Doxorubicin (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0742594
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0732151
CES1 carboxylesterase 1 0.0487528
FAM13A family with sequence similarity 13, member A 0.0429698
NGLY1 N-glycanase 1 0.0395948
SOD2 superoxide dismutase 2, mitochondrial 0.0387909
CAMTA1 calmodulin binding transcription activator 1 0.0360911
NAMPT nicotinamide phosphoribosyltransferase 0.0357978
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0355752
ARRDC3 arrestin domain containing 3 0.0325429
HELZ helicase with zinc finger 0.0312647
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0311338
TMEM165 transmembrane protein 165 0.0296955
OGA O-GlcNAcase 0.0274866
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0269472
HOOK2 hook microtubule-tethering protein 2 0.026812
ADAM17 ADAM metallopeptidase domain 17 0.0249212
GRB10 growth factor receptor-bound protein 10 0.0239469
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0228825
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0225078
CCNL1 cyclin L1 0.0223679
UBA6 ubiquitin-like modifier activating enzyme 6 0.0214843
ANKRD10 ankyrin repeat domain 10 0.0210546
KDM2A lysine (K)-specific demethylase 2A 0.0210492
ZFC3H1 zinc finger, C3H1-type containing 0.0209246
ZC3H11A zinc finger CCCH-type containing 11A 0.0207965
KDM6A lysine (K)-specific demethylase 6A 0.0207705
AGO2 argonaute RISC catalytic component 2 0.0202177
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0200822
USP9X ubiquitin specific peptidase 9, X-linked 0.0198241
UBE2O ubiquitin-conjugating enzyme E2O 0.0195314
YEATS2 YEATS domain containing 2 0.0194815
SUCO SUN domain containing ossification factor 0.0190848
DTNA dystrobrevin, alpha 0.0190686
TNIP1 TNFAIP3 interacting protein 1 0.018823
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.018564
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0183742
FNIP1 folliculin interacting protein 1 0.0178279
RUNX1 runt-related transcription factor 1 0.0177495
SPAG9 sperm associated antigen 9 0.0174633
TBC1D22A TBC1 domain family, member 22A 0.0173748
GPATCH2L G patch domain containing 2-like 0.0171383
CYLD cylindromatosis (turban tumor syndrome) 0.0169063
PUM2 pumilio RNA-binding family member 2 0.0167021
TSC22D2 TSC22 domain family, member 2 0.016441
TPD52 tumor protein D52 0.0162592
MRPS6 mitochondrial ribosomal protein S6 0.0162395
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0161358
BIRC2 baculoviral IAP repeat containing 2 0.0161114
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0160684
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.0160233
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0159331
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0158893
MYO1B myosin IB 0.0156214
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0155229
TM9SF3 transmembrane 9 superfamily member 3 0.014919
SEC31A SEC31 homolog A (S. cerevisiae) 0.0148898
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0148101
RLIM ring finger protein, LIM domain interacting 0.0147893
SRP54 signal recognition particle 54kDa 0.014596
ZNF292 zinc finger protein 292 0.0145753
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0144019
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0143985
MYH9 myosin, heavy chain 9, non-muscle 0.0143295
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0141552
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0139347
INSIG2 insulin induced gene 2 0.0138396
KDM3A lysine (K)-specific demethylase 3A 0.0136804
PLEC plectin 0.0136512
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0135833
TMEM39A transmembrane protein 39A 0.0134992
STRN3 striatin, calmodulin binding protein 3 0.0134179
ANO6 anoctamin 6 0.0134069
NPTN neuroplastin 0.0133683
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0133641
ZFR zinc finger RNA binding protein 0.0133487
ATP13A3 ATPase type 13A3 0.0133379
ARL5B ADP-ribosylation factor-like 5B 0.0132558
COG5 component of oligomeric golgi complex 5 0.0131777
YAP1 Yes-associated protein 1 0.0130942
NUP58 nucleoporin 58 0.0130743
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0130689
NCKAP1 NCK-associated protein 1 0.0130063
HBP1 HMG-box transcription factor 1 0.012867
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.012844
MARF1 meiosis regulator and mRNA stability factor 1 0.012801
TENT5A terminal nucleotidyltransferase 5A 0.0127
HYOU1 hypoxia up-regulated 1 0.0126103
NEK7 NIMA-related kinase 7 0.0125931
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0125485
SP3 Sp3 transcription factor 0.0124811
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0123809
BRWD3 bromodomain and WD repeat domain containing 3 0.0122957
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0122485
RNF169 ring finger protein 169 0.0122356
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0122214
MXI1 MAX interactor 1, dimerization protein 0.0121908
KMT2E lysine (K)-specific methyltransferase 2E 0.0121196
PCNX1 pecanex 1 0.0120433
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0119573

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228787
TMSB10 thymosin beta 10 -0.166001
MT2A metallothionein 2A -0.127905
ASPH aspartate beta-hydroxylase -0.126264
THSD4 thrombospondin, type I, domain containing 4 -0.124328
EGFR epidermal growth factor receptor -0.1101
PTPRM protein tyrosine phosphatase, receptor type, M -0.0933468
CAV1 caveolin 1, caveolae protein, 22kDa -0.0914483
RPS3 ribosomal protein S3 -0.0794278
PTMA prothymosin, alpha -0.0790423
FTL ferritin, light polypeptide -0.0773221
PDE4D phosphodiesterase 4D, cAMP-specific -0.0747913
ACTG1 actin gamma 1 -0.0713363
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0692206
RPLP1 ribosomal protein, large, P1 -0.0606176
RPL37A ribosomal protein L37a -0.0574336
PDLIM5 PDZ and LIM domain 5 -0.0572685
SEC61G Sec61 gamma subunit -0.0553582
SCEL sciellin -0.0551628
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0547555
RPL35A ribosomal protein L35a -0.054741
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0537439
LDHA lactate dehydrogenase A -0.0521295
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0519782
PKM pyruvate kinase, muscle -0.0501083
RPS12 ribosomal protein S12 -0.0490522
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0480233
INTS6 integrator complex subunit 6 -0.0467444
S100A10 S100 calcium binding protein A10 -0.046564
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0459671
ENO1 enolase 1, (alpha) -0.0455849
ANXA2 annexin A2 -0.0454576
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0440925
RPS8 ribosomal protein S8 -0.0438783
LMO7 LIM domain 7 -0.0435585
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0431382
RPS6 ribosomal protein S6 -0.0424447
TPT1 tumor protein, translationally-controlled 1 -0.041757
RPL34 ribosomal protein L34 -0.0411332
LOC112694756 uncharaterized LOC112694756 -0.0401593
S100P S100 calcium binding protein P -0.0393393
RIMS2 regulating synaptic membrane exocytosis 2 -0.0391186
IGFBP5 insulin-like growth factor binding protein 5 -0.0390103
EGR1 early growth response 1 -0.0387267
RPS27A ribosomal protein S27a -0.0386371
LPP LIM domain containing preferred translocation partner in lipoma -0.0377055
RPL31 ribosomal protein L31 -0.0343739
EFNA5 ephrin-A5 -0.0341774
MYO1E myosin IE -0.0336845
MAML3 mastermind-like 3 (Drosophila) -0.0333398
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0331032
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0330966
RPL12 ribosomal protein L12 -0.0329483
RPL37 ribosomal protein L37 -0.0328469
RPL11 ribosomal protein L11 -0.0326643
RPS17 ribosomal protein S17 -0.0324698
KRT7 keratin 7, type II -0.0318069
PM20D1 peptidase M20 domain containing 1 -0.0314817
KRT18 keratin 18, type I -0.0313575
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0312328
CST3 cystatin C -0.0307695
LAMA4 laminin, alpha 4 -0.0307239
RPS25 ribosomal protein S25 -0.0306841
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0306538
B2M beta-2-microglobulin -0.0301099
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0298746
RPL30 ribosomal protein L30 -0.0296437
RPL19 ribosomal protein L19 -0.0294327
CUX1 cut-like homeobox 1 -0.0293622
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0293029
RPS19 ribosomal protein S19 -0.0290997
CCND1 cyclin D1 -0.0289848
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0289282
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0286182
IGFBP3 insulin-like growth factor binding protein 3 -0.0285702
NABP1 nucleic acid binding protein 1 -0.0282742
AREG amphiregulin -0.02803
SLC38A1 solute carrier family 38, member 1 -0.027871
FTH1 ferritin, heavy polypeptide 1 -0.0277654
EIF1 eukaryotic translation initiation factor 1 -0.027675
RPS27 ribosomal protein S27 -0.0273368
DOCK5 dedicator of cytokinesis 5 -0.0270992
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.027004
RPL9 ribosomal protein L9 -0.026999
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0268274
AKAP12 A kinase (PRKA) anchor protein 12 -0.0264954
CPE carboxypeptidase E -0.0263865
FOXP1 forkhead box P1 -0.0260866
CCSER1 coiled-coil serine-rich protein 1 -0.025887
RPL36 ribosomal protein L36 -0.0249411
MYOF myoferlin -0.024852
RPL23 ribosomal protein L23 -0.0246093
OSMR oncostatin M receptor -0.0245749
CAV2 caveolin 2 -0.0239849
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0238219
IFI6 interferon, alpha-inducible protein 6 -0.0233641
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0232413
S100A11 S100 calcium binding protein A11 -0.0230848
RACK1 receptor for activated C kinase 1 -0.023008
VCL vinculin -0.0227353