Dorzolamide (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.277599
RPL4 ribosomal protein L4 0.0942357
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0900346
RPS2 ribosomal protein S2 0.0811415
RPL37A ribosomal protein L37a 0.0694566
RPS3 ribosomal protein S3 0.0689345
RPS6 ribosomal protein S6 0.0662885
CENPF centromere protein F, 350/400kDa 0.064735
RPL26 ribosomal protein L26 0.0642011
EZR ezrin 0.0630352
RPS12 ribosomal protein S12 0.062215
GOLGA4 golgin A4 0.0601095
RPS8 ribosomal protein S8 0.0585311
RPL13A ribosomal protein L13a 0.055121
RPLP1 ribosomal protein, large, P1 0.0537595
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0521112
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0507844
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0502856
RPL12 ribosomal protein L12 0.0494956
EIF1 eukaryotic translation initiation factor 1 0.0486289
SET SET nuclear proto-oncogene 0.048447
MKI67 marker of proliferation Ki-67 0.0469084
PRRC2C proline-rich coiled-coil 2C 0.0463847
RPL9 ribosomal protein L9 0.0448896
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0439377
RBM25 RNA binding motif protein 25 0.0439129
RPL35A ribosomal protein L35a 0.0429626
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0407148
SMC3 structural maintenance of chromosomes 3 0.0404194
ENO1 enolase 1, (alpha) 0.0389759
AKAP9 A kinase (PRKA) anchor protein 9 0.0382
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.037941
RPS19 ribosomal protein S19 0.037532
RPL18 ribosomal protein L18 0.0367196
RPS27A ribosomal protein S27a 0.0361689
DUSP4 dual specificity phosphatase 4 0.0341311
RPL36 ribosomal protein L36 0.0340135
ANKRD12 ankyrin repeat domain 12 0.0330441
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0321146
TMSB4X thymosin beta 4, X-linked 0.032012
NAV2 neuron navigator 2 0.0317605
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0316786
NAP1L1 nucleosome assembly protein 1-like 1 0.0311006
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0309741
RPLP2 ribosomal protein, large, P2 0.030548
PRELID2 PRELI domain containing 2 0.0301096
RPL23 ribosomal protein L23 0.0300632
TMF1 TATA element modulatory factor 1 0.0298641
DIAPH3 diaphanous-related formin 3 0.0296959
SQSTM1 sequestosome 1 0.0296448
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.029338
MT2A metallothionein 2A 0.0292921
RPL31 ribosomal protein L31 0.0290286
B2M beta-2-microglobulin 0.0282157
FTL ferritin, light polypeptide 0.0281123
RPL5 ribosomal protein L5 0.0278441
SRRM2 serine/arginine repetitive matrix 2 0.0278399
ARL4C ADP-ribosylation factor-like 4C 0.0272575
HMGB2 high mobility group box 2 0.0271996
ENO2 enolase 2 (gamma, neuronal) 0.0268083
CBX3 chromobox homolog 3 0.0264935
RPS18 ribosomal protein S18 0.0264746
OGA O-GlcNAcase 0.0264312
TMSB10 thymosin beta 10 0.0261617
RPS17 ribosomal protein S17 0.0259937
RPS27 ribosomal protein S27 0.0254607
NPAS2 neuronal PAS domain protein 2 0.0254498
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0253883
CENPE centromere protein E, 312kDa 0.0252225
MXI1 MAX interactor 1, dimerization protein 0.0252115
ASPH aspartate beta-hydroxylase 0.0250354
KTN1 kinectin 1 (kinesin receptor) 0.024708
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0245607
HILPDA hypoxia inducible lipid droplet-associated 0.0243138
PABPN1 poly(A) binding protein, nuclear 1 0.0242091
RPL35 ribosomal protein L35 0.0239396
RACK1 receptor for activated C kinase 1 0.0237355
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0236197
RPL37 ribosomal protein L37 0.0234224
HDGF hepatoma-derived growth factor 0.0230063
AKAP12 A kinase (PRKA) anchor protein 12 0.0224388
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0223997
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.022346
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0223314
SMC4 structural maintenance of chromosomes 4 0.0221332
CDV3 CDV3 homolog (mouse) 0.0221173
KIF5B kinesin family member 5B 0.0211916
RRBP1 ribosome binding protein 1 0.0210423
PNN pinin, desmosome associated protein 0.0209633
APLP2 amyloid beta (A4) precursor-like protein 2 0.0202384
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.020216
VIM vimentin 0.0200068
TMEM14B transmembrane protein 14B 0.0199824
TBC1D22A TBC1 domain family, member 22A 0.0199125
RPL34 ribosomal protein L34 0.0199066
PTPRF protein tyrosine phosphatase, receptor type, F 0.0198439
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0193439
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0192284
GYS1 glycogen synthase 1 (muscle) 0.0192274
CKAP2 cytoskeleton associated protein 2 0.0190125

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.281562
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.163809
SSBP2 single-stranded DNA binding protein 2 -0.117454
PDE4D phosphodiesterase 4D, cAMP-specific -0.113571
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.112517
AHNAK AHNAK nucleoprotein -0.101111
VCL vinculin -0.087152
EGFR epidermal growth factor receptor -0.0791887
FOXP1 forkhead box P1 -0.0769144
ZFAND3 zinc finger, AN1-type domain 3 -0.0748616
PDE4B phosphodiesterase 4B, cAMP-specific -0.0739642
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0718909
HDAC9 histone deacetylase 9 -0.0711163
EML4 echinoderm microtubule associated protein like 4 -0.0684483
ADAM10 ADAM metallopeptidase domain 10 -0.06032
ECT2 epithelial cell transforming 2 -0.0554129
PKM pyruvate kinase, muscle -0.052269
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0504112
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0503354
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0495436
RHOA ras homolog family member A -0.0489475
ANKRD17 ankyrin repeat domain 17 -0.048418
PARD3 par-3 family cell polarity regulator -0.0464798
KDM3A lysine (K)-specific demethylase 3A -0.0446759
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0439745
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0425503
RTN4 reticulon 4 -0.0414037
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0411406
PTPRG protein tyrosine phosphatase, receptor type, G -0.0397891
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0396936
ANKRD11 ankyrin repeat domain 11 -0.0371783
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0369001
CCNL1 cyclin L1 -0.0365728
POTEF POTE ankyrin domain family, member F -0.0362141
NBEA neurobeachin -0.0360954
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0359786
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0353705
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0351825
RHEB Ras homolog enriched in brain -0.0349768
PUM2 pumilio RNA-binding family member 2 -0.0340984
WAC WW domain containing adaptor with coiled-coil -0.0337496
IARS1 isoleucyl-tRNA synthetase 1 -0.0333252
SOX6 SRY (sex determining region Y)-box 6 -0.033282
USP3 ubiquitin specific peptidase 3 -0.0326497
CDC73 cell division cycle 73 -0.0325491
RAB1A RAB1A, member RAS oncogene family -0.0320825
ZEB1 zinc finger E-box binding homeobox 1 -0.0319478
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0315678
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0315429
TPT1 tumor protein, translationally-controlled 1 -0.0312754
TJP1 tight junction protein 1 -0.0311378
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.030844
MSI2 musashi RNA-binding protein 2 -0.0307992
NAMPT nicotinamide phosphoribosyltransferase -0.0305676
ZNF644 zinc finger protein 644 -0.0303745
DOCK3 dedicator of cytokinesis 3 -0.0303732
GARS1 glycyl-tRNA synthetase 1 -0.0301674
NCKAP1 NCK-associated protein 1 -0.0299692
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0299054
NF1 neurofibromin 1 -0.0299008
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0296892
GLI3 GLI family zinc finger 3 -0.0290091
DPYD dihydropyrimidine dehydrogenase -0.0288667
TFG TRK-fused gene -0.0287046
NCEH1 neutral cholesterol ester hydrolase 1 -0.0284683
ADAM9 ADAM metallopeptidase domain 9 -0.0283473
BMP2K BMP2 inducible kinase -0.0281741
TNPO1 transportin 1 -0.0281215
FBXO11 F-box protein 11 -0.0280086
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0279297
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0278105
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0276441
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0271146
ELOVL5 ELOVL fatty acid elongase 5 -0.0270698
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0268974
PDGFC platelet derived growth factor C -0.0268513
YAP1 Yes-associated protein 1 -0.0264171
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0263569
NFIA nuclear factor I/A -0.0262606
CD47 CD47 molecule -0.0261926
APP amyloid beta (A4) precursor protein -0.0260481
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0257978
NT5C2 5'-nucleotidase, cytosolic II -0.0254067
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0252796
OSMR oncostatin M receptor -0.0250523
TXNRD1 thioredoxin reductase 1 -0.0249806
MLIP muscular LMNA-interacting protein -0.0248002
ZNF438 zinc finger protein 438 -0.0246081
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.024241
QKI QKI, KH domain containing, RNA binding -0.0242283
PRRC1 proline-rich coiled-coil 1 -0.0240927
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0239238
TSC22D1 TSC22 domain family, member 1 -0.0235245
XRN2 5'-3' exoribonuclease 2 -0.0235157
SENP6 SUMO1/sentrin specific peptidase 6 -0.0234456
POU2F1 POU class 2 homeobox 1 -0.0233556
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.023265
GPHN gephyrin -0.023154
UBC ubiquitin C -0.0231435
CORO1C coronin, actin binding protein, 1C -0.0230642