Doxorubicin (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.081189
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0563602
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0485459
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0474021
ADARB1 adenosine deaminase, RNA-specific, B1 0.0463443
APLP2 amyloid beta (A4) precursor-like protein 2 0.0459513
ATAD2 ATPase family, AAA domain containing 2 0.0441268
KDM6A lysine (K)-specific demethylase 6A 0.0424171
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0407235
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0384392
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0384172
ARL15 ADP-ribosylation factor-like 15 0.0376272
HELZ helicase with zinc finger 0.0333792
CEMIP2 cell migration inducing hyaluronidase 2 0.0330662
BCAS3 breast carcinoma amplified sequence 3 0.0318338
OGA O-GlcNAcase 0.0317913
TOP1 topoisomerase (DNA) I 0.0317276
WNK1 WNK lysine deficient protein kinase 1 0.0316444
ZSWIM6 zinc finger, SWIM-type containing 6 0.0313856
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0311534
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0307056
SRPK2 SRSF protein kinase 2 0.0305748
LNX2 ligand of numb-protein X 2 0.0304863
INTS6 integrator complex subunit 6 0.0294963
TSC22D2 TSC22 domain family, member 2 0.0289172
GLS2 glutaminase 2 (liver, mitochondrial) 0.0286528
PRKCA protein kinase C, alpha 0.0284765
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0284035
HSPH1 heat shock 105kDa/110kDa protein 1 0.0273968
KDM2A lysine (K)-specific demethylase 2A 0.0272014
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0271275
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.02666
UBAP2 ubiquitin associated protein 2 0.0265343
FBXO32 F-box protein 32 0.026294
PCBP2 poly(rC) binding protein 2 0.0261843
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0251694
GPHN gephyrin 0.0242702
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0237723
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0237291
ANKRD12 ankyrin repeat domain 12 0.0236814
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0235141
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230974
KLHL29 kelch-like family member 29 0.0226916
AHCYL2 adenosylhomocysteinase-like 2 0.0224133
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.022283
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0220417
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0219529
LCORL ligand dependent nuclear receptor corepressor-like 0.0213866
SAMD4A sterile alpha motif domain containing 4A 0.0212149
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0206991
PHF20L1 PHD finger protein 20-like 1 0.0206965
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0206715
PBX3 pre-B-cell leukemia homeobox 3 0.0205404
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0204796
ZMYM2 zinc finger, MYM-type 2 0.0202845
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0202191
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0200933
BBX bobby sox homolog (Drosophila) 0.0199687
PSPC1 paraspeckle component 1 0.0196031
FANCI Fanconi anemia, complementation group I 0.0193843
MICU1 mitochondrial calcium uptake 1 0.0192417
ADAM10 ADAM metallopeptidase domain 10 0.019198
BRD2 bromodomain containing 2 0.0191778
KIF1B kinesin family member 1B 0.0190903
FBXL20 F-box and leucine-rich repeat protein 20 0.0190614
HELLS helicase, lymphoid-specific 0.0189017
NUP58 nucleoporin 58 0.0188041
IPO7 importin 7 0.0186772
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0186254
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0185509
NPTN neuroplastin 0.0185465
CENPP centromere protein P 0.0185302
ATOSA atos homolog A 0.0183801
ANKRD17 ankyrin repeat domain 17 0.0180472
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0180418
SENP5 SUMO1/sentrin specific peptidase 5 0.0178411
USP47 ubiquitin specific peptidase 47 0.0177171
NEK7 NIMA-related kinase 7 0.0174329
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.0172574
HOXA3 homeobox A3 0.0172422
ZNF638 zinc finger protein 638 0.0171544
HSPA8 heat shock 70kDa protein 8 0.0171036
EEF2 eukaryotic translation elongation factor 2 0.0168075
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0167294
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0166242
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0165807
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0162737
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0162695
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0161917
AMBRA1 autophagy/beclin-1 regulator 1 0.0161359
SSBP2 single-stranded DNA binding protein 2 0.0161222
DIAPH3 diaphanous-related formin 3 0.0160736
GRHL2 grainyhead-like 2 (Drosophila) 0.0158964
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0158037
VCL vinculin 0.0157881
TBC1D4 TBC1 domain family, member 4 0.0157059
MED13 mediator complex subunit 13 0.0156473
ELP4 elongator acetyltransferase complex subunit 4 0.0156303
IFRD1 interferon-related developmental regulator 1 0.0154473
NHSL1 NHS-like 1 0.0154181

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.119428
ANXA2 annexin A2 -0.116503
LMO7 LIM domain 7 -0.109385
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.097487
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.095136
EZR ezrin -0.0934146
ACTN4 actinin, alpha 4 -0.0911282
KRT18 keratin 18, type I -0.0902797
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.081219
PLAUR plasminogen activator, urokinase receptor -0.0796205
AHNAK AHNAK nucleoprotein -0.07731
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0769548
MYH14 myosin, heavy chain 14, non-muscle -0.0751132
NECTIN2 nectin cell adhesion molecule 2 -0.0749199
SLC45A4 solute carrier family 45, member 4 -0.0729852
KRT8 keratin 8, type II -0.0726903
KRT20 keratin 20, type I -0.0667303
TMSB10 thymosin beta 10 -0.0638736
FRY furry homolog (Drosophila) -0.0635642
KLF3 Kruppel-like factor 3 (basic) -0.0630695
DIAPH2 diaphanous-related formin 2 -0.0627724
PTMA prothymosin, alpha -0.0614211
TJP1 tight junction protein 1 -0.0589198
GMDS GDP-mannose 4,6-dehydratase -0.0581096
LDHA lactate dehydrogenase A -0.0580807
WASF2 WAS protein family, member 2 -0.0574005
PATJ PATJ crumbs cell polarity complex component -0.0573153
ITPKC inositol-trisphosphate 3-kinase C -0.0559642
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0559083
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0555162
NDRG1 N-myc downstream regulated 1 -0.0554907
MAML3 mastermind-like 3 (Drosophila) -0.055387
PGK1 phosphoglycerate kinase 1 -0.0546247
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0526966
ZBTB20 zinc finger and BTB domain containing 20 -0.0523825
LAMA4 laminin, alpha 4 -0.0520354
ITGA6 integrin, alpha 6 -0.05116
ZMYND8 zinc finger, MYND-type containing 8 -0.0501329
FTL ferritin, light polypeptide -0.0500963
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0500662
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0496072
CCSER1 coiled-coil serine-rich protein 1 -0.0486072
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.048455
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0481942
TXNRD1 thioredoxin reductase 1 -0.046383
ACACA acetyl-CoA carboxylase alpha -0.0463168
LYZ lysozyme -0.0459743
STK24 serine/threonine kinase 24 -0.0458999
TMEM123 transmembrane protein 123 -0.0458434
NIBAN2 niban apoptosis regulator 2 -0.0450382
FTH1 ferritin, heavy polypeptide 1 -0.0449813
RAD21 RAD21 homolog (S. pombe) -0.0448806
CD2AP CD2-associated protein -0.0447984
LOC102724023 ES1 protein homolog, mitochondrial -0.0440134
NF1 neurofibromin 1 -0.0437721
RRBP1 ribosome binding protein 1 -0.042508
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0423963
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0423785
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0423549
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0410796
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0407861
ATXN1 ataxin 1 -0.0406633
LAMB3 laminin, beta 3 -0.0401605
FAT1 FAT atypical cadherin 1 -0.0399392
FOXP1 forkhead box P1 -0.0396337
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0395937
TMC5 transmembrane channel-like 5 -0.0395282
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0393741
TM4SF4 transmembrane 4 L six family member 4 -0.0379459
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0379451
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0379063
KLF5 Kruppel-like factor 5 (intestinal) -0.0377238
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0368305
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0367934
KRT19 keratin 19, type I -0.0367763
MYO1E myosin IE -0.0355948
ASPH aspartate beta-hydroxylase -0.0353766
FLNB filamin B, beta -0.0351692
S100A6 S100 calcium binding protein A6 -0.0349618
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0348784
BCL2L1 BCL2-like 1 -0.0347094
KLF10 Kruppel-like factor 10 -0.0340094
ANXA11 annexin A11 -0.0337684
JUP junction plakoglobin -0.0334883
PTPRK protein tyrosine phosphatase, receptor type, K -0.0333346
TRPS1 trichorhinophalangeal syndrome I -0.0331511
ACTG1 actin gamma 1 -0.0331169
AKAP13 A kinase (PRKA) anchor protein 13 -0.0327033
WWC1 WW and C2 domain containing 1 -0.0326277
POF1B premature ovarian failure, 1B -0.0323728
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0321372
PYGB phosphorylase, glycogen; brain -0.0319199
MUC13 mucin 13, cell surface associated -0.0317711
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0315319
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0314759
DST dystonin -0.0312608
ABLIM1 actin binding LIM protein 1 -0.0300918
DNM2 dynamin 2 -0.0300448
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0300434
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0300009