| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Doxorubicin (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.17385 |
| COL6A3 | collagen, type VI, alpha 3 | 0.142461 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.079932 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0698135 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0622416 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0596333 |
| LOXL2 | lysyl oxidase-like 2 | 0.0503807 |
| CANX | calnexin | 0.0485744 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0465038 |
| COL1A2 | collagen, type I, alpha 2 | 0.0463515 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0422093 |
| FLNA | filamin A, alpha | 0.0401844 |
| CALR | calreticulin | 0.040166 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.03575 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0352264 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0349297 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0336979 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0318312 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0313233 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0312906 |
| TMSB4X | thymosin beta 4, X-linked | 0.0290177 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0288226 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0285428 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0275234 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0266224 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0265575 |
| HLA-E | major histocompatibility complex, class I, E | 0.0260093 |
| EFNA5 | ephrin-A5 | 0.0253159 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0248592 |
| APP | amyloid beta (A4) precursor protein | 0.0247545 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.0245092 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0241031 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0235664 |
| GANAB | glucosidase, alpha; neutral AB | 0.022971 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0229028 |
| CADM1 | cell adhesion molecule 1 | 0.0224578 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0224253 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0219784 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0214289 |
| EPHA4 | EPH receptor A4 | 0.0214134 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0210818 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0208939 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0207468 |
| HYOU1 | hypoxia up-regulated 1 | 0.0199889 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.019932 |
| PCBP2 | poly(rC) binding protein 2 | 0.0198893 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0190149 |
| CTSB | cathepsin B | 0.0189516 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0184968 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0184333 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0184065 |
| PRELID2 | PRELI domain containing 2 | 0.0179913 |
| IRF3 | interferon regulatory factor 3 | 0.0176293 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0175996 |
| RPSA | ribosomal protein SA | 0.0175764 |
| FBN1 | fibrillin 1 | 0.0175692 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0173205 |
| PLEC | plectin | 0.017102 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0168078 |
| HLA-A | major histocompatibility complex, class I, A | 0.0166903 |
| CCNL1 | cyclin L1 | 0.0164377 |
| SMAP2 | small ArfGAP2 | 0.0161857 |
| YBX1 | Y box binding protein 1 | 0.0159412 |
| RSRP1 | arginine/serine-rich protein 1 | 0.015825 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0157574 |
| CDH13 | cadherin 13 | 0.0157426 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0154055 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0152851 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.015137 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0151339 |
| PRR16 | proline rich 16 | 0.0148465 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0147811 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0147667 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0147562 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0146918 |
| COL5A2 | collagen, type V, alpha 2 | 0.0144831 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0144664 |
| BBX | bobby sox homolog (Drosophila) | 0.0142552 |
| RNF213 | ring finger protein 213 | 0.0142257 |
| CDK19 | cyclin-dependent kinase 19 | 0.0141479 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0139673 |
| EGFR | epidermal growth factor receptor | 0.0137271 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.01353 |
| COL3A1 | collagen, type III, alpha 1 | 0.013408 |
| STC2 | stanniocalcin 2 | 0.0133475 |
| PRKCA | protein kinase C, alpha | 0.0132878 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0129763 |
| HMCN1 | hemicentin 1 | 0.0129336 |
| IGSF11 | immunoglobulin superfamily, member 11 | 0.0128787 |
| TOP1 | topoisomerase (DNA) I | 0.0125224 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0125052 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.012271 |
| CCNL2 | cyclin L2 | 0.0122584 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0119997 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0119691 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0119478 |
| CDC37 | cell division cycle 37 | 0.0118316 |
| CD109 | CD109 molecule | 0.0117491 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0117285 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0116972 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.282573 |
| MT2A | metallothionein 2A | -0.206184 |
| CD44 | CD44 molecule (Indian blood group) | -0.101094 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0889762 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0831605 |
| VIM | vimentin | -0.0812936 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0781827 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0740976 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0704749 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.066371 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0564315 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0548564 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0540671 |
| MAP1B | microtubule-associated protein 1B | -0.0502439 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0482879 |
| NDRG1 | N-myc downstream regulated 1 | -0.0471327 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0464868 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0428113 |
| MTSS1 | metastasis suppressor 1 | -0.0416889 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0405462 |
| MT1X | metallothionein 1X | -0.0396806 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0371573 |
| LDHA | lactate dehydrogenase A | -0.0358174 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0346586 |
| ACTG1 | actin gamma 1 | -0.0339119 |
| IER3 | immediate early response 3 | -0.0333595 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0330401 |
| GOLGA4 | golgin A4 | -0.032867 |
| SQLE | squalene epoxidase | -0.0324097 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0322826 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0322079 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0316637 |
| VCAN | versican | -0.0315634 |
| PTMA | prothymosin, alpha | -0.0301572 |
| CLIC4 | chloride intracellular channel 4 | -0.029988 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0291652 |
| FTL | ferritin, light polypeptide | -0.0287888 |
| MAP4 | microtubule-associated protein 4 | -0.0279042 |
| SBF2 | SET binding factor 2 | -0.0275146 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0272402 |
| HAS2 | hyaluronan synthase 2 | -0.0266446 |
| STC1 | stanniocalcin 1 | -0.0263368 |
| PTK2 | protein tyrosine kinase 2 | -0.0263109 |
| NAV1 | neuron navigator 1 | -0.0262139 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0258953 |
| GLIS3 | GLIS family zinc finger 3 | -0.025543 |
| RPS2 | ribosomal protein S2 | -0.025433 |
| HMGA2 | high mobility group AT-hook 2 | -0.0253723 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0252835 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0239168 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0235433 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0232993 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0232331 |
| LOX | lysyl oxidase | -0.0231633 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0228167 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.022807 |
| B2M | beta-2-microglobulin | -0.0227029 |
| ATP13A3 | ATPase type 13A3 | -0.0225014 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0224842 |
| S100A9 | S100 calcium binding protein A9 | -0.0224102 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.022362 |
| CENPF | centromere protein F, 350/400kDa | -0.0222896 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0218081 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0217999 |
| RPS6 | ribosomal protein S6 | -0.0215757 |
| WASF2 | WAS protein family, member 2 | -0.0208011 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0204159 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0203409 |
| SPAG9 | sperm associated antigen 9 | -0.0200892 |
| SP100 | SP100 nuclear antigen | -0.0194643 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0192923 |
| TMSB10 | thymosin beta 10 | -0.0192905 |
| RTN4 | reticulon 4 | -0.0192072 |
| UBC | ubiquitin C | -0.0191562 |
| ECE1 | endothelin converting enzyme 1 | -0.0191098 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0190095 |
| DST | dystonin | -0.0189223 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0184677 |
| ENO1 | enolase 1, (alpha) | -0.0180767 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0179496 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0179061 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.017895 |
| SMYD3 | SET and MYND domain containing 3 | -0.0177082 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.017676 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0175881 |
| RAB2A | RAB2A, member RAS oncogene family | -0.017353 |
| SETD5 | SET domain containing 5 | -0.0172256 |
| STK17A | serine/threonine kinase 17a | -0.0171453 |
| USP34 | ubiquitin specific peptidase 34 | -0.0170501 |
| TMF1 | TATA element modulatory factor 1 | -0.0169874 |
| MX2 | MX dynamin-like GTPase 2 | -0.0169666 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0169184 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0168015 |
| ZNF292 | zinc finger protein 292 | -0.0166793 |
| INHBA | inhibin, beta A | -0.0165863 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0165627 |
| NUMB | numb homolog (Drosophila) | -0.016269 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0161239 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0159019 |
| COL1A1 | collagen, type I, alpha 1 | -0.0158893 |
