| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.0933556 |
| RPS2 | ribosomal protein S2 | 0.0710242 |
| EGR1 | early growth response 1 | 0.0602347 |
| RPS12 | ribosomal protein S12 | 0.0563563 |
| RPL26 | ribosomal protein L26 | 0.0539978 |
| RPL37A | ribosomal protein L37a | 0.0487446 |
| RPS3 | ribosomal protein S3 | 0.0484097 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0453999 |
| RPL35A | ribosomal protein L35a | 0.0435439 |
| HMGA2 | high mobility group AT-hook 2 | 0.0415125 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0397064 |
| EZR | ezrin | 0.0386798 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0386718 |
| RPS18 | ribosomal protein S18 | 0.0376271 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0343206 |
| RACK1 | receptor for activated C kinase 1 | 0.0323697 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0323097 |
| RPS17 | ribosomal protein S17 | 0.0302314 |
| FLOT1 | flotillin 1 | 0.0291031 |
| FHIT | fragile histidine triad | 0.0281194 |
| MT2A | metallothionein 2A | 0.0280415 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0268898 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0267735 |
| RPS15A | ribosomal protein S15a | 0.0266967 |
| LAMC2 | laminin, gamma 2 | 0.0261003 |
| RPL37 | ribosomal protein L37 | 0.0253375 |
| SET | SET nuclear proto-oncogene | 0.0248288 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0229586 |
| RPS27 | ribosomal protein S27 | 0.0229033 |
| DUSP4 | dual specificity phosphatase 4 | 0.0228641 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.022176 |
| LAMA4 | laminin, alpha 4 | 0.021963 |
| VIM | vimentin | 0.0217363 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0216608 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0215246 |
| RPL5 | ribosomal protein L5 | 0.0213738 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.020958 |
| RPS14 | ribosomal protein S14 | 0.0204111 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0203989 |
| RPS8 | ribosomal protein S8 | 0.0203009 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0201416 |
| DST | dystonin | 0.0195804 |
| SEPTIN9 | septin 9 | 0.019413 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0193478 |
| CBX3 | chromobox homolog 3 | 0.0189463 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0186172 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0181697 |
| RPS27A | ribosomal protein S27a | 0.0180333 |
| TMF1 | TATA element modulatory factor 1 | 0.0179552 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0172167 |
| HLA-B | major histocompatibility complex, class I, B | 0.0170497 |
| RPL18 | ribosomal protein L18 | 0.0169267 |
| CALR | calreticulin | 0.0166763 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.016498 |
| NONO | non-POU domain containing, octamer-binding | 0.0164709 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0164651 |
| FLNB | filamin B, beta | 0.0157815 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.015118 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0150135 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0149747 |
| GOLGA3 | golgin A3 | 0.0148779 |
| ITGB4 | integrin, beta 4 | 0.0146444 |
| EXOC4 | exocyst complex component 4 | 0.0146251 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0145479 |
| HLA-A | major histocompatibility complex, class I, A | 0.0145358 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0144927 |
| RPL35 | ribosomal protein L35 | 0.0144711 |
| S100A6 | S100 calcium binding protein A6 | 0.0143972 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0143328 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0142807 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0138763 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0138346 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0137478 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0135317 |
| FUS | FUS RNA binding protein | 0.0134988 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.013496 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0133849 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0133788 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0132276 |
| RNF213 | ring finger protein 213 | 0.0131901 |
| BMP4 | bone morphogenetic protein 4 | 0.0130892 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0130258 |
| MYO6 | myosin VI | 0.0130184 |
| RPL36 | ribosomal protein L36 | 0.0129819 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0129494 |
| RPS29 | ribosomal protein S29 | 0.0128429 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0128088 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0127484 |
| NOM1 | nucleolar protein with MIF4G domain 1 | 0.0126774 |
| DKC1 | dyskeratosis congenita 1, dyskerin | 0.0126578 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0125732 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 | 0.0125611 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.0124989 |
| TRIP11 | thyroid hormone receptor interactor 11 | 0.0124868 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0124182 |
| ITSN2 | intersectin 2 | 0.0124009 |
| RCC1 | regulator of chromosome condensation 1 | 0.0123834 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0123592 |
| GLCCI1 | glucocorticoid induced 1 | 0.0123563 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0123081 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.341647 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.231934 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.16692 |
| IER3 | immediate early response 3 | -0.109448 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0965765 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0956633 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0914292 |
| LDHA | lactate dehydrogenase A | -0.0795837 |
| PTMA | prothymosin, alpha | -0.0706219 |
| OXR1 | oxidation resistance 1 | -0.0649752 |
| UBC | ubiquitin C | -0.0645249 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0627032 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0626751 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.061192 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0610707 |
| TMSB10 | thymosin beta 10 | -0.0598518 |
| GDF15 | growth differentiation factor 15 | -0.0559276 |
| ANXA2 | annexin A2 | -0.0550751 |
| ANXA1 | annexin A1 | -0.0550106 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0532794 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.052457 |
| PARD3 | par-3 family cell polarity regulator | -0.0521063 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0503033 |
| RPS24 | ribosomal protein S24 | -0.0499312 |
| AHNAK | AHNAK nucleoprotein | -0.0490889 |
| RPLP0 | ribosomal protein, large, P0 | -0.0476127 |
| RPS23 | ribosomal protein S23 | -0.0454263 |
| RLF | rearranged L-myc fusion | -0.0454115 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0441479 |
| SLMAP | sarcolemma associated protein | -0.0436029 |
| CANX | calnexin | -0.0433321 |
| NDRG1 | N-myc downstream regulated 1 | -0.0432195 |
| USP3 | ubiquitin specific peptidase 3 | -0.043106 |
| S100A10 | S100 calcium binding protein A10 | -0.0421311 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0415326 |
| GOLGA4 | golgin A4 | -0.0407881 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0405402 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0403268 |
| SERINC5 | serine incorporator 5 | -0.0398813 |
| GLG1 | golgi glycoprotein 1 | -0.0371487 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0366515 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0360874 |
| TXNIP | thioredoxin interacting protein | -0.0358273 |
| TAOK1 | TAO kinase 1 | -0.0354932 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0352436 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0346431 |
| AK1 | adenylate kinase 1 | -0.0342681 |
| RREB1 | ras responsive element binding protein 1 | -0.034184 |
| CLTC | clathrin, heavy chain (Hc) | -0.0339595 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.033748 |
| GNAT3 | guanine nucleotide binding protein, alpha transducing 3 | -0.0337436 |
| RPL8 | ribosomal protein L8 | -0.033708 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0333868 |
| EGFR | epidermal growth factor receptor | -0.0331987 |
| COG5 | component of oligomeric golgi complex 5 | -0.0331683 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0328609 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0326618 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0325017 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0322753 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.032199 |
| HMGA1 | high mobility group AT-hook 1 | -0.0320878 |
| MYO5B | myosin VB | -0.032005 |
| NEK7 | NIMA-related kinase 7 | -0.0318474 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0317188 |
| MT1X | metallothionein 1X | -0.0313615 |
| TNPO1 | transportin 1 | -0.0312243 |
| YY1 | YY1 transcription factor | -0.0310446 |
| NF1 | neurofibromin 1 | -0.0306325 |
| ECT2 | epithelial cell transforming 2 | -0.0304936 |
| ACTN4 | actinin, alpha 4 | -0.0304479 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0304236 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0303201 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0301786 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0301161 |
| DSG2 | desmoglein 2 | -0.029997 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0297062 |
| DEK | DEK proto-oncogene | -0.0294404 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0294228 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0290637 |
| TFRC | transferrin receptor | -0.0290612 |
| CALU | calumenin | -0.0289038 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0286875 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0285658 |
| SETD5 | SET domain containing 5 | -0.0283775 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0283303 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.028264 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0282366 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0282144 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0280228 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0277295 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0275503 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0274386 |
| NBAS | neuroblastoma amplified sequence | -0.0274115 |
| RPL19 | ribosomal protein L19 | -0.0273728 |
| BBX | bobby sox homolog (Drosophila) | -0.0273243 |
| ZNF292 | zinc finger protein 292 | -0.0271812 |
| YME1L1 | YME1-like 1 ATPase | -0.0271806 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0268294 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0267603 |
| RPS11 | ribosomal protein S11 | -0.0267009 |
