Doxorubicin (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0700391
CCNL1 cyclin L1 0.0602763
ELOVL5 ELOVL fatty acid elongase 5 0.0583296
GLS2 glutaminase 2 (liver, mitochondrial) 0.0536389
NAMPT nicotinamide phosphoribosyltransferase 0.049266
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0490732
KDM6A lysine (K)-specific demethylase 6A 0.0458648
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0430192
NUP58 nucleoporin 58 0.0426372
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0420855
EEF2 eukaryotic translation elongation factor 2 0.0419271
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0409729
PTPRG protein tyrosine phosphatase, receptor type, G 0.040256
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.039693
KDM3A lysine (K)-specific demethylase 3A 0.0383474
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0379388
RBM39 RNA binding motif protein 39 0.0375127
KDM4C lysine (K)-specific demethylase 4C 0.0370634
TOP1 topoisomerase (DNA) I 0.0362543
ZFAND3 zinc finger, AN1-type domain 3 0.0343703
SRPK2 SRSF protein kinase 2 0.033798
CAMTA1 calmodulin binding transcription activator 1 0.0337002
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0329351
MEF2A myocyte enhancer factor 2A 0.0318696
ADAM9 ADAM metallopeptidase domain 9 0.0314824
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0306394
HELZ helicase with zinc finger 0.0306384
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0291107
TFG TRK-fused gene 0.0289396
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0281567
MON2 MON2 homolog (S. cerevisiae) 0.0280782
MSI2 musashi RNA-binding protein 2 0.0279393
NCKAP1 NCK-associated protein 1 0.0278885
PCBP2 poly(rC) binding protein 2 0.027887
WDR43 WD repeat domain 43 0.0278781
ZNF292 zinc finger protein 292 0.0273582
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0272936
TMEM117 transmembrane protein 117 0.0272011
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0265656
NCOR1 nuclear receptor corepressor 1 0.0264772
OLA1 Obg-like ATPase 1 0.026451
MED13 mediator complex subunit 13 0.0258669
MED13L mediator complex subunit 13-like 0.0252389
ZMYM2 zinc finger, MYM-type 2 0.0250905
SRP54 signal recognition particle 54kDa 0.0247795
DENND4A DENN/MADD domain containing 4A 0.024503
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0240736
WAC WW domain containing adaptor with coiled-coil 0.0239499
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0235995
ZCCHC7 zinc finger, CCHC domain containing 7 0.0234948
SPAG9 sperm associated antigen 9 0.0233916
TOP2B topoisomerase (DNA) II beta 180kDa 0.023366
PER1 period circadian clock 1 0.0231935
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0228674
AK1 adenylate kinase 1 0.0227218
KMT2C lysine (K)-specific methyltransferase 2C 0.022696
HSPA8 heat shock 70kDa protein 8 0.0226504
QKI QKI, KH domain containing, RNA binding 0.0225382
ECT2 epithelial cell transforming 2 0.0224991
PTBP2 polypyrimidine tract binding protein 2 0.0222094
ETNK1 ethanolamine kinase 1 0.0219064
CDC73 cell division cycle 73 0.0218691
FXR1 fragile X mental retardation, autosomal homolog 1 0.0217146
SPRED2 sprouty-related, EVH1 domain containing 2 0.021457
FNDC3B fibronectin type III domain containing 3B 0.0211856
MATR3 matrin 3 0.0210059
UBA6 ubiquitin-like modifier activating enzyme 6 0.0207799
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0207734
NBAS neuroblastoma amplified sequence 0.0203392
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.019845
PTK2 protein tyrosine kinase 2 0.0198395
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0197214
MRTFA myocardin related transcription factor A 0.0197136
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.019317
ZMAT3 zinc finger, matrin-type 3 0.019183
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0191369
YAP1 Yes-associated protein 1 0.0187582
GARS1 glycyl-tRNA synthetase 1 0.0187395
RLF rearranged L-myc fusion 0.0186841
ANKRD10 ankyrin repeat domain 10 0.0186652
TIGAR TP53 induced glycolysis regulatory phosphatase 0.0185969
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0185585
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0185484
DSCAM Down syndrome cell adhesion molecule 0.0185279
CD46 CD46 molecule, complement regulatory protein 0.0184647
WDFY3 WD repeat and FYVE domain containing 3 0.0184135
ZNF37A zinc finger protein 37A 0.0183109
SLMAP sarcolemma associated protein 0.0180958
TLK2 tousled-like kinase 2 0.0179921
ECPAS Ecm29 proteasome adaptor and scaffold 0.0179408
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0178108
TRA2A transformer 2 alpha homolog (Drosophila) 0.0177892
PNPLA8 patatin-like phospholipase domain containing 8 0.0177824
ITCH itchy E3 ubiquitin protein ligase 0.0176838
SCAF4 SR-related CTD-associated factor 4 0.0175764
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0175047
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0174163
POU2F1 POU class 2 homeobox 1 0.0173391
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0173138
RYBP RING1 and YY1 binding protein 0.0170004

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.303837
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.247044
PDE4B phosphodiesterase 4B, cAMP-specific -0.185424
VCL vinculin -0.152504
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.125285
PDE4D phosphodiesterase 4D, cAMP-specific -0.120032
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.119215
CPED1 cadherin-like and PC-esterase domain containing 1 -0.104787
FOXP1 forkhead box P1 -0.100675
AHNAK AHNAK nucleoprotein -0.0957706
EGFR epidermal growth factor receptor -0.0817089
RPS6 ribosomal protein S6 -0.0743715
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0741935
ACTG1 actin gamma 1 -0.0727494
BMP10 bone morphogenetic protein 10 -0.0716558
NBEA neurobeachin -0.0693429
TJP1 tight junction protein 1 -0.0666229
TPT1 tumor protein, translationally-controlled 1 -0.0650591
RPL35A ribosomal protein L35a -0.0635895
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0619292
RPS8 ribosomal protein S8 -0.0604255
RPL34 ribosomal protein L34 -0.0588081
HDAC9 histone deacetylase 9 -0.0577472
DLG1 discs, large homolog 1 (Drosophila) -0.0572539
PKM pyruvate kinase, muscle -0.0559108
ANXA1 annexin A1 -0.0555396
SOX6 SRY (sex determining region Y)-box 6 -0.0541879
RPLP1 ribosomal protein, large, P1 -0.0525946
CCND1 cyclin D1 -0.0507406
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0495209
TMSB4X thymosin beta 4, X-linked -0.0487914
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0486828
ARL4C ADP-ribosylation factor-like 4C -0.0486289
NPAS2 neuronal PAS domain protein 2 -0.048333
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0482143
EZR ezrin -0.0471151
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0464116
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0455798
GLI3 GLI family zinc finger 3 -0.044988
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0448821
ZMYND8 zinc finger, MYND-type containing 8 -0.0447363
MKI67 marker of proliferation Ki-67 -0.0442894
ENO1 enolase 1, (alpha) -0.0441716
SLC38A2 solute carrier family 38, member 2 -0.0437176
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0432501
RPL19 ribosomal protein L19 -0.0431828
S100A6 S100 calcium binding protein A6 -0.0430636
RPL26 ribosomal protein L26 -0.0422925
RPL31 ribosomal protein L31 -0.0415159
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0414962
TM4SF1 transmembrane 4 L six family member 1 -0.0405474
DUSP4 dual specificity phosphatase 4 -0.0401585
MYO5C myosin VC -0.0396191
RPLP2 ribosomal protein, large, P2 -0.0374818
HSPB1 heat shock 27kDa protein 1 -0.037382
EFNA5 ephrin-A5 -0.0373075
RPL12 ribosomal protein L12 -0.0369281
ZEB1 zinc finger E-box binding homeobox 1 -0.0354542
RPS13 ribosomal protein S13 -0.0351679
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0344918
RPL23 ribosomal protein L23 -0.0344055
GLI2 GLI family zinc finger 2 -0.0343912
PDE7B phosphodiesterase 7B -0.0332436
RPL37A ribosomal protein L37a -0.0330059
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0324507
TTC28 tetratricopeptide repeat domain 28 -0.0314505
S100A9 S100 calcium binding protein A9 -0.0312153
S100A4 S100 calcium binding protein A4 -0.0307979
S100A10 S100 calcium binding protein A10 -0.0305225
RPS27A ribosomal protein S27a -0.0303138
ENO2 enolase 2 (gamma, neuronal) -0.0302879
CENPF centromere protein F, 350/400kDa -0.030213
DUSP6 dual specificity phosphatase 6 -0.0299143
RPS3 ribosomal protein S3 -0.029823
KPNB1 karyopherin (importin) beta 1 -0.0293824
EBNA1BP2 EBNA1 binding protein 2 -0.0283905
EIF1 eukaryotic translation initiation factor 1 -0.0283748
TAS2R14 taste receptor, type 2, member 14 -0.0277637
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0277337
LPP LIM domain containing preferred translocation partner in lipoma -0.0276884
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.027647
CAMKMT calmodulin-lysine N-methyltransferase -0.0276097
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0275861
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0274268
RPS19 ribosomal protein S19 -0.0273366
RPS23 ribosomal protein S23 -0.0272601
RPS24 ribosomal protein S24 -0.0271861
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0269828
RPS21 ribosomal protein S21 -0.0269822
TRERF1 transcriptional regulating factor 1 -0.0269213
TPM4 tropomyosin 4 -0.0266396
RPL9 ribosomal protein L9 -0.0258754
RPL7A ribosomal protein L7a -0.0254775
ZNF438 zinc finger protein 438 -0.0254271
PYGB phosphorylase, glycogen; brain -0.0252757
RPL36 ribosomal protein L36 -0.0252144
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0248504
RPLP0 ribosomal protein, large, P0 -0.0246336
LOC102724023 ES1 protein homolog, mitochondrial -0.024596
RPS25 ribosomal protein S25 -0.0245639