| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.1276 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.094389 |
| EGFR | epidermal growth factor receptor | 0.0708443 |
| HELZ | helicase with zinc finger | 0.0707205 |
| GOLGA4 | golgin A4 | 0.0661073 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0638421 |
| RNF149 | ring finger protein 149 | 0.0616848 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0614293 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0593766 |
| LAMB3 | laminin, beta 3 | 0.0582987 |
| CTBP2 | C-terminal binding protein 2 | 0.0568375 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0561397 |
| SEPTIN2 | septin 2 | 0.0548322 |
| SETD5 | SET domain containing 5 | 0.0526398 |
| COG5 | component of oligomeric golgi complex 5 | 0.0524314 |
| TMEM65 | transmembrane protein 65 | 0.0522894 |
| PGM3 | phosphoglucomutase 3 | 0.0522388 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0517827 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0514172 |
| ANO6 | anoctamin 6 | 0.0511707 |
| MT2A | metallothionein 2A | 0.0511111 |
| DENND4C | DENN/MADD domain containing 4C | 0.0509186 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0499679 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0495551 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0493523 |
| SMAD3 | SMAD family member 3 | 0.0488357 |
| CA12 | carbonic anhydrase XII | 0.0475812 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0467921 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0467141 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0463735 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0455524 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0449692 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0447522 |
| PYGB | phosphorylase, glycogen; brain | 0.044502 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0442424 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0436423 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0431972 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0424105 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0423168 |
| POTEF | POTE ankyrin domain family, member F | 0.0416592 |
| PCBP2 | poly(rC) binding protein 2 | 0.0415872 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0410955 |
| SRP54 | signal recognition particle 54kDa | 0.0407523 |
| SMYD3 | SET and MYND domain containing 3 | 0.0399715 |
| HDLBP | high density lipoprotein binding protein | 0.0399052 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0394809 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0392141 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0389501 |
| ANKRD17 | ankyrin repeat domain 17 | 0.038499 |
| SLTM | SAFB-like, transcription modulator | 0.0382985 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0379004 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0378308 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0377616 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.036894 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0361147 |
| RBM25 | RNA binding motif protein 25 | 0.0358771 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.035386 |
| BBX | bobby sox homolog (Drosophila) | 0.0342104 |
| RPL11 | ribosomal protein L11 | 0.0337067 |
| OGA | O-GlcNAcase | 0.033477 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0325328 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0325058 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0323883 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0322723 |
| TMF1 | TATA element modulatory factor 1 | 0.0321323 |
| SPAG9 | sperm associated antigen 9 | 0.0319484 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0311776 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0311188 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0311028 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0310565 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0306749 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0306005 |
| LOXL2 | lysyl oxidase-like 2 | 0.030444 |
| PDE10A | phosphodiesterase 10A | 0.0303067 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0301921 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0298608 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0297419 |
| RPL23 | ribosomal protein L23 | 0.0287966 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0287961 |
| CALR | calreticulin | 0.02879 |
| RPS16 | ribosomal protein S16 | 0.0286426 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0284876 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0283378 |
| RPL31 | ribosomal protein L31 | 0.0276766 |
| B2M | beta-2-microglobulin | 0.0276287 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0269467 |
| RASA2 | RAS p21 protein activator 2 | 0.0269405 |
| RUNX1 | runt-related transcription factor 1 | 0.0265594 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0265266 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0264478 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0264402 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0263153 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0258438 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0251448 |
| RPS11 | ribosomal protein S11 | 0.0250899 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0247074 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0246342 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | 0.0244423 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0237997 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0237398 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.178224 |
| LMO7 | LIM domain 7 | -0.147908 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.134453 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.126426 |
| FN1 | fibronectin 1 | -0.106762 |
| S100A9 | S100 calcium binding protein A9 | -0.104347 |
| DSCAM | Down syndrome cell adhesion molecule | -0.102509 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0890464 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0865153 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0857814 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0821142 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0784543 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0731433 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0719156 |
| ATOSA | atos homolog A | -0.0695669 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0638024 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0631505 |
| ASPH | aspartate beta-hydroxylase | -0.0623002 |
| KYNU | kynureninase | -0.0620123 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0602808 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0598206 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0592693 |
| ABHD17C | abhydrolase domain containing 17C | -0.0592607 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0592155 |
| JMJD1C | jumonji domain containing 1C | -0.0587725 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0584513 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0572824 |
| THBS1 | thrombospondin 1 | -0.0551272 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0540453 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0534761 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.052725 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0524926 |
| INHBA | inhibin, beta A | -0.0519984 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0516485 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0507864 |
| TMSB10 | thymosin beta 10 | -0.0500439 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0485985 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0484411 |
| RAI14 | retinoic acid induced 14 | -0.0483191 |
| VCL | vinculin | -0.047183 |
| RBM47 | RNA binding motif protein 47 | -0.0465869 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0460412 |
| STC1 | stanniocalcin 1 | -0.0459249 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0459117 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0446049 |
| VIM | vimentin | -0.0442251 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0437 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0436536 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.04202 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0418896 |
| TPM4 | tropomyosin 4 | -0.0408598 |
| EZR | ezrin | -0.0408109 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0402918 |
| GOLGB1 | golgin B1 | -0.0394978 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0393067 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0391108 |
| KRT17 | keratin 17, type I | -0.0385339 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0380207 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0376668 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0369489 |
| SIK3 | SIK family kinase 3 | -0.0352557 |
| MYO1E | myosin IE | -0.0340453 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0340044 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0339536 |
| CD44 | CD44 molecule (Indian blood group) | -0.0339353 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0339234 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0328843 |
| PGK1 | phosphoglycerate kinase 1 | -0.0328467 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0324543 |
| EFNA5 | ephrin-A5 | -0.0324236 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0314695 |
| MED13L | mediator complex subunit 13-like | -0.0306866 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0304544 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0301779 |
| GNAS | GNAS complex locus | -0.0291873 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0291136 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0283975 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0283471 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0282811 |
| ADNP | activity-dependent neuroprotector homeobox | -0.028009 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0275457 |
| ENO1 | enolase 1, (alpha) | -0.02752 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0269812 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0267175 |
| TXNIP | thioredoxin interacting protein | -0.0265138 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0262703 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0261074 |
| SLC38A1 | solute carrier family 38, member 1 | -0.025798 |
| TJP1 | tight junction protein 1 | -0.0251012 |
| RAB10 | RAB10, member RAS oncogene family | -0.0249841 |
| GLIS3 | GLIS family zinc finger 3 | -0.0246411 |
| RPS8 | ribosomal protein S8 | -0.0246295 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0244027 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.024184 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0237917 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0235161 |
| S100A10 | S100 calcium binding protein A10 | -0.0232401 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.023205 |
| RBM39 | RNA binding motif protein 39 | -0.0227509 |
| ANXA2 | annexin A2 | -0.0224367 |
