Doxorubicin (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.234608
P4HB prolyl 4-hydroxylase, beta polypeptide 0.115483
PRELID2 PRELI domain containing 2 0.101166
EEF2 eukaryotic translation elongation factor 2 0.0978209
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.095269
PCBP2 poly(rC) binding protein 2 0.0878598
TXNRD1 thioredoxin reductase 1 0.0802515
RAD51B RAD51 paralog B 0.0675221
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0661709
SEC31A SEC31 homolog A (S. cerevisiae) 0.0660921
GOLGA4 golgin A4 0.0656526
CANX calnexin 0.0655304
HDLBP high density lipoprotein binding protein 0.0639544
MYH9 myosin, heavy chain 9, non-muscle 0.0632894
AKAP9 A kinase (PRKA) anchor protein 9 0.0599514
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0574449
ZNF638 zinc finger protein 638 0.0535851
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0524753
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0509704
KDM4C lysine (K)-specific demethylase 4C 0.0496931
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0489679
TTC3 tetratricopeptide repeat domain 3 0.0488134
COG6 component of oligomeric golgi complex 6 0.048813
OGA O-GlcNAcase 0.0485512
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0470993
MCL1 myeloid cell leukemia 1 0.0468874
SUCO SUN domain containing ossification factor 0.0467736
HELZ helicase with zinc finger 0.0464879
APLP2 amyloid beta (A4) precursor-like protein 2 0.0448597
SEC24D SEC24 family member D 0.0447363
ZFAND3 zinc finger, AN1-type domain 3 0.0443706
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0438642
MON2 MON2 homolog (S. cerevisiae) 0.0434484
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0432931
NBAS neuroblastoma amplified sequence 0.0431955
ARF4 ADP-ribosylation factor 4 0.0425084
PDIA3 protein disulfide isomerase family A, member 3 0.0421144
ANKRD11 ankyrin repeat domain 11 0.0421131
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0404924
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0402412
TBC1D22A TBC1 domain family, member 22A 0.0398731
NUP58 nucleoporin 58 0.0397877
KMT2C lysine (K)-specific methyltransferase 2C 0.0387798
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0386417
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0386315
ZC3H11A zinc finger CCCH-type containing 11A 0.0384243
FNDC3B fibronectin type III domain containing 3B 0.0382731
BIRC6 baculoviral IAP repeat containing 6 0.038148
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0375419
SRP54 signal recognition particle 54kDa 0.0374672
GOLGB1 golgin B1 0.0371056
KIAA1217 KIAA1217 0.0367732
DSCAM Down syndrome cell adhesion molecule 0.0362446
USP37 ubiquitin specific peptidase 37 0.0358455
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0356197
LCOR ligand dependent nuclear receptor corepressor 0.0354847
ANKHD1 ankyrin repeat and KH domain containing 1 0.0348488
CDK19 cyclin-dependent kinase 19 0.0341668
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0340055
SQSTM1 sequestosome 1 0.0339529
COPB1 coatomer protein complex, subunit beta 1 0.0333574
MBD5 methyl-CpG binding domain protein 5 0.0332975
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0330624
BBX bobby sox homolog (Drosophila) 0.0327362
YME1L1 YME1-like 1 ATPase 0.0325016
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0324292
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0323968
IARS1 isoleucyl-tRNA synthetase 1 0.0323817
COG5 component of oligomeric golgi complex 5 0.0323105
ARL5B ADP-ribosylation factor-like 5B 0.0323049
PTEN phosphatase and tensin homolog 0.0322962
ZSWIM6 zinc finger, SWIM-type containing 6 0.0322799
TMEM41B transmembrane protein 41B 0.0321393
KDM6A lysine (K)-specific demethylase 6A 0.0321186
N4BP2L2 NEDD4 binding protein 2-like 2 0.0319365
CTNND1 catenin (cadherin-associated protein), delta 1 0.0314028
COPA coatomer protein complex, subunit alpha 0.0311844
TBC1D5 TBC1 domain family, member 5 0.0309546
HYOU1 hypoxia up-regulated 1 0.0308844
YEATS2 YEATS domain containing 2 0.0308659
TRIP12 thyroid hormone receptor interactor 12 0.0306404
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0306087
SND1 staphylococcal nuclease and tudor domain containing 1 0.0305251
GIGYF2 GRB10 interacting GYF protein 2 0.0302369
TOR1AIP2 torsin A interacting protein 2 0.03017
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0299995
YTHDC1 YTH domain containing 1 0.0298811
BRD2 bromodomain containing 2 0.0298493
UBA6 ubiquitin-like modifier activating enzyme 6 0.0295175
ZNF654 zinc finger protein 654 0.0294956
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.029316
PGM3 phosphoglucomutase 3 0.0292716
TFG TRK-fused gene 0.0292063
VMP1 vacuole membrane protein 1 0.0290929
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290337
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.02889
RARS1 arginyl-tRNA synthetase 1 0.0288803
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0288791
PMM2 phosphomannomutase 2 0.0288513
PDIA4 protein disulfide isomerase family A, member 4 0.0286412

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.180793
FAT1 FAT atypical cadherin 1 -0.165136
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133427
TPT1 tumor protein, translationally-controlled 1 -0.115982
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.113841
TMSB10 thymosin beta 10 -0.109391
NDRG1 N-myc downstream regulated 1 -0.0944662
AHNAK AHNAK nucleoprotein -0.0884651
ENO1 enolase 1, (alpha) -0.0649065
MT2A metallothionein 2A -0.0646456
KRT18 keratin 18, type I -0.050845
RPS8 ribosomal protein S8 -0.0455412
TPM4 tropomyosin 4 -0.0450379
RPL35A ribosomal protein L35a -0.0440508
KRT19 keratin 19, type I -0.039672
S100A10 S100 calcium binding protein A10 -0.0358459
RPS6 ribosomal protein S6 -0.0354528
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0348968
EPCAM epithelial cell adhesion molecule -0.0336878
FTL ferritin, light polypeptide -0.033332
RACK1 receptor for activated C kinase 1 -0.0329919
RPS27A ribosomal protein S27a -0.0328043
S100A9 S100 calcium binding protein A9 -0.032511
ACTG1 actin gamma 1 -0.0324983
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0321587
IFITM3 interferon induced transmembrane protein 3 -0.0321021
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0319284
S100A6 S100 calcium binding protein A6 -0.0312098
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0301306
HMGA2 high mobility group AT-hook 2 -0.0300979
CCND1 cyclin D1 -0.0300423
TUBA1B tubulin, alpha 1b -0.0293739
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0292871
RPLP2 ribosomal protein, large, P2 -0.0270308
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0261092
RPLP0 ribosomal protein, large, P0 -0.0257279
RPL36 ribosomal protein L36 -0.0256211
RPS3 ribosomal protein S3 -0.0255597
H1-0 H1.0 linker histone -0.0251522
CDCP1 CUB domain containing protein 1 -0.024797
CADPS Ca++-dependent secretion activator -0.0247601
POTEF POTE ankyrin domain family, member F -0.0244239
RPL26 ribosomal protein L26 -0.0241088
RPL19 ribosomal protein L19 -0.0239826
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0237371
RPL34 ribosomal protein L34 -0.0236108
HMGB1 high mobility group box 1 -0.023537
RPL5 ribosomal protein L5 -0.023274
RPL9 ribosomal protein L9 -0.0231645
RPL12 ribosomal protein L12 -0.0228527
RPL18 ribosomal protein L18 -0.0223173
RPLP1 ribosomal protein, large, P1 -0.0222897
LMNA lamin A/C -0.0220719
RPL30 ribosomal protein L30 -0.0220186
RPS16 ribosomal protein S16 -0.0217488
SH3BP4 SH3-domain binding protein 4 -0.021705
TUBB tubulin, beta class I -0.0215569
LOC112694756 uncharaterized LOC112694756 -0.0201946
RPL32 ribosomal protein L32 -0.0197692
FRMD5 FERM domain containing 5 -0.0194159
SERBP1 SERPINE1 mRNA binding protein 1 -0.0186683
RPS19 ribosomal protein S19 -0.0186251
HMGA1 high mobility group AT-hook 1 -0.0183966
RSL1D1 ribosomal L1 domain containing 1 -0.0182449
RPS13 ribosomal protein S13 -0.0180787
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.018066
RPS29 ribosomal protein S29 -0.0179719
RPL37A ribosomal protein L37a -0.0179329
IFITM2 interferon induced transmembrane protein 2 -0.0177938
RPL28 ribosomal protein L28 -0.0175481
HLA-B major histocompatibility complex, class I, B -0.0175284
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0173477
DIAPH2 diaphanous-related formin 2 -0.0172042
RPL35 ribosomal protein L35 -0.0171284
FBXL2 F-box and leucine-rich repeat protein 2 -0.0171058
IGFBP4 insulin-like growth factor binding protein 4 -0.0170421
SERINC5 serine incorporator 5 -0.0170236
BACE2 beta-site APP-cleaving enzyme 2 -0.0168778
RPS27 ribosomal protein S27 -0.0165905
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0165684
PTPRF protein tyrosine phosphatase, receptor type, F -0.0165532
PA2G4 proliferation-associated 2G4, 38kDa -0.0163788
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0161013
NPEPPS aminopeptidase puromycin sensitive -0.0156684
H1-4 H1.4 linker histone, cluster member -0.0156402
RPL8 ribosomal protein L8 -0.0155595
VDAC1 voltage-dependent anion channel 1 -0.0155277
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0154826
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0154251
PKM pyruvate kinase, muscle -0.0150414
YBX3 Y box binding protein 3 -0.0149423
ITGB4 integrin, beta 4 -0.0148942
TMEM123 transmembrane protein 123 -0.0148472
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0147687
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0147246
MKI67 marker of proliferation Ki-67 -0.014713
RPS24 ribosomal protein S24 -0.0147067
NOP56 NOP56 ribonucleoprotein -0.0146213
PCDH7 protocadherin 7 -0.0142632
RNF43 ring finger protein 43 -0.014242