Doxorubicin (hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxorubicin (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxorubicin (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.247975
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.188734
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.153679
STC1 stanniocalcin 1 0.105913
CXCL8 chemokine (C-X-C motif) ligand 8 0.0752448
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.069344
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0649136
FAM13A family with sequence similarity 13, member A 0.0634996
INHBA inhibin, beta A 0.0623288
TGFBI transforming growth factor, beta-induced, 68kDa 0.0614871
ARHGAP21 Rho GTPase activating protein 21 0.0574103
EEF2 eukaryotic translation elongation factor 2 0.0569581
ELL2 elongation factor, RNA polymerase II, 2 0.0565726
MYH9 myosin, heavy chain 9, non-muscle 0.0523265
COL6A1 collagen, type VI, alpha 1 0.0517379
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0513762
SOD2 superoxide dismutase 2, mitochondrial 0.0513271
LIMS1 LIM and senescent cell antigen-like domains 1 0.0511461
ASCC3 activating signal cointegrator 1 complex subunit 3 0.04961
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0451652
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0436568
HIPK2 homeodomain interacting protein kinase 2 0.0412272
LDHA lactate dehydrogenase A 0.0401284
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0398594
NUP58 nucleoporin 58 0.0394545
MMP1 matrix metallopeptidase 1 0.0393666
GOLGA4 golgin A4 0.0381584
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0374381
CANX calnexin 0.0370004
DST dystonin 0.0356866
LOXL2 lysyl oxidase-like 2 0.0347722
CLTC clathrin, heavy chain (Hc) 0.0328662
FNDC3A fibronectin type III domain containing 3A 0.0318477
KDM3A lysine (K)-specific demethylase 3A 0.0314986
FNIP1 folliculin interacting protein 1 0.030122
FDXR ferredoxin reductase 0.029757
SQSTM1 sequestosome 1 0.028886
FGFR1 fibroblast growth factor receptor 1 0.0285261
RNF150 ring finger protein 150 0.0278906
FLNA filamin A, alpha 0.0278175
PDIA6 protein disulfide isomerase family A, member 6 0.0277122
TFPI2 tissue factor pathway inhibitor 2 0.0274092
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0266669
TM4SF1 transmembrane 4 L six family member 1 0.025616
XPC xeroderma pigmentosum, complementation group C 0.0255934
MEIS1 Meis homeobox 1 0.0250815
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0249991
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0248606
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.02485
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0246098
ADAM9 ADAM metallopeptidase domain 9 0.0244873
HELZ helicase with zinc finger 0.0244153
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0242067
FMNL2 formin-like 2 0.0241084
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0235319
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0234094
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0232461
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0231843
UBA6 ubiquitin-like modifier activating enzyme 6 0.0225786
CALR calreticulin 0.0225036
CYLD cylindromatosis (turban tumor syndrome) 0.0223557
NBAS neuroblastoma amplified sequence 0.0222526
DUSP10 dual specificity phosphatase 10 0.0221058
DENND4A DENN/MADD domain containing 4A 0.0221002
HLA-E major histocompatibility complex, class I, E 0.0220861
SEC31A SEC31 homolog A (S. cerevisiae) 0.0220721
WDR45B WD repeat domain 45B 0.0220262
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0217584
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0217105
DDB2 damage-specific DNA binding protein 2, 48kDa 0.021586
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0215761
SPAG9 sperm associated antigen 9 0.0215165
AHR aryl hydrocarbon receptor 0.0213968
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0213057
MON2 MON2 homolog (S. cerevisiae) 0.0212778
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210734
RARS1 arginyl-tRNA synthetase 1 0.0204824
FRMD6 FERM domain containing 6 0.0204561
GOLGB1 golgin B1 0.0202933
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0201095
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0199992
EPS8 epidermal growth factor receptor pathway substrate 8 0.0199646
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198487
LTN1 listerin E3 ubiquitin protein ligase 1 0.0197472
AHI1 Abelson helper integration site 1 0.0196755
NAMPT nicotinamide phosphoribosyltransferase 0.0194802
UBC ubiquitin C 0.0193602
RB1CC1 RB1-inducible coiled-coil 1 0.0192981
KTN1 kinectin 1 (kinesin receptor) 0.0191373
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0190691
CD59 CD59 molecule, complement regulatory protein 0.0190035
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0188395
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0187771
RASA2 RAS p21 protein activator 2 0.0187743
TRIM22 tripartite motif containing 22 0.0184479
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0182286
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0182273
FAM107B family with sequence similarity 107, member B 0.0181854
DSCAM Down syndrome cell adhesion molecule 0.0181599
BHLHE40 basic helix-loop-helix family, member e40 0.0180744

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.177869
ADGRB3 adhesion G protein-coupled receptor B3 -0.170718
PRKG1 protein kinase, cGMP-dependent, type I -0.140266
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131515
COL6A3 collagen, type VI, alpha 3 -0.1051
ASPH aspartate beta-hydroxylase -0.101778
NALF1 NALCN channel auxiliary factor 1 -0.100986
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0971523
FTL ferritin, light polypeptide -0.0960681
MT2A metallothionein 2A -0.0950242
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0838425
VIM vimentin -0.0786713
COL6A2 collagen, type VI, alpha 2 -0.0783829
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0708294
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.070539
OXR1 oxidation resistance 1 -0.0672573
VCL vinculin -0.0610112
RPS12 ribosomal protein S12 -0.0603408
AKAP12 A kinase (PRKA) anchor protein 12 -0.0584698
GLIS3 GLIS family zinc finger 3 -0.0569558
DIAPH2 diaphanous-related formin 2 -0.0549217
FNDC3B fibronectin type III domain containing 3B -0.0544618
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0502112
HMGA2 high mobility group AT-hook 2 -0.0499413
FRMD4A FERM domain containing 4A -0.0498156
NAV1 neuron navigator 1 -0.0489285
RAI14 retinoic acid induced 14 -0.048391
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0440995
RPLP1 ribosomal protein, large, P1 -0.0414125
COL1A2 collagen, type I, alpha 2 -0.0402592
RPL35A ribosomal protein L35a -0.0392721
RPL37A ribosomal protein L37a -0.0384569
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0383394
CALD1 caldesmon 1 -0.0375582
RPL23 ribosomal protein L23 -0.0369571
PTMA prothymosin, alpha -0.0363648
COL1A1 collagen, type I, alpha 1 -0.0356526
RPL36 ribosomal protein L36 -0.0353846
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0351315
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0333375
RPL34 ribosomal protein L34 -0.033212
PFN1 profilin 1 -0.0325341
INTS6 integrator complex subunit 6 -0.0323629
RPL13A ribosomal protein L13a -0.0322854
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0319905
RPL26 ribosomal protein L26 -0.0319189
ANKRD28 ankyrin repeat domain 28 -0.0306558
RPL12 ribosomal protein L12 -0.030652
ACTG1 actin gamma 1 -0.0298495
RPS6 ribosomal protein S6 -0.0295702
RPL31 ribosomal protein L31 -0.0293693
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0292432
VCAN versican -0.0291301
ATP13A3 ATPase type 13A3 -0.0280615
PLAUR plasminogen activator, urokinase receptor -0.0278132
RPS19 ribosomal protein S19 -0.0277
RPL11 ribosomal protein L11 -0.0276141
CDH13 cadherin 13 -0.0275576
RPS3 ribosomal protein S3 -0.0272262
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0270078
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0269183
RPS8 ribosomal protein S8 -0.0268575
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0261197
EFCAB13 EF-hand calcium binding domain 13 -0.026098
RPS17 ribosomal protein S17 -0.026086
LPP LIM domain containing preferred translocation partner in lipoma -0.02595
FTH1 ferritin, heavy polypeptide 1 -0.0256305
DOCK5 dedicator of cytokinesis 5 -0.0255937
COL5A1 collagen, type V, alpha 1 -0.0253496
RPL18 ribosomal protein L18 -0.0246371
RPL35 ribosomal protein L35 -0.0244944
LOX lysyl oxidase -0.0243353
SBF2 SET binding factor 2 -0.024315
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0243143
RRBP1 ribosome binding protein 1 -0.0240769
FUS FUS RNA binding protein -0.0240648
TPT1 tumor protein, translationally-controlled 1 -0.0238755
PRRX1 paired related homeobox 1 -0.0236842
RPL9 ribosomal protein L9 -0.0235398
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0234439
CEMIP cell migration inducing protein, hyaluronan binding -0.0231592
ABI3BP ABI family, member 3 (NESH) binding protein -0.0231422
CDK14 cyclin-dependent kinase 14 -0.0229648
COL5A2 collagen, type V, alpha 2 -0.0227882
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0225968
TTC23L tetratricopeptide repeat domain 23-like -0.0225807
RPS21 ribosomal protein S21 -0.0223929
PRELID2 PRELI domain containing 2 -0.0222957
MAML2 mastermind-like 2 (Drosophila) -0.0222382
RPLP2 ribosomal protein, large, P2 -0.0220702
PRSS23 protease, serine, 23 -0.0219519
CCDC102B coiled-coil domain containing 102B -0.021876
GNAS GNAS complex locus -0.0218487
EHBP1 EH domain binding protein 1 -0.0216462
COL4A2 collagen, type IV, alpha 2 -0.0215851
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0215738
ATM ATM serine/threonine kinase -0.0215153
PNISR PNN-interacting serine/arginine-rich protein -0.0214364
RPL32 ribosomal protein L32 -0.0210971
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0210317