| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0501909 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0405033 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0352978 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0291737 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0242437 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0218025 |
| CCNL1 | cyclin L1 | 0.021776 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0214471 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0208671 |
| SRPK2 | SRSF protein kinase 2 | 0.0201371 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0188843 |
| TOP1 | topoisomerase (DNA) I | 0.0185691 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0180983 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0176017 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0167662 |
| ETNK1 | ethanolamine kinase 1 | 0.01669 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0165864 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0164579 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.015947 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0155942 |
| WDR43 | WD repeat domain 43 | 0.0155405 |
| OLA1 | Obg-like ATPase 1 | 0.0153878 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0140024 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0139548 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0139289 |
| KAZN | kazrin, periplakin interacting protein | 0.0136755 |
| FLNA | filamin A, alpha | 0.0136307 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.0134472 |
| CASD1 | CAS1 domain containing 1 | 0.0134322 |
| MRTFA | myocardin related transcription factor A | 0.0132266 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0130048 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0129796 |
| NOP58 | NOP58 ribonucleoprotein | 0.0125554 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0125134 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0124535 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0123912 |
| ANXA4 | annexin A4 | 0.0119673 |
| YBX1 | Y box binding protein 1 | 0.0118946 |
| SMAP2 | small ArfGAP2 | 0.0117708 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0117621 |
| OGA | O-GlcNAcase | 0.011719 |
| ATOSA | atos homolog A | 0.0112809 |
| PCBP2 | poly(rC) binding protein 2 | 0.011114 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0110328 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.0110031 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0109461 |
| SERINC5 | serine incorporator 5 | 0.0109077 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.010875 |
| HELZ | helicase with zinc finger | 0.010741 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0106909 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0106736 |
| ADAMTS4 | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | 0.0106691 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.010469 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0103182 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.010307 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0102695 |
| USP15 | ubiquitin specific peptidase 15 | 0.010263 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0102627 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.0102003 |
| E2F7 | E2F transcription factor 7 | 0.0101464 |
| MED13 | mediator complex subunit 13 | 0.0101272 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0100302 |
| YTHDC1 | YTH domain containing 1 | 0.0100174 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.00997425 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00983977 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00981825 |
| NEK7 | NIMA-related kinase 7 | 0.00978998 |
| FDXR | ferredoxin reductase | 0.00976703 |
| SESN1 | sestrin 1 | 0.00975152 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0097391 |
| MANBA | mannosidase, beta A, lysosomal | 0.00964365 |
| DGKH | diacylglycerol kinase, eta | 0.00958085 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00955189 |
| AK1 | adenylate kinase 1 | 0.00937276 |
| ANKRD7 | ankyrin repeat domain 7 | 0.00925908 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.00924104 |
| RBM39 | RNA binding motif protein 39 | 0.0092147 |
| PTCHD4 | patched domain containing 4 | 0.00917697 |
| FAR1 | fatty acyl CoA reductase 1 | 0.00915534 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.00914402 |
| EPHA4 | EPH receptor A4 | 0.00913356 |
| LEMD3 | LEM domain containing 3 | 0.00911814 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.00909639 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.00907139 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0090434 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.00898873 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00891372 |
| SLC41A1 | solute carrier family 41 (magnesium transporter), member 1 | 0.00889311 |
| ATP13A3 | ATPase type 13A3 | 0.00885036 |
| RPL3 | ribosomal protein L3 | 0.00883262 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.00880037 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | 0.00879021 |
| MCC | mutated in colorectal cancers | 0.00877531 |
| DSCAM | Down syndrome cell adhesion molecule | 0.00873274 |
| KALRN | kalirin, RhoGEF kinase | 0.00872769 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.00872648 |
| TMEM87A | transmembrane protein 87A | 0.0086583 |
| NOPCHAP1 | NOP protein chaperone 1 | 0.0086512 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.00861447 |
| CPNE8 | copine VIII | 0.00861368 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.226073 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.212377 |
| GPC6 | glypican 6 | -0.207568 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.147597 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.141592 |
| NLGN1 | neuroligin 1 | -0.126644 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.122356 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.113329 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.110532 |
| ASPH | aspartate beta-hydroxylase | -0.096095 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0867197 |
| PRELID2 | PRELI domain containing 2 | -0.0777122 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0771628 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0768353 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0755137 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0752344 |
| VIM | vimentin | -0.070315 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0695774 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0688863 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.068347 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.064418 |
| ENO1 | enolase 1, (alpha) | -0.0622324 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0557876 |
| NAV2 | neuron navigator 2 | -0.0554914 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0544896 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0536982 |
| VGF | VGF nerve growth factor inducible | -0.0536286 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.05303 |
| ATXN1 | ataxin 1 | -0.0516555 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0499622 |
| CUX1 | cut-like homeobox 1 | -0.0493116 |
| PTK2 | protein tyrosine kinase 2 | -0.0490333 |
| CTTNBP2 | cortactin binding protein 2 | -0.0480464 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0452679 |
| EHBP1 | EH domain binding protein 1 | -0.044143 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0430662 |
| RUNX1 | runt-related transcription factor 1 | -0.0413399 |
| NAV1 | neuron navigator 1 | -0.0404472 |
| CDK14 | cyclin-dependent kinase 14 | -0.0397653 |
| CENPF | centromere protein F, 350/400kDa | -0.0395413 |
| PHF21A | PHD finger protein 21A | -0.0392618 |
| OXR1 | oxidation resistance 1 | -0.0388368 |
| PARVB | parvin, beta | -0.0379276 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0375398 |
| FMNL2 | formin-like 2 | -0.0374275 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0370252 |
| TRIM2 | tripartite motif containing 2 | -0.0357098 |
| LDHA | lactate dehydrogenase A | -0.0352661 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.035254 |
| CALU | calumenin | -0.0351975 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0348119 |
| PCDH7 | protocadherin 7 | -0.0340868 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0338633 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0334616 |
| SETBP1 | SET binding protein 1 | -0.0331458 |
| AHNAK | AHNAK nucleoprotein | -0.0326088 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0324594 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0323977 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0319953 |
| MT2A | metallothionein 2A | -0.0319269 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0317109 |
| ACTG1 | actin gamma 1 | -0.0309084 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0308532 |
| PGK1 | phosphoglycerate kinase 1 | -0.0306108 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0305641 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0304182 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0303715 |
| ZNF704 | zinc finger protein 704 | -0.0303392 |
| DIAPH2 | diaphanous-related formin 2 | -0.0302544 |
| CALD1 | caldesmon 1 | -0.0296085 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0290717 |
| CANX | calnexin | -0.0289329 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0288711 |
| TMEM178B | transmembrane protein 178B | -0.0285236 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0281766 |
| CLMN | calmin (calponin-like, transmembrane) | -0.0281074 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.027476 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0274202 |
| RNF24 | ring finger protein 24 | -0.0273476 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0272031 |
| SMYD3 | SET and MYND domain containing 3 | -0.0271667 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0268772 |
| FLNB | filamin B, beta | -0.0255245 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.025487 |
| ARFGEF3 | ARFGEF family member 3 | -0.0251582 |
| MEF2A | myocyte enhancer factor 2A | -0.0250832 |
| MYO1E | myosin IE | -0.0249965 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0249706 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0248223 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0246326 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0246318 |
| TMEM123 | transmembrane protein 123 | -0.024589 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0245457 |
| USP34 | ubiquitin specific peptidase 34 | -0.0244718 |
| EGR1 | early growth response 1 | -0.024415 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0243459 |
| FRMD4A | FERM domain containing 4A | -0.0241638 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0240992 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.024054 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.023765 |
