Doxorubicin (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.179817
AKAP12 A kinase (PRKA) anchor protein 12 0.0752167
VCL vinculin 0.0550453
EXT1 exostosin glycosyltransferase 1 0.0522096
RNF213 ring finger protein 213 0.0506552
PLAT plasminogen activator, tissue 0.0494288
FAM13A family with sequence similarity 13, member A 0.0492198
PRKCA protein kinase C, alpha 0.0484595
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0475185
NRG1 neuregulin 1 0.0447531
NALF1 NALCN channel auxiliary factor 1 0.0441025
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0403694
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0400512
ZSWIM6 zinc finger, SWIM-type containing 6 0.0399189
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0397804
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0386006
TIMP3 TIMP metallopeptidase inhibitor 3 0.0384897
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0375956
THSD4 thrombospondin, type I, domain containing 4 0.0348425
PSD3 pleckstrin and Sec7 domain containing 3 0.0342497
ITPRID2 ITPR interacting domain containing 2 0.0331502
IGFBP3 insulin-like growth factor binding protein 3 0.0330897
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0327906
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0326857
RNF150 ring finger protein 150 0.0325046
PDLIM5 PDZ and LIM domain 5 0.0304465
PTPRM protein tyrosine phosphatase, receptor type, M 0.0302484
PRRC2B proline-rich coiled-coil 2B 0.0301168
SPAG9 sperm associated antigen 9 0.0301078
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.02955
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0294888
FNBP1 formin binding protein 1 0.0287708
CUX1 cut-like homeobox 1 0.0287458
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.028512
ZC3H11A zinc finger CCCH-type containing 11A 0.02788
MSI2 musashi RNA-binding protein 2 0.0277392
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0273376
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0273303
FDXR ferredoxin reductase 0.0267099
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0262813
DTNA dystrobrevin, alpha 0.0251292
LINGO2 leucine rich repeat and Ig domain containing 2 0.0246922
MACF1 microtubule-actin crosslinking factor 1 0.0245073
ATXN2 ataxin 2 0.0239594
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0235301
ZNF638 zinc finger protein 638 0.0233648
NFE2L1 nuclear factor, erythroid 2-like 1 0.0233189
NBEA neurobeachin 0.0232493
ZBTB20 zinc finger and BTB domain containing 20 0.0230946
CPED1 cadherin-like and PC-esterase domain containing 1 0.0229568
CADM1 cell adhesion molecule 1 0.0229086
AUTS2 autism susceptibility candidate 2 0.0228102
PTPRS protein tyrosine phosphatase, receptor type, S 0.0227366
CLTC clathrin, heavy chain (Hc) 0.022614
NES nestin 0.0225872
PCBP2 poly(rC) binding protein 2 0.0225522
DPH6 diphthamine biosynthesis 6 0.0224247
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0222697
FNDC3B fibronectin type III domain containing 3B 0.0221595
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.022157
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0220217
GOLGB1 golgin B1 0.0217596
RAD51B RAD51 paralog B 0.0217292
VEGFA vascular endothelial growth factor A 0.0215769
SMAD3 SMAD family member 3 0.0212688
VCAN versican 0.0212027
SREBF2 sterol regulatory element binding transcription factor 2 0.0211713
MYH9 myosin, heavy chain 9, non-muscle 0.0211451
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0208684
GSE1 Gse1 coiled-coil protein 0.0207968
PDE4D phosphodiesterase 4D, cAMP-specific 0.0206438
SLITRK6 SLIT and NTRK-like family, member 6 0.0206006
ANTXR1 anthrax toxin receptor 1 0.0204752
BPTF bromodomain PHD finger transcription factor 0.020457
ZNF146 zinc finger protein 146 0.0204124
SETD5 SET domain containing 5 0.0203612
BICD1 bicaudal D homolog 1 (Drosophila) 0.0203562
FAM107B family with sequence similarity 107, member B 0.0202671
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0202361
GMDS GDP-mannose 4,6-dehydratase 0.0201797
IGFBP5 insulin-like growth factor binding protein 5 0.0200445
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0199915
ACTN1 actinin, alpha 1 0.0199446
FKBP1A FK506 binding protein 1A, 12kDa 0.0197209
MCL1 myeloid cell leukemia 1 0.0195374
SEPTIN9 septin 9 0.0195189
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0194772
PRKCE protein kinase C, epsilon 0.0194111
LARP4B La ribonucleoprotein domain family, member 4B 0.0192619
RUNX2 runt-related transcription factor 2 0.0192536
KCTD16 potassium channel tetramerization domain containing 16 0.0191098
COL4A1 collagen, type IV, alpha 1 0.0189687
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0189288
VMP1 vacuole membrane protein 1 0.0188684
FLT1 fms-related tyrosine kinase 1 0.0183184
SIK3 SIK family kinase 3 0.0183087
PLK2 polo-like kinase 2 0.0182786
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0182049
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0182041
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0179438

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.168808
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108625
RPL23 ribosomal protein L23 -0.0874777
RPLP1 ribosomal protein, large, P1 -0.0822016
VIM vimentin -0.0781989
RPL35A ribosomal protein L35a -0.0726824
TMSB10 thymosin beta 10 -0.06859
TPT1 tumor protein, translationally-controlled 1 -0.0650128
FTL ferritin, light polypeptide -0.0634979
EIF1 eukaryotic translation initiation factor 1 -0.0617977
RPS6 ribosomal protein S6 -0.0583854
RPS3 ribosomal protein S3 -0.0574174
RPL19 ribosomal protein L19 -0.056917
RPL34 ribosomal protein L34 -0.0546432
RPS19 ribosomal protein S19 -0.0515539
RPL38 ribosomal protein L38 -0.050984
NAMPT nicotinamide phosphoribosyltransferase -0.0507928
RPL12 ribosomal protein L12 -0.0493631
RPLP0 ribosomal protein, large, P0 -0.0489736
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0483777
RPS27A ribosomal protein S27a -0.0478905
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0452987
RPL13A ribosomal protein L13a -0.0452375
RPS24 ribosomal protein S24 -0.0441045
RPS12 ribosomal protein S12 -0.0439249
FMN1 formin 1 -0.0424681
GNAS GNAS complex locus -0.0417576
RPL27 ribosomal protein L27 -0.0405104
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0395117
MAP1B microtubule-associated protein 1B -0.0393272
S100A6 S100 calcium binding protein A6 -0.0388107
B2M beta-2-microglobulin -0.0386994
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0386524
RPL37A ribosomal protein L37a -0.0376659
HMGB2 high mobility group box 2 -0.0369155
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0364721
RPL32 ribosomal protein L32 -0.035881
RPL35 ribosomal protein L35 -0.0354842
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0323623
RPL31 ribosomal protein L31 -0.0321515
ARHGAP5 Rho GTPase activating protein 5 -0.0319179
RPL30 ribosomal protein L30 -0.031793
KPNB1 karyopherin (importin) beta 1 -0.0309655
COL1A1 collagen, type I, alpha 1 -0.0306944
RPS27 ribosomal protein S27 -0.0304605
RPL26 ribosomal protein L26 -0.0302815
TPI1 triosephosphate isomerase 1 -0.0298902
SYT1 synaptotagmin I -0.0288709
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0286997
NAP1L1 nucleosome assembly protein 1-like 1 -0.0285583
NCAM2 neural cell adhesion molecule 2 -0.0282557
UQCRB ubiquinol-cytochrome c reductase binding protein -0.028137
CD36 CD36 molecule (thrombospondin receptor) -0.0281082
RPL36 ribosomal protein L36 -0.0277764
S100A9 S100 calcium binding protein A9 -0.0276689
RPS21 ribosomal protein S21 -0.0274176
RPS14 ribosomal protein S14 -0.0273351
IGF2 insulin-like growth factor 2 -0.0269769
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0268446
ENO1 enolase 1, (alpha) -0.0267508
PRRC2C proline-rich coiled-coil 2C -0.0266514
MT2A metallothionein 2A -0.0266267
H3-3B H3.3 histone B -0.0265565
RPL8 ribosomal protein L8 -0.0262242
DDIT4 DNA-damage-inducible transcript 4 -0.0261301
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0260854
RPS29 ribosomal protein S29 -0.0259623
ACTG1 actin gamma 1 -0.025931
RPLP2 ribosomal protein, large, P2 -0.0258439
LMNA lamin A/C -0.0256482
SQSTM1 sequestosome 1 -0.0251166
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249477
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0245595
TNPO1 transportin 1 -0.0243866
RACK1 receptor for activated C kinase 1 -0.0242129
AHNAK AHNAK nucleoprotein -0.0241076
TRIO trio Rho guanine nucleotide exchange factor -0.0240969
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.023594
THOC2 THO complex 2 -0.0230092
FN1 fibronectin 1 -0.0228296
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.022755
RPS17 ribosomal protein S17 -0.022712
PNISR PNN-interacting serine/arginine-rich protein -0.0227033
PKM pyruvate kinase, muscle -0.0226315
RPS8 ribosomal protein S8 -0.0224837
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0224401
RPL4 ribosomal protein L4 -0.0223923
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0222663
CANX calnexin -0.0222603
RPS16 ribosomal protein S16 -0.0219585
RPL9 ribosomal protein L9 -0.0214007
SSBP2 single-stranded DNA binding protein 2 -0.0213847
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0213685
GOLGA4 golgin A4 -0.0212846
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0212531
RPL11 ribosomal protein L11 -0.021247
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0210793
GARS1 glycyl-tRNA synthetase 1 -0.0210126
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0208989
RPS4X ribosomal protein S4, X-linked -0.0208209