Doxycycline (monohydrate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.0417363
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0282772
AOPEP aminopeptidase O (putative) 0.0276087
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0257398
KAZN kazrin, periplakin interacting protein 0.0242127
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.02373
TIMP2 TIMP metallopeptidase inhibitor 2 0.0234064
KIRREL1 kirre like nephrin family adhesion molecule 1 0.022897
NBEA neurobeachin 0.0228254
AKAP13 A kinase (PRKA) anchor protein 13 0.0220103
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0216583
SOX6 SRY (sex determining region Y)-box 6 0.0215198
RAB21 RAB21, member RAS oncogene family 0.0214078
SOD2 superoxide dismutase 2, mitochondrial 0.02116
AMBRA1 autophagy/beclin-1 regulator 1 0.0209707
TRAPPC9 trafficking protein particle complex 9 0.0207768
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0202282
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0198494
TSHZ2 teashirt zinc finger homeobox 2 0.0194224
THSD4 thrombospondin, type I, domain containing 4 0.0193108
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0192587
RBM33 RNA binding motif protein 33 0.0189784
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0185912
PRKG1 protein kinase, cGMP-dependent, type I 0.0181805
ANKRD36C ankyrin repeat domain 36C 0.0178523
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0177451
WDR27 WD repeat domain 27 0.0177321
RASA3 RAS p21 protein activator 3 0.0175871
AATF apoptosis antagonizing transcription factor 0.0173499
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0171908
EXOC4 exocyst complex component 4 0.0171779
TPK1 thiamin pyrophosphokinase 1 0.0169533
ZNF608 zinc finger protein 608 0.0166782
TMEM131 transmembrane protein 131 0.0164509
THBS1 thrombospondin 1 0.0164172
SNX4 sorting nexin 4 0.0164115
TNRC6B trinucleotide repeat containing 6B 0.0163857
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0161414
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0161209
TBCD tubulin folding cofactor D 0.0161159
UTRN utrophin 0.0160826
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.015885
EEF2 eukaryotic translation elongation factor 2 0.0157622
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0155925
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0155218
TMCC1 transmembrane and coiled-coil domain family 1 0.0154598
FOXK1 forkhead box K1 0.0153921
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0153738
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 0.0153036
IDE insulin-degrading enzyme 0.0152343
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.0151913
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0151873
NUDCD3 NudC domain containing 3 0.0150114
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.0149547
CBX5 chromobox homolog 5 0.0149186
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0148897
PRKCE protein kinase C, epsilon 0.0148166
SLC39A11 solute carrier family 39, member 11 0.014808
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0146254
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0145119
ZNF160 zinc finger protein 160 0.0145021
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0144734
FNIP1 folliculin interacting protein 1 0.0144521
MTUS1 microtubule associated tumor suppressor 1 0.0142861
RDX radixin 0.0142331
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0142213
GOLGB1 golgin B1 0.0142183
ERCC3 excision repair cross-complementation group 3 0.0141958
UBE3A ubiquitin protein ligase E3A 0.0141633
ERI3 ERI1 exoribonuclease family member 3 0.0141368
FBXW4 F-box and WD repeat domain containing 4 0.0140138
DLG5 discs, large homolog 5 (Drosophila) 0.0140082
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.013906
CCDC93 coiled-coil domain containing 93 0.0138671
XIRP2 xin actin binding repeat containing 2 0.0138562
IWS1 IWS1 homolog (S. cerevisiae) 0.0138193
CDK13 cyclin-dependent kinase 13 0.0137488
SKIL SKI-like proto-oncogene 0.01373
TAS2R14 taste receptor, type 2, member 14 0.01373
KDM6B lysine (K)-specific demethylase 6B 0.0136922
PRPF18 pre-mRNA processing factor 18 0.0136539
PBX3 pre-B-cell leukemia homeobox 3 0.0136485
SH3PXD2A SH3 and PX domains 2A 0.0136457
ZMIZ1 zinc finger, MIZ-type containing 1 0.0135527
ARHGAP35 Rho GTPase activating protein 35 0.0134798
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0134624
GLS2 glutaminase 2 (liver, mitochondrial) 0.0132953
RBAK-RBAKDN RBAK-RBAKDN readthrough 0.0131259
PTEN phosphatase and tensin homolog 0.0130775
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0129701
TCF12 transcription factor 12 0.0129506
SMAD4 SMAD family member 4 0.0128942
DCAF8 DDB1 and CUL4 associated factor 8 0.0127476
PDE7A phosphodiesterase 7A 0.0127349
PKDCC protein kinase domain containing, cytoplasmic 0.012703
BCL2L1 BCL2-like 1 0.0126782
LIMD1 LIM domains containing 1 0.012641
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.0126218
CENPP centromere protein P 0.012619
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.0125925

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.264137
VIM vimentin -0.200826
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.138912
MEST mesoderm specific transcript -0.128599
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0810372
PTMA prothymosin, alpha -0.0807412
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0779278
RPS6 ribosomal protein S6 -0.0767537
PEG10 paternally expressed 10 -0.0730225
PDE4D phosphodiesterase 4D, cAMP-specific -0.066328
NIPBL Nipped-B homolog (Drosophila) -0.0658872
ZNF292 zinc finger protein 292 -0.0625852
CENPF centromere protein F, 350/400kDa -0.0598509
RPLP0 ribosomal protein, large, P0 -0.0592295
FTL ferritin, light polypeptide -0.0590737
RPS8 ribosomal protein S8 -0.056078
MGP matrix Gla protein -0.0523848
RPLP1 ribosomal protein, large, P1 -0.0523602
RACK1 receptor for activated C kinase 1 -0.0500915
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0495521
RPS19 ribosomal protein S19 -0.0491927
IER3 immediate early response 3 -0.0488637
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0485917
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0478769
RPL11 ribosomal protein L11 -0.0461933
ENO1 enolase 1, (alpha) -0.0451392
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0450216
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0447257
RPL12 ribosomal protein L12 -0.0442005
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0436861
PDIA3 protein disulfide isomerase family A, member 3 -0.043334
NDRG1 N-myc downstream regulated 1 -0.042041
RPS24 ribosomal protein S24 -0.04144
TPI1 triosephosphate isomerase 1 -0.0409826
TPT1 tumor protein, translationally-controlled 1 -0.0407519
ACTG1 actin gamma 1 -0.0403189
TPX2 TPX2, microtubule-associated -0.0402746
SOX4 SRY (sex determining region Y)-box 4 -0.0394397
NAP1L1 nucleosome assembly protein 1-like 1 -0.0391785
RPL23 ribosomal protein L23 -0.039076
JMJD1C jumonji domain containing 1C -0.038306
QKI QKI, KH domain containing, RNA binding -0.037677
RLF rearranged L-myc fusion -0.0370727
RPL19 ribosomal protein L19 -0.0369986
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0369362
TMSB4X thymosin beta 4, X-linked -0.0368748
RPS11 ribosomal protein S11 -0.0366225
B2M beta-2-microglobulin -0.0360478
RPS14 ribosomal protein S14 -0.0359905
MT2A metallothionein 2A -0.03526
TRIO trio Rho guanine nucleotide exchange factor -0.0347313
TUBB tubulin, beta class I -0.0344742
CANX calnexin -0.0344235
RPS23 ribosomal protein S23 -0.0343036
MATR3 matrin 3 -0.0342112
MARCHF6 membrane associated ring-CH-type finger 6 -0.0338979
EIF1 eukaryotic translation initiation factor 1 -0.0333822
FOXC1 forkhead box C1 -0.0327446
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0321437
RPS5 ribosomal protein S5 -0.0317942
COL1A2 collagen, type I, alpha 2 -0.0317436
CENPE centromere protein E, 312kDa -0.0316088
LDHA lactate dehydrogenase A -0.0314414
OGA O-GlcNAcase -0.0313949
RPL35A ribosomal protein L35a -0.0313117
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0308985
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0308378
RPL27A ribosomal protein L27a -0.0308375
SSBP2 single-stranded DNA binding protein 2 -0.0308057
KTN1 kinectin 1 (kinesin receptor) -0.0307184
POU2F1 POU class 2 homeobox 1 -0.0306243
PDIA6 protein disulfide isomerase family A, member 6 -0.030586
KPNB1 karyopherin (importin) beta 1 -0.030576
SEPTIN7 septin 7 -0.0304796
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0303294
TRA2A transformer 2 alpha homolog (Drosophila) -0.0302706
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0298431
ZFAND3 zinc finger, AN1-type domain 3 -0.0294777
HMGB1 high mobility group box 1 -0.029139
TPR translocated promoter region, nuclear basket protein -0.0291303
RPS10 ribosomal protein S10 -0.02912
RPS4X ribosomal protein S4, X-linked -0.0289582
PKM pyruvate kinase, muscle -0.0286225
DEK DEK proto-oncogene -0.0286019
MSRB3 methionine sulfoxide reductase B3 -0.0284716
LOC112694756 uncharaterized LOC112694756 -0.0278589
RPL8 ribosomal protein L8 -0.0277002
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.027655
PGK1 phosphoglycerate kinase 1 -0.027146
NEK7 NIMA-related kinase 7 -0.0270588
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0270311
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0269649
ITM2B integral membrane protein 2B -0.0268912
CCNI cyclin I -0.026508
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0264016
RPL7A ribosomal protein L7a -0.0263349
FBXO11 F-box protein 11 -0.0260375
S100A9 S100 calcium binding protein A9 -0.0260043
RPS3 ribosomal protein S3 -0.0260001
GOLGA4 golgin A4 -0.0258742