Doxorubicin (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0851711
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0733508
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0665398
EEF2 eukaryotic translation elongation factor 2 0.0624933
PCBP2 poly(rC) binding protein 2 0.0584898
GLS2 glutaminase 2 (liver, mitochondrial) 0.057159
FLNA filamin A, alpha 0.0523801
APLP2 amyloid beta (A4) precursor-like protein 2 0.0516852
PLEC plectin 0.0469422
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0460051
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0441052
YAP1 Yes-associated protein 1 0.0424285
ZSWIM6 zinc finger, SWIM-type containing 6 0.0420001
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0393757
HSPA8 heat shock 70kDa protein 8 0.0389522
DSPP dentin sialophosphoprotein 0.0369275
MYH9 myosin, heavy chain 9, non-muscle 0.0360872
SMAD3 SMAD family member 3 0.035526
ARHGAP26 Rho GTPase activating protein 26 0.0351414
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0341491
GPHN gephyrin 0.0337415
VCL vinculin 0.0332
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0328761
UBAP2 ubiquitin associated protein 2 0.0327281
CCNL1 cyclin L1 0.031553
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0314851
CEMIP2 cell migration inducing hyaluronidase 2 0.0309228
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0295196
TUFT1 tuftelin 1 0.0293899
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0293622
KDM6A lysine (K)-specific demethylase 6A 0.0293453
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0284383
RNF213 ring finger protein 213 0.0279419
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0278737
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0276334
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0274628
PRKCA protein kinase C, alpha 0.0272686
DOCK4 dedicator of cytokinesis 4 0.0271951
EEF1G eukaryotic translation elongation factor 1 gamma 0.0270196
INTS6 integrator complex subunit 6 0.0269535
NPTN neuroplastin 0.0263706
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0262456
MYO10 myosin X 0.0257991
NDRG1 N-myc downstream regulated 1 0.0254921
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0251565
PTPRK protein tyrosine phosphatase, receptor type, K 0.0249127
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0242722
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0241158
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0240124
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.023451
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0233495
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0232509
DIAPH1 diaphanous-related formin 1 0.0232214
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0231583
HELLS helicase, lymphoid-specific 0.0230254
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0228446
SHB Src homology 2 domain containing adaptor protein B 0.0227141
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.02248
USP9X ubiquitin specific peptidase 9, X-linked 0.0224047
PARD3B par-3 family cell polarity regulator beta 0.0223876
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0223731
WNK1 WNK lysine deficient protein kinase 1 0.0219907
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0219761
RPL3 ribosomal protein L3 0.0217996
NFE2L1 nuclear factor, erythroid 2-like 1 0.0217956
PDLIM5 PDZ and LIM domain 5 0.0216246
KIAA1671 KIAA1671 0.0214735
TGFBI transforming growth factor, beta-induced, 68kDa 0.0214428
RPSA ribosomal protein SA 0.0209965
RCOR1 REST corepressor 1 0.0207229
EPHA4 EPH receptor A4 0.0206766
VMP1 vacuole membrane protein 1 0.0206427
FXR1 fragile X mental retardation, autosomal homolog 1 0.0205729
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0203149
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0203099
ZNF638 zinc finger protein 638 0.0200578
VEGFA vascular endothelial growth factor A 0.0199006
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0197977
ATL2 atlastin GTPase 2 0.0193288
TPM3 tropomyosin 3 0.0192295
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0192249
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0191647
MEF2A myocyte enhancer factor 2A 0.019034
PPME1 protein phosphatase methylesterase 1 0.0190305
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.018996
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0188988
ETNK1 ethanolamine kinase 1 0.0187787
GATAD2A GATA zinc finger domain containing 2A 0.0187332
LIMS1 LIM and senescent cell antigen-like domains 1 0.0187301
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0186841
XPO1 exportin 1 0.018673
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.018645
EXT1 exostosin glycosyltransferase 1 0.0185808
OLA1 Obg-like ATPase 1 0.0184964
MED13L mediator complex subunit 13-like 0.018471
MYO5B myosin VB 0.0184314
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.018378
AP3B2 adaptor-related protein complex 3, beta 2 subunit 0.0183511
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.0182356
ARRDC3 arrestin domain containing 3 0.0181987

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.241582
PTMA prothymosin, alpha -0.228779
TMSB10 thymosin beta 10 -0.12852
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0945112
GOLGA4 golgin A4 -0.0784098
EHBP1 EH domain binding protein 1 -0.0780647
MAML2 mastermind-like 2 (Drosophila) -0.0778731
H1-0 H1.0 linker histone -0.0748761
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0706017
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0695414
EZR ezrin -0.066579
KRT18 keratin 18, type I -0.0654193
MACC1 metastasis associated in colon cancer 1 -0.0612627
EIF1 eukaryotic translation initiation factor 1 -0.0611064
DLG1 discs, large homolog 1 (Drosophila) -0.0610416
RPL35A ribosomal protein L35a -0.0593709
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0555643
ESYT2 extended synaptotagmin-like protein 2 -0.0536526
RPS21 ribosomal protein S21 -0.0532015
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0531035
LOC102724023 ES1 protein homolog, mitochondrial -0.0526459
ZMYND8 zinc finger, MYND-type containing 8 -0.0512599
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0508706
TPT1 tumor protein, translationally-controlled 1 -0.0485402
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0479573
RPL18 ribosomal protein L18 -0.0478007
RPL12 ribosomal protein L12 -0.0477526
RPS13 ribosomal protein S13 -0.0470769
IER3 immediate early response 3 -0.0461001
GSTP1 glutathione S-transferase pi 1 -0.0455512
SLC38A1 solute carrier family 38, member 1 -0.0453815
BCL2L1 BCL2-like 1 -0.0453198
S100A6 S100 calcium binding protein A6 -0.0451425
NF1 neurofibromin 1 -0.0449599
RPLP2 ribosomal protein, large, P2 -0.0444788
GARS1 glycyl-tRNA synthetase 1 -0.0444478
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0436521
CD2AP CD2-associated protein -0.0436454
FRMD5 FERM domain containing 5 -0.0429824
EPCAM epithelial cell adhesion molecule -0.0429325
RPS19 ribosomal protein S19 -0.0428126
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0415832
RPL23 ribosomal protein L23 -0.0402893
S100A9 S100 calcium binding protein A9 -0.0388589
RPL31 ribosomal protein L31 -0.0385392
UBC ubiquitin C -0.0382954
RPLP1 ribosomal protein, large, P1 -0.0375374
RPS5 ribosomal protein S5 -0.0371802
RPL32 ribosomal protein L32 -0.037025
ARHGAP5 Rho GTPase activating protein 5 -0.0367603
PLAUR plasminogen activator, urokinase receptor -0.0364544
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0362955
RPL28 ribosomal protein L28 -0.0359257
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0354489
KRT19 keratin 19, type I -0.0348849
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0337089
B2M beta-2-microglobulin -0.0335014
RPS27A ribosomal protein S27a -0.0328793
RSL1D1 ribosomal L1 domain containing 1 -0.0326939
RPS24 ribosomal protein S24 -0.0326649
RPL8 ribosomal protein L8 -0.0324092
GCC2 GRIP and coiled-coil domain containing 2 -0.0317554
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0317051
RPS3 ribosomal protein S3 -0.03121
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0312047
IFITM1 interferon induced transmembrane protein 1 -0.0306996
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0297993
KDM7A lysine (K)-specific demethylase 7A -0.0297243
NIPBL Nipped-B homolog (Drosophila) -0.0292041
MX2 MX dynamin-like GTPase 2 -0.0291456
RPL19 ribosomal protein L19 -0.0291075
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0291055
RAB1A RAB1A, member RAS oncogene family -0.0289678
AHNAK AHNAK nucleoprotein -0.0288135
PARD3 par-3 family cell polarity regulator -0.0287998
CALU calumenin -0.0287473
TMEM123 transmembrane protein 123 -0.0285958
RPS25 ribosomal protein S25 -0.02852
ADNP activity-dependent neuroprotector homeobox -0.0283993
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0282674
ACTG1 actin gamma 1 -0.0280522
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0278942
CST3 cystatin C -0.0275956
LOC112694756 uncharaterized LOC112694756 -0.0274375
GTF2IRD1 GTF2I repeat domain containing 1 -0.027415
SVIL supervillin -0.0273998
PRELID2 PRELI domain containing 2 -0.0272986
SNX9 sorting nexin 9 -0.0271952
RPS14 ribosomal protein S14 -0.0271513
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.027138
LDHA lactate dehydrogenase A -0.0271128
KDM3A lysine (K)-specific demethylase 3A -0.0270521
PLSCR1 phospholipid scramblase 1 -0.0269932
MYL12B myosin, light chain 12B, regulatory -0.0268626
COPB1 coatomer protein complex, subunit beta 1 -0.0268365
PPARG peroxisome proliferator-activated receptor gamma -0.0267166
RPL36A ribosomal protein L36a -0.026643
MYOF myoferlin -0.0265069
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0264509
RPL37A ribosomal protein L37a -0.0263603