| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Dorzolamide (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL4 | ribosomal protein L4 | 0.134746 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0908179 |
| RPS12 | ribosomal protein S12 | 0.0683017 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0586672 |
| RPS27A | ribosomal protein S27a | 0.0577957 |
| ENO1 | enolase 1, (alpha) | 0.0565096 |
| RPS2 | ribosomal protein S2 | 0.0560857 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0541524 |
| RPS3 | ribosomal protein S3 | 0.0523784 |
| RBM39 | RNA binding motif protein 39 | 0.0510031 |
| RPL26 | ribosomal protein L26 | 0.0494747 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0462102 |
| SET | SET nuclear proto-oncogene | 0.0456948 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0450476 |
| RPS18 | ribosomal protein S18 | 0.0438811 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0438739 |
| OGA | O-GlcNAcase | 0.0395089 |
| HMGB2 | high mobility group box 2 | 0.0390593 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 0.038293 |
| LMO7 | LIM domain 7 | 0.0378826 |
| UBC | ubiquitin C | 0.0370649 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0365257 |
| ANLN | anillin, actin binding protein | 0.0357398 |
| RPL37A | ribosomal protein L37a | 0.0353303 |
| MKI67 | marker of proliferation Ki-67 | 0.0350227 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0342646 |
| NONO | non-POU domain containing, octamer-binding | 0.0341389 |
| DSPP | dentin sialophosphoprotein | 0.0339882 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0339826 |
| RPL5 | ribosomal protein L5 | 0.0331107 |
| RPL14 | ribosomal protein L14 | 0.0329995 |
| PLEC | plectin | 0.0326433 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0308578 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0300305 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0294453 |
| JUN | jun proto-oncogene | 0.0292301 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0280526 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0280287 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0272724 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0272374 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0265318 |
| TPM3 | tropomyosin 3 | 0.0264998 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0254268 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0253162 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0251789 |
| HDAC4 | histone deacetylase 4 | 0.0243511 |
| RPS15A | ribosomal protein S15a | 0.0242778 |
| RBM25 | RNA binding motif protein 25 | 0.0237582 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0235126 |
| VGLL4 | vestigial-like family member 4 | 0.023262 |
| RPS17 | ribosomal protein S17 | 0.0231739 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0228348 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0227434 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0227429 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.022261 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0220112 |
| SMAD3 | SMAD family member 3 | 0.0217876 |
| ANO6 | anoctamin 6 | 0.0214262 |
| HSPA8 | heat shock 70kDa protein 8 | 0.021146 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0211435 |
| ARGLU1 | arginine and glutamate rich 1 | 0.021136 |
| TLN1 | talin 1 | 0.0209901 |
| H1-4 | H1.4 linker histone, cluster member | 0.0209308 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0209045 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0205359 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.020148 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0198141 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0194284 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0188994 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0187011 |
| EZR | ezrin | 0.0186153 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0183011 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0181638 |
| SERINC1 | serine incorporator 1 | 0.0181326 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0180479 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0179414 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0175371 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0170946 |
| HLA-A | major histocompatibility complex, class I, A | 0.0169804 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0168534 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | 0.0168425 |
| PLPP3 | phospholipid phosphatase 3 | 0.0168016 |
| RPL3 | ribosomal protein L3 | 0.0168008 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0167061 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0164222 |
| LAMB3 | laminin, beta 3 | 0.0158311 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0157262 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0156262 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0154798 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0154492 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0152519 |
| CEP250 | centrosomal protein 250kDa | 0.0152098 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0152094 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.0152092 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0151583 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0151423 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0150755 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0150668 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0150471 |
| RPL9 | ribosomal protein L9 | 0.0148516 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.306807 |
| CDH13 | cadherin 13 | -0.103604 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0953714 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0947869 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0917422 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0899612 |
| CDK6 | cyclin-dependent kinase 6 | -0.0858298 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.077732 |
| ANXA2 | annexin A2 | -0.0705625 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0671922 |
| HMGA1 | high mobility group AT-hook 1 | -0.0670733 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0655803 |
| KRT18 | keratin 18, type I | -0.0636706 |
| LDHA | lactate dehydrogenase A | -0.0633235 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0629496 |
| CCND1 | cyclin D1 | -0.0628263 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0587932 |
| NDRG1 | N-myc downstream regulated 1 | -0.0542161 |
| POTEF | POTE ankyrin domain family, member F | -0.0536841 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0533032 |
| ETNK1 | ethanolamine kinase 1 | -0.052307 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.052184 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0516888 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.051304 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0503616 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0499367 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0498832 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0491082 |
| ACTG1 | actin gamma 1 | -0.0489122 |
| TMEM123 | transmembrane protein 123 | -0.0484562 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0480353 |
| VCL | vinculin | -0.0476501 |
| RPLP0 | ribosomal protein, large, P0 | -0.0472745 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0466326 |
| TPM4 | tropomyosin 4 | -0.0463104 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0459349 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0457462 |
| RPL35A | ribosomal protein L35a | -0.0447117 |
| PGK1 | phosphoglycerate kinase 1 | -0.0446289 |
| PFN1 | profilin 1 | -0.0444259 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0421435 |
| ITGA6 | integrin, alpha 6 | -0.041408 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0408412 |
| FTL | ferritin, light polypeptide | -0.0408231 |
| RPS24 | ribosomal protein S24 | -0.0404325 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0397687 |
| S100A10 | S100 calcium binding protein A10 | -0.0389565 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0386535 |
| TUBA1B | tubulin, alpha 1b | -0.0382486 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0377662 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.037289 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0372394 |
| JMJD1C | jumonji domain containing 1C | -0.0368177 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0367449 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0365607 |
| TMSB10 | thymosin beta 10 | -0.0364231 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0363815 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0362465 |
| ARF4 | ADP-ribosylation factor 4 | -0.036196 |
| RBMX | RNA binding motif protein, X-linked | -0.035993 |
| SYT1 | synaptotagmin I | -0.0356159 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0355291 |
| GLG1 | golgi glycoprotein 1 | -0.0353593 |
| OXR1 | oxidation resistance 1 | -0.0350945 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0346282 |
| RPL27A | ribosomal protein L27a | -0.0344804 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.034073 |
| WASF2 | WAS protein family, member 2 | -0.033912 |
| SETD5 | SET domain containing 5 | -0.0338046 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0337658 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0337492 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0333479 |
| CANX | calnexin | -0.0330259 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.032842 |
| KRT8 | keratin 8, type II | -0.0328052 |
| TNIK | TRAF2 and NCK interacting kinase | -0.032714 |
| RPS23 | ribosomal protein S23 | -0.0326422 |
| EXOC4 | exocyst complex component 4 | -0.0321813 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.03204 |
| RPS25 | ribosomal protein S25 | -0.0318934 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0317413 |
| DSTN | destrin (actin depolymerizing factor) | -0.0315362 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0313533 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0313007 |
| PERP | PERP, TP53 apoptosis effector | -0.031276 |
| COG5 | component of oligomeric golgi complex 5 | -0.0312391 |
| ABLIM1 | actin binding LIM protein 1 | -0.0311705 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0310175 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0308246 |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor | -0.0306263 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0299763 |
| BPTF | bromodomain PHD finger transcription factor | -0.0299716 |
| MORF4L2 | mortality factor 4 like 2 | -0.0296772 |
| NAV2 | neuron navigator 2 | -0.0296539 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0296468 |
| INTS6 | integrator complex subunit 6 | -0.0296163 |
| ATXN1 | ataxin 1 | -0.0293076 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.029245 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0290282 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0288877 |
