Doxorubicin (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0393055
MATR3 matrin 3 0.0327608
CCNL1 cyclin L1 0.028828
HELZ helicase with zinc finger 0.0277613
KDM3A lysine (K)-specific demethylase 3A 0.0261499
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.018911
OGA O-GlcNAcase 0.0189098
APP amyloid beta (A4) precursor protein 0.0182858
TNIP1 TNFAIP3 interacting protein 1 0.0180127
PCBP2 poly(rC) binding protein 2 0.0179485
KDM6A lysine (K)-specific demethylase 6A 0.0176639
YTHDC1 YTH domain containing 1 0.0176284
NEK7 NIMA-related kinase 7 0.0174743
RNF145 ring finger protein 145 0.0174723
TOP2B topoisomerase (DNA) II beta 180kDa 0.0173685
USP9X ubiquitin specific peptidase 9, X-linked 0.0166483
RPSA ribosomal protein SA 0.0162643
TNRC6A trinucleotide repeat containing 6A 0.0162152
NCKAP1 NCK-associated protein 1 0.0156698
CCDC93 coiled-coil domain containing 93 0.0156438
WDFY3 WD repeat and FYVE domain containing 3 0.0154894
ZNF292 zinc finger protein 292 0.0150462
RLF rearranged L-myc fusion 0.0148972
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0146662
FXR1 fragile X mental retardation, autosomal homolog 1 0.0146079
NUP54 nucleoporin 54kDa 0.0138314
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0137094
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0137089
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0135863
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0134726
PDS5B PDS5 cohesin associated factor B 0.0134407
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0134358
SPOPL speckle-type POZ protein-like 0.0133878
ATP11B ATPase, class VI, type 11B 0.0133816
RNF213 ring finger protein 213 0.0131116
EEF2 eukaryotic translation elongation factor 2 0.0131041
ANKRD28 ankyrin repeat domain 28 0.012994
ADAM9 ADAM metallopeptidase domain 9 0.0128831
USP3 ubiquitin specific peptidase 3 0.0127978
ZMYM2 zinc finger, MYM-type 2 0.0127586
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0127473
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0127342
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0126247
WDR43 WD repeat domain 43 0.012607
KDM1A lysine (K)-specific demethylase 1A 0.0125543
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0125005
CD46 CD46 molecule, complement regulatory protein 0.0124745
KIF5B kinesin family member 5B 0.0122828
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0122229
SNX4 sorting nexin 4 0.0121209
MSI2 musashi RNA-binding protein 2 0.0120629
ECPAS Ecm29 proteasome adaptor and scaffold 0.0118357
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0117677
PAWR PRKC, apoptosis, WT1, regulator 0.0117659
EIF4H eukaryotic translation initiation factor 4H 0.0117368
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0115826
ARL15 ADP-ribosylation factor-like 15 0.0114595
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0114498
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0113965
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0113808
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0113584
CREBRF CREB3 regulatory factor 0.0112803
ZNF148 zinc finger protein 148 0.0112008
PDCD6IP programmed cell death 6 interacting protein 0.0111934
QKI QKI, KH domain containing, RNA binding 0.0111664
COG5 component of oligomeric golgi complex 5 0.0110169
OLA1 Obg-like ATPase 1 0.0110116
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0108919
PUM1 pumilio RNA-binding family member 1 0.0108684
FUBP1 far upstream element (FUSE) binding protein 1 0.0108058
UGCG UDP-glucose ceramide glucosyltransferase 0.0108054
SRPK2 SRSF protein kinase 2 0.0108042
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0107408
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0107156
EIF4A2 eukaryotic translation initiation factor 4A2 0.0105993
WAC WW domain containing adaptor with coiled-coil 0.0105469
AMBRA1 autophagy/beclin-1 regulator 1 0.0104367
PCM1 pericentriolar material 1 0.0104143
RAD23B RAD23 homolog B (S. cerevisiae) 0.0103811
CENPC centromere protein C 0.0103786
KMT2E lysine (K)-specific methyltransferase 2E 0.0103651
PTBP2 polypyrimidine tract binding protein 2 0.0103439
DENND4A DENN/MADD domain containing 4A 0.0103429
TPD52 tumor protein D52 0.01034
LNPK lunapark, ER junction formation factor 0.0103234
TFG TRK-fused gene 0.0102838
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0102376
TENT2 terminal nucleotidyltransferase 2 0.0102304
SCAF4 SR-related CTD-associated factor 4 0.010218
RBM33 RNA binding motif protein 33 0.0102154
PPME1 protein phosphatase methylesterase 1 0.0100562
GMPS guanine monphosphate synthase 0.00999777
USP33 ubiquitin specific peptidase 33 0.00998456
MED13 mediator complex subunit 13 0.00997004
SNX9 sorting nexin 9 0.00996356
KLHL24 kelch-like family member 24 0.00989444
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.00982639
GAPVD1 GTPase activating protein and VPS9 domains 1 0.00981996
NUP58 nucleoporin 58 0.009815
PCNX1 pecanex 1 0.00969736

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.157574
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140627
TMSB10 thymosin beta 10 -0.138241
ASPH aspartate beta-hydroxylase -0.122561
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.105125
ALCAM activated leukocyte cell adhesion molecule -0.0819984
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0776283
ACTG1 actin gamma 1 -0.076496
PAX8 paired box 8 -0.0750613
RPL35A ribosomal protein L35a -0.0724527
PSD3 pleckstrin and Sec7 domain containing 3 -0.0708953
PTMA prothymosin, alpha -0.0633604
FTL ferritin, light polypeptide -0.0623518
RPL23 ribosomal protein L23 -0.060454
SVIL supervillin -0.0597153
RPS6 ribosomal protein S6 -0.0586456
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0572712
RPS8 ribosomal protein S8 -0.0572259
ENO1 enolase 1, (alpha) -0.0570286
AHNAK AHNAK nucleoprotein -0.0549428
PRELID2 PRELI domain containing 2 -0.0545137
CD44 CD44 molecule (Indian blood group) -0.0536604
TPT1 tumor protein, translationally-controlled 1 -0.0528009
CCND1 cyclin D1 -0.0516166
LAMB3 laminin, beta 3 -0.0514277
RPL31 ribosomal protein L31 -0.0488185
TPM4 tropomyosin 4 -0.0484005
HMGA2 high mobility group AT-hook 2 -0.048322
RPL19 ribosomal protein L19 -0.047983
RPS19 ribosomal protein S19 -0.0478307
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0474552
RPL12 ribosomal protein L12 -0.0473836
RPL34 ribosomal protein L34 -0.0468245
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0458123
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0452401
LAMC2 laminin, gamma 2 -0.044239
ZBTB20 zinc finger and BTB domain containing 20 -0.0442172
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0433284
KRT7 keratin 7, type II -0.0427705
RAD51B RAD51 paralog B -0.0420787
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.041802
LPP LIM domain containing preferred translocation partner in lipoma -0.0412137
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0410566
MACROD2 MACRO domain containing 2 -0.040911
RPLP1 ribosomal protein, large, P1 -0.0395807
FHIT fragile histidine triad -0.0389216
RPS3 ribosomal protein S3 -0.0383216
RPL37A ribosomal protein L37a -0.0380924
RPS27A ribosomal protein S27a -0.0378614
EGFR epidermal growth factor receptor -0.0377156
CREB5 cAMP responsive element binding protein 5 -0.0372272
ANXA2 annexin A2 -0.0368458
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0363768
FLNB filamin B, beta -0.036119
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0352914
LDHA lactate dehydrogenase A -0.0352012
RPL9 ribosomal protein L9 -0.0349214
RPL26 ribosomal protein L26 -0.0349177
S100A10 S100 calcium binding protein A10 -0.0349104
S100A9 S100 calcium binding protein A9 -0.0348104
RPL11 ribosomal protein L11 -0.0343816
BPTF bromodomain PHD finger transcription factor -0.0343253
RPS12 ribosomal protein S12 -0.033948
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0328947
INTS6 integrator complex subunit 6 -0.0328627
VCL vinculin -0.0326836
RACK1 receptor for activated C kinase 1 -0.0325391
DLC1 DLC1 Rho GTPase activating protein -0.0323972
RPS17 ribosomal protein S17 -0.0320016
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0314988
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0313736
B2M beta-2-microglobulin -0.0311998
RPL35 ribosomal protein L35 -0.0303542
RPLP2 ribosomal protein, large, P2 -0.0301335
ATXN1 ataxin 1 -0.0300589
SMYD3 SET and MYND domain containing 3 -0.0299796
SH3KBP1 SH3-domain kinase binding protein 1 -0.0299037
PKM pyruvate kinase, muscle -0.0298708
RPL5 ribosomal protein L5 -0.0295453
RPS14 ribosomal protein S14 -0.029184
BICD1 bicaudal D homolog 1 (Drosophila) -0.0290986
HMGA1 high mobility group AT-hook 1 -0.0289636
NDRG1 N-myc downstream regulated 1 -0.02883
PATJ PATJ crumbs cell polarity complex component -0.028821
LAMA4 laminin, alpha 4 -0.028534
S100A6 S100 calcium binding protein A6 -0.0272447
RPL32 ribosomal protein L32 -0.0271485
OSBPL10 oxysterol binding protein-like 10 -0.026693
RPS13 ribosomal protein S13 -0.0261562
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0258773
FNDC3B fibronectin type III domain containing 3B -0.0257852
RPL36 ribosomal protein L36 -0.0256193
CAPN2 calpain 2, (m/II) large subunit -0.0255485
ITGB8 integrin, beta 8 -0.0255192
ANXA3 annexin A3 -0.0251352
EIF1 eukaryotic translation initiation factor 1 -0.0247919
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0246771
RPS16 ribosomal protein S16 -0.024427
LIMCH1 LIM and calponin homology domains 1 -0.0242439
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0240598