Doxorubicin (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.130299
C3 complement component 3 0.098216
FN1 fibronectin 1 0.0963878
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0821784
LRMDA leucine rich melanocyte differentiation associated 0.0626525
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0606695
ERRFI1 ERBB receptor feedback inhibitor 1 0.0519129
AFDN afadin, adherens junction formation factor 0.05187
SAMD4A sterile alpha motif domain containing 4A 0.0492695
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0471482
APOB apolipoprotein B 0.046751
DSPP dentin sialophosphoprotein 0.0452114
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0446206
ELL2 elongation factor, RNA polymerase II, 2 0.0397996
PEG3 paternally expressed 3 0.0388687
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0359709
EEF2 eukaryotic translation elongation factor 2 0.035369
SOD2 superoxide dismutase 2, mitochondrial 0.0324948
SDC4 syndecan 4 0.032489
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0310434
A2M alpha-2-macroglobulin 0.0283274
DTNA dystrobrevin, alpha 0.0282731
SVIL supervillin 0.0279566
PHF3 PHD finger protein 3 0.0256814
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.025605
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0255806
CAMTA1 calmodulin binding transcription activator 1 0.0242574
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0239337
KIF1B kinesin family member 1B 0.0236014
DSCAM Down syndrome cell adhesion molecule 0.0232957
PTK2 protein tyrosine kinase 2 0.0230652
ANXA5 annexin A5 0.0227277
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0227073
ICAM1 intercellular adhesion molecule 1 0.0224566
ANKRD10 ankyrin repeat domain 10 0.0222735
WDFY2 WD repeat and FYVE domain containing 2 0.0221133
IGF2R insulin-like growth factor 2 receptor 0.022063
MYH9 myosin, heavy chain 9, non-muscle 0.0219889
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0216992
RBM39 RNA binding motif protein 39 0.0212932
MAN1A1 mannosidase, alpha, class 1A, member 1 0.021069
ATXN1 ataxin 1 0.0209519
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0209489
TNS1 tensin 1 0.0208801
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0208081
PUM2 pumilio RNA-binding family member 2 0.0208068
DENND1A DENN/MADD domain containing 1A 0.0207678
ZFAND3 zinc finger, AN1-type domain 3 0.0206656
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0206024
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0202242
EPS8 epidermal growth factor receptor pathway substrate 8 0.0201339
CRLS1 cardiolipin synthase 1 0.0197999
SMAD3 SMAD family member 3 0.0196532
NKD1 naked cuticle homolog 1 (Drosophila) 0.0195136
MALT1 MALT1 paracaspase 0.0194905
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.019248
MYO1B myosin IB 0.0191043
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0190634
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0189805
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0189701
ZMIZ1 zinc finger, MIZ-type containing 1 0.0189099
HELZ helicase with zinc finger 0.0187346
ACSL4 acyl-CoA synthetase long-chain family member 4 0.018616
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.01856
SESTD1 SEC14 and spectrin domains 1 0.0185204
RSRC2 arginine/serine-rich coiled-coil 2 0.0181585
TRIO trio Rho guanine nucleotide exchange factor 0.0180321
ANO6 anoctamin 6 0.017908
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0177593
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0176596
MATR3 matrin 3 0.0175749
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0174612
INSIG2 insulin induced gene 2 0.0173496
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0173374
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0169472
USP6NL USP6 N-terminal like 0.0168393
DOCK4 dedicator of cytokinesis 4 0.0167672
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0167491
KIZ kizuna centrosomal protein 0.016551
FAT1 FAT atypical cadherin 1 0.0164246
NCKAP1 NCK-associated protein 1 0.0163464
MACF1 microtubule-actin crosslinking factor 1 0.0162669
USP34 ubiquitin specific peptidase 34 0.0161395
TGFBI transforming growth factor, beta-induced, 68kDa 0.0160401
GMDS GDP-mannose 4,6-dehydratase 0.0159954
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0159505
LRRC1 leucine rich repeat containing 1 0.0157874
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0156985
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0156977
TBCK TBC1 domain containing kinase 0.0156793
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0153882
CFB complement factor B 0.0153409
MED13L mediator complex subunit 13-like 0.015205
PCNX1 pecanex 1 0.015203
PTPRM protein tyrosine phosphatase, receptor type, M 0.0151883
WAC WW domain containing adaptor with coiled-coil 0.0151605
CCNL1 cyclin L1 0.0151487
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0151334
DIAPH1 diaphanous-related formin 1 0.0151167
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0150531

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.319834
MT2A metallothionein 2A -0.187674
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.120822
RPS6 ribosomal protein S6 -0.086209
RPL37A ribosomal protein L37a -0.0802499
RPS12 ribosomal protein S12 -0.0778745
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0775457
APOA2 apolipoprotein A-II -0.0729163
TPT1 tumor protein, translationally-controlled 1 -0.072902
FTL ferritin, light polypeptide -0.071057
RPL11 ribosomal protein L11 -0.0684303
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0681809
RPLP1 ribosomal protein, large, P1 -0.066013
RPS8 ribosomal protein S8 -0.063464
RPS19 ribosomal protein S19 -0.0587535
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0569086
TMSB10 thymosin beta 10 -0.0556085
RPL34 ribosomal protein L34 -0.0546322
RPL35A ribosomal protein L35a -0.0546184
IGFBP1 insulin-like growth factor binding protein 1 -0.0538438
RPL23 ribosomal protein L23 -0.0490176
RPS3 ribosomal protein S3 -0.0454321
RPL12 ribosomal protein L12 -0.0453419
RPL26 ribosomal protein L26 -0.0431383
AKAP12 A kinase (PRKA) anchor protein 12 -0.0428311
RPL9 ribosomal protein L9 -0.0418815
PTMA prothymosin, alpha -0.0399975
RACK1 receptor for activated C kinase 1 -0.0397901
RPS27A ribosomal protein S27a -0.038541
APOA1 apolipoprotein A-I -0.0380905
ENO1 enolase 1, (alpha) -0.0373832
RPS13 ribosomal protein S13 -0.0369502
RPL31 ribosomal protein L31 -0.0366708
RPS29 ribosomal protein S29 -0.0365357
RPS24 ribosomal protein S24 -0.0362664
AHSG alpha-2-HS-glycoprotein -0.0359465
RPLP0 ribosomal protein, large, P0 -0.0356495
RPS14 ribosomal protein S14 -0.0356317
APOE apolipoprotein E -0.0346113
RPS17 ribosomal protein S17 -0.0339034
S100A9 S100 calcium binding protein A9 -0.0336564
RPLP2 ribosomal protein, large, P2 -0.0336495
FBF1 Fas (TNFRSF6) binding factor 1 -0.0336194
RPL19 ribosomal protein L19 -0.0319862
RPS21 ribosomal protein S21 -0.0311174
TM4SF1 transmembrane 4 L six family member 1 -0.0310624
RPL36 ribosomal protein L36 -0.0309109
B2M beta-2-microglobulin -0.0295419
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0292069
RPL5 ribosomal protein L5 -0.0275424
RPL10A ribosomal protein L10a -0.0265622
RPL32 ribosomal protein L32 -0.0259119
RPL38 ribosomal protein L38 -0.0259115
RPL37 ribosomal protein L37 -0.025531
RPL28 ribosomal protein L28 -0.0249021
RPL13A ribosomal protein L13a -0.0247719
RPS27 ribosomal protein S27 -0.0245541
RPL18 ribosomal protein L18 -0.0239013
RPS5 ribosomal protein S5 -0.0236036
RPL27 ribosomal protein L27 -0.0234106
RPS16 ribosomal protein S16 -0.0230337
RPS23 ribosomal protein S23 -0.0229612
EIF1 eukaryotic translation initiation factor 1 -0.0229122
RRBP1 ribosome binding protein 1 -0.0223409
ISG15 ISG15 ubiquitin-like modifier -0.022225
RPS25 ribosomal protein S25 -0.0221885
ACTG1 actin gamma 1 -0.0218541
ATP5F1E ATP synthase F1 subunit epsilon -0.0216553
AMBP alpha-1-microglobulin/bikunin precursor -0.0207932
GPC3 glypican 3 -0.0207139
RPL30 ribosomal protein L30 -0.0206535
HMGA1 high mobility group AT-hook 1 -0.0203371
EHBP1 EH domain binding protein 1 -0.0201077
CST3 cystatin C -0.0196649
SLC38A2 solute carrier family 38, member 2 -0.019374
RPL35 ribosomal protein L35 -0.019299
RPS10 ribosomal protein S10 -0.0191538
BPIFB2 BPI fold containing family B, member 2 -0.0189128
IFITM1 interferon induced transmembrane protein 1 -0.0186297
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0185025
RPL8 ribosomal protein L8 -0.0181318
IFITM3 interferon induced transmembrane protein 3 -0.0179962
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0179021
GDF15 growth differentiation factor 15 -0.0177668
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0175917
RPL7 ribosomal protein L7 -0.0174052
RPL7A ribosomal protein L7a -0.0172495
PKM pyruvate kinase, muscle -0.0171291
RPL27A ribosomal protein L27a -0.0169923
CPE carboxypeptidase E -0.0169401
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0168416
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0166681
PLIN2 perilipin 2 -0.0165413
GNAS GNAS complex locus -0.0162427
APOC1 apolipoprotein C-I -0.0158779
IFI6 interferon, alpha-inducible protein 6 -0.0156886
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0156647
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0156512
TF transferrin -0.015649
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0154431