Dorzolamide (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Dorzolamide (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Dorzolamide (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.322811
FTL ferritin, light polypeptide 0.176
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112588
RPS6 ribosomal protein S6 0.112564
TMSB10 thymosin beta 10 0.0944294
RPS3 ribosomal protein S3 0.0921473
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0889264
GOLGA4 golgin A4 0.0864789
RPS12 ribosomal protein S12 0.0863099
RPL12 ribosomal protein L12 0.0832026
LOC102724023 ES1 protein homolog, mitochondrial 0.0758734
B2M beta-2-microglobulin 0.0755908
RPL35A ribosomal protein L35a 0.0707576
RPL37A ribosomal protein L37a 0.0697624
RPL18 ribosomal protein L18 0.067571
RPLP1 ribosomal protein, large, P1 0.065563
RPS19 ribosomal protein S19 0.0649844
RPS2 ribosomal protein S2 0.0631113
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0622209
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0622039
RPL26 ribosomal protein L26 0.0595007
RPLP2 ribosomal protein, large, P2 0.0545376
PRRC2C proline-rich coiled-coil 2C 0.0542177
DSPP dentin sialophosphoprotein 0.0532718
ESYT2 extended synaptotagmin-like protein 2 0.0515946
RPL31 ribosomal protein L31 0.0509117
SET SET nuclear proto-oncogene 0.0495773
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0489366
EIF1 eukaryotic translation initiation factor 1 0.0486019
KTN1 kinectin 1 (kinesin receptor) 0.0485967
RPS8 ribosomal protein S8 0.0484665
RPS21 ribosomal protein S21 0.0477155
RPL23 ribosomal protein L23 0.0475768
HLA-A major histocompatibility complex, class I, A 0.0472496
MAML2 mastermind-like 2 (Drosophila) 0.0470174
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0460438
RPL37 ribosomal protein L37 0.0458408
TMSB4X thymosin beta 4, X-linked 0.045072
KRT18 keratin 18, type I 0.0445754
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0445279
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0433503
CBX3 chromobox homolog 3 0.0432619
RPS17 ribosomal protein S17 0.0427974
EPCAM epithelial cell adhesion molecule 0.0427008
EZR ezrin 0.042051
RPS13 ribosomal protein S13 0.0417684
TMF1 TATA element modulatory factor 1 0.0415401
PKM pyruvate kinase, muscle 0.0412961
RBM25 RNA binding motif protein 25 0.0410044
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0406463
S100A6 S100 calcium binding protein A6 0.0400675
RPS5 ribosomal protein S5 0.03971
KRT19 keratin 19, type I 0.0389511
ZMYND8 zinc finger, MYND-type containing 8 0.0384426
RACK1 receptor for activated C kinase 1 0.038159
RPS14 ribosomal protein S14 0.0379716
RPL4 ribosomal protein L4 0.0372744
TPM3 tropomyosin 3 0.0371586
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0364818
RPL13A ribosomal protein L13a 0.0364171
RPL36 ribosomal protein L36 0.0363136
RPL19 ribosomal protein L19 0.0361988
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0360795
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0360462
RPL28 ribosomal protein L28 0.0360193
MKI67 marker of proliferation Ki-67 0.0356305
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0356134
EIF5B eukaryotic translation initiation factor 5B 0.0356002
SRRM2 serine/arginine repetitive matrix 2 0.0348651
RPS27A ribosomal protein S27a 0.0345235
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0343766
KIF5B kinesin family member 5B 0.034181
S100A9 S100 calcium binding protein A9 0.0341084
CST3 cystatin C 0.033904
SDK1 sidekick cell adhesion molecule 1 0.0330726
RPL32 ribosomal protein L32 0.0329163
HMGB2 high mobility group box 2 0.0321111
GSTP1 glutathione S-transferase pi 1 0.0319986
FOSL1 FOS-like antigen 1 0.031966
KRT8 keratin 8, type II 0.0318959
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0310438
RPL35 ribosomal protein L35 0.0307821
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0307431
CEMIP cell migration inducing protein, hyaluronan binding 0.0303945
SOX4 SRY (sex determining region Y)-box 4 0.0298706
ENO1 enolase 1, (alpha) 0.029387
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0293245
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0293016
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0291696
RPL30 ribosomal protein L30 0.0291333
RPS4X ribosomal protein S4, X-linked 0.0289816
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0288524
RPL11 ribosomal protein L11 0.0284817
RPS27 ribosomal protein S27 0.0284542
ATP5F1E ATP synthase F1 subunit epsilon 0.0282865
PNN pinin, desmosome associated protein 0.0282051
GNAS GNAS complex locus 0.0281969
CENPF centromere protein F, 350/400kDa 0.0281581
XPO1 exportin 1 0.0280924
RBM39 RNA binding motif protein 39 0.0280662

decreased expression

Symbol Name Standardized Value
NCEH1 neutral cholesterol ester hydrolase 1 -0.0797255
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0529669
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0491588
RHEB Ras homolog enriched in brain -0.0457967
VCL vinculin -0.0386219
ACTN4 actinin, alpha 4 -0.0367752
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0331178
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0312698
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0308911
BCL2L1 BCL2-like 1 -0.0284003
UBE2H ubiquitin-conjugating enzyme E2H -0.0270978
SNX9 sorting nexin 9 -0.0254469
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0242202
FAM3C family with sequence similarity 3, member C -0.0241113
NCOA3 nuclear receptor coactivator 3 -0.0236944
IARS1 isoleucyl-tRNA synthetase 1 -0.0231249
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0228191
CTBP2 C-terminal binding protein 2 -0.0227287
TGFA transforming growth factor, alpha -0.0216004
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0212951
NEBL nebulette -0.0206326
ECT2 epithelial cell transforming 2 -0.02062
PLSCR1 phospholipid scramblase 1 -0.0196928
TES testin LIM domain protein -0.019604
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0195027
PTPRK protein tyrosine phosphatase, receptor type, K -0.0193391
SMAD2 SMAD family member 2 -0.0193328
PUM2 pumilio RNA-binding family member 2 -0.0192183
ARHGAP42 Rho GTPase activating protein 42 -0.0188644
EIF3H eukaryotic translation initiation factor 3, subunit H -0.018764
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0185216
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0182994
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0180594
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0179742
VMP1 vacuole membrane protein 1 -0.0178087
FHL2 four and a half LIM domains 2 -0.0175342
TOP1 topoisomerase (DNA) I -0.0174746
PICALM phosphatidylinositol binding clathrin assembly protein -0.0174582
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0173929
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0169901
OXSR1 oxidative stress responsive 1 -0.0169683
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0166436
ANKRD28 ankyrin repeat domain 28 -0.0166359
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0158042
PARD6B par-6 family cell polarity regulator beta -0.0157402
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0157276
CSNK1A1 casein kinase 1, alpha 1 -0.0155543
ZFAND6 zinc finger, AN1-type domain 6 -0.0154996
SIK3 SIK family kinase 3 -0.0150766
RYBP RING1 and YY1 binding protein -0.015017
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0148116
ARHGAP12 Rho GTPase activating protein 12 -0.014733
MYO1E myosin IE -0.0147083
ANKRD11 ankyrin repeat domain 11 -0.0146233
HBP1 HMG-box transcription factor 1 -0.0144249
DLC1 DLC1 Rho GTPase activating protein -0.0142337
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0140149
IFRD1 interferon-related developmental regulator 1 -0.0138123
TJP1 tight junction protein 1 -0.0137374
RALY RALY heterogeneous nuclear ribonucleoprotein -0.013721
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0136845
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0134785
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0134026
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0131901
EWSR1 EWS RNA-binding protein 1 -0.0131539
CADPS Ca++-dependent secretion activator -0.0128517
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0125894
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0123009
CARS1 cysteinyl-tRNA synthetase 1 -0.012188
TRIB1 tribbles pseudokinase 1 -0.0121699
NUP98 nucleoporin 98kDa -0.0121506
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0119565
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0119333
FNDC3A fibronectin type III domain containing 3A -0.0118835
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0117472
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0116824
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0116399
RCOR1 REST corepressor 1 -0.011595
USP3 ubiquitin specific peptidase 3 -0.0115651
CFAP73 cilia and flagella associated protein 73 -0.0115079
ANKRD17 ankyrin repeat domain 17 -0.0115009
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0113889
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.011376
USP6NL USP6 N-terminal like -0.0113711
CDK13 cyclin-dependent kinase 13 -0.0113487
STAU1 staufen double-stranded RNA binding protein 1 -0.0112955
OLA1 Obg-like ATPase 1 -0.011254
AGO2 argonaute RISC catalytic component 2 -0.0112293
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -0.0111375
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0110588
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0109906
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0109635
RAB1B RAB1B, member RAS oncogene family -0.0109275
RAD21 RAD21 homolog (S. pombe) -0.0108536
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.01083
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0107991
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.010797
ANXA2 annexin A2 -0.0106956
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0106629
PMM2 phosphomannomutase 2 -0.0104641