| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.133356 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0435932 |
| GPHN | gephyrin | 0.0259522 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0221121 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0217753 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0210619 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0208493 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.02033 |
| FLNA | filamin A, alpha | 0.0201514 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0198657 |
| HDAC4 | histone deacetylase 4 | 0.0196707 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0193632 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0191485 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.018429 |
| FBXO22 | F-box protein 22 | 0.0174852 |
| AK1 | adenylate kinase 1 | 0.0172939 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0171454 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.017061 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0167169 |
| OGA | O-GlcNAcase | 0.0162407 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.01561 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0155042 |
| NTN1 | netrin 1 | 0.0154186 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0149301 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0148216 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0147715 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.014094 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.01404 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0138516 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0138112 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0136435 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0135752 |
| TMEM117 | transmembrane protein 117 | 0.0133015 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0132194 |
| KLHL29 | kelch-like family member 29 | 0.0131779 |
| NOPCHAP1 | NOP protein chaperone 1 | 0.0131218 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0129847 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0127543 |
| POLH | polymerase (DNA directed), eta | 0.0127238 |
| HELZ | helicase with zinc finger | 0.0126408 |
| PRKCA | protein kinase C, alpha | 0.0125953 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0125846 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.0125284 |
| CENPP | centromere protein P | 0.0124794 |
| SRPK2 | SRSF protein kinase 2 | 0.0124154 |
| TLE4 | transducin-like enhancer of split 4 | 0.0123022 |
| ADAM23 | ADAM metallopeptidase domain 23 | 0.0121035 |
| MED13L | mediator complex subunit 13-like | 0.0120921 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0119866 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0117622 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0117053 |
| ETNK1 | ethanolamine kinase 1 | 0.0115473 |
| SERINC5 | serine incorporator 5 | 0.0115263 |
| PRRC2B | proline-rich coiled-coil 2B | 0.011367 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0112652 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0112485 |
| WDR43 | WD repeat domain 43 | 0.0111007 |
| FDXR | ferredoxin reductase | 0.0109434 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0108764 |
| E2F7 | E2F transcription factor 7 | 0.0108661 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0108446 |
| USP15 | ubiquitin specific peptidase 15 | 0.010749 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.0104281 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | 0.0104281 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0103476 |
| CERS6 | ceramide synthase 6 | 0.0102619 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.0101656 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0101605 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0101604 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0101591 |
| CEP95 | centrosomal protein 95kDa | 0.0100696 |
| MED13 | mediator complex subunit 13 | 0.00999796 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.00996006 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.00970564 |
| TOP1 | topoisomerase (DNA) I | 0.00953036 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0095141 |
| CYTH1 | cytohesin 1 | 0.00950956 |
| OLA1 | Obg-like ATPase 1 | 0.00949732 |
| SESN1 | sestrin 1 | 0.00945619 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.00927939 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.00922179 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.00919384 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00918838 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.00918401 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.00918198 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.00914004 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.00912599 |
| CARD16 | caspase recruitment domain family, member 16 | 0.00907487 |
| MLEC | malectin | 0.00898292 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.00896109 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.00892257 |
| CEP85L | centrosomal protein 85kDa-like | 0.00882096 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.00872602 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.00865733 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.00858715 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.00842749 |
| FUS | FUS RNA binding protein | 0.00829823 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0082373 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | 0.00819039 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.00811936 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.163974 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152855 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.145153 |
| FN1 | fibronectin 1 | -0.0988923 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0981769 |
| TMSB10 | thymosin beta 10 | -0.0895108 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0855948 |
| VIM | vimentin | -0.0809727 |
| ASPH | aspartate beta-hydroxylase | -0.0735534 |
| PTMA | prothymosin, alpha | -0.0696502 |
| COL5A2 | collagen, type V, alpha 2 | -0.0672008 |
| EFNA5 | ephrin-A5 | -0.0647202 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.061622 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0595907 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0522098 |
| SMYD3 | SET and MYND domain containing 3 | -0.0506947 |
| RPS6 | ribosomal protein S6 | -0.0504322 |
| FTL | ferritin, light polypeptide | -0.0504147 |
| GDA | guanine deaminase | -0.0485987 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.048134 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0480723 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0467224 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0433419 |
| RPLP1 | ribosomal protein, large, P1 | -0.042329 |
| MYOF | myoferlin | -0.0416292 |
| MT2A | metallothionein 2A | -0.0414554 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0405187 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0380748 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0376999 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0371507 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0371149 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0370675 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0349405 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0348013 |
| RPL37A | ribosomal protein L37a | -0.0341516 |
| RPL35A | ribosomal protein L35a | -0.0341285 |
| RPS12 | ribosomal protein S12 | -0.0341066 |
| PDE10A | phosphodiesterase 10A | -0.0339698 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0339213 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0335325 |
| CDH13 | cadherin 13 | -0.0335088 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0329816 |
| RPS8 | ribosomal protein S8 | -0.0328724 |
| RPL26 | ribosomal protein L26 | -0.032806 |
| PGK1 | phosphoglycerate kinase 1 | -0.0325861 |
| S100A6 | S100 calcium binding protein A6 | -0.0321449 |
| NPAS2 | neuronal PAS domain protein 2 | -0.031366 |
| RPL31 | ribosomal protein L31 | -0.0313498 |
| RPL12 | ribosomal protein L12 | -0.0312715 |
| RPS3 | ribosomal protein S3 | -0.0309899 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0308361 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0307158 |
| ENO1 | enolase 1, (alpha) | -0.0301552 |
| LDHA | lactate dehydrogenase A | -0.0300819 |
| NRCAM | neuronal cell adhesion molecule | -0.0298086 |
| RPL19 | ribosomal protein L19 | -0.0289578 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0287852 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.028524 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.027799 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0271529 |
| RPS19 | ribosomal protein S19 | -0.0271257 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0271148 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0263573 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0256206 |
| RPS27A | ribosomal protein S27a | -0.0254209 |
| B2M | beta-2-microglobulin | -0.0253948 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.025305 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0251562 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.024319 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0242723 |
| RGS2 | regulator of G-protein signaling 2 | -0.0239976 |
| RPL34 | ribosomal protein L34 | -0.0239614 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0234929 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0231437 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.02293 |
| RPL23 | ribosomal protein L23 | -0.0227638 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0224154 |
| ACTG1 | actin gamma 1 | -0.0220423 |
| RPL36 | ribosomal protein L36 | -0.0219378 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0217057 |
| RPL9 | ribosomal protein L9 | -0.0216711 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0216239 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0214396 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.021362 |
| RTN1 | reticulon 1 | -0.0213553 |
| RPS14 | ribosomal protein S14 | -0.0211002 |
| RPS23 | ribosomal protein S23 | -0.0210657 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0209562 |
| FLNB | filamin B, beta | -0.0209202 |
| RPS27 | ribosomal protein S27 | -0.0208243 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0207841 |
| DST | dystonin | -0.0207827 |
| LSAMP | limbic system-associated membrane protein | -0.0203528 |
| RACK1 | receptor for activated C kinase 1 | -0.0203286 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0200571 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0199679 |
| RPLP0 | ribosomal protein, large, P0 | -0.0196498 |
| CENPF | centromere protein F, 350/400kDa | -0.0196311 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0195938 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0195286 |
