Doxorubicin (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.144392
EEF2 eukaryotic translation elongation factor 2 0.0833331
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0821535
KDM6A lysine (K)-specific demethylase 6A 0.075802
DSCAM Down syndrome cell adhesion molecule 0.0657522
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0650446
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0599058
CD36 CD36 molecule (thrombospondin receptor) 0.0578338
OGA O-GlcNAcase 0.0497191
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0474865
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0462977
TOP1 topoisomerase (DNA) I 0.0458458
KDM3A lysine (K)-specific demethylase 3A 0.0457579
KMT2C lysine (K)-specific methyltransferase 2C 0.0444897
BBX bobby sox homolog (Drosophila) 0.044362
PUM1 pumilio RNA-binding family member 1 0.0441191
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0439088
TFRC transferrin receptor 0.0438216
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0430492
PCBP2 poly(rC) binding protein 2 0.0427831
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.042411
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0421546
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0398409
NEK7 NIMA-related kinase 7 0.0395809
NUP58 nucleoporin 58 0.039318
SERINC5 serine incorporator 5 0.0382562
OXR1 oxidation resistance 1 0.0374557
STRN3 striatin, calmodulin binding protein 3 0.0362966
PKM pyruvate kinase, muscle 0.0361216
DIAPH1 diaphanous-related formin 1 0.0359737
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0359209
WAC WW domain containing adaptor with coiled-coil 0.0352011
COG5 component of oligomeric golgi complex 5 0.0350721
EPS8 epidermal growth factor receptor pathway substrate 8 0.0350026
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0344215
NAMPT nicotinamide phosphoribosyltransferase 0.0339069
XPO1 exportin 1 0.0317419
CANX calnexin 0.031658
PDE4B phosphodiesterase 4B, cAMP-specific 0.0315807
HELZ helicase with zinc finger 0.0315621
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0314024
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0309982
DSPP dentin sialophosphoprotein 0.0304642
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.0303201
FLNA filamin A, alpha 0.0302985
PDIA3 protein disulfide isomerase family A, member 3 0.0300614
SPAG9 sperm associated antigen 9 0.0296632
NAP1L1 nucleosome assembly protein 1-like 1 0.029244
APP amyloid beta (A4) precursor protein 0.0290207
EPHA4 EPH receptor A4 0.0288414
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.028674
ANKRD11 ankyrin repeat domain 11 0.0282756
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0282015
ZMYM2 zinc finger, MYM-type 2 0.0275334
PDLIM5 PDZ and LIM domain 5 0.0274569
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0273915
RUNX2 runt-related transcription factor 2 0.0268557
ARL15 ADP-ribosylation factor-like 15 0.0267145
HSPA8 heat shock 70kDa protein 8 0.0266877
YTHDC1 YTH domain containing 1 0.0262915
CCNL1 cyclin L1 0.0262193
ZFAND3 zinc finger, AN1-type domain 3 0.0261853
WDR43 WD repeat domain 43 0.0260051
RPL3 ribosomal protein L3 0.0258678
PABPC1 poly(A) binding protein, cytoplasmic 1 0.025485
OSBPL3 oxysterol binding protein-like 3 0.0253746
MLEC malectin 0.0252901
ANXA4 annexin A4 0.0251503
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0249783
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0248918
CSNK1G1 casein kinase 1, gamma 1 0.0248751
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0248413
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0247131
NCKAP1 NCK-associated protein 1 0.0245352
SLMAP sarcolemma associated protein 0.0241992
MANBA mannosidase, beta A, lysosomal 0.0240226
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0239448
MED13L mediator complex subunit 13-like 0.0239373
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0238684
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0237087
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0232693
OLA1 Obg-like ATPase 1 0.0232559
SQSTM1 sequestosome 1 0.0231041
UBE2H ubiquitin-conjugating enzyme E2H 0.0228861
CD46 CD46 molecule, complement regulatory protein 0.0228164
CDK19 cyclin-dependent kinase 19 0.0227677
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0227324
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0227239
MED13 mediator complex subunit 13 0.0226385
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0226314
TNPO1 transportin 1 0.0224853
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0224209
NCOA2 nuclear receptor coactivator 2 0.0220706
ELL2 elongation factor, RNA polymerase II, 2 0.0220165
FBXL20 F-box and leucine-rich repeat protein 20 0.021868
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0218242
USP9X ubiquitin specific peptidase 9, X-linked 0.0216837
RSRP1 arginine/serine-rich protein 1 0.0216795
SEPTIN7 septin 7 0.0212575
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0211545

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.117699
PTMA prothymosin, alpha -0.113833
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.109387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0950322
EGR1 early growth response 1 -0.0886929
TMSB10 thymosin beta 10 -0.0843623
IER3 immediate early response 3 -0.0715705
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.067448
RPL35A ribosomal protein L35a -0.0627888
AREG amphiregulin -0.0593273
RCOR1 REST corepressor 1 -0.0573527
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0551006
FHIT fragile histidine triad -0.054204
HMGA2 high mobility group AT-hook 2 -0.0465187
EGFR epidermal growth factor receptor -0.0457991
RAD51B RAD51 paralog B -0.0444991
TPT1 tumor protein, translationally-controlled 1 -0.0444251
LAMB3 laminin, beta 3 -0.0430416
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0398038
LAMA4 laminin, alpha 4 -0.0394225
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0389386
FERMT1 fermitin family member 1 -0.0380742
LOC102724023 ES1 protein homolog, mitochondrial -0.0378269
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0367409
RPL9 ribosomal protein L9 -0.0346121
RPS24 ribosomal protein S24 -0.0341357
MT2A metallothionein 2A -0.0332422
RBM25 RNA binding motif protein 25 -0.031734
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0310524
EZR ezrin -0.0310096
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0299209
RPL34 ribosomal protein L34 -0.0295396
CCSER1 coiled-coil serine-rich protein 1 -0.0286872
S100A10 S100 calcium binding protein A10 -0.0272553
VCL vinculin -0.0271339
KLK10 kallikrein-related peptidase 10 -0.0269194
EFNB2 ephrin-B2 -0.0266247
AKAP12 A kinase (PRKA) anchor protein 12 -0.0264745
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0253898
DOCK5 dedicator of cytokinesis 5 -0.0250847
RPS19 ribosomal protein S19 -0.0245552
EMP1 epithelial membrane protein 1 -0.02445
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0241208
FLOT1 flotillin 1 -0.0240521
RPL23 ribosomal protein L23 -0.0237344
RPL26 ribosomal protein L26 -0.0235758
AKAP13 A kinase (PRKA) anchor protein 13 -0.023566
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0230743
NTSR1 neurotensin receptor 1 (high affinity) -0.0230016
TNS3 tensin 3 -0.0225565
POTEF POTE ankyrin domain family, member F -0.0224025
RPL19 ribosomal protein L19 -0.0223157
RPLP1 ribosomal protein, large, P1 -0.0220721
RPS13 ribosomal protein S13 -0.0219751
S100A6 S100 calcium binding protein A6 -0.0211856
RPL31 ribosomal protein L31 -0.0209175
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0206617
RPS27A ribosomal protein S27a -0.0205832
FHL2 four and a half LIM domains 2 -0.0204859
IGFBP3 insulin-like growth factor binding protein 3 -0.020268
KRT18 keratin 18, type I -0.0202236
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0201516
RPS3 ribosomal protein S3 -0.0201493
HMGA1 high mobility group AT-hook 1 -0.019801
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0197859
RPS29 ribosomal protein S29 -0.0196505
RPS6 ribosomal protein S6 -0.0195762
FOSL1 FOS-like antigen 1 -0.0194519
CENPF centromere protein F, 350/400kDa -0.0192494
RPS8 ribosomal protein S8 -0.0192487
RPS14 ribosomal protein S14 -0.019099
SERBP1 SERPINE1 mRNA binding protein 1 -0.0187663
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0187231
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0184881
S100A9 S100 calcium binding protein A9 -0.0184541
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0183247
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0180831
RPL36 ribosomal protein L36 -0.018075
RPL12 ribosomal protein L12 -0.0180148
BMP4 bone morphogenetic protein 4 -0.0176569
RPLP2 ribosomal protein, large, P2 -0.0175087
CDK13 cyclin-dependent kinase 13 -0.0174153
CREB5 cAMP responsive element binding protein 5 -0.0173946
ANXA1 annexin A1 -0.0169739
PHF14 PHD finger protein 14 -0.0169435
SGMS2 sphingomyelin synthase 2 -0.0169346
S100A11 S100 calcium binding protein A11 -0.0168812
FTL ferritin, light polypeptide -0.0167074
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0165702
LPP LIM domain containing preferred translocation partner in lipoma -0.0164381
MT1X metallothionein 1X -0.016432
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0163633
RPS17 ribosomal protein S17 -0.0163297
NDRG1 N-myc downstream regulated 1 -0.0159824
EIF5B eukaryotic translation initiation factor 5B -0.0159417
ITPKC inositol-trisphosphate 3-kinase C -0.0159203
LMNA lamin A/C -0.0157081
ATF4 activating transcription factor 4 -0.015337
GATAD2A GATA zinc finger domain containing 2A -0.015058
CLCF1 cardiotrophin-like cytokine factor 1 -0.0149498