| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.107171 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10201 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0584309 |
| TPM3 | tropomyosin 3 | 0.0566413 |
| PCBP2 | poly(rC) binding protein 2 | 0.0557514 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0528988 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0502221 |
| MKI67 | marker of proliferation Ki-67 | 0.0489197 |
| CENPF | centromere protein F, 350/400kDa | 0.0468042 |
| RRM2 | ribonucleotide reductase M2 | 0.0459951 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0455402 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0427891 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0408976 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0387207 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0379873 |
| TXNRD1 | thioredoxin reductase 1 | 0.0368045 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0343633 |
| CEP192 | centrosomal protein 192kDa | 0.0339943 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0325801 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0325707 |
| PHIP | pleckstrin homology domain interacting protein | 0.0324848 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0323775 |
| ADAR | adenosine deaminase, RNA-specific | 0.0320822 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0316996 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0316804 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0315261 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0308999 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0306201 |
| DIAPH3 | diaphanous-related formin 3 | 0.0303722 |
| XPO1 | exportin 1 | 0.0296583 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0295987 |
| MELK | maternal embryonic leucine zipper kinase | 0.0285641 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.028303 |
| TPX2 | TPX2, microtubule-associated | 0.0282286 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0278213 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0278187 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0271314 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0271202 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0271142 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.026907 |
| NOTCH2 | notch 2 | 0.0258583 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0253136 |
| ANLN | anillin, actin binding protein | 0.0252828 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0247568 |
| MIS18BP1 | MIS18 binding protein 1 | 0.024263 |
| XPOT | exportin, tRNA | 0.023934 |
| MED13L | mediator complex subunit 13-like | 0.0237344 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0235909 |
| SRPK2 | SRSF protein kinase 2 | 0.0234408 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0233558 |
| NUP58 | nucleoporin 58 | 0.0232171 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.023106 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0229619 |
| PCNX1 | pecanex 1 | 0.0227217 |
| EXOC4 | exocyst complex component 4 | 0.0226066 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0223963 |
| PNN | pinin, desmosome associated protein | 0.0220814 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0219768 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.021965 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0219204 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0216778 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0213346 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0212685 |
| RAD51B | RAD51 paralog B | 0.0211401 |
| IPO7 | importin 7 | 0.0211057 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0210543 |
| KIF18B | kinesin family member 18B | 0.0210053 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0208536 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0206375 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0205915 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0205033 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0204857 |
| RLIM | ring finger protein, LIM domain interacting | 0.0203749 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0203197 |
| MSH6 | mutS homolog 6 | 0.0202565 |
| KIF4A | kinesin family member 4A | 0.0201582 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0201191 |
| TWF1 | twinfilin actin binding protein 1 | 0.0198953 |
| GPSM2 | G-protein signaling modulator 2 | 0.0196774 |
| NCAPH | non-SMC condensin I complex, subunit H | 0.0196321 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0196174 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.019557 |
| GMPS | guanine monphosphate synthase | 0.0194487 |
| BRD2 | bromodomain containing 2 | 0.0193616 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0193493 |
| PLCB4 | phospholipase C, beta 4 | 0.0193257 |
| CLTC | clathrin, heavy chain (Hc) | 0.019304 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.01921 |
| CPNE1 | copine I | 0.0192092 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0192015 |
| BBX | bobby sox homolog (Drosophila) | 0.0191659 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0191615 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0190957 |
| PFKP | phosphofructokinase, platelet | 0.018941 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0188779 |
| SPAG9 | sperm associated antigen 9 | 0.018793 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0187827 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0187381 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0186019 |
| SP3 | Sp3 transcription factor | 0.0185963 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.354554 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.214962 |
| TMSB10 | thymosin beta 10 | -0.116263 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.106145 |
| YBX3 | Y box binding protein 3 | -0.0965793 |
| OSMR | oncostatin M receptor | -0.0928118 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0855773 |
| RPL35A | ribosomal protein L35a | -0.0743931 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0731415 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0690948 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0641985 |
| HLA-B | major histocompatibility complex, class I, B | -0.062789 |
| RPL37 | ribosomal protein L37 | -0.0623935 |
| RPL37A | ribosomal protein L37a | -0.0594641 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0590494 |
| PTMA | prothymosin, alpha | -0.0588644 |
| ACTG1 | actin gamma 1 | -0.0569886 |
| RPS8 | ribosomal protein S8 | -0.0567738 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0550165 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0527669 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0513402 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0507657 |
| RPS3 | ribosomal protein S3 | -0.0494494 |
| MT2A | metallothionein 2A | -0.0491547 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0488286 |
| PDE10A | phosphodiesterase 10A | -0.0480412 |
| RPL26 | ribosomal protein L26 | -0.0476077 |
| RPL31 | ribosomal protein L31 | -0.0475586 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0472277 |
| FTL | ferritin, light polypeptide | -0.0464391 |
| IER3 | immediate early response 3 | -0.046277 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0459048 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0456436 |
| HMGA2 | high mobility group AT-hook 2 | -0.0453409 |
| TPM4 | tropomyosin 4 | -0.0451449 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0428622 |
| CAVIN1 | caveolae associated protein 1 | -0.0426426 |
| RPS29 | ribosomal protein S29 | -0.0417035 |
| VCL | vinculin | -0.0413254 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.040916 |
| RPLP1 | ribosomal protein, large, P1 | -0.0405063 |
| RPL38 | ribosomal protein L38 | -0.0404033 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0396182 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0391384 |
| RPL11 | ribosomal protein L11 | -0.0381123 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0380176 |
| RPS21 | ribosomal protein S21 | -0.0379071 |
| RPS10 | ribosomal protein S10 | -0.0378389 |
| RPL23 | ribosomal protein L23 | -0.0377792 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0376037 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0374696 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0371553 |
| RPS27A | ribosomal protein S27a | -0.0371249 |
| RPS19 | ribosomal protein S19 | -0.0366366 |
| RPS24 | ribosomal protein S24 | -0.0363102 |
| RPS27 | ribosomal protein S27 | -0.0357962 |
| STC1 | stanniocalcin 1 | -0.0354241 |
| RPS6 | ribosomal protein S6 | -0.0353601 |
| RPL9 | ribosomal protein L9 | -0.0352004 |
| RPL36A | ribosomal protein L36a | -0.0350602 |
| RPLP2 | ribosomal protein, large, P2 | -0.0349511 |
| RBM39 | RNA binding motif protein 39 | -0.0347386 |
| RPS15 | ribosomal protein S15 | -0.0346878 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0346872 |
| GNAS | GNAS complex locus | -0.0335304 |
| S100A10 | S100 calcium binding protein A10 | -0.0334231 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0324553 |
| RPL34 | ribosomal protein L34 | -0.0324541 |
| DOCK5 | dedicator of cytokinesis 5 | -0.032333 |
| RPL36 | ribosomal protein L36 | -0.0322547 |
| FBXO11 | F-box protein 11 | -0.0313092 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.031013 |
| FMNL2 | formin-like 2 | -0.0306274 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0301479 |
| RPL19 | ribosomal protein L19 | -0.0299666 |
| RPL12 | ribosomal protein L12 | -0.0297713 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0295546 |
| ATG7 | autophagy related 7 | -0.0290825 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0289067 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0287234 |
| RPS25 | ribosomal protein S25 | -0.0283455 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0282133 |
| IGF2 | insulin-like growth factor 2 | -0.0280145 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0278588 |
| KPNB1 | karyopherin (importin) beta 1 | -0.027354 |
| VIM | vimentin | -0.026915 |
| RPL8 | ribosomal protein L8 | -0.0268609 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0268093 |
| RYR3 | ryanodine receptor 3 | -0.0266174 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0265792 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0265409 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0263754 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0260306 |
| RPL30 | ribosomal protein L30 | -0.0251825 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0251471 |
| KLF6 | Kruppel-like factor 6 | -0.0250881 |
| RPS12 | ribosomal protein S12 | -0.0241911 |
| COL5A2 | collagen, type V, alpha 2 | -0.0239717 |
| S100A11 | S100 calcium binding protein A11 | -0.0236719 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0235722 |
