| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Doxorubicin (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.256175 |
| RNF213 | ring finger protein 213 | 0.112828 |
| FLNA | filamin A, alpha | 0.0493627 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0448604 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0438094 |
| FBXO22 | F-box protein 22 | 0.0377377 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0336172 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0328619 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0325173 |
| FDXR | ferredoxin reductase | 0.032408 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0323069 |
| RHCG | Rh family, C glycoprotein | 0.0312213 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0310469 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0304567 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0300242 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | 0.0290643 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0287233 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0286939 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0286389 |
| PLEC | plectin | 0.0285776 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.0280386 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0270932 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0265388 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0256078 |
| NTN1 | netrin 1 | 0.0249223 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0248969 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0241814 |
| MSI2 | musashi RNA-binding protein 2 | 0.023841 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0237018 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.0234274 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0231093 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0228845 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.0227525 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.0225913 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0222794 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0221456 |
| AK1 | adenylate kinase 1 | 0.0219937 |
| ASTN2 | astrotactin 2 | 0.0219829 |
| SULF2 | sulfatase 2 | 0.0219524 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0219261 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0217708 |
| POLH | polymerase (DNA directed), eta | 0.0216246 |
| AHNAK | AHNAK nucleoprotein | 0.0210361 |
| SRPK2 | SRSF protein kinase 2 | 0.020881 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0206163 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0199885 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0199861 |
| NXN | nucleoredoxin | 0.0197885 |
| ETV6 | ets variant 6 | 0.0195577 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0191891 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0191406 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.018913 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0187331 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0186643 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0186239 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0185956 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0184369 |
| ZNF337 | zinc finger protein 337 | 0.0184247 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.018227 |
| TLE4 | transducin-like enhancer of split 4 | 0.0180643 |
| HDAC4 | histone deacetylase 4 | 0.0179881 |
| PLD5 | phospholipase D family, member 5 | 0.0179435 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.0173683 |
| GSE1 | Gse1 coiled-coil protein | 0.0172612 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.0172353 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0171097 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0170639 |
| ANXA4 | annexin A4 | 0.0169748 |
| SQSTM1 | sequestosome 1 | 0.016883 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0168519 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0167578 |
| C3 | complement component 3 | 0.0166774 |
| FBN2 | fibrillin 2 | 0.016548 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0165431 |
| GPHN | gephyrin | 0.0161248 |
| ABR | active BCR-related | 0.0157437 |
| MLEC | malectin | 0.0156383 |
| PRKCE | protein kinase C, epsilon | 0.0155694 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0154354 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0152814 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0148818 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0147648 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.0146047 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0143065 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.0142581 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0142275 |
| RHBDD1 | rhomboid domain containing 1 | 0.0141902 |
| COL27A1 | collagen, type XXVII, alpha 1 | 0.0141072 |
| PLAU | plasminogen activator, urokinase | 0.0141058 |
| GK | glycerol kinase | 0.0140571 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0140015 |
| ZNF37A | zinc finger protein 37A | 0.0138899 |
| CERS6 | ceramide synthase 6 | 0.0137595 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0137135 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.013703 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0136221 |
| ACER2 | alkaline ceramidase 2 | 0.0136104 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.01358 |
| HLA-B | major histocompatibility complex, class I, B | 0.0135628 |
| ZNF654 | zinc finger protein 654 | 0.0134974 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.322874 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.157579 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.133884 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131949 |
| MT2A | metallothionein 2A | -0.131631 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0937702 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0899634 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0826961 |
| ASPH | aspartate beta-hydroxylase | -0.0825066 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0768699 |
| MT1X | metallothionein 1X | -0.0765322 |
| KYNU | kynureninase | -0.0758905 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0654995 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0653573 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0651917 |
| STC1 | stanniocalcin 1 | -0.0646685 |
| EFNA5 | ephrin-A5 | -0.0638585 |
| ANXA2 | annexin A2 | -0.0635983 |
| PDE10A | phosphodiesterase 10A | -0.0589273 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0587565 |
| FLNB | filamin B, beta | -0.0587271 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0579592 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0578738 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0578515 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0567674 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0562742 |
| FTL | ferritin, light polypeptide | -0.0558975 |
| RPS6 | ribosomal protein S6 | -0.0557581 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0532834 |
| SPAG9 | sperm associated antigen 9 | -0.0516404 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.050521 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0491418 |
| RPS2 | ribosomal protein S2 | -0.0484869 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0483488 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0469376 |
| TMSB10 | thymosin beta 10 | -0.0461028 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.046082 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0456293 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0451819 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0438495 |
| SMAD3 | SMAD family member 3 | -0.0433614 |
| RTN4 | reticulon 4 | -0.0430011 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0424147 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0420815 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0419377 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0412169 |
| TXNRD1 | thioredoxin reductase 1 | -0.04069 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0402695 |
| OSMR | oncostatin M receptor | -0.0397781 |
| NDRG1 | N-myc downstream regulated 1 | -0.0389302 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0384717 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.03783 |
| FAM107B | family with sequence similarity 107, member B | -0.0376699 |
| POTEF | POTE ankyrin domain family, member F | -0.0372905 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0372373 |
| ACTG1 | actin gamma 1 | -0.0367845 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0357725 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0355944 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0350033 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0343859 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0343061 |
| KLF6 | Kruppel-like factor 6 | -0.0339038 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0336053 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0334459 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0330967 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0330947 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0318795 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0316986 |
| PARD3 | par-3 family cell polarity regulator | -0.0312846 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0308465 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0307216 |
| RAI14 | retinoic acid induced 14 | -0.0304637 |
| RNF145 | ring finger protein 145 | -0.0302572 |
| CENPF | centromere protein F, 350/400kDa | -0.0302411 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0299108 |
| MSN | moesin | -0.0294432 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0293878 |
| LDHA | lactate dehydrogenase A | -0.0293836 |
| PFN1 | profilin 1 | -0.0292252 |
| MKI67 | marker of proliferation Ki-67 | -0.0288253 |
| CD44 | CD44 molecule (Indian blood group) | -0.0287242 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.028463 |
| FMNL2 | formin-like 2 | -0.0281115 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0280636 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0279983 |
| SBF2 | SET binding factor 2 | -0.0279649 |
| ITGB5 | integrin, beta 5 | -0.027864 |
| GOLGA4 | golgin A4 | -0.027672 |
| RASA2 | RAS p21 protein activator 2 | -0.0274549 |
| CCDC88A | coiled-coil domain containing 88A | -0.0273668 |
| UBC | ubiquitin C | -0.0270104 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0269706 |
| MAP1B | microtubule-associated protein 1B | -0.0267295 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0264456 |
| GPC6 | glypican 6 | -0.0262582 |
| USP3 | ubiquitin specific peptidase 3 | -0.0257518 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0257048 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0255967 |
| ECT2 | epithelial cell transforming 2 | -0.0255231 |
| SETD5 | SET domain containing 5 | -0.0253104 |
