Doxorubicin (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0654449
PTPRG protein tyrosine phosphatase, receptor type, G 0.0586034
RAD51B RAD51 paralog B 0.051947
FLNA filamin A, alpha 0.0450663
FRMD4A FERM domain containing 4A 0.0431592
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0422696
EEF2 eukaryotic translation elongation factor 2 0.0411647
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0402227
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0392509
EXOC4 exocyst complex component 4 0.0365903
GPHN gephyrin 0.0365216
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0363726
SMAD3 SMAD family member 3 0.0361569
MSI2 musashi RNA-binding protein 2 0.0344965
LSAMP limbic system-associated membrane protein 0.0344001
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0340017
PRELID2 PRELI domain containing 2 0.0331946
CAMTA1 calmodulin binding transcription activator 1 0.0323198
HSPA8 heat shock 70kDa protein 8 0.0322827
RNF213 ring finger protein 213 0.0320997
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.031932
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.031707
SEPTIN9 septin 9 0.0313806
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0307086
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0298312
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0296199
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0294466
PTPRM protein tyrosine phosphatase, receptor type, M 0.0292134
LRMDA leucine rich melanocyte differentiation associated 0.0284331
DSCAM Down syndrome cell adhesion molecule 0.028033
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0271395
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0271246
PRKCE protein kinase C, epsilon 0.0271151
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.026966
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0266147
TUSC3 tumor suppressor candidate 3 0.0264971
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0263876
SLC39A11 solute carrier family 39, member 11 0.0259893
TRIP12 thyroid hormone receptor interactor 12 0.025943
SFTPA2 surfactant protein A2 0.0258106
TCF20 transcription factor 20 (AR1) 0.0254904
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0249493
CXCL8 chemokine (C-X-C motif) ligand 8 0.0249396
TXNRD1 thioredoxin reductase 1 0.0248551
NFE2L1 nuclear factor, erythroid 2-like 1 0.0244358
MED13 mediator complex subunit 13 0.0237899
CANX calnexin 0.0236932
ARL15 ADP-ribosylation factor-like 15 0.0236778
SOD2 superoxide dismutase 2, mitochondrial 0.0232518
KLHL29 kelch-like family member 29 0.0232355
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0232324
PCLO piccolo presynaptic cytomatrix protein 0.0230941
IPO7 importin 7 0.0229225
EPS8 epidermal growth factor receptor pathway substrate 8 0.0228827
PEAK1 pseudopodium-enriched atypical kinase 1 0.02243
CD109 CD109 molecule 0.0223227
SENP5 SUMO1/sentrin specific peptidase 5 0.0222118
EIF4H eukaryotic translation initiation factor 4H 0.0220811
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.0220234
GLS2 glutaminase 2 (liver, mitochondrial) 0.0219934
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0216789
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0216052
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.02131
MAN1A2 mannosidase, alpha, class 1A, member 2 0.021252
HMGA2 high mobility group AT-hook 2 0.0212077
RUNX1 runt-related transcription factor 1 0.0210536
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0210398
KAZN kazrin, periplakin interacting protein 0.0208148
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0207611
FER fer (fps/fes related) tyrosine kinase 0.020478
IGF1R insulin-like growth factor 1 receptor 0.0202489
RPTOR regulatory associated protein of MTOR, complex 1 0.0198566
AFF3 AF4/FMR2 family, member 3 0.0197841
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0197264
ZBTB20 zinc finger and BTB domain containing 20 0.0196144
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0196037
DIAPH1 diaphanous-related formin 1 0.0194317
TAS2R14 taste receptor, type 2, member 14 0.0193867
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0193296
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0192397
HDAC4 histone deacetylase 4 0.019059
TFRC transferrin receptor 0.0189826
MEIS2 Meis homeobox 2 0.0189424
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.018796
OGA O-GlcNAcase 0.0187398
CTTN cortactin 0.0186631
ZNF638 zinc finger protein 638 0.0186516
FAM219A family with sequence similarity 219, member A 0.018513
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0185049
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0183861
ATP13A3 ATPase type 13A3 0.0183721
ATF6 activating transcription factor 6 0.0178203
CCDC47 coiled-coil domain containing 47 0.0177864
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0176724
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0176392
ZC3H12B zinc finger CCCH-type containing 12B 0.0176313
CADM1 cell adhesion molecule 1 0.0175255
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0175021
FNIP1 folliculin interacting protein 1 0.0174941
KDM4C lysine (K)-specific demethylase 4C 0.0173846

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.271089
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195008
MT2A metallothionein 2A -0.143399
FN1 fibronectin 1 -0.133054
FTL ferritin, light polypeptide -0.085674
RPS3 ribosomal protein S3 -0.06771
TMSB10 thymosin beta 10 -0.0644264
RPS6 ribosomal protein S6 -0.062823
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0595988
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0572561
RPL35A ribosomal protein L35a -0.0550724
LDHA lactate dehydrogenase A -0.052552
EIF1 eukaryotic translation initiation factor 1 -0.0484427
GOLGA4 golgin A4 -0.047965
RPLP1 ribosomal protein, large, P1 -0.0432997
POTEF POTE ankyrin domain family, member F -0.0429149
PTMA prothymosin, alpha -0.0428153
MT1X metallothionein 1X -0.0424871
HMGA1 high mobility group AT-hook 1 -0.0398412
CENPF centromere protein F, 350/400kDa -0.039062
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0389906
RPL23 ribosomal protein L23 -0.0388945
RACK1 receptor for activated C kinase 1 -0.0387096
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0380685
ENO1 enolase 1, (alpha) -0.0376826
RPS8 ribosomal protein S8 -0.0352579
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0345374
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0334284
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0316817
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0312878
TM4SF1 transmembrane 4 L six family member 1 -0.0301447
FNDC3B fibronectin type III domain containing 3B -0.030022
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0298313
IGFBP3 insulin-like growth factor binding protein 3 -0.0298242
S100A9 S100 calcium binding protein A9 -0.0295094
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0291221
ANGPTL4 angiopoietin-like 4 -0.0290582
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0289042
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0285055
TENM1 teneurin transmembrane protein 1 -0.0283204
B2M beta-2-microglobulin -0.0281904
RPL34 ribosomal protein L34 -0.0281137
NDRG1 N-myc downstream regulated 1 -0.0275182
FRMD5 FERM domain containing 5 -0.0273271
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0269662
RPS16 ribosomal protein S16 -0.025648
RPL36 ribosomal protein L36 -0.0255362
TPM4 tropomyosin 4 -0.0245179
S100A6 S100 calcium binding protein A6 -0.0244505
RPS13 ribosomal protein S13 -0.0243865
KMT2E lysine (K)-specific methyltransferase 2E -0.0243318
AKAP12 A kinase (PRKA) anchor protein 12 -0.0242763
WDR45B WD repeat domain 45B -0.0242428
LOC112694756 uncharaterized LOC112694756 -0.0241133
RPL12 ribosomal protein L12 -0.0237787
RPS21 ribosomal protein S21 -0.0234403
RPS27A ribosomal protein S27a -0.0233454
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0232698
ACTG1 actin gamma 1 -0.0231132
RPL37A ribosomal protein L37a -0.0225707
IFI6 interferon, alpha-inducible protein 6 -0.0220761
LITAF lipopolysaccharide-induced TNF factor -0.0220583
HILPDA hypoxia inducible lipid droplet-associated -0.0219837
RNF145 ring finger protein 145 -0.0219148
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0219145
RPL19 ribosomal protein L19 -0.0217865
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0216767
KTN1 kinectin 1 (kinesin receptor) -0.021367
RPS17 ribosomal protein S17 -0.0213665
PFN1 profilin 1 -0.0211858
SETD5 SET domain containing 5 -0.0208375
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0208231
RPS14 ribosomal protein S14 -0.0207962
S100A10 S100 calcium binding protein A10 -0.0206198
UBC ubiquitin C -0.0205415
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0204617
SQSTM1 sequestosome 1 -0.0204174
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0203533
SOX10 SRY (sex determining region Y)-box 10 -0.020289
RPLP0 ribosomal protein, large, P0 -0.0202106
IFITM3 interferon induced transmembrane protein 3 -0.0200353
RPS12 ribosomal protein S12 -0.0199987
RPLP2 ribosomal protein, large, P2 -0.0198648
INPP5F inositol polyphosphate-5-phosphatase F -0.0198411
RPL31 ribosomal protein L31 -0.0198214
MSN moesin -0.0197163
SKIC3 SKI3 subunit of superkiller complex -0.0196655
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0196268
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0192911
RPS23 ribosomal protein S23 -0.0192104
ENO2 enolase 2 (gamma, neuronal) -0.0185283
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0183966
RPL11 ribosomal protein L11 -0.0183885
WDPCP WD repeat containing planar cell polarity effector -0.0182703
PLAUR plasminogen activator, urokinase receptor -0.0180016
RHOA ras homolog family member A -0.017691
DDIT4 DNA-damage-inducible transcript 4 -0.0176682
KLF6 Kruppel-like factor 6 -0.0175322
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0175177
TUBB tubulin, beta class I -0.0175049