| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.10238 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0945635 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0810938 |
| PCBP2 | poly(rC) binding protein 2 | 0.0623272 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0616915 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0604583 |
| SEPTIN9 | septin 9 | 0.0571181 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0526281 |
| SMAD3 | SMAD family member 3 | 0.0516779 |
| CDK19 | cyclin-dependent kinase 19 | 0.0510849 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.0493022 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0492949 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0462294 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0458083 |
| ZNF292 | zinc finger protein 292 | 0.0404146 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0402532 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0394049 |
| TXNRD1 | thioredoxin reductase 1 | 0.0385442 |
| NAV2 | neuron navigator 2 | 0.0375053 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0371625 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0363788 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0348765 |
| HELLS | helicase, lymphoid-specific | 0.0344676 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0339656 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0333592 |
| OGA | O-GlcNAcase | 0.0331624 |
| ANLN | anillin, actin binding protein | 0.0328023 |
| PRELID2 | PRELI domain containing 2 | 0.0314732 |
| ARRDC3 | arrestin domain containing 3 | 0.0313219 |
| XPO1 | exportin 1 | 0.0312636 |
| RSF1 | remodeling and spacing factor 1 | 0.0308745 |
| CTBP2 | C-terminal binding protein 2 | 0.0299154 |
| PKM | pyruvate kinase, muscle | 0.0298398 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0295586 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0293073 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0291379 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0284028 |
| CCNL1 | cyclin L1 | 0.0281676 |
| YAP1 | Yes-associated protein 1 | 0.027892 |
| CENPF | centromere protein F, 350/400kDa | 0.0277719 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0273109 |
| FLNA | filamin A, alpha | 0.026919 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.026539 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.0260208 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0259488 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0257903 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0252299 |
| MATR3 | matrin 3 | 0.0251766 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0250826 |
| MAP3K10 | mitogen-activated protein kinase kinase kinase 10 | 0.024987 |
| CCDC88A | coiled-coil domain containing 88A | 0.024684 |
| PTEN | phosphatase and tensin homolog | 0.0245572 |
| FOSL1 | FOS-like antigen 1 | 0.0241653 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0239264 |
| BRD2 | bromodomain containing 2 | 0.0237399 |
| TPM3 | tropomyosin 3 | 0.0237279 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0235956 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0234928 |
| VEGFA | vascular endothelial growth factor A | 0.0234623 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0234123 |
| MYOF | myoferlin | 0.0231064 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0228768 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0227805 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0226457 |
| MELK | maternal embryonic leucine zipper kinase | 0.0222625 |
| PHIP | pleckstrin homology domain interacting protein | 0.0222459 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0222095 |
| ZNF638 | zinc finger protein 638 | 0.0219705 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.021878 |
| TBK1 | TANK-binding kinase 1 | 0.0215942 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0214269 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0213715 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0212681 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0208215 |
| FNIP1 | folliculin interacting protein 1 | 0.0207498 |
| FMNL2 | formin-like 2 | 0.0207418 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0206675 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0205239 |
| PLEC | plectin | 0.0204116 |
| DIAPH3 | diaphanous-related formin 3 | 0.0202889 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0202003 |
| DEK | DEK proto-oncogene | 0.0200789 |
| PKN2 | protein kinase N2 | 0.0200304 |
| FOXO3 | forkhead box O3 | 0.0198409 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0196791 |
| PDE8A | phosphodiesterase 8A | 0.0194921 |
| CA8 | carbonic anhydrase VIII | 0.0194347 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0193946 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0193529 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0192842 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0190931 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0189153 |
| YEATS2 | YEATS domain containing 2 | 0.018904 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0187824 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0186805 |
| SPAG9 | sperm associated antigen 9 | 0.0186763 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0185975 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0185625 |
| DENND4A | DENN/MADD domain containing 4A | 0.0185471 |
| CEP192 | centrosomal protein 192kDa | 0.0185221 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.311402 |
| VCL | vinculin | -0.276367 |
| VIM | vimentin | -0.259845 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.186298 |
| RPS16 | ribosomal protein S16 | -0.172753 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.124437 |
| CD44 | CD44 molecule (Indian blood group) | -0.114358 |
| PTMA | prothymosin, alpha | -0.107845 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.104912 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0813102 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0792339 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0789551 |
| ACTG1 | actin gamma 1 | -0.0636607 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0574053 |
| EXT1 | exostosin glycosyltransferase 1 | -0.057344 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0557426 |
| EGR1 | early growth response 1 | -0.0552309 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0524066 |
| S100A6 | S100 calcium binding protein A6 | -0.0515377 |
| TMEM41B | transmembrane protein 41B | -0.051271 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.050054 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0484595 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0478287 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0473907 |
| TMSB10 | thymosin beta 10 | -0.0467077 |
| CARD18 | caspase recruitment domain family, member 18 | -0.045323 |
| AHNAK | AHNAK nucleoprotein | -0.0442023 |
| TPM1 | tropomyosin 1 (alpha) | -0.0438828 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0431509 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0410677 |
| FHL2 | four and a half LIM domains 2 | -0.0405824 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0401973 |
| RTN4 | reticulon 4 | -0.0390063 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.0376151 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0361806 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0347215 |
| MYO1E | myosin IE | -0.0346139 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0345119 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0343966 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0343317 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0342455 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0338909 |
| KLF6 | Kruppel-like factor 6 | -0.0332894 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0327782 |
| EHBP1 | EH domain binding protein 1 | -0.032663 |
| ZNF644 | zinc finger protein 644 | -0.0321176 |
| RPS24 | ribosomal protein S24 | -0.0315583 |
| ACTN4 | actinin, alpha 4 | -0.0312249 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0310833 |
| SBF2 | SET binding factor 2 | -0.0309596 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0309218 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0305292 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.030391 |
| OSMR | oncostatin M receptor | -0.0303887 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0300517 |
| RSU1 | Ras suppressor protein 1 | -0.0300151 |
| ITGAV | integrin, alpha V | -0.0297221 |
| RPS3 | ribosomal protein S3 | -0.0287497 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0286822 |
| ASPH | aspartate beta-hydroxylase | -0.0285532 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.028514 |
| ATG7 | autophagy related 7 | -0.0280546 |
| ANXA2 | annexin A2 | -0.0275656 |
| NF1 | neurofibromin 1 | -0.0271657 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0270515 |
| RPL35A | ribosomal protein L35a | -0.0270473 |
| RASAL2 | RAS protein activator like 2 | -0.0264317 |
| MAP1B | microtubule-associated protein 1B | -0.0260752 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0259845 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0258694 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0258521 |
| STK17A | serine/threonine kinase 17a | -0.0244493 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0242837 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0241675 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0240719 |
| RPLP0 | ribosomal protein, large, P0 | -0.023714 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.023638 |
| H1-0 | H1.0 linker histone | -0.0231774 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0231036 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0227587 |
| RAB31 | RAB31, member RAS oncogene family | -0.0226247 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0225244 |
| BMP6 | bone morphogenetic protein 6 | -0.0224687 |
| EGFR | epidermal growth factor receptor | -0.0223954 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0223727 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0222067 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.0220485 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0217215 |
| VMP1 | vacuole membrane protein 1 | -0.0216797 |
| RPS27A | ribosomal protein S27a | -0.0212932 |
| HMGA2 | high mobility group AT-hook 2 | -0.0212773 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0208201 |
| ANGPTL4 | angiopoietin-like 4 | -0.0207249 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0207112 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0206072 |
| RPL12 | ribosomal protein L12 | -0.0205953 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0203868 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0198691 |
| IER3 | immediate early response 3 | -0.0198642 |
| JUN | jun proto-oncogene | -0.0197519 |
