Doxorubicin (hydrochloride)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0660996
DST dystonin 0.0648097
MKI67 marker of proliferation Ki-67 0.0565625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0560301
CENPF centromere protein F, 350/400kDa 0.0497391
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0435909
ECT2 epithelial cell transforming 2 0.0429133
ZFAND3 zinc finger, AN1-type domain 3 0.0405415
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.036887
RHEB Ras homolog enriched in brain 0.0364261
ZNF217 zinc finger protein 217 0.0349317
IGF1R insulin-like growth factor 1 receptor 0.0343612
WDR43 WD repeat domain 43 0.0340283
CDC73 cell division cycle 73 0.0328932
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0327016
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0325514
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0313647
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0313302
TPX2 TPX2, microtubule-associated 0.0312791
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0310393
RYBP RING1 and YY1 binding protein 0.0303502
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0299488
ANLN anillin, actin binding protein 0.0298963
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0296002
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0285344
TSC22D2 TSC22 domain family, member 2 0.0285187
DPYD dihydropyrimidine dehydrogenase 0.0283087
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0280526
NCKAP1 NCK-associated protein 1 0.026235
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0262105
ZEB2 zinc finger E-box binding homeobox 2 0.0262003
NAMPT nicotinamide phosphoribosyltransferase 0.0258078
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0254708
GLS2 glutaminase 2 (liver, mitochondrial) 0.0252559
MARCHF6 membrane associated ring-CH-type finger 6 0.025006
CENPE centromere protein E, 312kDa 0.0249225
MACF1 microtubule-actin crosslinking factor 1 0.024767
PEG10 paternally expressed 10 0.0246909
TRIO trio Rho guanine nucleotide exchange factor 0.0246483
THBS1 thrombospondin 1 0.0243133
DIAPH3 diaphanous-related formin 3 0.0238788
CAMTA1 calmodulin binding transcription activator 1 0.0238059
STAG2 stromal antigen 2 0.0237748
KIF4A kinesin family member 4A 0.0237075
SMC4 structural maintenance of chromosomes 4 0.0234841
CDC14A cell division cycle 14A 0.0233512
USP12 ubiquitin specific peptidase 12 0.0229245
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0227791
CKAP2 cytoskeleton associated protein 2 0.0226124
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0222196
KDM3A lysine (K)-specific demethylase 3A 0.0219999
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0218649
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.021693
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0216092
PLK2 polo-like kinase 2 0.0214367
PAWR PRKC, apoptosis, WT1, regulator 0.0213073
ACTN4 actinin, alpha 4 0.0212249
FAM171B family with sequence similarity 171, member B 0.0210852
CTNNBL1 catenin, beta like 1 0.020952
UTRN utrophin 0.0207582
CCNA2 cyclin A2 0.0206379
TMEM123 transmembrane protein 123 0.0206185
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0205905
KIF11 kinesin family member 11 0.0204698
ADAM9 ADAM metallopeptidase domain 9 0.0203426
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0199959
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0199479
MEMO1 mediator of cell motility 1 0.0199419
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0198725
HP1BP3 heterochromatin protein 1, binding protein 3 0.0196719
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0196641
PHF3 PHD finger protein 3 0.0195979
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0195877
NUP153 nucleoporin 153kDa 0.0195448
SPAG9 sperm associated antigen 9 0.0194775
RAD23B RAD23 homolog B (S. cerevisiae) 0.0194689
CANX calnexin 0.0193104
FXR1 fragile X mental retardation, autosomal homolog 1 0.0192756
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0192186
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0191185
FIGN fidgetin 0.0191002
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0190167
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0188019
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0187064
PUM1 pumilio RNA-binding family member 1 0.0186695
MEF2A myocyte enhancer factor 2A 0.0186239
LHFPL6 LHFPL tetraspan subfamily member 6 0.0185236
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.018491
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0183413
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0182625
TOP2A topoisomerase (DNA) II alpha 170kDa 0.018153
CEP135 centrosomal protein 135kDa 0.0181395
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0181316
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0179496
CDK6 cyclin-dependent kinase 6 0.0179449
SPAG5 sperm associated antigen 5 0.0179077
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.0178964
CLTC clathrin, heavy chain (Hc) 0.0177977
ATP5F1B ATP synthase F1 subunit beta 0.0177568
CCNL1 cyclin L1 0.0175685

decreased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 -0.166998
VIM vimentin -0.154764
TMSB10 thymosin beta 10 -0.145967
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.124721
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.105272
PTMA prothymosin, alpha -0.0882238
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0865144
RPS16 ribosomal protein S16 -0.0845853
RPS6 ribosomal protein S6 -0.0807925
CDH10 cadherin 10, type 2 (T2-cadherin) -0.080558
RPS12 ribosomal protein S12 -0.0733427
CADM2 cell adhesion molecule 2 -0.069426
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0656366
PCDH9 protocadherin 9 -0.06561
RPLP1 ribosomal protein, large, P1 -0.0639357
WSB1 WD repeat and SOCS box containing 1 -0.0618433
RPS8 ribosomal protein S8 -0.0597587
RPL35A ribosomal protein L35a -0.0545027
ENO1 enolase 1, (alpha) -0.0527369
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0523261
LRRC4C leucine rich repeat containing 4C -0.0522539
RPL23 ribosomal protein L23 -0.0466967
RPS19 ribosomal protein S19 -0.0447409
RPS3 ribosomal protein S3 -0.0442203
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0437146
FTL ferritin, light polypeptide -0.0434965
RPL19 ribosomal protein L19 -0.0433973
PCLO piccolo presynaptic cytomatrix protein -0.0426466
RPL37A ribosomal protein L37a -0.0425979
RPS13 ribosomal protein S13 -0.0405797
RPL37 ribosomal protein L37 -0.0403828
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0401017
SNX6 sorting nexin 6 -0.0390827
RPL9 ribosomal protein L9 -0.0387744
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0384289
SOX2 SRY (sex determining region Y)-box 2 -0.0382524
RPL30 ribosomal protein L30 -0.0378881
RPS27A ribosomal protein S27a -0.03782
PFN1 profilin 1 -0.0373685
MDK midkine (neurite growth-promoting factor 2) -0.0371871
ACTG1 actin gamma 1 -0.0371067
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0362549
PHIP pleckstrin homology domain interacting protein -0.035947
LDHA lactate dehydrogenase A -0.035766
RPS2 ribosomal protein S2 -0.0357606
RPL11 ribosomal protein L11 -0.0355427
RPL31 ribosomal protein L31 -0.0351676
RPLP2 ribosomal protein, large, P2 -0.035066
CNRIP1 cannabinoid receptor interacting protein 1 -0.0349676
RPL12 ribosomal protein L12 -0.0328247
RPS29 ribosomal protein S29 -0.0320287
RPLP0 ribosomal protein, large, P0 -0.0320281
S100A9 S100 calcium binding protein A9 -0.0314546
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0307371
TPT1 tumor protein, translationally-controlled 1 -0.0304196
LOC102724023 ES1 protein homolog, mitochondrial -0.0302577
PGK1 phosphoglycerate kinase 1 -0.0300535
RPL34 ribosomal protein L34 -0.02908
CSMD3 CUB and Sushi multiple domains 3 -0.0287667
ADGRL2 adhesion G protein-coupled receptor L2 -0.0285357
SFRP4 secreted frizzled-related protein 4 -0.0281286
GNAS GNAS complex locus -0.0280857
ITGAV integrin, alpha V -0.0280009
RPL36 ribosomal protein L36 -0.027873
RPL5 ribosomal protein L5 -0.0275797
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0274944
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0267324
RPS21 ribosomal protein S21 -0.0264491
RPL26 ribosomal protein L26 -0.0263149
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0262855
RPS25 ribosomal protein S25 -0.0260285
NACA nascent polypeptide-associated complex alpha subunit -0.0256071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0251779
ADGRV1 adhesion G protein-coupled receptor V1 -0.024979
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0248035
RPL7 ribosomal protein L7 -0.0244946
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0243898
RPL18 ribosomal protein L18 -0.0239358
EIF1 eukaryotic translation initiation factor 1 -0.0238973
PDIA3 protein disulfide isomerase family A, member 3 -0.0238347
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.023738
NEBL nebulette -0.0233022
GARS1 glycyl-tRNA synthetase 1 -0.0232746
MYL12B myosin, light chain 12B, regulatory -0.0231017
RAD51B RAD51 paralog B -0.0229778
ZC3H12B zinc finger CCCH-type containing 12B -0.0229295
NBEAL1 neurobeachin-like 1 -0.0228252
SERBP1 SERPINE1 mRNA binding protein 1 -0.0228217
ISG15 ISG15 ubiquitin-like modifier -0.0227084
RPS27 ribosomal protein S27 -0.0225159
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.022474
RPL28 ribosomal protein L28 -0.022458
NTM neurotrimin -0.0224511
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0223738
EIF5B eukaryotic translation initiation factor 5B -0.0222105
ANKRD12 ankyrin repeat domain 12 -0.0219077
RPS17 ribosomal protein S17 -0.0216428
FAM177A1 family with sequence similarity 177, member A1 -0.021515
PNISR PNN-interacting serine/arginine-rich protein -0.021513
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.02151