| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.311063 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.158245 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0889529 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0850798 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.071618 |
| FLNA | filamin A, alpha | 0.0510579 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0493671 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0486548 |
| POTEF | POTE ankyrin domain family, member F | 0.0389492 |
| NDRG1 | N-myc downstream regulated 1 | 0.0385622 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0382028 |
| LOXL2 | lysyl oxidase-like 2 | 0.0380583 |
| EPHA4 | EPH receptor A4 | 0.0353676 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0317318 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0308411 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0300464 |
| PLAT | plasminogen activator, tissue | 0.0291515 |
| SQSTM1 | sequestosome 1 | 0.0290799 |
| CD109 | CD109 molecule | 0.0289883 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0289617 |
| FAM107B | family with sequence similarity 107, member B | 0.0283793 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0264335 |
| PKM | pyruvate kinase, muscle | 0.0253958 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0253602 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0246215 |
| ANXA4 | annexin A4 | 0.0243778 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.024339 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0241399 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0241123 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0238446 |
| CTSB | cathepsin B | 0.0230648 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.0230601 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0230179 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0229243 |
| PCBP2 | poly(rC) binding protein 2 | 0.0227295 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0220907 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0220749 |
| HIP1 | huntingtin interacting protein 1 | 0.0213163 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0212318 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0208721 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0208541 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0203561 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0201455 |
| SEPTIN9 | septin 9 | 0.0199394 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0194343 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0192843 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0192838 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0190686 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0189234 |
| GPHN | gephyrin | 0.0187358 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0185115 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0184958 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0184269 |
| STC1 | stanniocalcin 1 | 0.0182549 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0179307 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0177803 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0177629 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0177044 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0173513 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0173289 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0168904 |
| BBX | bobby sox homolog (Drosophila) | 0.0168377 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0168265 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0162997 |
| FTL | ferritin, light polypeptide | 0.016181 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0159818 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.0157719 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.015738 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0157191 |
| TMEFF2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | 0.0156947 |
| DENND4A | DENN/MADD domain containing 4A | 0.0156893 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0156837 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0153892 |
| POLH | polymerase (DNA directed), eta | 0.0153286 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0152144 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0151482 |
| CCNL1 | cyclin L1 | 0.0151197 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.0150173 |
| MANBA | mannosidase, beta A, lysosomal | 0.0149111 |
| FDXR | ferredoxin reductase | 0.0147719 |
| AUTS2 | autism susceptibility candidate 2 | 0.0147525 |
| RPS11 | ribosomal protein S11 | 0.0147435 |
| COL1A2 | collagen, type I, alpha 2 | 0.0146196 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0144913 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0144096 |
| GDF15 | growth differentiation factor 15 | 0.0143069 |
| C1D | C1D nuclear receptor corepressor | 0.0142805 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0142686 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0142669 |
| FOSL1 | FOS-like antigen 1 | 0.0142643 |
| PER1 | period circadian clock 1 | 0.0141318 |
| CTBP2 | C-terminal binding protein 2 | 0.014081 |
| DTNA | dystrobrevin, alpha | 0.0140248 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0140115 |
| HELZ | helicase with zinc finger | 0.0138654 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0138064 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0138007 |
| UVRAG | UV radiation resistance associated | 0.0137819 |
| MYOF | myoferlin | 0.0136273 |
| CLU | clusterin | 0.0135993 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.196009 |
| TMSB10 | thymosin beta 10 | -0.162871 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.148108 |
| MT2A | metallothionein 2A | -0.14448 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.127862 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.124352 |
| MAP1B | microtubule-associated protein 1B | -0.107054 |
| LOX | lysyl oxidase | -0.105459 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0928444 |
| NAV1 | neuron navigator 1 | -0.0925596 |
| PODXL | podocalyxin-like | -0.0766615 |
| GLIS3 | GLIS family zinc finger 3 | -0.0684572 |
| VIM | vimentin | -0.0671964 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.066717 |
| CD44 | CD44 molecule (Indian blood group) | -0.0649635 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0631494 |
| AHNAK | AHNAK nucleoprotein | -0.0624335 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0616416 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0604951 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0584202 |
| RIGI | RNA sensor RIG-I | -0.0575431 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0562211 |
| PRSS23 | protease, serine, 23 | -0.0547346 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0521945 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0521249 |
| FN1 | fibronectin 1 | -0.0509059 |
| DST | dystonin | -0.0482461 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0453015 |
| COL5A1 | collagen, type V, alpha 1 | -0.0451095 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.043355 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0417981 |
| MT1X | metallothionein 1X | -0.0413248 |
| COL5A2 | collagen, type V, alpha 2 | -0.041285 |
| RAI14 | retinoic acid induced 14 | -0.040365 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0402737 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0398627 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0395552 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0387064 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0382505 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0380184 |
| THBS2 | thrombospondin 2 | -0.0378455 |
| CENPF | centromere protein F, 350/400kDa | -0.0375371 |
| ANXA2 | annexin A2 | -0.037434 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0364513 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0359699 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0355166 |
| SP100 | SP100 nuclear antigen | -0.0349379 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0344072 |
| EHBP1 | EH domain binding protein 1 | -0.0339155 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0324243 |
| DIAPH3 | diaphanous-related formin 3 | -0.0322271 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0321641 |
| RRBP1 | ribosome binding protein 1 | -0.0320478 |
| SMYD3 | SET and MYND domain containing 3 | -0.0317841 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0313939 |
| DCLK2 | doublecortin-like kinase 2 | -0.0312844 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0307511 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0299396 |
| MEIS2 | Meis homeobox 2 | -0.0290292 |
| TMSB4X | thymosin beta 4, X-linked | -0.0288402 |
| RUNX1 | runt-related transcription factor 1 | -0.0283538 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0280164 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0280008 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0278695 |
| PRELID2 | PRELI domain containing 2 | -0.027325 |
| PLSCR1 | phospholipid scramblase 1 | -0.026967 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0268495 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0267432 |
| VEGFC | vascular endothelial growth factor C | -0.0255187 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0254756 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.025458 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0247419 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0245853 |
| MX2 | MX dynamin-like GTPase 2 | -0.0244789 |
| NAV2 | neuron navigator 2 | -0.0240999 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.024097 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0238938 |
| ZNF292 | zinc finger protein 292 | -0.0238751 |
| HDAC9 | histone deacetylase 9 | -0.0237262 |
| MAP4 | microtubule-associated protein 4 | -0.0237149 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0233144 |
| S100A4 | S100 calcium binding protein A4 | -0.0233079 |
| TUBB | tubulin, beta class I | -0.0229804 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0228956 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0225283 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0224833 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0224464 |
| TAGLN2 | transgelin 2 | -0.0223873 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0219915 |
| MKI67 | marker of proliferation Ki-67 | -0.0217494 |
| VCL | vinculin | -0.0215308 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0214641 |
| RTN4 | reticulon 4 | -0.0214547 |
| B2M | beta-2-microglobulin | -0.0211501 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0210976 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0210854 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0210847 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0209737 |
| RBM25 | RNA binding motif protein 25 | -0.020907 |
| RAI1 | retinoic acid induced 1 | -0.0208496 |
