Doxorubicin (hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.186581
TMSB10 thymosin beta 10 0.116081
COL6A1 collagen, type VI, alpha 1 0.115012
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0817382
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0809411
CDH13 cadherin 13 0.0791459
TGFBI transforming growth factor, beta-induced, 68kDa 0.0786627
CXCL8 chemokine (C-X-C motif) ligand 8 0.0691946
LAMB3 laminin, beta 3 0.0590759
COL5A1 collagen, type V, alpha 1 0.0540575
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0536286
FLNA filamin A, alpha 0.0452678
EEF2 eukaryotic translation elongation factor 2 0.042781
COL6A3 collagen, type VI, alpha 3 0.0426997
COL6A2 collagen, type VI, alpha 2 0.0409032
RPL35A ribosomal protein L35a 0.0354511
PCBP2 poly(rC) binding protein 2 0.0341679
IGF2 insulin-like growth factor 2 0.0340928
MAML3 mastermind-like 3 (Drosophila) 0.0333327
ANXA2 annexin A2 0.0323237
CALR calreticulin 0.0320224
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0314299
GRB10 growth factor receptor-bound protein 10 0.0309367
COL7A1 collagen, type VII, alpha 1 0.029879
VEGFA vascular endothelial growth factor A 0.0292092
ANKRD11 ankyrin repeat domain 11 0.0287273
MCL1 myeloid cell leukemia 1 0.0282737
RPLP1 ribosomal protein, large, P1 0.0273203
CANX calnexin 0.0271815
MRPS6 mitochondrial ribosomal protein S6 0.0271729
AFF3 AF4/FMR2 family, member 3 0.027127
EGR1 early growth response 1 0.0265966
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0265187
NFE2L1 nuclear factor, erythroid 2-like 1 0.0264215
PTPRG protein tyrosine phosphatase, receptor type, G 0.0257463
PKM pyruvate kinase, muscle 0.0255257
EFNA5 ephrin-A5 0.024899
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0243425
GNAS GNAS complex locus 0.0242646
GLS2 glutaminase 2 (liver, mitochondrial) 0.023981
SDK1 sidekick cell adhesion molecule 1 0.0239245
FN1 fibronectin 1 0.0236998
SLIT2 slit homolog 2 (Drosophila) 0.0236976
FRMD4A FERM domain containing 4A 0.0235584
ADM adrenomedullin 0.0233719
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0228804
RPS19 ribosomal protein S19 0.0226947
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.022596
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0223634
TPI1 triosephosphate isomerase 1 0.0219337
GANAB glucosidase, alpha; neutral AB 0.0218535
ENO2 enolase 2 (gamma, neuronal) 0.0215525
TNS1 tensin 1 0.0210414
SAMD4A sterile alpha motif domain containing 4A 0.0209496
FGFR1 fibroblast growth factor receptor 1 0.0209494
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0207702
INHBA inhibin, beta A 0.0206897
RUNX1 runt-related transcription factor 1 0.0204698
NSUN6 NOP2/Sun domain family, member 6 0.0202941
HLA-A major histocompatibility complex, class I, A 0.0202931
IGF1R insulin-like growth factor 1 receptor 0.0200089
PLEC plectin 0.019953
PTMA prothymosin, alpha 0.0197484
RPS6 ribosomal protein S6 0.0195618
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0194925
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.019451
PTPRK protein tyrosine phosphatase, receptor type, K 0.0194248
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0194054
MYH9 myosin, heavy chain 9, non-muscle 0.0193299
RPL13A ribosomal protein L13a 0.0193194
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0191543
RPL37 ribosomal protein L37 0.0189924
YBX1 Y box binding protein 1 0.0188896
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0187397
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0186761
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0185905
RPL37A ribosomal protein L37a 0.0185548
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0184487
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0184155
EPHA4 EPH receptor A4 0.0183406
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.017958
AKAP12 A kinase (PRKA) anchor protein 12 0.0178854
ADAM9 ADAM metallopeptidase domain 9 0.0177957
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0175416
EEF1G eukaryotic translation elongation factor 1 gamma 0.0174672
RPL23 ribosomal protein L23 0.0173923
LOXL2 lysyl oxidase-like 2 0.017372
RPS4X ribosomal protein S4, X-linked 0.0173487
FTH1 ferritin, heavy polypeptide 1 0.017245
PDE10A phosphodiesterase 10A 0.0171933
PDIA3 protein disulfide isomerase family A, member 3 0.0169472
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0164686
NAP1L1 nucleosome assembly protein 1-like 1 0.0162602
RPL8 ribosomal protein L8 0.0160173
WSB1 WD repeat and SOCS box containing 1 0.0158784
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0157965
TNIP1 TNFAIP3 interacting protein 1 0.0157213
OGA O-GlcNAcase 0.015705
IGFBP3 insulin-like growth factor binding protein 3 0.0156731
THBS1 thrombospondin 1 0.0156693

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.441268
CD44 CD44 molecule (Indian blood group) -0.128576
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.118139
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0964556
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0891256
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0724634
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0633951
CDCP1 CUB domain containing protein 1 -0.063017
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0574848
ELL2 elongation factor, RNA polymerase II, 2 -0.0526144
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0377122
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0341968
FNDC3B fibronectin type III domain containing 3B -0.0328056
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0318029
CENPF centromere protein F, 350/400kDa -0.0298631
GOLGA4 golgin A4 -0.0295574
PLAUR plasminogen activator, urokinase receptor -0.0292087
GLIS3 GLIS family zinc finger 3 -0.0291536
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0284331
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.028359
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0274169
NECTIN2 nectin cell adhesion molecule 2 -0.0267143
TM4SF1 transmembrane 4 L six family member 1 -0.026622
DST dystonin -0.0265762
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0258605
ANKRD28 ankyrin repeat domain 28 -0.0254246
TXNIP thioredoxin interacting protein -0.0252686
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0249472
CLTC clathrin, heavy chain (Hc) -0.0241432
MAP1B microtubule-associated protein 1B -0.0239888
USP34 ubiquitin specific peptidase 34 -0.0239343
DNMBP dynamin binding protein -0.0239074
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0226347
HSPA8 heat shock 70kDa protein 8 -0.0226321
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0219972
MT2A metallothionein 2A -0.0213896
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0206183
NDRG1 N-myc downstream regulated 1 -0.0202157
ZNF292 zinc finger protein 292 -0.0201682
CLIC4 chloride intracellular channel 4 -0.0185267
SBF2 SET binding factor 2 -0.0185009
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0184468
SMYD3 SET and MYND domain containing 3 -0.017904
RNF24 ring finger protein 24 -0.017101
RPS2 ribosomal protein S2 -0.0170793
WDPCP WD repeat containing planar cell polarity effector -0.0169937
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0169605
GOLT1B golgi transport 1B -0.0163148
CUL4B cullin 4B -0.0160653
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0159963
LAMP2 lysosomal-associated membrane protein 2 -0.0155467
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0153233
H1-4 H1.4 linker histone, cluster member -0.0152815
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0151397
CHD1 chromodomain helicase DNA binding protein 1 -0.0151329
LDHA lactate dehydrogenase A -0.0147926
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0145852
SETD5 SET domain containing 5 -0.0144886
CKAP2 cytoskeleton associated protein 2 -0.0144464
WWTR1 WW domain containing transcription regulator 1 -0.014311
MSN moesin -0.0142959
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0140507
ZFAND3 zinc finger, AN1-type domain 3 -0.0139913
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0139796
NUMB numb homolog (Drosophila) -0.0139326
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0137299
CKAP5 cytoskeleton associated protein 5 -0.0132587
TENM2 teneurin transmembrane protein 2 -0.0131641
TMF1 TATA element modulatory factor 1 -0.0130919
PUM2 pumilio RNA-binding family member 2 -0.0129199
ANLN anillin, actin binding protein -0.0128197
SPAG9 sperm associated antigen 9 -0.0127548
GRAMD1B GRAM domain containing 1B -0.0126829
TPX2 TPX2, microtubule-associated -0.0125521
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0125191
NF1 neurofibromin 1 -0.0124245
KMT2E lysine (K)-specific methyltransferase 2E -0.0121008
ARFGEF3 ARFGEF family member 3 -0.0119452
RAB10 RAB10, member RAS oncogene family -0.011938
RTN4 reticulon 4 -0.0118954
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0118501
YEATS2 YEATS domain containing 2 -0.0116532
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0115294
SPATS2 spermatogenesis associated, serine-rich 2 -0.011483
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0114219
CLINT1 clathrin interactor 1 -0.0114073
CEP350 centrosomal protein 350kDa -0.0113884
RBM39 RNA binding motif protein 39 -0.0112761
SFXN1 sideroflexin 1 -0.0112046
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0111599
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0111113
MEF2A myocyte enhancer factor 2A -0.0110603
SPIRE1 spire-type actin nucleation factor 1 -0.0109211
CDC73 cell division cycle 73 -0.0108015
BHLHE41 basic helix-loop-helix family, member e41 -0.0107008
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0106818
FAM13B family with sequence similarity 13, member B -0.0106187
DUSP6 dual specificity phosphatase 6 -0.0104912
UBQLN1 ubiquilin 1 -0.0104909
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0104469