Doxorubicin (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SDK1 sidekick cell adhesion molecule 1 0.150066
PCBP2 poly(rC) binding protein 2 0.0891976
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.068802
FN1 fibronectin 1 0.0488944
EEF2 eukaryotic translation elongation factor 2 0.0440774
HMGA2 high mobility group AT-hook 2 0.0435851
GRB10 growth factor receptor-bound protein 10 0.0422367
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0401734
SOD2 superoxide dismutase 2, mitochondrial 0.0382513
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0368925
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0367149
TBC1D5 TBC1 domain family, member 5 0.0354532
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0350338
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0337322
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0332723
SMAD3 SMAD family member 3 0.0331624
LRMDA leucine rich melanocyte differentiation associated 0.0319288
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0314143
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0302433
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0298647
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.028795
ETV6 ets variant 6 0.0277373
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0274309
MRPS6 mitochondrial ribosomal protein S6 0.0262593
RNF213 ring finger protein 213 0.0258249
PRKCE protein kinase C, epsilon 0.0246859
GLS2 glutaminase 2 (liver, mitochondrial) 0.0243673
EXOC4 exocyst complex component 4 0.0243487
NHSL1 NHS-like 1 0.0239571
PRKCA protein kinase C, alpha 0.023755
HDAC4 histone deacetylase 4 0.0235945
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0234994
THSD4 thrombospondin, type I, domain containing 4 0.0229163
RUNX1 runt-related transcription factor 1 0.0226421
FLNA filamin A, alpha 0.0217339
EGFR epidermal growth factor receptor 0.0216893
EIF4H eukaryotic translation initiation factor 4H 0.0215897
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0213491
MEIS2 Meis homeobox 2 0.0212661
ANKRD11 ankyrin repeat domain 11 0.0211284
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0210871
PRELID2 PRELI domain containing 2 0.0209332
PFKP phosphofructokinase, platelet 0.0208805
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0206119
AHNAK AHNAK nucleoprotein 0.0203715
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0201545
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0200606
DENND4A DENN/MADD domain containing 4A 0.0198201
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0196067
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0195806
PTPRK protein tyrosine phosphatase, receptor type, K 0.0194274
NAV2 neuron navigator 2 0.0194082
MYOF myoferlin 0.0192357
NFE2L1 nuclear factor, erythroid 2-like 1 0.0191651
ZNF638 zinc finger protein 638 0.0190278
MECOM MDS1 and EVI1 complex locus 0.018948
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.018537
SMC4 structural maintenance of chromosomes 4 0.0183631
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0181688
ARHGAP32 Rho GTPase activating protein 32 0.0179778
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0178707
SHB Src homology 2 domain containing adaptor protein B 0.0177821
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0176189
ZNF407 zinc finger protein 407 0.0175258
FAM107B family with sequence similarity 107, member B 0.0174057
MYH9 myosin, heavy chain 9, non-muscle 0.01732
CEP250 centrosomal protein 250kDa 0.0171792
ADAM12 ADAM metallopeptidase domain 12 0.016862
CENPF centromere protein F, 350/400kDa 0.0167877
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0167489
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.01668
DENND1A DENN/MADD domain containing 1A 0.0165692
EXOC6B exocyst complex component 6B 0.0162908
APOLD1 apolipoprotein L domain containing 1 0.016257
CEP128 centrosomal protein 128kDa 0.0160721
LOXL2 lysyl oxidase-like 2 0.0160195
BCAS3 breast carcinoma amplified sequence 3 0.0157444
OXR1 oxidation resistance 1 0.0157177
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0156953
SND1 staphylococcal nuclease and tudor domain containing 1 0.015685
RPSA ribosomal protein SA 0.0156239
TENT4A terminal nucleotidyltransferase 4A 0.0155785
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0155521
AAK1 AP2 associated kinase 1 0.0152942
MON2 MON2 homolog (S. cerevisiae) 0.0152454
SPIDR scaffolding protein involved in DNA repair 0.0149746
EPS8 epidermal growth factor receptor pathway substrate 8 0.0148858
DNER delta/notch-like EGF repeat containing 0.014781
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0143781
POU2F1 POU class 2 homeobox 1 0.0142975
TXNRD1 thioredoxin reductase 1 0.0142909
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0142226
ZEB1 zinc finger E-box binding homeobox 1 0.0140714
LIMCH1 LIM and calponin homology domains 1 0.0140293
RUNX2 runt-related transcription factor 2 0.0139972
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0139495
GPATCH2L G patch domain containing 2-like 0.013881
HLA-E major histocompatibility complex, class I, E 0.0138339
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0137494
R3HDM2 R3H domain containing 2 0.0137335

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.267353
AKAP12 A kinase (PRKA) anchor protein 12 -0.165326
MT2A metallothionein 2A -0.127936
NAMPT nicotinamide phosphoribosyltransferase -0.11889
FTL ferritin, light polypeptide -0.112065
TMSB10 thymosin beta 10 -0.106331
VIM vimentin -0.0874137
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0807597
ELL2 elongation factor, RNA polymerase II, 2 -0.0729633
RPS6 ribosomal protein S6 -0.072546
RPLP1 ribosomal protein, large, P1 -0.0719952
GOLGA4 golgin A4 -0.0669813
NDRG1 N-myc downstream regulated 1 -0.0668322
RPS19 ribosomal protein S19 -0.0664985
PTMA prothymosin, alpha -0.0661125
EIF1 eukaryotic translation initiation factor 1 -0.0616009
RPL35A ribosomal protein L35a -0.0550883
RPS12 ribosomal protein S12 -0.0540529
RPS2 ribosomal protein S2 -0.0530859
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0524139
PDE4D phosphodiesterase 4D, cAMP-specific -0.0520032
RPS8 ribosomal protein S8 -0.0503448
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0485707
RPL36 ribosomal protein L36 -0.0485378
BASP1 brain abundant, membrane attached signal protein 1 -0.0477123
RPS21 ribosomal protein S21 -0.0473898
RPL37A ribosomal protein L37a -0.0447082
CD44 CD44 molecule (Indian blood group) -0.0444759
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0441682
RBM39 RNA binding motif protein 39 -0.0441255
RPL34 ribosomal protein L34 -0.0431925
RPLP2 ribosomal protein, large, P2 -0.0429175
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0425775
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0422151
B2M beta-2-microglobulin -0.0418459
RAB1A RAB1A, member RAS oncogene family -0.0417339
RPL32 ribosomal protein L32 -0.0407147
RPL11 ribosomal protein L11 -0.0404981
RPS3 ribosomal protein S3 -0.0404043
RPS29 ribosomal protein S29 -0.0401935
RPL31 ribosomal protein L31 -0.0399285
RPL12 ribosomal protein L12 -0.0399125
GPC6 glypican 6 -0.0390154
IER3 immediate early response 3 -0.0384464
TPT1 tumor protein, translationally-controlled 1 -0.0384206
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0380047
RPS13 ribosomal protein S13 -0.037795
YBX3 Y box binding protein 3 -0.0377797
STC1 stanniocalcin 1 -0.0373525
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0366281
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0358874
C15ORF48 chromosome 15 open reading frame 48 -0.035503
KTN1 kinectin 1 (kinesin receptor) -0.0353639
CDCP1 CUB domain containing protein 1 -0.0353199
JMJD1C jumonji domain containing 1C -0.0353093
ARHGAP5 Rho GTPase activating protein 5 -0.0346791
RPL9 ribosomal protein L9 -0.034384
RPL37 ribosomal protein L37 -0.033845
RPL19 ribosomal protein L19 -0.0335418
RAB27B RAB27B, member RAS oncogene family -0.0333391
RIOK3 RIO kinase 3 -0.032988
USP34 ubiquitin specific peptidase 34 -0.0319849
RPL23 ribosomal protein L23 -0.0315312
LOX lysyl oxidase -0.0309599
PRRC2C proline-rich coiled-coil 2C -0.0309537
S100A10 S100 calcium binding protein A10 -0.030754
PDGFA platelet-derived growth factor alpha polypeptide -0.0303069
RPL38 ribosomal protein L38 -0.0302755
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.029927
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0298604
RPL5 ribosomal protein L5 -0.0295495
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0294918
TM4SF1 transmembrane 4 L six family member 1 -0.029064
RNF24 ring finger protein 24 -0.0289874
S100A6 S100 calcium binding protein A6 -0.0288466
ENO1 enolase 1, (alpha) -0.0283192
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0279132
ANGPTL4 angiopoietin-like 4 -0.0278536
LMAN1 lectin, mannose-binding, 1 -0.0277864
S100A9 S100 calcium binding protein A9 -0.0276231
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0274998
RPS27 ribosomal protein S27 -0.0273962
RPS24 ribosomal protein S24 -0.0272975
GLCCI1 glucocorticoid induced 1 -0.0270917
RPL18 ribosomal protein L18 -0.0266818
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0266807
ESYT2 extended synaptotagmin-like protein 2 -0.026143
RPLP0 ribosomal protein, large, P0 -0.0260279
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0260019
RPS17 ribosomal protein S17 -0.0259957
RPL7 ribosomal protein L7 -0.0258671
RPS16 ribosomal protein S16 -0.0258543
RPS23 ribosomal protein S23 -0.0256574
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0255394
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0251456
RPS5 ribosomal protein S5 -0.0249407
RPL28 ribosomal protein L28 -0.024846
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0246022
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0243455
RPL26 ribosomal protein L26 -0.0241267