Doxorubicin (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NCOA3 nuclear receptor coactivator 3 0.0442491
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0388524
FBXL20 F-box and leucine-rich repeat protein 20 0.034939
GRB10 growth factor receptor-bound protein 10 0.0282348
ELOVL5 ELOVL fatty acid elongase 5 0.0261221
CCNL1 cyclin L1 0.0240674
SMAD3 SMAD family member 3 0.0239862
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0238336
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0234933
FAM168A family with sequence similarity 168, member A 0.0233083
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0229724
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0219323
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0211634
TRAPPC9 trafficking protein particle complex 9 0.0210301
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0193279
VMP1 vacuole membrane protein 1 0.0178041
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0175838
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0175692
EXT1 exostosin glycosyltransferase 1 0.0174365
UNC13B unc-13 homolog B (C. elegans) 0.0173982
MCL1 myeloid cell leukemia 1 0.0170768
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0168584
AHCTF1 AT hook containing transcription factor 1 0.0166418
KAZN kazrin, periplakin interacting protein 0.016507
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0163041
HELZ helicase with zinc finger 0.0161797
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0153151
KDM6A lysine (K)-specific demethylase 6A 0.0148833
DENND1A DENN/MADD domain containing 1A 0.0148233
ZSWIM6 zinc finger, SWIM-type containing 6 0.014747
HSPA8 heat shock 70kDa protein 8 0.0147042
ARHGAP26 Rho GTPase activating protein 26 0.0145815
SOD2 superoxide dismutase 2, mitochondrial 0.0142353
IGF1R insulin-like growth factor 1 receptor 0.014183
CEMIP2 cell migration inducing hyaluronidase 2 0.0140566
GSDMB gasdermin B 0.0133559
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0133306
EPHA4 EPH receptor A4 0.0133163
YAP1 Yes-associated protein 1 0.0132388
MYO10 myosin X 0.0131069
ICAM1 intercellular adhesion molecule 1 0.0130753
FNDC3B fibronectin type III domain containing 3B 0.0129689
SUSD6 sushi domain containing 6 0.0128721
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0127861
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0126994
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0126177
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0123595
RELT RELT tumor necrosis factor receptor 0.0122523
BCAS3 breast carcinoma amplified sequence 3 0.0120834
PRRC2A proline-rich coiled-coil 2A 0.0119901
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0119822
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0119485
MSI2 musashi RNA-binding protein 2 0.0118957
NEK7 NIMA-related kinase 7 0.0118844
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0118464
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0115683
NCOA7 nuclear receptor coactivator 7 0.0114868
KDM3A lysine (K)-specific demethylase 3A 0.0114681
FNBP1L formin binding protein 1-like 0.0114119
WWOX WW domain containing oxidoreductase 0.0113921
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0112089
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0111917
GSE1 Gse1 coiled-coil protein 0.0111895
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0111807
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0111598
RBM4 RNA binding motif protein 4 0.0108289
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0108023
JARID2 jumonji, AT rich interactive domain 2 0.0107684
PARD3B par-3 family cell polarity regulator beta 0.0107633
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.010691
VAV2 vav 2 guanine nucleotide exchange factor 0.0106837
GPHN gephyrin 0.0103897
CAMTA1 calmodulin binding transcription activator 1 0.0103784
MBNL2 muscleblind-like splicing regulator 2 0.0103307
PTPRG protein tyrosine phosphatase, receptor type, G 0.0102686
OLA1 Obg-like ATPase 1 0.0101934
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0101647
LRRC1 leucine rich repeat containing 1 0.0101179
STOM stomatin 0.00997945
TUFT1 tuftelin 1 0.00994375
PIAS2 protein inhibitor of activated STAT, 2 0.00993359
EXOC4 exocyst complex component 4 0.00983359
TFRC transferrin receptor 0.00979472
TIGAR TP53 induced glycolysis regulatory phosphatase 0.00976822
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00974272
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.00973726
UBAP2 ubiquitin associated protein 2 0.00972379
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0097192
VIPR2 vasoactive intestinal peptide receptor 2 0.00963192
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.00955308
SETX senataxin 0.00955168
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00951747
FOXN3 forkhead box N3 0.00951111
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.00948493
DENND5A DENN/MADD domain containing 5A 0.00937118
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00933388
DNHD1 dynein heavy chain domain 1 0.00916577
MTMR4 myotubularin related protein 4 0.00912658
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.00908303
LRP6 low density lipoprotein receptor-related protein 6 0.0090354

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.246884
RPL19 ribosomal protein L19 -0.24096
ZMYND8 zinc finger, MYND-type containing 8 -0.209325
PTMA prothymosin, alpha -0.101579
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0935356
CATSPERB catsper channel auxiliary subunit beta -0.0888734
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0882734
ACACA acetyl-CoA carboxylase alpha -0.0875888
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0862243
ASPH aspartate beta-hydroxylase -0.0811863
ACTG1 actin gamma 1 -0.0707374
TMSB10 thymosin beta 10 -0.0687586
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0640083
RPS3 ribosomal protein S3 -0.0638032
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.063353
MT2A metallothionein 2A -0.0607064
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0599424
RPL35A ribosomal protein L35a -0.0522269
LDHA lactate dehydrogenase A -0.0498143
SLC38A1 solute carrier family 38, member 1 -0.0488685
FTH1 ferritin, heavy polypeptide 1 -0.0467137
PGK1 phosphoglycerate kinase 1 -0.0455277
TPT1 tumor protein, translationally-controlled 1 -0.0446265
TRPS1 trichorhinophalangeal syndrome I -0.0411866
KRT19 keratin 19, type I -0.0395947
ENO1 enolase 1, (alpha) -0.0395938
CLTC clathrin, heavy chain (Hc) -0.0390403
RIMS2 regulating synaptic membrane exocytosis 2 -0.0379354
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0379111
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0368963
LPP LIM domain containing preferred translocation partner in lipoma -0.0363159
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0352825
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0352059
RPL12 ribosomal protein L12 -0.0345335
CCND1 cyclin D1 -0.0345292
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.034379
LOC112694756 uncharaterized LOC112694756 -0.0339306
SET SET nuclear proto-oncogene -0.0338843
TMSB4X thymosin beta 4, X-linked -0.0336058
ZBTB20 zinc finger and BTB domain containing 20 -0.0325229
CEP250 centrosomal protein 250kDa -0.0321834
S100A9 S100 calcium binding protein A9 -0.0315061
MYL12B myosin, light chain 12B, regulatory -0.031128
S100A6 S100 calcium binding protein A6 -0.0308376
LOC102724023 ES1 protein homolog, mitochondrial -0.0307084
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.030606
RPS8 ribosomal protein S8 -0.0304969
CCNI cyclin I -0.0303094
DSTN destrin (actin depolymerizing factor) -0.0301191
NCOA6 nuclear receptor coactivator 6 -0.0294915
OSMR oncostatin M receptor -0.0294198
RPS19 ribosomal protein S19 -0.0291373
AHNAK AHNAK nucleoprotein -0.0284794
RPS6 ribosomal protein S6 -0.02847
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.028304
FTL ferritin, light polypeptide -0.0278597
S100A14 S100 calcium binding protein A14 -0.0277912
RPL34 ribosomal protein L34 -0.0275881
TMC5 transmembrane channel-like 5 -0.0273925
PRRC2C proline-rich coiled-coil 2C -0.0273672
GRB7 growth factor receptor-bound protein 7 -0.0273218
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0272376
RPLP1 ribosomal protein, large, P1 -0.0269317
LMNA lamin A/C -0.0266505
SOX4 SRY (sex determining region Y)-box 4 -0.0263719
EIF1 eukaryotic translation initiation factor 1 -0.0263175
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0261494
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0260198
ANXA2 annexin A2 -0.0257864
RPS27 ribosomal protein S27 -0.0256239
PATJ PATJ crumbs cell polarity complex component -0.0255106
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.025424
LASP1 LIM and SH3 protein 1 -0.0252813
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0249702
TOM1L1 target of myb1 (chicken)-like 1 -0.024801
BZW1 basic leucine zipper and W2 domains 1 -0.0245909
RPL8 ribosomal protein L8 -0.0245794
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0245104
GNAS GNAS complex locus -0.0244465
MIEN1 migration and invasion enhancer 1 -0.0244351
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0236042
DYNLRB1 dynein, light chain, roadblock-type 1 -0.023548
RPL9 ribosomal protein L9 -0.0233573
ZNF652 zinc finger protein 652 -0.0232827
POTEF POTE ankyrin domain family, member F -0.0232564
MIPOL1 mirror-image polydactyly 1 -0.0232161
NIPSNAP2 nipsnap homolog 2 -0.0229014
NIPBL Nipped-B homolog (Drosophila) -0.0225363
RAB22A RAB22A, member RAS oncogene family -0.0225036
B2M beta-2-microglobulin -0.0223587
S100P S100 calcium binding protein P -0.0222922
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0222011
SBF2 SET binding factor 2 -0.0221951
KMT5B lysine methyltransferase 5B -0.0221907
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0221504
KRT18 keratin 18, type I -0.0221038
RPL31 ribosomal protein L31 -0.0218854
RPL11 ribosomal protein L11 -0.0218385
JMJD1C jumonji domain containing 1C -0.0217436
AREG amphiregulin -0.0217228