Doxycycline (monohydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CSF1 colony stimulating factor 1 (macrophage) 0.0460821
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0431611
POTEF POTE ankyrin domain family, member F 0.0350992
MYH9 myosin, heavy chain 9, non-muscle 0.0321239
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0276375
ZFP36L1 ZFP36 ring finger protein-like 1 0.027438
NRP2 neuropilin 2 0.0270966
FNDC3B fibronectin type III domain containing 3B 0.0261369
FTH1 ferritin, heavy polypeptide 1 0.0252356
MSN moesin 0.0250536
SP3 Sp3 transcription factor 0.0212277
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0192498
ARHGAP26 Rho GTPase activating protein 26 0.01898
P3H2 prolyl 3-hydroxylase 2 0.0186775
ARRDC3 arrestin domain containing 3 0.0185399
DENND2B DENN domain containing 2B 0.0184847
TNRC6A trinucleotide repeat containing 6A 0.017741
STOM stomatin 0.0174566
ADAM17 ADAM metallopeptidase domain 17 0.0166097
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0163896
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0151823
METTL15 methyltransferase like 15 0.0144498
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0141614
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0140776
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0140386
TNIP1 TNFAIP3 interacting protein 1 0.0136622
EML4 echinoderm microtubule associated protein like 4 0.0136369
PTEN phosphatase and tensin homolog 0.0132576
DIAPH3 diaphanous-related formin 3 0.0130259
CKAP5 cytoskeleton associated protein 5 0.0129912
FLNA filamin A, alpha 0.0128828
KCTD3 potassium channel tetramerization domain containing 3 0.0126415
TPM3 tropomyosin 3 0.0122159
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0121248
WDFY3 WD repeat and FYVE domain containing 3 0.0117677
CBX5 chromobox homolog 5 0.0115758
KDM6A lysine (K)-specific demethylase 6A 0.0115526
IRS2 insulin receptor substrate 2 0.0115435
UGCG UDP-glucose ceramide glucosyltransferase 0.0115279
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0115233
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0113307
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0112863
NLGN1 neuroligin 1 0.011215
FOSL2 FOS-like antigen 2 0.011109
AGFG1 ArfGAP with FG repeats 1 0.0109181
IQGAP3 IQ motif containing GTPase activating protein 3 0.0108862
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0108808
CASC3 cancer susceptibility candidate 3 0.0107713
ANKRD10 ankyrin repeat domain 10 0.0107608
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0106636
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0106234
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0106126
CAPRIN1 cell cycle associated protein 1 0.0105808
RAD23B RAD23 homolog B (S. cerevisiae) 0.0105666
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0105499
AKAP13 A kinase (PRKA) anchor protein 13 0.0105161
CAAP1 caspase activity and apoptosis inhibitor 1 0.0104861
SRPK2 SRSF protein kinase 2 0.0104789
TBC1D5 TBC1 domain family, member 5 0.010474
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0103774
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0102784
RYK receptor-like tyrosine kinase 0.0101663
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0101644
CEP170 centrosomal protein 170kDa 0.0100922
DAPK1 death-associated protein kinase 1 0.0100807
OSBPL3 oxysterol binding protein-like 3 0.00996045
MANBA mannosidase, beta A, lysosomal 0.00995205
ITGAV integrin, alpha V 0.00994703
CENPE centromere protein E, 312kDa 0.00981399
LENG8 leukocyte receptor cluster (LRC) member 8 0.00980547
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.00978446
USP12 ubiquitin specific peptidase 12 0.00971747
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0096966
PHIP pleckstrin homology domain interacting protein 0.00967672
RPL3 ribosomal protein L3 0.00962891
NCOR1 nuclear receptor corepressor 1 0.00956843
NUDCD3 NudC domain containing 3 0.00947344
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.00945884
SKAP2 src kinase associated phosphoprotein 2 0.00943465
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.00934768
MBNL2 muscleblind-like splicing regulator 2 0.00933472
ANPEP alanyl (membrane) aminopeptidase 0.00926288
CEP55 centrosomal protein 55kDa 0.00921154
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.00907168
ARF3 ADP-ribosylation factor 3 0.00899045
RNF145 ring finger protein 145 0.00895528
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00892759
CPAP centrosome assembly and centriole elongation protein 0.00891692
NCAPG2 non-SMC condensin II complex, subunit G2 0.00890911
RALB v-ral simian leukemia viral oncogene homolog B 0.00888201
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.00883258
MAST2 microtubule associated serine/threonine kinase 2 0.00875108
TNS1 tensin 1 0.00872331
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00865161
ZNF706 zinc finger protein 706 0.00863096
TBC1D12 TBC1 domain family, member 12 0.00857442
KDM1A lysine (K)-specific demethylase 1A 0.00850603
RPL21 ribosomal protein L21 0.00843264
RSRC1 arginine/serine-rich coiled-coil 1 0.00842732
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 0.00839525

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.230086
VIM vimentin -0.209298
IGFBP3 insulin-like growth factor binding protein 3 -0.171921
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165156
FRMD4A FERM domain containing 4A -0.133903
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126759
FTL ferritin, light polypeptide -0.102591
TPT1 tumor protein, translationally-controlled 1 -0.0881682
TMSB10 thymosin beta 10 -0.0797984
ASPH aspartate beta-hydroxylase -0.0789072
EIF1 eukaryotic translation initiation factor 1 -0.074658
HLA-B major histocompatibility complex, class I, B -0.0744954
EXT1 exostosin glycosyltransferase 1 -0.0728575
VCL vinculin -0.0638679
TFPI2 tissue factor pathway inhibitor 2 -0.0625784
RPS6 ribosomal protein S6 -0.0614031
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0607755
CANX calnexin -0.0596975
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0591597
PLIN2 perilipin 2 -0.0591449
PRRC2C proline-rich coiled-coil 2C -0.0574683
RPS8 ribosomal protein S8 -0.0555215
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0545457
UBC ubiquitin C -0.0541296
MAP1B microtubule-associated protein 1B -0.0540747
RND3 Rho family GTPase 3 -0.0539383
RRBP1 ribosome binding protein 1 -0.0538693
CXCL8 chemokine (C-X-C motif) ligand 8 -0.053755
AHNAK AHNAK nucleoprotein -0.0517118
SDCBP syndecan binding protein (syntenin) -0.0514784
B2M beta-2-microglobulin -0.049437
RAI14 retinoic acid induced 14 -0.0489392
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0481885
GPC6 glypican 6 -0.0467764
ZSWIM6 zinc finger, SWIM-type containing 6 -0.045455
CALR calreticulin -0.0443526
HM13 histocompatibility (minor) 13 -0.0440513
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0439659
ANXA2 annexin A2 -0.0438403
HSPB1 heat shock 27kDa protein 1 -0.0435612
PDIA3 protein disulfide isomerase family A, member 3 -0.0417873
GOLGB1 golgin B1 -0.0416707
RPL23 ribosomal protein L23 -0.0415873
RPS24 ribosomal protein S24 -0.0414326
MTDH metadherin -0.041348
PALM2AKAP2 PALM2 and AKAP2 fusion -0.041347
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.041166
RPL26 ribosomal protein L26 -0.0404881
RPL34 ribosomal protein L34 -0.0398683
NAMPT nicotinamide phosphoribosyltransferase -0.0397549
ARL4C ADP-ribosylation factor-like 4C -0.0387781
RPL19 ribosomal protein L19 -0.0382358
S100A10 S100 calcium binding protein A10 -0.0381845
MORF4L2 mortality factor 4 like 2 -0.0380843
SQSTM1 sequestosome 1 -0.0377328
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.037447
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0374319
TPM4 tropomyosin 4 -0.0370572
RPL31 ribosomal protein L31 -0.0368046
RPL7 ribosomal protein L7 -0.0362152
SP100 SP100 nuclear antigen -0.0362093
IQGAP1 IQ motif containing GTPase activating protein 1 -0.036196
RPLP1 ribosomal protein, large, P1 -0.0361106
RPL12 ribosomal protein L12 -0.0360391
ACTG1 actin gamma 1 -0.0359573
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0356352
KPNB1 karyopherin (importin) beta 1 -0.0356181
HLA-E major histocompatibility complex, class I, E -0.0354063
RPS27A ribosomal protein S27a -0.0352972
CAVIN1 caveolae associated protein 1 -0.0351395
SEC31A SEC31 homolog A (S. cerevisiae) -0.0350226
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.03461
STK17A serine/threonine kinase 17a -0.0342307
PALLD palladin, cytoskeletal associated protein -0.0338705
FUS FUS RNA binding protein -0.0338192
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0334547
NDRG1 N-myc downstream regulated 1 -0.033422
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0329625
RPL35A ribosomal protein L35a -0.0327329
UBE2H ubiquitin-conjugating enzyme E2H -0.0325682
PDIA4 protein disulfide isomerase family A, member 4 -0.0325621
CP ceruloplasmin (ferroxidase) -0.0324006
RAB1A RAB1A, member RAS oncogene family -0.0321376
PTMA prothymosin, alpha -0.0320776
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0317252
TKT transketolase -0.0312756
KYNU kynureninase -0.0310503
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0308167
RPL37A ribosomal protein L37a -0.0307112
ARF1 ADP-ribosylation factor 1 -0.0306137
CALD1 caldesmon 1 -0.0304439
COPB1 coatomer protein complex, subunit beta 1 -0.0301814
RSL1D1 ribosomal L1 domain containing 1 -0.0300343
RPL8 ribosomal protein L8 -0.0300231
GARS1 glycyl-tRNA synthetase 1 -0.0296412
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0294629
FAM107B family with sequence similarity 107, member B -0.0293927
S100A6 S100 calcium binding protein A6 -0.0289506
RPS4X ribosomal protein S4, X-linked -0.0288636
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.028725