| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension. (Chemical Entities of Biological Interest Ontology, CHEBI_4702) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5284549 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Dorzolamide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC57 | coiled-coil domain containing 57 | 1.38 |
| SPAG17 | sperm associated antigen 17 | 1.02 |
| THAP9 | THAP domain containing 9 | 1.01 |
| TMEM222 | transmembrane protein 222 | 0.79 |
| NEB | nebulin | 0.71 |
| ENO1 | enolase 1, (alpha) | 0.68 |
| MOCOS | molybdenum cofactor sulfurase | 0.66 |
| RNF111 | ring finger protein 111 | 0.66 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.64 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.6 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.58 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.54 |
| E2F2 | E2F transcription factor 2 | 0.53 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.52 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.46 |
| SERF2 | small EDRK-rich factor 2 | 0.42 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.41 |
| TBC1D32 | TBC1 domain family, member 32 | 0.41 |
| ZG16B | zymogen granule protein 16B | 0.41 |
| AEBP2 | AE binding protein 2 | 0.4 |
| GSE1 | Gse1 coiled-coil protein | 0.39 |
| RAET1G | retinoic acid early transcript 1G | 0.39 |
| SPHK2 | sphingosine kinase 2 | 0.36 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | 0.36 |
| ANKRD24 | ankyrin repeat domain 24 | 0.36 |
| MROH6 | maestro heat-like repeat family member 6 | 0.34 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.33 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.33 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | 0.33 |
| RAB36 | RAB36, member RAS oncogene family | 0.33 |
| SPATA2 | spermatogenesis associated 2 | 0.33 |
| MKS1 | Meckel syndrome, type 1 | 0.32 |
| FAM189B | family with sequence similarity 189, member B | 0.32 |
| TRIM9 | tripartite motif containing 9 | 0.32 |
| WTIP | Wilms tumor 1 interacting protein | 0.32 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.32 |
| ABRACL | ABRA C-terminal like | 0.31 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | 0.31 |
| OTUD7A | OTU deubiquitinase 7A | 0.31 |
| B2M | beta-2-microglobulin | 0.31 |
| RTN2 | reticulon 2 | 0.3 |
| ZNF691 | zinc finger protein 691 | 0.3 |
| TPM4 | tropomyosin 4 | 0.3 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | 0.3 |
| TPM2 | tropomyosin 2 (beta) | 0.29 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | 0.29 |
| FJX1 | four jointed box 1 (Drosophila) | 0.29 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | 0.29 |
| C19ORF44 | chromosome 19 open reading frame 44 | 0.29 |
| CEP112 | centrosomal protein 112kDa | 0.29 |
| KIFC3 | kinesin family member C3 | 0.29 |
| NAGS | N-acetylglutamate synthase | 0.29 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.28 |
| TRERF1 | transcriptional regulating factor 1 | 0.28 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.28 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 0.27 |
| DUSP7 | dual specificity phosphatase 7 | 0.27 |
| ZNF814 | zinc finger protein 814 | 0.27 |
| PPP1R2B | PPP1R2 family member B | 0.27 |
| ZKSCAN3 | zinc finger with KRAB and SCAN domains 3 | 0.26 |
| SOX7 | SRY (sex determining region Y)-box 7 | 0.26 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.26 |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | 0.26 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.26 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.26 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.25 |
| TMEM67 | transmembrane protein 67 | 0.25 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.25 |
| FANCM | Fanconi anemia, complementation group M | 0.25 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.25 |
| KIAA0556 | KIAA0556 | 0.25 |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | 0.24 |
| S100PBP | S100P binding protein | 0.24 |
| ATP6V1E2 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 | 0.24 |
| TTC13 | tetratricopeptide repeat domain 13 | 0.24 |
| ICOSLG | inducible T-cell co-stimulator ligand | 0.24 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.24 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.24 |
| FBXW4 | F-box and WD repeat domain containing 4 | 0.24 |
| TMEM102 | transmembrane protein 102 | 0.24 |
| TTC31 | tetratricopeptide repeat domain 31 | 0.24 |
| TMEM39A | transmembrane protein 39A | 0.24 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.23 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.23 |
| MEGF6 | multiple EGF-like-domains 6 | 0.23 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.23 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | 0.23 |
| ZNF675 | zinc finger protein 675 | 0.23 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.23 |
| PPP1R12C | protein phosphatase 1, regulatory subunit 12C | 0.23 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.23 |
| TTC21B | tetratricopeptide repeat domain 21B | 0.23 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.23 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.23 |
| ZNF692 | zinc finger protein 692 | 0.23 |
| MIEF1 | mitochondrial elongation factor 1 | 0.23 |
| ZNF107 | zinc finger protein 107 | 0.23 |
| HYLS1 | hydrolethalus syndrome 1 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -0.88 |
| CLSTN3 | calsyntenin 3 | -0.61 |
| MYH15 | myosin, heavy chain 15 | -0.59 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.57 |
| KCTD21 | potassium channel tetramerization domain containing 21 | -0.55 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.55 |
| GPATCH3 | G patch domain containing 3 | -0.54 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.54 |
| ZNF714 | zinc finger protein 714 | -0.54 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.54 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.52 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.52 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | -0.51 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.51 |
| TRIM35 | tripartite motif containing 35 | -0.49 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.49 |
| PAH | phenylalanine hydroxylase | -0.44 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.44 |
| ANKRD36 | ankyrin repeat domain 36 | -0.43 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 | -0.43 |
| PRR5 | proline rich 5 (renal) | -0.42 |
| PITX2 | paired-like homeodomain 2 | -0.41 |
| C11ORF49 | chromosome 11 open reading frame 49 | -0.41 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.4 |
| TESK1 | testis-specific kinase 1 | -0.4 |
| PLXND1 | plexin D1 | -0.4 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | -0.39 |
| SNX33 | sorting nexin 33 | -0.38 |
| SULF2 | sulfatase 2 | -0.38 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -0.38 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.38 |
| TLR3 | toll-like receptor 3 | -0.36 |
| TRIM68 | tripartite motif containing 68 | -0.35 |
| CBX7 | chromobox homolog 7 | -0.35 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.35 |
| ZNF101 | zinc finger protein 101 | -0.35 |
| TMC4 | transmembrane channel-like 4 | -0.34 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.34 |
| ZC4H2 | zinc finger, C4H2 domain containing | -0.34 |
| MAGEA2 | melanoma antigen family A2 | -0.34 |
| AKTIP | AKT interacting protein | -0.33 |
| GLI2 | GLI family zinc finger 2 | -0.32 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | -0.32 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | -0.32 |
| SH2D3A | SH2 domain containing 3A | -0.32 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.31 |
| PUM2 | pumilio RNA-binding family member 2 | -0.31 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.31 |
| ZNF124 | zinc finger protein 124 | -0.31 |
| MGLL | monoglyceride lipase | -0.31 |
| JAG1 | jagged 1 | -0.3 |
| JOSD1 | Josephin domain containing 1 | -0.3 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.3 |
| DNM1 | dynamin 1 | -0.3 |
| KCTD6 | potassium channel tetramerization domain containing 6 | -0.29 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.29 |
| PHF1 | PHD finger protein 1 | -0.29 |
| FN1 | fibronectin 1 | -0.29 |
| USP53 | ubiquitin specific peptidase 53 | -0.29 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -0.29 |
| H1-5 | H1.5 linker histone, cluster member | -0.28 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.28 |
| ZXDC | ZXD family zinc finger C | -0.28 |
| ZNF669 | zinc finger protein 669 | -0.28 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.27 |
| ANKRD39 | ankyrin repeat domain 39 | -0.27 |
| CCDC73 | coiled-coil domain containing 73 | -0.27 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -0.27 |
| PPP1R16A | protein phosphatase 1, regulatory subunit 16A | -0.27 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | -0.27 |
| SH2B3 | SH2B adaptor protein 3 | -0.27 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.27 |
| CD81 | CD81 molecule | -0.27 |
| BCO2 | beta-carotene oxygenase 2 | -0.26 |
| ZNF775 | zinc finger protein 775 | -0.26 |
| FANCL | Fanconi anemia, complementation group L | -0.26 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.26 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | -0.26 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.26 |
| MED28 | mediator complex subunit 28 | -0.26 |
| SS18 | synovial sarcoma translocation, chromosome 18 | -0.26 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.26 |
| TCHP | trichoplein, keratin filament binding | -0.26 |
| CTSA | cathepsin A | -0.25 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.25 |
| FLNB | filamin B, beta | -0.25 |
| ZXDB | zinc finger, X-linked, duplicated B | -0.25 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | -0.25 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | -0.25 |
| SMO | smoothened, frizzled class receptor | -0.25 |
| CLU | clusterin | -0.25 |
| ERCC8 | excision repair cross-complementation group 8 | -0.24 |
| KLHL23 | kelch-like family member 23 | -0.24 |
| CDK14 | cyclin-dependent kinase 14 | -0.24 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | -0.24 |
| LMX1B | LIM homeobox transcription factor 1, beta | -0.24 |
| GLMP | glycosylated lysosomal membrane protein | -0.24 |
| EMC10 | ER membrane protein complex subunit 10 | -0.24 |
| CD63 | CD63 molecule | -0.24 |
