Doxycycline (monohydrate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ARHGAP26 Rho GTPase activating protein 26 0.0506831
SMAD3 SMAD family member 3 0.0416535
NBAS neuroblastoma amplified sequence 0.0349858
NRIP1 nuclear receptor interacting protein 1 0.0349242
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0347795
TXNRD1 thioredoxin reductase 1 0.0337802
SPAG9 sperm associated antigen 9 0.0324656
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0318165
HELZ helicase with zinc finger 0.0315864
ADAM17 ADAM metallopeptidase domain 17 0.0306015
ECT2 epithelial cell transforming 2 0.0299153
USP3 ubiquitin specific peptidase 3 0.0293763
NAV2 neuron navigator 2 0.0278084
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.027701
OLA1 Obg-like ATPase 1 0.0255997
FNDC3B fibronectin type III domain containing 3B 0.02551
WDR43 WD repeat domain 43 0.0240135
ANKRD11 ankyrin repeat domain 11 0.0239576
DGKD diacylglycerol kinase, delta 130kDa 0.0238454
NUP58 nucleoporin 58 0.0225612
USP9X ubiquitin specific peptidase 9, X-linked 0.0223264
PTK2 protein tyrosine kinase 2 0.021977
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0219352
TRIO trio Rho guanine nucleotide exchange factor 0.0213602
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0202377
CA8 carbonic anhydrase VIII 0.0201652
ADAM9 ADAM metallopeptidase domain 9 0.0191531
AGFG1 ArfGAP with FG repeats 1 0.0189401
KDM6A lysine (K)-specific demethylase 6A 0.0187726
RNF145 ring finger protein 145 0.0187606
NAMPT nicotinamide phosphoribosyltransferase 0.0186019
ARL5B ADP-ribosylation factor-like 5B 0.01834
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0182315
ATP13A3 ATPase type 13A3 0.0172438
GLS2 glutaminase 2 (liver, mitochondrial) 0.0171019
RB1CC1 RB1-inducible coiled-coil 1 0.0170406
CMIP c-Maf inducing protein 0.0166899
WAC WW domain containing adaptor with coiled-coil 0.0166673
UBA2 ubiquitin-like modifier activating enzyme 2 0.0166641
CCNL1 cyclin L1 0.0165942
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0164395
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0162303
SMYD3 SET and MYND domain containing 3 0.0162091
DENND4A DENN/MADD domain containing 4A 0.0161565
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0158702
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0155643
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0155065
QKI QKI, KH domain containing, RNA binding 0.0154002
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0153541
NCKAP1 NCK-associated protein 1 0.0153086
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0151793
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0150537
PUM2 pumilio RNA-binding family member 2 0.0150468
TPD52 tumor protein D52 0.0149813
ZFAND6 zinc finger, AN1-type domain 6 0.0148513
KDM3A lysine (K)-specific demethylase 3A 0.0148024
RASA2 RAS p21 protein activator 2 0.0145099
UBA6 ubiquitin-like modifier activating enzyme 6 0.0141578
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0140134
MYH9 myosin, heavy chain 9, non-muscle 0.0139479
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0138206
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0138203
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0137304
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0136919
CEP192 centrosomal protein 192kDa 0.0135232
MON2 MON2 homolog (S. cerevisiae) 0.0133319
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0132685
MED13L mediator complex subunit 13-like 0.0132487
DENND1A DENN/MADD domain containing 1A 0.0132225
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0129378
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.01293
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0129217
DSCAM Down syndrome cell adhesion molecule 0.012773
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.012741
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0127275
GOLGA4 golgin A4 0.0126696
FXR1 fragile X mental retardation, autosomal homolog 1 0.0124728
TFG TRK-fused gene 0.0124294
CASC3 cancer susceptibility candidate 3 0.0123626
ZEB1 zinc finger E-box binding homeobox 1 0.012343
PICALM phosphatidylinositol binding clathrin assembly protein 0.0123103
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0122226
SIN3A SIN3 transcription regulator family member A 0.0121534
TNPO1 transportin 1 0.0120041
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0119276
ZFAND3 zinc finger, AN1-type domain 3 0.0118015
KMT2E lysine (K)-specific methyltransferase 2E 0.0117996
PDE8A phosphodiesterase 8A 0.0117788
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0117513
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0117242
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0116821
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0116431
MSI2 musashi RNA-binding protein 2 0.0115969
MYO1B myosin IB 0.0115233
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0114912
SP3 Sp3 transcription factor 0.0114239
MSN moesin 0.0114234
PRELID2 PRELI domain containing 2 0.0113716
TOP2B topoisomerase (DNA) II beta 180kDa 0.0113625
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0113013

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.208683
TMSB10 thymosin beta 10 -0.173189
IGFBP3 insulin-like growth factor binding protein 3 -0.160504
MT2A metallothionein 2A -0.126273
PDE4D phosphodiesterase 4D, cAMP-specific -0.114628
VIM vimentin -0.112299
FTL ferritin, light polypeptide -0.102067
RPS19 ribosomal protein S19 -0.0998194
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0997474
NDRG1 N-myc downstream regulated 1 -0.0799487
ANXA2 annexin A2 -0.079311
EFNA5 ephrin-A5 -0.0784605
RPS6 ribosomal protein S6 -0.0761242
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0741238
RPLP1 ribosomal protein, large, P1 -0.0722763
EIF1 eukaryotic translation initiation factor 1 -0.0710387
BASP1 brain abundant, membrane attached signal protein 1 -0.0707356
IGFBP4 insulin-like growth factor binding protein 4 -0.0672667
ACTG1 actin gamma 1 -0.063372
STC1 stanniocalcin 1 -0.0627968
PTMA prothymosin, alpha -0.0616244
RPS16 ribosomal protein S16 -0.0584901
MT1X metallothionein 1X -0.0582904
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0562411
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.05582
TPT1 tumor protein, translationally-controlled 1 -0.0548213
RPL26 ribosomal protein L26 -0.0547452
S100A6 S100 calcium binding protein A6 -0.0547017
RPL37A ribosomal protein L37a -0.053203
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0521532
RPL19 ribosomal protein L19 -0.0501775
EGFR epidermal growth factor receptor -0.0498291
RPL12 ribosomal protein L12 -0.0498236
RPS3 ribosomal protein S3 -0.0496759
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0477491
RPL23 ribosomal protein L23 -0.0455545
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0436826
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0430714
RPL35A ribosomal protein L35a -0.0430009
RPS8 ribosomal protein S8 -0.0408153
TM4SF1 transmembrane 4 L six family member 1 -0.0403592
RPS12 ribosomal protein S12 -0.0398855
MYO1E myosin IE -0.0392857
RNF213 ring finger protein 213 -0.0387194
DOCK5 dedicator of cytokinesis 5 -0.0386019
AHNAK AHNAK nucleoprotein -0.0384276
CA12 carbonic anhydrase XII -0.0383908
RPS27A ribosomal protein S27a -0.0375647
RPLP2 ribosomal protein, large, P2 -0.0369393
RPL31 ribosomal protein L31 -0.0365488
GRB10 growth factor receptor-bound protein 10 -0.0357957
RPL13A ribosomal protein L13a -0.0355943
RACK1 receptor for activated C kinase 1 -0.0341068
LDHA lactate dehydrogenase A -0.0334883
VCL vinculin -0.0329638
RPS24 ribosomal protein S24 -0.0328365
EHBP1 EH domain binding protein 1 -0.032776
ALCAM activated leukocyte cell adhesion molecule -0.0326618
THSD4 thrombospondin, type I, domain containing 4 -0.0323312
KRT81 keratin 81, type II -0.0322551
RPS17 ribosomal protein S17 -0.0321209
PRKCA protein kinase C, alpha -0.031872
RPL18 ribosomal protein L18 -0.0316606
BTG1 B-cell translocation gene 1, anti-proliferative -0.0304858
LOXL2 lysyl oxidase-like 2 -0.0302083
RPS13 ribosomal protein S13 -0.0300239
AUTS2 autism susceptibility candidate 2 -0.0287805
RRBP1 ribosome binding protein 1 -0.0281697
RPL7A ribosomal protein L7a -0.027832
EXT1 exostosin glycosyltransferase 1 -0.0277915
IFI6 interferon, alpha-inducible protein 6 -0.0263939
DUSP16 dual specificity phosphatase 16 -0.026326
RPLP0 ribosomal protein, large, P0 -0.0262774
RPL28 ribosomal protein L28 -0.0257467
RPL34 ribosomal protein L34 -0.0254724
H1-0 H1.0 linker histone -0.0250612
EGR1 early growth response 1 -0.024898
EPAS1 endothelial PAS domain protein 1 -0.024752
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0247287
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0242245
KLF6 Kruppel-like factor 6 -0.0240839
AHNAK2 AHNAK nucleoprotein 2 -0.0240791
LMNA lamin A/C -0.0236476
HMGA2 high mobility group AT-hook 2 -0.0234125
RIGI RNA sensor RIG-I -0.023389
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0233522
RPL36A ribosomal protein L36a -0.0233315
RPL30 ribosomal protein L30 -0.0231142
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0230101
RPS14 ribosomal protein S14 -0.0229098
AKR1C2 aldo-keto reductase family 1, member C2 -0.0228417
RPL9 ribosomal protein L9 -0.0226759
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0225045
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0224719
RPS29 ribosomal protein S29 -0.0223926
ANXA4 annexin A4 -0.022319
ARL4C ADP-ribosylation factor-like 4C -0.0223153
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0222334
SLC38A1 solute carrier family 38, member 1 -0.0221841
KANK1 KN motif and ankyrin repeat domains 1 -0.0221599