Doxorubicin (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

131 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MBNL2 muscleblind-like splicing regulator 2 0.147509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.130559
NAP1L1 nucleosome assembly protein 1-like 1 0.120545
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.109737
CANX calnexin 0.105922
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.105479
MATR3 matrin 3 0.0898671
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0874663
EEF2 eukaryotic translation elongation factor 2 0.0807421
UBAP1 ubiquitin associated protein 1 0.0799119
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0798986
JMJD1C jumonji domain containing 1C 0.0791822
ADIPOR2 adiponectin receptor 2 0.0787467
PDE10A phosphodiesterase 10A 0.0753257
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0732229
MEF2A myocyte enhancer factor 2A 0.0713896
ZFAND3 zinc finger, AN1-type domain 3 0.0691776
NAV1 neuron navigator 1 0.067695
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0641712
ANXA2 annexin A2 0.0629095
TCF12 transcription factor 12 0.0613841
FNDC3A fibronectin type III domain containing 3A 0.0611674
KMT2C lysine (K)-specific methyltransferase 2C 0.0595216
RPL36 ribosomal protein L36 0.0567524
USP9X ubiquitin specific peptidase 9, X-linked 0.0558373
PCBP2 poly(rC) binding protein 2 0.0520136
FNDC3B fibronectin type III domain containing 3B 0.0518803
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0514122
RPS19 ribosomal protein S19 0.0509603
ARHGAP21 Rho GTPase activating protein 21 0.0501067
DDIT4 DNA-damage-inducible transcript 4 0.0492924
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0490858
TPT1 tumor protein, translationally-controlled 1 0.0490048
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0477494
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0476961
HOOK2 hook microtubule-tethering protein 2 0.0466043
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0426478
DLG1 discs, large homolog 1 (Drosophila) 0.0419915
OGA O-GlcNAcase 0.0386321
RBM39 RNA binding motif protein 39 0.0368166
ASPH aspartate beta-hydroxylase 0.0365757
FAM13A family with sequence similarity 13, member A 0.0352626
PRRC2C proline-rich coiled-coil 2C 0.0334824
RPL37A ribosomal protein L37a 0.0326064
RPS12 ribosomal protein S12 0.0306202
SPAG9 sperm associated antigen 9 0.028529
B2M beta-2-microglobulin 0.0283391
HLA-B major histocompatibility complex, class I, B 0.0272022
KMT2E lysine (K)-specific methyltransferase 2E 0.0267128
GOLGB1 golgin B1 0.0266096
RPL13A ribosomal protein L13a 0.0263772
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0258495
NAMPT nicotinamide phosphoribosyltransferase 0.0221678
PARD3 par-3 family cell polarity regulator 0.0171407
PDE4D phosphodiesterase 4D, cAMP-specific 0.0169777
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0161915
EIF1 eukaryotic translation initiation factor 1 0.0150763
IGFBP3 insulin-like growth factor binding protein 3 0.0127815
RPLP1 ribosomal protein, large, P1 0.012486
PDLIM5 PDZ and LIM domain 5 0.0124264
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0115066
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0114508
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0108411
RPL35A ribosomal protein L35a 0.00975175
MON2 MON2 homolog (S. cerevisiae) 0.00843458
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.00829916
ENO1 enolase 1, (alpha) 0.00786111
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0067998
ACTG1 actin gamma 1 0.00481797
KDM5B lysine (K)-specific demethylase 5B 0.00180028
PGK1 phosphoglycerate kinase 1 0.00179373
RPS27A ribosomal protein S27a 8.43286E-4
NPAS2 neuronal PAS domain protein 2 2.2698E-4

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.280394
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.255495
EGFR epidermal growth factor receptor -0.195964
MYO1E myosin IE -0.114971
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.113103
TRIO trio Rho guanine nucleotide exchange factor -0.111357
LDHA lactate dehydrogenase A -0.105696
RPS3 ribosomal protein S3 -0.082732
MYO6 myosin VI -0.082227
MT2A metallothionein 2A -0.0770169
CD44 CD44 molecule (Indian blood group) -0.0723833
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0618675
USP34 ubiquitin specific peptidase 34 -0.0584293
TPM4 tropomyosin 4 -0.0572167
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0570843
TMSB10 thymosin beta 10 -0.0542937
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0533794
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0523019
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0499147
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0486325
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0483812
SBF2 SET binding factor 2 -0.0466023
MYOF myoferlin -0.0447722
GPC6 glypican 6 -0.0418094
VIM vimentin -0.041083
PKM pyruvate kinase, muscle -0.0403955
FTL ferritin, light polypeptide -0.0392901
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0381038
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0355024
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0352257
SLTM SAFB-like, transcription modulator -0.0349044
PTMA prothymosin, alpha -0.0329909
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0317774
KTN1 kinectin 1 (kinesin receptor) -0.0304926
RPL23 ribosomal protein L23 -0.027399
ELL2 elongation factor, RNA polymerase II, 2 -0.0249309
LMO7 LIM domain 7 -0.0236712
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0236412
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0212121
YBX3 Y box binding protein 3 -0.0208068
NDRG1 N-myc downstream regulated 1 -0.0191701
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.018844
RPS8 ribosomal protein S8 -0.0173117
PRELID2 PRELI domain containing 2 -0.0172344
MAML3 mastermind-like 3 (Drosophila) -0.0171996
SRPK2 SRSF protein kinase 2 -0.0119844
RPS6 ribosomal protein S6 -0.0112159
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0107572
IGFBP5 insulin-like growth factor binding protein 5 -0.0101042
DSCAM Down syndrome cell adhesion molecule -0.00965715
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.00643455
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00618102
PTK2 protein tyrosine kinase 2 -0.0049478
CHD9 chromodomain helicase DNA binding protein 9 -0.00265891
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.00152757
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -8.50046E-4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -3.69191E-4
LRP1B low density lipoprotein receptor-related protein 1B -1.52524E-4