Doxorubicin (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.114267
FNDC3B fibronectin type III domain containing 3B 0.0710042
SMAD3 SMAD family member 3 0.0709429
MYH9 myosin, heavy chain 9, non-muscle 0.0673483
FAM13A family with sequence similarity 13, member A 0.0612501
APP amyloid beta (A4) precursor protein 0.0569808
TSC22D2 TSC22 domain family, member 2 0.0544385
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0527367
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0520708
ADAM9 ADAM metallopeptidase domain 9 0.0516806
NAMPT nicotinamide phosphoribosyltransferase 0.050068
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0464582
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0446845
ELL2 elongation factor, RNA polymerase II, 2 0.0437947
OGA O-GlcNAcase 0.0421688
TRIO trio Rho guanine nucleotide exchange factor 0.0416771
SAMD4A sterile alpha motif domain containing 4A 0.0408339
SPAG9 sperm associated antigen 9 0.040483
CCNY cyclin Y 0.037935
MYOF myoferlin 0.0376522
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0372822
RUNX1 runt-related transcription factor 1 0.0371429
HELZ helicase with zinc finger 0.0368938
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0367254
ANKRD11 ankyrin repeat domain 11 0.03651
VEGFA vascular endothelial growth factor A 0.036483
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0363684
HOOK2 hook microtubule-tethering protein 2 0.0353562
CANX calnexin 0.0351471
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0341605
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0338553
TNIP1 TNFAIP3 interacting protein 1 0.0332722
DST dystonin 0.0329573
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0327955
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0325556
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0323862
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0323
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.031677
PCBP2 poly(rC) binding protein 2 0.0306525
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0304243
ARRDC3 arrestin domain containing 3 0.0303468
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.029578
DTNA dystrobrevin, alpha 0.0293819
FLNB filamin B, beta 0.0292186
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0291679
GRB10 growth factor receptor-bound protein 10 0.0289326
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.028039
PLAU plasminogen activator, urokinase 0.0275986
TPM3 tropomyosin 3 0.0272221
UBA6 ubiquitin-like modifier activating enzyme 6 0.0270023
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0267076
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0259585
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0256547
DDIT4 DNA-damage-inducible transcript 4 0.0252894
KMT2E lysine (K)-specific methyltransferase 2E 0.0251402
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0246041
YTHDC1 YTH domain containing 1 0.0245345
CCNL1 cyclin L1 0.0240641
AKAP12 A kinase (PRKA) anchor protein 12 0.0240316
FXR1 fragile X mental retardation, autosomal homolog 1 0.0237855
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0237621
APLP2 amyloid beta (A4) precursor-like protein 2 0.0235109
KMT2C lysine (K)-specific methyltransferase 2C 0.0233953
NFE2L1 nuclear factor, erythroid 2-like 1 0.0233161
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0232355
RAB8B RAB8B, member RAS oncogene family 0.0229469
CDC73 cell division cycle 73 0.0227686
PLEC plectin 0.0225175
NUP58 nucleoporin 58 0.0220329
KDM3A lysine (K)-specific demethylase 3A 0.0215171
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0214077
FGFR1 fibroblast growth factor receptor 1 0.0209954
PGK1 phosphoglycerate kinase 1 0.0208899
USP3 ubiquitin specific peptidase 3 0.0206733
RBM39 RNA binding motif protein 39 0.0206426
EEF2 eukaryotic translation elongation factor 2 0.0202135
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0201788
MACF1 microtubule-actin crosslinking factor 1 0.0201408
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0200237
MATR3 matrin 3 0.0198653
ZNF292 zinc finger protein 292 0.0196929
FNBP1L formin binding protein 1-like 0.0194004
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0191435
ERRFI1 ERBB receptor feedback inhibitor 1 0.0191101
CTNND1 catenin (cadherin-associated protein), delta 1 0.0190284
SUCO SUN domain containing ossification factor 0.0187883
HSPA8 heat shock 70kDa protein 8 0.0186734
MYO1B myosin IB 0.0185762
YME1L1 YME1-like 1 ATPase 0.0185666
RLF rearranged L-myc fusion 0.0184278
CXCL8 chemokine (C-X-C motif) ligand 8 0.0183015
ANXA2 annexin A2 0.0179747
MARCHF6 membrane associated ring-CH-type finger 6 0.0175979
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0175882
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0175821
KDM6A lysine (K)-specific demethylase 6A 0.0175467
FLNA filamin A, alpha 0.0174543
SLMAP sarcolemma associated protein 0.0174316
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.017389
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0171726

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.237995
MT2A metallothionein 2A -0.184968
TMSB10 thymosin beta 10 -0.168875
IFI27 interferon, alpha-inducible protein 27 -0.108717
B2M beta-2-microglobulin -0.106234
HLA-B major histocompatibility complex, class I, B -0.105261
KRT19 keratin 19, type I -0.104277
MMP7 matrix metallopeptidase 7 -0.095604
TPT1 tumor protein, translationally-controlled 1 -0.0950726
FTL ferritin, light polypeptide -0.0845484
S100A6 S100 calcium binding protein A6 -0.081347
ACTG1 actin gamma 1 -0.0721105
EIF1 eukaryotic translation initiation factor 1 -0.0682382
MT1X metallothionein 1X -0.0657821
ISG15 ISG15 ubiquitin-like modifier -0.0619509
CP ceruloplasmin (ferroxidase) -0.0619207
RPL23 ribosomal protein L23 -0.05988
RPL35A ribosomal protein L35a -0.0548307
POTEF POTE ankyrin domain family, member F -0.0535826
APOL1 apolipoprotein L, 1 -0.0534495
PTMA prothymosin, alpha -0.0519506
S100A10 S100 calcium binding protein A10 -0.0512977
LCN2 lipocalin 2 -0.0501692
RPLP1 ribosomal protein, large, P1 -0.0497896
RPL19 ribosomal protein L19 -0.0495692
VIM vimentin -0.0490142
RPS8 ribosomal protein S8 -0.0479565
IFI6 interferon, alpha-inducible protein 6 -0.0468394
TM4SF1 transmembrane 4 L six family member 1 -0.04547
CSTB cystatin B (stefin B) -0.0448141
C15ORF48 chromosome 15 open reading frame 48 -0.0446001
HMGA1 high mobility group AT-hook 1 -0.0440221
RPS19 ribosomal protein S19 -0.0435258
CNRIP1 cannabinoid receptor interacting protein 1 -0.0426788
EGR1 early growth response 1 -0.0426606
RPS24 ribosomal protein S24 -0.0407808
RPL34 ribosomal protein L34 -0.0404932
RPS21 ribosomal protein S21 -0.0393875
IFITM1 interferon induced transmembrane protein 1 -0.0389051
LY6E lymphocyte antigen 6 complex, locus E -0.0368042
RPS29 ribosomal protein S29 -0.0366665
PLAT plasminogen activator, tissue -0.0362134
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0356499
RPS23 ribosomal protein S23 -0.0349213
RPL9 ribosomal protein L9 -0.0347021
IFITM3 interferon induced transmembrane protein 3 -0.0340265
S100A11 S100 calcium binding protein A11 -0.0336513
RPL11 ribosomal protein L11 -0.033513
RPL31 ribosomal protein L31 -0.0334911
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0329246
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0317261
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0297628
ENO1 enolase 1, (alpha) -0.0294177
RPS25 ribosomal protein S25 -0.0288698
FTH1 ferritin, heavy polypeptide 1 -0.0285604
LOC102724023 ES1 protein homolog, mitochondrial -0.0285584
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0284834
RPL28 ribosomal protein L28 -0.0279076
RPL37A ribosomal protein L37a -0.0278722
RPS14 ribosomal protein S14 -0.0277545
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0275988
RPS6 ribosomal protein S6 -0.0269339
RPL36AL ribosomal protein L36a-like -0.0245142
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.023189
SP100 SP100 nuclear antigen -0.0231623
RAB7A RAB7A, member RAS oncogene family -0.0229324
RPS27 ribosomal protein S27 -0.0225997
MUC1 mucin 1, cell surface associated -0.0225685
RPLP2 ribosomal protein, large, P2 -0.022472
IFI16 interferon, gamma-inducible protein 16 -0.0223694
HLA-A major histocompatibility complex, class I, A -0.0219745
RPL36A ribosomal protein L36a -0.0217304
SACK1A scaffolding CK1 anchoring protein A -0.0215356
ALCAM activated leukocyte cell adhesion molecule -0.0211932
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.021188
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0211322
MT1E metallothionein 1E -0.0210739
RPL12 ribosomal protein L12 -0.0209413
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0208667
LAMB3 laminin, beta 3 -0.0204959
LMNA lamin A/C -0.0204738
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0203912
SLC38A1 solute carrier family 38, member 1 -0.0202989
GCC2 GRIP and coiled-coil domain containing 2 -0.0198572
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0198322
VDAC1 voltage-dependent anion channel 1 -0.0197179
RPS13 ribosomal protein S13 -0.0196901
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0194916
MDK midkine (neurite growth-promoting factor 2) -0.0192813
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0192792
RPLP0 ribosomal protein, large, P0 -0.0191684
LAMA4 laminin, alpha 4 -0.0190439
PMP22 peripheral myelin protein 22 -0.0188957
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0187494
RPS16 ribosomal protein S16 -0.0185486
RPS5 ribosomal protein S5 -0.018422
MX2 MX dynamin-like GTPase 2 -0.0182359
RPS27A ribosomal protein S27a -0.018199
CLDN4 claudin 4 -0.0180628
GNAS GNAS complex locus -0.0179428