| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0476197 |
| IGF2 | insulin-like growth factor 2 | 0.0369722 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0329008 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0289466 |
| RPL35A | ribosomal protein L35a | 0.0254657 |
| NDRG1 | N-myc downstream regulated 1 | 0.0236408 |
| PYGL | phosphorylase, glycogen, liver | 0.0197314 |
| RPL13A | ribosomal protein L13a | 0.0184011 |
| HLA-A | major histocompatibility complex, class I, A | 0.0167344 |
| EGFR | epidermal growth factor receptor | 0.0167287 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0154154 |
| PRR16 | proline rich 16 | 0.0152369 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0151335 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.014893 |
| CYTH1 | cytohesin 1 | 0.0147031 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0146048 |
| CABIN1 | calcineurin binding protein 1 | 0.0145476 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0137401 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.013608 |
| STC2 | stanniocalcin 2 | 0.0133558 |
| EGR1 | early growth response 1 | 0.0132927 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0125329 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0123375 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.012112 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0116412 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0115449 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0113978 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0113334 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0112179 |
| HLA-B | major histocompatibility complex, class I, B | 0.0107186 |
| FMNL2 | formin-like 2 | 0.010597 |
| ADM | adrenomedullin | 0.0105101 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0104295 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0103813 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0103783 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0103361 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0103359 |
| RAD51B | RAD51 paralog B | 0.010006 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.00999532 |
| VEGFA | vascular endothelial growth factor A | 0.00987437 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.00984401 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0096264 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.00944197 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.00940203 |
| RBM25 | RNA binding motif protein 25 | 0.00935922 |
| CCNL1 | cyclin L1 | 0.00923932 |
| GOLGA4 | golgin A4 | 0.00920572 |
| WAC | WW domain containing adaptor with coiled-coil | 0.00919596 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.00914014 |
| HMGA1 | high mobility group AT-hook 1 | 0.00903108 |
| PNN | pinin, desmosome associated protein | 0.00899821 |
| ITGB5 | integrin, beta 5 | 0.00891264 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00874453 |
| RPS27 | ribosomal protein S27 | 0.0086658 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.00846398 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.00846068 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.00845575 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.00844645 |
| RPS2 | ribosomal protein S2 | 0.00842517 |
| PRKCA | protein kinase C, alpha | 0.00834757 |
| ANKRD11 | ankyrin repeat domain 11 | 0.00825212 |
| MYO1B | myosin IB | 0.00824724 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.00824525 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.00821762 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00820945 |
| MED15 | mediator complex subunit 15 | 0.00813686 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.00795423 |
| HM13 | histocompatibility (minor) 13 | 0.00790002 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.00781489 |
| BMPR1B | bone morphogenetic protein receptor, type IB | 0.00778034 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.00776044 |
| DOCK4 | dedicator of cytokinesis 4 | 0.00762819 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.00760232 |
| ANGPTL4 | angiopoietin-like 4 | 0.00759157 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.00757688 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.00754179 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | 0.00752946 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.00748078 |
| FLNB | filamin B, beta | 0.00743863 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.00730307 |
| USP37 | ubiquitin specific peptidase 37 | 0.00729355 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.00729134 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.00722176 |
| TNS3 | tensin 3 | 0.00705166 |
| RPRD1B | regulation of nuclear pre-mRNA domain containing 1B | 0.00704094 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.00695945 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.00692331 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.00676799 |
| PMM2 | phosphomannomutase 2 | 0.00674234 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00671923 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.00667965 |
| ANKRD33B | ankyrin repeat domain 33B | 0.00667147 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.00662824 |
| CASC3 | cancer susceptibility candidate 3 | 0.00656939 |
| USP36 | ubiquitin specific peptidase 36 | 0.00655375 |
| RAB8B | RAB8B, member RAS oncogene family | 0.00649924 |
| HMGA2 | high mobility group AT-hook 2 | 0.00648477 |
| ZFP36 | ZFP36 ring finger protein | 0.0064724 |
| LOXL2 | lysyl oxidase-like 2 | 0.00642365 |
| PCBP2 | poly(rC) binding protein 2 | 0.00639561 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | -0.184874 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.163206 |
| PM20D1 | peptidase M20 domain containing 1 | -0.136133 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.125915 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.12301 |
| VIM | vimentin | -0.117603 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.10889 |
| RPS27A | ribosomal protein S27a | -0.106391 |
| TXNRD1 | thioredoxin reductase 1 | -0.0980212 |
| UBC | ubiquitin C | -0.0937131 |
| RPL23 | ribosomal protein L23 | -0.0899308 |
| MT2A | metallothionein 2A | -0.0849588 |
| FTL | ferritin, light polypeptide | -0.0807603 |
| TMSB10 | thymosin beta 10 | -0.0752111 |
| FGB | fibrinogen beta chain | -0.0630186 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0628066 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.059855 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0594888 |
| AHNAK | AHNAK nucleoprotein | -0.0586544 |
| PTMA | prothymosin, alpha | -0.0579721 |
| ENO1 | enolase 1, (alpha) | -0.056945 |
| ASPH | aspartate beta-hydroxylase | -0.056607 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0527607 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.050558 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0466552 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0460789 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0453595 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0427585 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0418544 |
| RPL19 | ribosomal protein L19 | -0.0418202 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0410944 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0404755 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.039334 |
| RTN4 | reticulon 4 | -0.0391969 |
| ACTG1 | actin gamma 1 | -0.0374 |
| S100A6 | S100 calcium binding protein A6 | -0.0369659 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0364066 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0362543 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0361573 |
| PKM | pyruvate kinase, muscle | -0.035742 |
| FAM107B | family with sequence similarity 107, member B | -0.0348105 |
| POTEF | POTE ankyrin domain family, member F | -0.0339954 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0334561 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0322374 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0314537 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0308087 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0299746 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0299108 |
| RPL4 | ribosomal protein L4 | -0.0298344 |
| SLC38A2 | solute carrier family 38, member 2 | -0.029677 |
| WWOX | WW domain containing oxidoreductase | -0.0293277 |
| IER3 | immediate early response 3 | -0.0285432 |
| TNPO1 | transportin 1 | -0.028517 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0281045 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0276417 |
| BICC1 | BicC family RNA binding protein 1 | -0.0265263 |
| NTN4 | netrin 4 | -0.0263408 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.025799 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.025707 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0255845 |
| YBX1 | Y box binding protein 1 | -0.0251387 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | -0.0249467 |
| CALU | calumenin | -0.024528 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0240723 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.023114 |
| MKI67 | marker of proliferation Ki-67 | -0.0230287 |
| KIF5B | kinesin family member 5B | -0.0225799 |
| AREG | amphiregulin | -0.0224792 |
| DST | dystonin | -0.0223857 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0217858 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0216634 |
| TPM3 | tropomyosin 3 | -0.0216538 |
| RHOA | ras homolog family member A | -0.0214285 |
| RPS25 | ribosomal protein S25 | -0.0210002 |
| RPL15 | ribosomal protein L15 | -0.0209677 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.020895 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0208613 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0207868 |
| TUBA1B | tubulin, alpha 1b | -0.0207637 |
| AHR | aryl hydrocarbon receptor | -0.0206746 |
| JMJD1C | jumonji domain containing 1C | -0.0206397 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0206333 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0206301 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0205099 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0204769 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0203942 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0203395 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0202978 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0200892 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0199754 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0199352 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0197842 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0197379 |
| SRGN | serglycin | -0.0196982 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0196146 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0195485 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0193015 |
| NNMT | nicotinamide N-methyltransferase | -0.0192129 |
| NEGR1 | neuronal growth regulator 1 | -0.0191978 |
| FGG | fibrinogen gamma chain | -0.0191561 |
