Doxorubicin (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0686784
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0384847
RNF213 ring finger protein 213 0.0362686
SRPK2 SRSF protein kinase 2 0.0295939
GSE1 Gse1 coiled-coil protein 0.0291098
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0284608
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0281319
CD46 CD46 molecule, complement regulatory protein 0.0273059
DENND2B DENN domain containing 2B 0.0262986
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0259303
MAST4 microtubule associated serine/threonine kinase family member 4 0.0245472
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.0241684
MRPS6 mitochondrial ribosomal protein S6 0.0240278
ADAM9 ADAM metallopeptidase domain 9 0.0225666
CSNK1G1 casein kinase 1, gamma 1 0.0220682
ANKRD33B ankyrin repeat domain 33B 0.0220481
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0215927
PCLO piccolo presynaptic cytomatrix protein 0.021467
FBXO22 F-box protein 22 0.0214474
COL27A1 collagen, type XXVII, alpha 1 0.0207915
PLEC plectin 0.0197259
AK1 adenylate kinase 1 0.0193207
TGFBI transforming growth factor, beta-induced, 68kDa 0.0189869
FLNA filamin A, alpha 0.0186733
NXN nucleoredoxin 0.0184335
ANXA4 annexin A4 0.0181479
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.017792
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0173974
EPS8 epidermal growth factor receptor pathway substrate 8 0.0171827
HSDL2 hydroxysteroid dehydrogenase like 2 0.0169232
LHFPL6 LHFPL tetraspan subfamily member 6 0.0165557
CENPP centromere protein P 0.0162182
HELZ helicase with zinc finger 0.0158733
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.0157056
ZMAT3 zinc finger, matrin-type 3 0.0154393
APAF1 apoptotic peptidase activating factor 1 0.0152019
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0151818
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0150401
NFE2L1 nuclear factor, erythroid 2-like 1 0.0150048
KMT2C lysine (K)-specific methyltransferase 2C 0.0148483
SDK1 sidekick cell adhesion molecule 1 0.0148204
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0145536
FDXR ferredoxin reductase 0.0143929
DERA deoxyribose-phosphate aldolase (putative) 0.0141948
ASTN2 astrotactin 2 0.0140504
WDR43 WD repeat domain 43 0.0138682
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0138008
TRAPPC9 trafficking protein particle complex 9 0.0136774
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0136284
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0135764
STOM stomatin 0.0133136
GPHN gephyrin 0.0133056
PCBP2 poly(rC) binding protein 2 0.0132369
KDM6A lysine (K)-specific demethylase 6A 0.013232
BTBD10 BTB (POZ) domain containing 10 0.0131788
SULF2 sulfatase 2 0.0130527
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.012993
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0129621
FCHSD2 FCH and double SH3 domains 2 0.0127835
KIRREL1 kirre like nephrin family adhesion molecule 1 0.012726
ANKRD10 ankyrin repeat domain 10 0.012698
GDF15 growth differentiation factor 15 0.0126687
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0125989
DDB2 damage-specific DNA binding protein 2, 48kDa 0.012551
SUGCT succinyl-CoA:glutarate-CoA transferase 0.0124651
MYO10 myosin X 0.012455
SEPTIN9 septin 9 0.0121587
MANBA mannosidase, beta A, lysosomal 0.0121318
POLH polymerase (DNA directed), eta 0.0121079
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.012009
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0118665
XPC xeroderma pigmentosum, complementation group C 0.0118276
TMEM117 transmembrane protein 117 0.0117335
RIC1 RAB6A GEF complex partner 1 0.0117188
SLMAP sarcolemma associated protein 0.0116399
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0116331
EXOC6B exocyst complex component 6B 0.0115728
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0114777
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0114751
OSBPL3 oxysterol binding protein-like 3 0.0114532
KALRN kalirin, RhoGEF kinase 0.0114384
CPNE8 copine VIII 0.011438
QKI QKI, KH domain containing, RNA binding 0.0114268
ETNK1 ethanolamine kinase 1 0.0114172
TMEM178B transmembrane protein 178B 0.0113389
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0113351
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.0113182
HSPA4L heat shock 70kDa protein 4-like 0.011273
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0111613
SLCO5A1 solute carrier organic anion transporter family, member 5A1 0.0111236
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0111211
ACER2 alkaline ceramidase 2 0.0110893
TBC1D5 TBC1 domain family, member 5 0.0110838
MSI2 musashi RNA-binding protein 2 0.01102
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0109646
NPAS3 neuronal PAS domain protein 3 0.0108947
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0108255
KIF26B kinesin family member 26B 0.0108229
NAP1L4 nucleosome assembly protein 1-like 4 0.0107866
PBX3 pre-B-cell leukemia homeobox 3 0.0107547

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.22064
VIM vimentin -0.18048
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139365
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132612
CD44 CD44 molecule (Indian blood group) -0.109804
GPC6 glypican 6 -0.102945
TMSB10 thymosin beta 10 -0.0995271
FTL ferritin, light polypeptide -0.0960566
EXT1 exostosin glycosyltransferase 1 -0.0913065
UBC ubiquitin C -0.0883929
NAMPT nicotinamide phosphoribosyltransferase -0.084723
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0757068
TXNRD1 thioredoxin reductase 1 -0.0652729
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0611624
RPS27A ribosomal protein S27a -0.0607212
TPT1 tumor protein, translationally-controlled 1 -0.0602821
IGFBP3 insulin-like growth factor binding protein 3 -0.0593071
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.058417
RAI14 retinoic acid induced 14 -0.0583428
CALU calumenin -0.0570341
MAP1B microtubule-associated protein 1B -0.0538851
B2M beta-2-microglobulin -0.0536993
RPL23 ribosomal protein L23 -0.0512227
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0465993
MT2A metallothionein 2A -0.0436078
CA12 carbonic anhydrase XII -0.0434838
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.043109
EIF1 eukaryotic translation initiation factor 1 -0.0411277
AHNAK AHNAK nucleoprotein -0.0405535
GLIS3 GLIS family zinc finger 3 -0.0394046
HLA-B major histocompatibility complex, class I, B -0.0385149
RPS8 ribosomal protein S8 -0.0383419
HSPB1 heat shock 27kDa protein 1 -0.037678
JUN jun proto-oncogene -0.0359158
NAV2 neuron navigator 2 -0.0357321
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0352261
FNDC3B fibronectin type III domain containing 3B -0.0348315
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0336962
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0331939
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0331937
RPS6 ribosomal protein S6 -0.0329871
PTMA prothymosin, alpha -0.0329594
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0325642
RPS5 ribosomal protein S5 -0.032211
TSHZ2 teashirt zinc finger homeobox 2 -0.0318938
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0318289
RPLP2 ribosomal protein, large, P2 -0.0316837
RRBP1 ribosome binding protein 1 -0.0316045
PLIN2 perilipin 2 -0.0314364
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0307748
KYNU kynureninase -0.0305616
RPL19 ribosomal protein L19 -0.0304478
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0298766
RPL28 ribosomal protein L28 -0.0298258
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0297104
S100A10 S100 calcium binding protein A10 -0.0289402
RPL12 ribosomal protein L12 -0.0288769
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0286583
VCL vinculin -0.0286425
STK17A serine/threonine kinase 17a -0.0284802
RPL34 ribosomal protein L34 -0.0284693
CDCP1 CUB domain containing protein 1 -0.02797
SPDYA speedy/RINGO cell cycle regulator family member A -0.0278551
ENO1 enolase 1, (alpha) -0.027814
ACTG1 actin gamma 1 -0.0278073
ANXA2 annexin A2 -0.0276628
CREB5 cAMP responsive element binding protein 5 -0.0276374
MX1 MX dynamin-like GTPase 1 -0.0273573
RPL31 ribosomal protein L31 -0.027292
GARS1 glycyl-tRNA synthetase 1 -0.0271438
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0268878
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0265211
RPS24 ribosomal protein S24 -0.0263041
NRP2 neuropilin 2 -0.0262535
PDIA4 protein disulfide isomerase family A, member 4 -0.0261877
TUBA1B tubulin, alpha 1b -0.0261608
PRRC2C proline-rich coiled-coil 2C -0.0261075
HM13 histocompatibility (minor) 13 -0.0260847
RPLP1 ribosomal protein, large, P1 -0.0260191
TPM4 tropomyosin 4 -0.02576
RHEB Ras homolog enriched in brain -0.0257
RPL26 ribosomal protein L26 -0.025581
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0254877
SP100 SP100 nuclear antigen -0.0251268
MTDH metadherin -0.025106
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0247423
SDCBP syndecan binding protein (syntenin) -0.0245924
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0245837
CALR calreticulin -0.0244872
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0244203
FAT1 FAT atypical cadherin 1 -0.024144
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0241059
RIGI RNA sensor RIG-I -0.0239616
RACK1 receptor for activated C kinase 1 -0.0238025
G0S2 G0/G1 switch 2 -0.0231171
LDHA lactate dehydrogenase A -0.0230674
SOD2 superoxide dismutase 2, mitochondrial -0.0229755
CENPF centromere protein F, 350/400kDa -0.0227377
EHBP1 EH domain binding protein 1 -0.0225161
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0225109