Doxycycline (monohydrate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.0674916
CCNL1 cyclin L1 0.0635526
MED13L mediator complex subunit 13-like 0.0601452
PCBP2 poly(rC) binding protein 2 0.0559465
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0556679
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0544353
BIRC3 baculoviral IAP repeat containing 3 0.0512271
TXNRD1 thioredoxin reductase 1 0.0511881
VMP1 vacuole membrane protein 1 0.0490894
ATP5F1B ATP synthase F1 subunit beta 0.0487871
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0473367
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0469639
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0462353
ECT2 epithelial cell transforming 2 0.0455212
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0442086
BIRC2 baculoviral IAP repeat containing 2 0.0439019
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0431721
CDK17 cyclin-dependent kinase 17 0.0431037
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0424764
STARD4 StAR-related lipid transfer (START) domain containing 4 0.042076
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0417348
PDGFC platelet derived growth factor C 0.0402794
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0398484
TFG TRK-fused gene 0.039845
YAP1 Yes-associated protein 1 0.0397879
ADGRG6 adhesion G protein-coupled receptor G6 0.0390006
POTEF POTE ankyrin domain family, member F 0.0387672
PUM2 pumilio RNA-binding family member 2 0.0381257
NEK7 NIMA-related kinase 7 0.0366718
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0359325
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0355513
ADAM17 ADAM metallopeptidase domain 17 0.0354144
EPHA6 EPH receptor A6 0.0339781
ETNK1 ethanolamine kinase 1 0.0329751
TENM3 teneurin transmembrane protein 3 0.0324189
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0314903
ERRFI1 ERBB receptor feedback inhibitor 1 0.0311549
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0307824
ZBTB20 zinc finger and BTB domain containing 20 0.0306182
FXR1 fragile X mental retardation, autosomal homolog 1 0.0304989
XPO1 exportin 1 0.0298117
FNDC3B fibronectin type III domain containing 3B 0.0293059
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0288469
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0285313
CPOX coproporphyrinogen oxidase 0.0282199
RTN4 reticulon 4 0.0282096
CELF2 CUGBP, Elav-like family member 2 0.0277235
UBA6 ubiquitin-like modifier activating enzyme 6 0.0272524
KDM6A lysine (K)-specific demethylase 6A 0.0268507
DSCAM Down syndrome cell adhesion molecule 0.0268398
SLC38A2 solute carrier family 38, member 2 0.0268256
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0267276
NUP58 nucleoporin 58 0.0265343
ARHGAP12 Rho GTPase activating protein 12 0.0264431
CLDND1 claudin domain containing 1 0.0263939
SPAG9 sperm associated antigen 9 0.0263874
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0261928
PDE4D phosphodiesterase 4D, cAMP-specific 0.0258705
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0258306
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0256205
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0253411
TBK1 TANK-binding kinase 1 0.0251781
TSC22D2 TSC22 domain family, member 2 0.0251176
ARL5B ADP-ribosylation factor-like 5B 0.0247578
GASK1B golgi associated kinase 1B 0.0246634
GSK3B glycogen synthase kinase 3 beta 0.0246456
NBAS neuroblastoma amplified sequence 0.0246195
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.024494
MGAT4C MGAT4 family, member C 0.024436
SETD5 SET domain containing 5 0.0243361
MEMO1 mediator of cell motility 1 0.0241336
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0237819
QKI QKI, KH domain containing, RNA binding 0.0236412
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0234681
ATP11A ATPase, class VI, type 11A 0.0228901
OXR1 oxidation resistance 1 0.022697
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0226204
NCKAP1 NCK-associated protein 1 0.0224536
MMP12 matrix metallopeptidase 12 0.0224136
MATR3 matrin 3 0.0223907
BCAS3 breast carcinoma amplified sequence 3 0.0223727
RICTOR RPTOR independent companion of MTOR, complex 2 0.0223713
BRWD1 bromodomain and WD repeat domain containing 1 0.0223165
CARD16 caspase recruitment domain family, member 16 0.0222438
NKTR natural killer cell triggering receptor 0.022021
USP34 ubiquitin specific peptidase 34 0.0218473
ADAM9 ADAM metallopeptidase domain 9 0.0217696
TNRC6A trinucleotide repeat containing 6A 0.0216836
WDR43 WD repeat domain 43 0.0216749
SFPQ splicing factor proline/glutamine-rich 0.0212858
RB1CC1 RB1-inducible coiled-coil 1 0.0211468
CHD1 chromodomain helicase DNA binding protein 1 0.021104
CLTC clathrin, heavy chain (Hc) 0.0209994
MPG N-methylpurine-DNA glycosylase 0.0208925
RNF145 ring finger protein 145 0.0208817
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0207991
PDIA6 protein disulfide isomerase family A, member 6 0.0206853
ZFAND3 zinc finger, AN1-type domain 3 0.0206325
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0202994
KDM3A lysine (K)-specific demethylase 3A 0.0202167

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.278364
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.131143
TPT1 tumor protein, translationally-controlled 1 -0.0776096
NLGN1 neuroligin 1 -0.0743592
RPL35A ribosomal protein L35a -0.0719361
PTMA prothymosin, alpha -0.0689917
RPS8 ribosomal protein S8 -0.0627485
RPS3 ribosomal protein S3 -0.0626635
EHBP1 EH domain binding protein 1 -0.0600397
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0561134
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0533288
NAP1L1 nucleosome assembly protein 1-like 1 -0.0526722
MYL12B myosin, light chain 12B, regulatory -0.0518204
RPS27A ribosomal protein S27a -0.0493654
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0462741
RPS12 ribosomal protein S12 -0.0455816
TMSB10 thymosin beta 10 -0.0455519
ACTG1 actin gamma 1 -0.0450269
AHNAK AHNAK nucleoprotein -0.0436013
RPL37A ribosomal protein L37a -0.042976
RPL26 ribosomal protein L26 -0.0428601
ZNF804A zinc finger protein 804A -0.0413603
FTL ferritin, light polypeptide -0.0400942
S100A6 S100 calcium binding protein A6 -0.0390823
PCDH7 protocadherin 7 -0.0387934
MKI67 marker of proliferation Ki-67 -0.0382444
HMGA2 high mobility group AT-hook 2 -0.0379889
RPLP1 ribosomal protein, large, P1 -0.0378564
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0373208
RPL12 ribosomal protein L12 -0.0370943
IFIH1 interferon induced with helicase C domain 1 -0.0359393
RPL34 ribosomal protein L34 -0.0358169
ANXA1 annexin A1 -0.0353169
KPNB1 karyopherin (importin) beta 1 -0.0352637
AKAP12 A kinase (PRKA) anchor protein 12 -0.0351383
CAVIN1 caveolae associated protein 1 -0.0348367
CANX calnexin -0.0347742
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0341324
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.032595
RSL1D1 ribosomal L1 domain containing 1 -0.0301429
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0298596
RPL19 ribosomal protein L19 -0.0291848
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0290927
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0289291
RPS19 ribosomal protein S19 -0.0289117
RPL31 ribosomal protein L31 -0.0288684
YBX3 Y box binding protein 3 -0.0288485
PRDX1 peroxiredoxin 1 -0.0282463
RPS6 ribosomal protein S6 -0.0279582
RPL23 ribosomal protein L23 -0.0275257
TPM4 tropomyosin 4 -0.0272145
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0271434
BRI3BP BRI3 binding protein -0.0269516
CLDN1 claudin 1 -0.026473
RACK1 receptor for activated C kinase 1 -0.0262383
RPS2 ribosomal protein S2 -0.0253917
RPL38 ribosomal protein L38 -0.0248965
VDAC1 voltage-dependent anion channel 1 -0.0245597
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0244343
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0243814
GNAS GNAS complex locus -0.0237643
CUX1 cut-like homeobox 1 -0.023603
PCDH9 protocadherin 9 -0.0228726
ASPH aspartate beta-hydroxylase -0.0226752
RIMS2 regulating synaptic membrane exocytosis 2 -0.0226368
RPS29 ribosomal protein S29 -0.0223685
GCG glucagon -0.0222037
ANKRD12 ankyrin repeat domain 12 -0.0219985
DOCK1 dedicator of cytokinesis 1 -0.0218307
GJA1 gap junction protein, alpha 1, 43kDa -0.0216693
FGFR1 fibroblast growth factor receptor 1 -0.0215018
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0212217
RPL36 ribosomal protein L36 -0.020866
LRRC23 leucine rich repeat containing 23 -0.0207472
RASAL2 RAS protein activator like 2 -0.0204444
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0203774
RPL36A ribosomal protein L36a -0.0202309
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0200161
RPL18 ribosomal protein L18 -0.019466
RPS27 ribosomal protein S27 -0.0194392
INTS6 integrator complex subunit 6 -0.0191483
HSPA8 heat shock 70kDa protein 8 -0.0191288
R3HDM2 R3H domain containing 2 -0.0191198
RPL7A ribosomal protein L7a -0.0190679
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0189343
CCND1 cyclin D1 -0.0188865
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0188801
TPI1 triosephosphate isomerase 1 -0.0187906
TBCA tubulin folding cofactor A -0.0185379
MACF1 microtubule-actin crosslinking factor 1 -0.0185238
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0183884
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.018297
PA2G4 proliferation-associated 2G4, 38kDa -0.0181497
NARS1 asparaginyl-tRNA synthetase 1 -0.0179873
ENO1 enolase 1, (alpha) -0.0177939
SLC38A1 solute carrier family 38, member 1 -0.0177791
DIAPH2 diaphanous-related formin 2 -0.017698
RPL10A ribosomal protein L10a -0.01764
CCDC47 coiled-coil domain containing 47 -0.0175317
RNF213 ring finger protein 213 -0.0175166