| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Doxorubicin (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Doxorubicin (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.175145 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.123938 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0831246 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.072803 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.06314 |
| PCBP2 | poly(rC) binding protein 2 | 0.0625715 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0622548 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0582777 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0574797 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0534471 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0516658 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0511227 |
| DIAPH3 | diaphanous-related formin 3 | 0.0494171 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0493462 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.048623 |
| FLNA | filamin A, alpha | 0.0473221 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0464566 |
| RPSA | ribosomal protein SA | 0.0451115 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0440827 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.0422872 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0420054 |
| HLA-A | major histocompatibility complex, class I, A | 0.0414826 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0410698 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0395701 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0380782 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0375612 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0375416 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0375097 |
| CALR | calreticulin | 0.0374881 |
| RPL13A | ribosomal protein L13a | 0.0371877 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0369292 |
| OLA1 | Obg-like ATPase 1 | 0.0366056 |
| CANX | calnexin | 0.0362941 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0358077 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.035709 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0356917 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.035564 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0347983 |
| COL27A1 | collagen, type XXVII, alpha 1 | 0.0347449 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0346155 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0346056 |
| EXOC4 | exocyst complex component 4 | 0.0341729 |
| WDR43 | WD repeat domain 43 | 0.0333245 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0331958 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0331402 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0319374 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0313958 |
| SRPK2 | SRSF protein kinase 2 | 0.0312805 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0307279 |
| HMGA2 | high mobility group AT-hook 2 | 0.0305565 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.030022 |
| OGA | O-GlcNAcase | 0.0299669 |
| FBXO22 | F-box protein 22 | 0.0297908 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0297587 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0297416 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.029592 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0295209 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0288272 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0287969 |
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.0284521 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0283362 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0281703 |
| ETV6 | ets variant 6 | 0.0278644 |
| POU2F1 | POU class 2 homeobox 1 | 0.0276854 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0276504 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.027318 |
| DIAPH1 | diaphanous-related formin 1 | 0.0272066 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0271885 |
| HDAC9 | histone deacetylase 9 | 0.0266828 |
| RPL35A | ribosomal protein L35a | 0.0264899 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.0264891 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0264245 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0262658 |
| HMGB2 | high mobility group box 2 | 0.0257195 |
| PTMA | prothymosin, alpha | 0.0256044 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0253888 |
| APP | amyloid beta (A4) precursor protein | 0.0253532 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0253435 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0252304 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.0248532 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0246578 |
| ANKRD12 | ankyrin repeat domain 12 | 0.024615 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0244045 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0243147 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0241767 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0241762 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0241517 |
| YTHDC1 | YTH domain containing 1 | 0.023956 |
| ZNF37A | zinc finger protein 37A | 0.0239315 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0237097 |
| POLH | polymerase (DNA directed), eta | 0.0233911 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0232303 |
| CADM1 | cell adhesion molecule 1 | 0.0232193 |
| TOP1 | topoisomerase (DNA) I | 0.0230174 |
| RPS11 | ribosomal protein S11 | 0.0230109 |
| ACTN1 | actinin, alpha 1 | 0.022926 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0227753 |
| RPL37 | ribosomal protein L37 | 0.0227592 |
| FUS | FUS RNA binding protein | 0.022591 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0224785 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | -0.189968 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.178643 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.165029 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.133376 |
| JMJD1C | jumonji domain containing 1C | -0.116797 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.114478 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.111851 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.111444 |
| NAV3 | neuron navigator 3 | -0.0775527 |
| MT2A | metallothionein 2A | -0.0774333 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0707615 |
| STC1 | stanniocalcin 1 | -0.0703692 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0636566 |
| SMYD3 | SET and MYND domain containing 3 | -0.0607124 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0602718 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0583279 |
| TXNRD1 | thioredoxin reductase 1 | -0.057473 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0561114 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0542101 |
| USP34 | ubiquitin specific peptidase 34 | -0.0533718 |
| UPP1 | uridine phosphorylase 1 | -0.0522219 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0518168 |
| FRMD4A | FERM domain containing 4A | -0.0497001 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0469489 |
| SBF2 | SET binding factor 2 | -0.0456164 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0450688 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0445039 |
| CAPRIN2 | caprin family member 2 | -0.0430198 |
| RASA2 | RAS p21 protein activator 2 | -0.0422072 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0415074 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0406498 |
| GLRX | glutaredoxin (thioltransferase) | -0.0369466 |
| SP100 | SP100 nuclear antigen | -0.0365079 |
| TMEM156 | transmembrane protein 156 | -0.0360924 |
| AHNAK | AHNAK nucleoprotein | -0.0360369 |
| RPS2 | ribosomal protein S2 | -0.0342904 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0338969 |
| TPD52 | tumor protein D52 | -0.0338176 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0333964 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0332641 |
| POTEF | POTE ankyrin domain family, member F | -0.0318864 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0311788 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0309902 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0308562 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0307446 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0306908 |
| RTN4 | reticulon 4 | -0.0306373 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0306292 |
| TMEM41B | transmembrane protein 41B | -0.0302212 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.030172 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0301618 |
| CALU | calumenin | -0.0300699 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0300318 |
| FKBP15 | FK506 binding protein 15, 133kDa | -0.0297869 |
| CDCP1 | CUB domain containing protein 1 | -0.0290287 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0284145 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0282971 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0277205 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0271204 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0269825 |
| TTR | transthyretin | -0.0266377 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0266298 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0263443 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0263098 |
| FOSL1 | FOS-like antigen 1 | -0.0259349 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0259066 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0257889 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.0254666 |
| RBM39 | RNA binding motif protein 39 | -0.0252899 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0252391 |
| JUN | jun proto-oncogene | -0.025227 |
| MTDH | metadherin | -0.0248919 |
| SGMS2 | sphingomyelin synthase 2 | -0.0245642 |
| SHANK1 | SH3 and multiple ankyrin repeat domains 1 | -0.0240822 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -0.0239008 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0236103 |
| ANK2 | ankyrin 2, neuronal | -0.0234435 |
| NF1 | neurofibromin 1 | -0.0232189 |
| ADTRP | androgen-dependent TFPI-regulating protein | -0.0232056 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0231818 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0230943 |
| EMP1 | epithelial membrane protein 1 | -0.0229373 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0229036 |
| RAB10 | RAB10, member RAS oncogene family | -0.0227053 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0224216 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0222245 |
| H1-4 | H1.4 linker histone, cluster member | -0.0221624 |
| FHL2 | four and a half LIM domains 2 | -0.0219356 |
| RPL7A | ribosomal protein L7a | -0.021894 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0218625 |
| CDK17 | cyclin-dependent kinase 17 | -0.0217523 |
| PDS5A | PDS5 cohesin associated factor A | -0.0217004 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0216969 |
| DST | dystonin | -0.0215551 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0215521 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0212537 |
| TUT4 | terminal uridylyl transferase 4 | -0.0211177 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0210524 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0209568 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0208359 |
