| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0951497 |
| PTMA | prothymosin, alpha | 0.0870151 |
| OGA | O-GlcNAcase | 0.0794244 |
| RPL4 | ribosomal protein L4 | 0.06241 |
| RPS3 | ribosomal protein S3 | 0.0605939 |
| RBM39 | RNA binding motif protein 39 | 0.0599359 |
| RPS12 | ribosomal protein S12 | 0.0537349 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0510182 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0503034 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0472813 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0469025 |
| RPL26 | ribosomal protein L26 | 0.0459814 |
| RPS2 | ribosomal protein S2 | 0.0456884 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0452448 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0406746 |
| RPL14 | ribosomal protein L14 | 0.0402285 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0399066 |
| RPL37A | ribosomal protein L37a | 0.039339 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0362014 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0357867 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0347566 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.034608 |
| ANLN | anillin, actin binding protein | 0.0337775 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0334239 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0320091 |
| TMSB4X | thymosin beta 4, X-linked | 0.0316006 |
| BICC1 | BicC family RNA binding protein 1 | 0.0311154 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0309191 |
| SDC4 | syndecan 4 | 0.0303714 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0300363 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0292863 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0286456 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0278678 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0275116 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0274984 |
| RPS15A | ribosomal protein S15a | 0.0272753 |
| DENND5A | DENN/MADD domain containing 5A | 0.0271043 |
| SET | SET nuclear proto-oncogene | 0.0269933 |
| AFDN | afadin, adherens junction formation factor | 0.0267963 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.02673 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0261867 |
| RAI1 | retinoic acid induced 1 | 0.025929 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0258284 |
| RPL12 | ribosomal protein L12 | 0.0255998 |
| RPS18 | ribosomal protein S18 | 0.0254669 |
| RPL18 | ribosomal protein L18 | 0.0254505 |
| RPL36 | ribosomal protein L36 | 0.0253984 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0251702 |
| GNAS | GNAS complex locus | 0.0246074 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0244941 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0243955 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0236346 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0235447 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0233166 |
| SERINC1 | serine incorporator 1 | 0.0232558 |
| RBM25 | RNA binding motif protein 25 | 0.0226545 |
| COL1A1 | collagen, type I, alpha 1 | 0.0225674 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0215637 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0208004 |
| GLIS3 | GLIS family zinc finger 3 | 0.0206909 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0206063 |
| THBS2 | thrombospondin 2 | 0.0203425 |
| CEP95 | centrosomal protein 95kDa | 0.0199893 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0199348 |
| MLPH | melanophilin | 0.0197153 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0195161 |
| YBX3 | Y box binding protein 3 | 0.0194765 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0192971 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0189349 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0189299 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.018921 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0187948 |
| CD63 | CD63 molecule | 0.0187462 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0187276 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0186959 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0186362 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0184327 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0176595 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.017581 |
| RPL13A | ribosomal protein L13a | 0.0175676 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0175194 |
| RACK1 | receptor for activated C kinase 1 | 0.0174605 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0173505 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0168254 |
| HMGB2 | high mobility group box 2 | 0.0167881 |
| DHFR | dihydrofolate reductase | 0.0167298 |
| RRBP1 | ribosome binding protein 1 | 0.0164252 |
| RPS17 | ribosomal protein S17 | 0.016411 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0161989 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0161551 |
| ATP13A3 | ATPase type 13A3 | 0.0160878 |
| PSG9 | pregnancy specific beta-1-glycoprotein 9 | 0.0157691 |
| RNF149 | ring finger protein 149 | 0.0155823 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0155732 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0155447 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0154886 |
| TMSB10 | thymosin beta 10 | 0.0154518 |
| THOC2 | THO complex 2 | 0.01539 |
| ZNF292 | zinc finger protein 292 | 0.0151674 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0151216 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.452585 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.205313 |
| VIM | vimentin | -0.204676 |
| FN1 | fibronectin 1 | -0.165844 |
| LDHA | lactate dehydrogenase A | -0.112908 |
| CD44 | CD44 molecule (Indian blood group) | -0.0999315 |
| NDRG1 | N-myc downstream regulated 1 | -0.0923939 |
| HDAC9 | histone deacetylase 9 | -0.0903041 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0872052 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0865674 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0756852 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0731053 |
| VEGFA | vascular endothelial growth factor A | -0.0717768 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0693652 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0660968 |
| UBC | ubiquitin C | -0.0649366 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0649088 |
| PLIN2 | perilipin 2 | -0.0643613 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0627526 |
| FTL | ferritin, light polypeptide | -0.0601723 |
| EGR1 | early growth response 1 | -0.0581189 |
| RPS23 | ribosomal protein S23 | -0.0569783 |
| SFTPA2 | surfactant protein A2 | -0.0564377 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0529875 |
| INTS6 | integrator complex subunit 6 | -0.0518947 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.051134 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0503521 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0496295 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0489815 |
| PKM | pyruvate kinase, muscle | -0.0489504 |
| CTSD | cathepsin D | -0.0470455 |
| FNIP1 | folliculin interacting protein 1 | -0.0467084 |
| GPC6 | glypican 6 | -0.0465338 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.046386 |
| ATXN1 | ataxin 1 | -0.0455782 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0452149 |
| B2M | beta-2-microglobulin | -0.0434481 |
| HMGA2 | high mobility group AT-hook 2 | -0.0427682 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0423305 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0422563 |
| CANX | calnexin | -0.0420515 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0419501 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0419128 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0412575 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0410594 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0404703 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0397081 |
| DIAPH2 | diaphanous-related formin 2 | -0.0396322 |
| MORF4L2 | mortality factor 4 like 2 | -0.0391254 |
| ASPH | aspartate beta-hydroxylase | -0.0389408 |
| HMGA1 | high mobility group AT-hook 1 | -0.0388112 |
| RAB7A | RAB7A, member RAS oncogene family | -0.038691 |
| GOLGB1 | golgin B1 | -0.0382935 |
| TAPBP | TAP binding protein (tapasin) | -0.0380825 |
| RPL7A | ribosomal protein L7a | -0.0375823 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0372282 |
| TNS3 | tensin 3 | -0.0364591 |
| ASTN2 | astrotactin 2 | -0.0362201 |
| SQSTM1 | sequestosome 1 | -0.0358088 |
| ACTG1 | actin gamma 1 | -0.0356685 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0356387 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0356343 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0354325 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0353445 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.035169 |
| BPTF | bromodomain PHD finger transcription factor | -0.0351438 |
| TXNIP | thioredoxin interacting protein | -0.0340424 |
| IER3 | immediate early response 3 | -0.0340332 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0336462 |
| RPS25 | ribosomal protein S25 | -0.033624 |
| PCBP2 | poly(rC) binding protein 2 | -0.033222 |
| EGFR | epidermal growth factor receptor | -0.0327277 |
| RND3 | Rho family GTPase 3 | -0.0325984 |
| WASF2 | WAS protein family, member 2 | -0.0324264 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0319664 |
| MSN | moesin | -0.031389 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0310569 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0307395 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0306487 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0304111 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0303765 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0301176 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.030096 |
| ENO1 | enolase 1, (alpha) | -0.029977 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.029867 |
| TPM1 | tropomyosin 1 (alpha) | -0.029857 |
| RPS13 | ribosomal protein S13 | -0.0298115 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0295891 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0295366 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0293167 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0292295 |
| MAGT1 | magnesium transporter 1 | -0.0292166 |
| RPL8 | ribosomal protein L8 | -0.0290505 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0287776 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.028774 |
| HLA-E | major histocompatibility complex, class I, E | -0.0287083 |
| PDE10A | phosphodiesterase 10A | -0.0284689 |
| NAV1 | neuron navigator 1 | -0.0280718 |
| POTEF | POTE ankyrin domain family, member F | -0.0278996 |
| RPLP0 | ribosomal protein, large, P0 | -0.0278842 |
