| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Dorzolamide (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Dorzolamide (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | 0.0882028 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0762617 |
| CD44 | CD44 molecule (Indian blood group) | 0.0735204 |
| ATP13A3 | ATPase type 13A3 | 0.0732029 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0717867 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0685449 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0684312 |
| INHBA | inhibin, beta A | 0.0664752 |
| FAM13A | family with sequence similarity 13, member A | 0.0625903 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0608259 |
| SPAG9 | sperm associated antigen 9 | 0.0593572 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.053445 |
| VIM | vimentin | 0.0534138 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0475611 |
| PDE8A | phosphodiesterase 8A | 0.0469272 |
| SMAD3 | SMAD family member 3 | 0.0437613 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0414971 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0402499 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0376153 |
| PLPP3 | phospholipid phosphatase 3 | 0.037231 |
| RNF145 | ring finger protein 145 | 0.0371148 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0368037 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0357621 |
| FNDC3B | fibronectin type III domain containing 3B | 0.035406 |
| SETD5 | SET domain containing 5 | 0.0346513 |
| CDK17 | cyclin-dependent kinase 17 | 0.0336799 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0334469 |
| SMOX | spermine oxidase | 0.0326043 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0325745 |
| NUP58 | nucleoporin 58 | 0.031635 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0311681 |
| RUNX1 | runt-related transcription factor 1 | 0.0309811 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0305253 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0297438 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0295523 |
| COL5A3 | collagen, type V, alpha 3 | 0.0294041 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0292792 |
| TNPO1 | transportin 1 | 0.0288732 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0287084 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0281337 |
| YBX3 | Y box binding protein 3 | 0.027897 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0278852 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0269203 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.025831 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0253637 |
| ANXA5 | annexin A5 | 0.0252108 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0250391 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0249639 |
| AXL | AXL receptor tyrosine kinase | 0.0248905 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0248612 |
| RAB6A | RAB6A, member RAS oncogene family | 0.024829 |
| OSMR | oncostatin M receptor | 0.0248143 |
| TFG | TRK-fused gene | 0.0247124 |
| CDC27 | cell division cycle 27 | 0.0246883 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0246438 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0244884 |
| COPA | coatomer protein complex, subunit alpha | 0.0239729 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0236836 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0236584 |
| LOXL2 | lysyl oxidase-like 2 | 0.0233335 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0233246 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0232706 |
| CENPF | centromere protein F, 350/400kDa | 0.0227223 |
| TOP1 | topoisomerase (DNA) I | 0.0220397 |
| ETV3 | ets variant 3 | 0.0220165 |
| SUCO | SUN domain containing ossification factor | 0.0219176 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0217328 |
| USP3 | ubiquitin specific peptidase 3 | 0.021717 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0216063 |
| SNX9 | sorting nexin 9 | 0.0214626 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0214392 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0214066 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0213568 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0208452 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.020791 |
| MEIS1 | Meis homeobox 1 | 0.020732 |
| CDK19 | cyclin-dependent kinase 19 | 0.0206395 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0206385 |
| TUBB6 | tubulin, beta 6 class V | 0.0203081 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0202727 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0198835 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0198533 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0197657 |
| WDR26 | WD repeat domain 26 | 0.0196175 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0196095 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0195633 |
| DSE | dermatan sulfate epimerase | 0.0195559 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0194638 |
| RPL4 | ribosomal protein L4 | 0.0194281 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0193183 |
| ANLN | anillin, actin binding protein | 0.0192616 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0192482 |
| SP3 | Sp3 transcription factor | 0.0191827 |
| CCNL1 | cyclin L1 | 0.0191568 |
| SYAP1 | synapse associated protein 1 | 0.0191221 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0189965 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0189853 |
| RHOQ | ras homolog family member Q | 0.0188191 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0187424 |
| CLTC | clathrin, heavy chain (Hc) | 0.0187408 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.245293 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.219154 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.218253 |
| HMGA2 | high mobility group AT-hook 2 | -0.180873 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.158993 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.153557 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.138696 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.124934 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.109878 |
| ASPH | aspartate beta-hydroxylase | -0.109355 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.07171 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0711494 |
| TMSB10 | thymosin beta 10 | -0.0692048 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0672479 |
| AHNAK | AHNAK nucleoprotein | -0.0670969 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0614948 |
| VCL | vinculin | -0.0606991 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0587847 |
| MMP1 | matrix metallopeptidase 1 | -0.058693 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0577107 |
| INTS6 | integrator complex subunit 6 | -0.0574048 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0571024 |
| FBN1 | fibrillin 1 | -0.0549757 |
| FRMD4A | FERM domain containing 4A | -0.05458 |
| GLIS3 | GLIS family zinc finger 3 | -0.0542657 |
| CDH13 | cadherin 13 | -0.0507502 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0500303 |
| PRELID2 | PRELI domain containing 2 | -0.0492767 |
| RPL37A | ribosomal protein L37a | -0.0489679 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0487702 |
| RAI14 | retinoic acid induced 14 | -0.0466684 |
| NDRG1 | N-myc downstream regulated 1 | -0.0459541 |
| ACTG1 | actin gamma 1 | -0.0458358 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0454128 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0452272 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0449114 |
| NAV1 | neuron navigator 1 | -0.0445001 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0438292 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0423809 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0415864 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0414166 |
| DGKI | diacylglycerol kinase, iota | -0.0409631 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0405983 |
| OXR1 | oxidation resistance 1 | -0.0405606 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0403198 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.039933 |
| NCKAP5 | NCK-associated protein 5 | -0.0396857 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0396365 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0394361 |
| FTL | ferritin, light polypeptide | -0.0383491 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0378857 |
| RPL26 | ribosomal protein L26 | -0.0377126 |
| DIAPH2 | diaphanous-related formin 2 | -0.0374434 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0370411 |
| TTC23L | tetratricopeptide repeat domain 23-like | -0.0367578 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.0362361 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0355539 |
| HLA-B | major histocompatibility complex, class I, B | -0.0350118 |
| CANX | calnexin | -0.0346291 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0344866 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0340831 |
| HDAC9 | histone deacetylase 9 | -0.0340781 |
| DST | dystonin | -0.0338814 |
| COL5A1 | collagen, type V, alpha 1 | -0.0336581 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0331558 |
| RPL31 | ribosomal protein L31 | -0.0331397 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0329893 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0327919 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0324415 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0320953 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0317916 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0315215 |
| RPS6 | ribosomal protein S6 | -0.0314786 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0310922 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0309451 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0304977 |
| AEBP2 | AE binding protein 2 | -0.0303218 |
| RPL34 | ribosomal protein L34 | -0.0302253 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.030123 |
| CUX1 | cut-like homeobox 1 | -0.0298601 |
| RPS3 | ribosomal protein S3 | -0.029857 |
| NABP1 | nucleic acid binding protein 1 | -0.0294988 |
| RAD51B | RAD51 paralog B | -0.0294375 |
| RPL12 | ribosomal protein L12 | -0.0293891 |
| IPO9 | importin 9 | -0.0292836 |
| MYO1E | myosin IE | -0.0289999 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0287752 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0287177 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0286312 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0283976 |
| RPL23 | ribosomal protein L23 | -0.0278622 |
| RPS8 | ribosomal protein S8 | -0.027699 |
| RACK1 | receptor for activated C kinase 1 | -0.0269368 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0268083 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0267668 |
| TMEM165 | transmembrane protein 165 | -0.026714 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0265462 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0265325 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0264188 |
| RPL9 | ribosomal protein L9 | -0.025788 |
