233225 |
| FN1 | fibronectin 1 | -0.229129 |
| FMN1 | formin 1 | -0.140974 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.109465 |
| HDAC9 | histone deacetylase 9 | -0.0658545 |
| RUNX1 | runt-related transcription factor 1 | -0.0637166 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.062644 |
| FRMD5 | FERM domain containing 5 | -0.0611641 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0580414 |
| FRMD4A | FERM domain containing 4A | -0.0559865 |
| NRG3 | neuregulin 3 | -0.0550991 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0523459 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0514517 |
| LSAMP | limbic system-associated membrane protein | -0.0508152 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0426788 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.041172 |
| POTEF | POTE ankyrin domain family, member F | -0.0405215 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0400922 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0386035 |
| RASAL2 | RAS protein activator like 2 | -0.0385936 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0380676 |
| TMSB10 | thymosin beta 10 | -0.0373411 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0350927 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0350336 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0328218 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0308044 |
| HMGA1 | high mobility group AT-hook 1 | -0.0299358 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0285784 |
| CDK6 | cyclin-dependent kinase 6 | -0.0282476 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0281094 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0278408 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0273405 |
| NLGN1 | neuroligin 1 | -0.0270864 |
| DST | dystonin | -0.0267849 |
| EVI5 | ecotropic viral integration site 5 | -0.0267331 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0265826 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0264328 |
| TCF12 | transcription factor 12 | -0.0261903 |
| GPHN | gephyrin | -0.0258547 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0257103 |
| ADAR | adenosine deaminase, RNA-specific | -0.0256856 |
| TP63 | tumor protein p63 | -0.0254953 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0254748 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0253006 |
| NOTCH2 | notch 2 | -0.0252563 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0247336 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0232468 |
| PKP4 | plakophilin 4 | -0.0232096 |
| PKM | pyruvate kinase, muscle | -0.0229934 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0228037 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0227687 |
| ZNF697 | zinc finger protein 697 | -0.0226894 |
| BPTF | bromodomain PHD finger transcription factor | -0.0226529 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.022548 |
| RHOA | ras homolog family member A | -0.0224632 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0224055 |
| ZNF644 | zinc finger protein 644 | -0.022141 |
| PCBP2 | poly(rC) binding protein 2 | -0.0219748 |
| RPL36 | ribosomal protein L36 | -0.0217149 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0213714 |
| DENND1A | DENN/MADD domain containing 1A | -0.0211792 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0209049 |
| RPS19 | ribosomal protein S19 | -0.0208394 |
| BRD4 | bromodomain containing 4 | -0.0205792 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0205787 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0204341 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0204138 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0201908 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0201049 |
| WDR27 | WD repeat domain 27 | -0.0200156 |
| SVIL | supervillin | -0.0199692 |
| RPL23 | ribosomal protein L23 | -0.0196519 |
| ERBIN | erbb2 interacting protein | -0.0195074 |
| QKI | QKI, KH domain containing, RNA binding | -0.0194784 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0194714 |
| ANKRD17 | ankyrin repeat domain 17 | -0.019267 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0191705 |
| CCNL1 | cyclin L1 | -0.0191018 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0190925 |
| ENAH | enabled homolog (Drosophila) | -0.0189594 |
| SMYD3 | SET and MYND domain containing 3 | -0.0188788 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0188195 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0188155 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0187363 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0186171 |
| AOPEP | aminopeptidase O (putative) | -0.0185952 |
| RNF213 | ring finger protein 213 | -0.018535 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0184607 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0184409 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0183754 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0183535 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.018347 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.0183113 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0182892 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0182732 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0181336 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.018036 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0179687 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0179477 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0178962 |
