| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.137888 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0655073 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0525984 |
| PCBP2 | poly(rC) binding protein 2 | 0.042828 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0425642 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0371619 |
| CCNL1 | cyclin L1 | 0.0366357 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0289271 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0288606 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0268533 |
| IPO7 | importin 7 | 0.0261657 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0257854 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0255623 |
| ASTN2 | astrotactin 2 | 0.0255238 |
| ETNK1 | ethanolamine kinase 1 | 0.0239359 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.0237345 |
| NEK7 | NIMA-related kinase 7 | 0.023552 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0231016 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0226015 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0226002 |
| THOC1 | THO complex 1 | 0.021524 |
| KLHL24 | kelch-like family member 24 | 0.0213239 |
| FDXR | ferredoxin reductase | 0.0211816 |
| MATR3 | matrin 3 | 0.0211182 |
| GPHN | gephyrin | 0.0207154 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0207016 |
| WDR43 | WD repeat domain 43 | 0.0206482 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0205351 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0205238 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.0201763 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.0200452 |
| TUBA1B | tubulin, alpha 1b | 0.0200345 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0200091 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0199981 |
| RHBDD1 | rhomboid domain containing 1 | 0.0199483 |
| USP15 | ubiquitin specific peptidase 15 | 0.019808 |
| POLH | polymerase (DNA directed), eta | 0.0198047 |
| HELLS | helicase, lymphoid-specific | 0.0194783 |
| KIF1B | kinesin family member 1B | 0.019118 |
| SRPK2 | SRSF protein kinase 2 | 0.0188897 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0187609 |
| TBK1 | TANK-binding kinase 1 | 0.0186243 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0185597 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0182579 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0181283 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0181156 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0180816 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0180557 |
| FLNA | filamin A, alpha | 0.017978 |
| CDK19 | cyclin-dependent kinase 19 | 0.0179624 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.0178578 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0178319 |
| MSH6 | mutS homolog 6 | 0.0175895 |
| E2F7 | E2F transcription factor 7 | 0.0175189 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0171209 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0170891 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0170678 |
| OGA | O-GlcNAcase | 0.0169655 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0167177 |
| ARRDC3 | arrestin domain containing 3 | 0.0167111 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0165343 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.0164982 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0164915 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | 0.0164126 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0163579 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0162756 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0160787 |
| CLDND1 | claudin domain containing 1 | 0.0160021 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0159721 |
| HELZ | helicase with zinc finger | 0.0158982 |
| FBXO22 | F-box protein 22 | 0.0158822 |
| PCM1 | pericentriolar material 1 | 0.015715 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0157123 |
| RPL3 | ribosomal protein L3 | 0.0154352 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0153959 |
| PREPL | prolyl endopeptidase-like | 0.0153199 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0151803 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0151685 |
| SQSTM1 | sequestosome 1 | 0.0150179 |
| RPS23 | ribosomal protein S23 | 0.0149778 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0149158 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0149067 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.0148128 |
| MMS22L | MMS22-like, DNA repair protein | 0.0147787 |
| SNX13 | sorting nexin 13 | 0.0145347 |
| FANCL | Fanconi anemia, complementation group L | 0.0142562 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0142526 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0142466 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0142412 |
| CEP95 | centrosomal protein 95kDa | 0.0142125 |
| RPSA | ribosomal protein SA | 0.0142063 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | 0.0140585 |
| COG5 | component of oligomeric golgi complex 5 | 0.0139951 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0139261 |
| PER1 | period circadian clock 1 | 0.0138921 |
| ZNF148 | zinc finger protein 148 | 0.013807 |
| HLA-A | major histocompatibility complex, class I, A | 0.0137892 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0137358 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | 0.0135673 |
| CCNY | cyclin Y | 0.0135586 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.394773 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.250739 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.148951 |
| PCDH7 | protocadherin 7 | -0.121791 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.121446 |
| TMSB10 | thymosin beta 10 | -0.111981 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.102549 |
| MMP12 | matrix metallopeptidase 12 | -0.0913241 |
| AREG | amphiregulin | -0.0874972 |
| TENM3 | teneurin transmembrane protein 3 | -0.0866089 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0819024 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0782539 |
| DST | dystonin | -0.0759767 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0753304 |
| VIM | vimentin | -0.0697517 |
| EHBP1 | EH domain binding protein 1 | -0.0647607 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0632117 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0596366 |
| CENPF | centromere protein F, 350/400kDa | -0.058089 |
| ZNF804A | zinc finger protein 804A | -0.0554724 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0547732 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0532281 |
| ANXA1 | annexin A1 | -0.0528379 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0510584 |
| NEBL | nebulette | -0.0485454 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0485175 |
| USP34 | ubiquitin specific peptidase 34 | -0.046592 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0457901 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0453569 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0444298 |
| HMGA2 | high mobility group AT-hook 2 | -0.0426692 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0414053 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.040254 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0397535 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0395982 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0389814 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0387812 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0385024 |
| MKI67 | marker of proliferation Ki-67 | -0.0384922 |
| YAP1 | Yes-associated protein 1 | -0.0376434 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0371796 |
| NHSL1 | NHS-like 1 | -0.0370545 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.03651 |
| HDAC9 | histone deacetylase 9 | -0.0350292 |
| CENPE | centromere protein E, 312kDa | -0.0330215 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0329601 |
| MGAT4C | MGAT4 family, member C | -0.0327073 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0323209 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0320674 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0319942 |
| PDGFC | platelet derived growth factor C | -0.0318543 |
| DTNA | dystrobrevin, alpha | -0.0316914 |
| MTAP | methylthioadenosine phosphorylase | -0.0315299 |
| CLDN1 | claudin 1 | -0.031431 |
| ADIPOR2 | adiponectin receptor 2 | -0.0314021 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0311077 |
| LMO7 | LIM domain 7 | -0.0303211 |
| EDARADD | EDAR-associated death domain | -0.0301921 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0299817 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0293346 |
| ACTG1 | actin gamma 1 | -0.0293059 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0291512 |
| PCDH9 | protocadherin 9 | -0.0290741 |
| RPL36 | ribosomal protein L36 | -0.0290493 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.028865 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0283863 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0280265 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0277373 |
| CDK6 | cyclin-dependent kinase 6 | -0.0277358 |
| RPL12 | ribosomal protein L12 | -0.0277188 |
| AHNAK | AHNAK nucleoprotein | -0.0271526 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0270714 |
| RPL35A | ribosomal protein L35a | -0.0264689 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0264569 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0263619 |
| MAP1B | microtubule-associated protein 1B | -0.0262422 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0260967 |
| CCDC88A | coiled-coil domain containing 88A | -0.0257343 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0251028 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0244674 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0243881 |
| CCN2 | cellular communication network factor 2 | -0.0234623 |
| TPX2 | TPX2, microtubule-associated | -0.0234264 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0232978 |
| INTS6 | integrator complex subunit 6 | -0.0230575 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0229405 |
| TMEM41B | transmembrane protein 41B | -0.0228695 |
| RPS19 | ribosomal protein S19 | -0.022843 |
| CBX3 | chromobox homolog 3 | -0.0226175 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0225774 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0225737 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0223278 |
| COMMD10 | COMM domain containing 10 | -0.0223251 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0221557 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0220325 |
| RSU1 | Ras suppressor protein 1 | -0.0211376 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0211279 |
| KIF18B | kinesin family member 18B | -0.0209439 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0209358 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0204718 |
