Doxycycline (monohydrate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.0993677
TRRAP transformation/transcription domain-associated protein 0.0702604
TXNRD1 thioredoxin reductase 1 0.0665583
ZSWIM6 zinc finger, SWIM-type containing 6 0.0600342
LAMB3 laminin, beta 3 0.0475815
LMTK2 lemur tyrosine kinase 2 0.0454158
PTK2 protein tyrosine kinase 2 0.0420637
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.037104
KLK10 kallikrein-related peptidase 10 0.0361771
THSD4 thrombospondin, type I, domain containing 4 0.0347035
EXT1 exostosin glycosyltransferase 1 0.0335833
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0323101
PMM2 phosphomannomutase 2 0.0313111
CLMP CXADR-like membrane protein 0.0307014
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0306723
HSPA8 heat shock 70kDa protein 8 0.0306265
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0306055
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0304892
ABTB3 ankyrin repeat and BTB domain containing 3 0.0303894
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0282555
SMC3 structural maintenance of chromosomes 3 0.0275594
RASAL2 RAS protein activator like 2 0.0274019
PPARD peroxisome proliferator-activated receptor delta 0.0272561
SIK3 SIK family kinase 3 0.0265328
MCL1 myeloid cell leukemia 1 0.0264599
FTH1 ferritin, heavy polypeptide 1 0.0263555
NAMPT nicotinamide phosphoribosyltransferase 0.0260471
IGFBP3 insulin-like growth factor binding protein 3 0.0260429
TRIP12 thyroid hormone receptor interactor 12 0.0246006
ZFAND3 zinc finger, AN1-type domain 3 0.0239202
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0234766
PDLIM5 PDZ and LIM domain 5 0.0216212
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0211031
AK1 adenylate kinase 1 0.0209244
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0209208
GREB1L growth regulation by estrogen in breast cancer-like 0.0207137
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0206489
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.020524
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.020505
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0202616
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0195472
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0194786
GLS2 glutaminase 2 (liver, mitochondrial) 0.0191585
PUM2 pumilio RNA-binding family member 2 0.0190168
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0189876
BMP6 bone morphogenetic protein 6 0.0189532
LARP4B La ribonucleoprotein domain family, member 4B 0.0189285
HDAC9 histone deacetylase 9 0.018769
PALM2AKAP2 PALM2 and AKAP2 fusion 0.018632
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0184611
NCKAP1 NCK-associated protein 1 0.0184011
NUP98 nucleoporin 98kDa 0.0183529
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0181029
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0176683
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0175466
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0173704
MYO5B myosin VB 0.0172585
TTC3 tetratricopeptide repeat domain 3 0.0171924
UBAP2 ubiquitin associated protein 2 0.0171893
CAMTA1 calmodulin binding transcription activator 1 0.017189
PARD3 par-3 family cell polarity regulator 0.0169395
SND1 staphylococcal nuclease and tudor domain containing 1 0.0168365
EFNB2 ephrin-B2 0.0167829
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0167221
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0166939
FXR1 fragile X mental retardation, autosomal homolog 1 0.0166181
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0165928
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0164881
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0163508
ZCCHC7 zinc finger, CCHC domain containing 7 0.0163486
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0162468
ANKRD10 ankyrin repeat domain 10 0.0162318
UPP1 uridine phosphorylase 1 0.0161484
SENP5 SUMO1/sentrin specific peptidase 5 0.0159486
ZEB1 zinc finger E-box binding homeobox 1 0.0159198
VMP1 vacuole membrane protein 1 0.0156618
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0154551
ZHX2 zinc fingers and homeoboxes 2 0.0153361
SACK1A scaffolding CK1 anchoring protein A 0.0152262
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0151771
HM13 histocompatibility (minor) 13 0.0149641
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0149615
ELOVL5 ELOVL fatty acid elongase 5 0.0149388
OSMR oncostatin M receptor 0.0149253
WDR43 WD repeat domain 43 0.0148088
MPRIP myosin phosphatase Rho interacting protein 0.0146805
PLEC plectin 0.0146685
THBD thrombomodulin 0.0146682
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.0146261
SEC31A SEC31 homolog A (S. cerevisiae) 0.0144591
ANTXR2 anthrax toxin receptor 2 0.0142774
RBM39 RNA binding motif protein 39 0.0141622
LAMC2 laminin, gamma 2 0.014002
ZNF83 zinc finger protein 83 0.0137187
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0137145
MAPK8 mitogen-activated protein kinase 8 0.0135532
MON2 MON2 homolog (S. cerevisiae) 0.0133509
XYLT1 xylosyltransferase I 0.0132297
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0131415
BMAL2 basic helix-loop-helix ARNT like 2 0.0131385

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230536
TMSB10 thymosin beta 10 -0.183791
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.17866
NDRG1 N-myc downstream regulated 1 -0.163037
S100A10 S100 calcium binding protein A10 -0.14874
VIM vimentin -0.141414
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.141224
BAIAP2L1 BAI1-associated protein 2-like 1 -0.128242
AKAP12 A kinase (PRKA) anchor protein 12 -0.127197
PTMA prothymosin, alpha -0.121526
ITGA6 integrin, alpha 6 -0.105849
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.09201
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0793245
LDHA lactate dehydrogenase A -0.0789213
SLC38A2 solute carrier family 38, member 2 -0.0723019
UBA6 ubiquitin-like modifier activating enzyme 6 -0.070825
ESYT2 extended synaptotagmin-like protein 2 -0.0684991
POTEF POTE ankyrin domain family, member F -0.0635991
UBC ubiquitin C -0.062655
FLNB filamin B, beta -0.0596634
ZFP36L1 ZFP36 ring finger protein-like 1 -0.059301
S100A11 S100 calcium binding protein A11 -0.0573895
ANXA2 annexin A2 -0.0555814
S100A6 S100 calcium binding protein A6 -0.0552879
LOC112694756 uncharaterized LOC112694756 -0.0548954
HMGA1 high mobility group AT-hook 1 -0.0547428
DSG2 desmoglein 2 -0.0546671
EZR ezrin -0.054285
SDC4 syndecan 4 -0.0540445
TSC22D2 TSC22 domain family, member 2 -0.0538849
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0534996
AHNAK AHNAK nucleoprotein -0.0533807
PERP PERP, TP53 apoptosis effector -0.0533429
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0533325
EIF1 eukaryotic translation initiation factor 1 -0.0511605
FAM107B family with sequence similarity 107, member B -0.0509137
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0490938
PTPRR protein tyrosine phosphatase, receptor type, R -0.0482028
VCAN versican -0.0449496
KLF6 Kruppel-like factor 6 -0.0448022
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0446634
LY6E lymphocyte antigen 6 complex, locus E -0.043771
ITGB4 integrin, beta 4 -0.0437147
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.043145
RICTOR RPTOR independent companion of MTOR, complex 2 -0.042756
RPL12 ribosomal protein L12 -0.0425758
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0414301
CD9 CD9 molecule -0.0405966
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0403258
EMP1 epithelial membrane protein 1 -0.0389466
PGK1 phosphoglycerate kinase 1 -0.0383125
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0378143
CSTB cystatin B (stefin B) -0.0378
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0377044
RIOK3 RIO kinase 3 -0.0376213
TPT1 tumor protein, translationally-controlled 1 -0.0376034
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0375435
RPS3 ribosomal protein S3 -0.0374788
ANLN anillin, actin binding protein -0.037026
S100A4 S100 calcium binding protein A4 -0.0369974
RPS6 ribosomal protein S6 -0.0366842
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0365811
GRB10 growth factor receptor-bound protein 10 -0.0365159
FTL ferritin, light polypeptide -0.0365091
ACTG1 actin gamma 1 -0.036326
RPL8 ribosomal protein L8 -0.0355953
MUC17 mucin 17, cell surface associated -0.0340801
RPLP1 ribosomal protein, large, P1 -0.0339056
OGA O-GlcNAcase -0.0338465
ARHGAP42 Rho GTPase activating protein 42 -0.0336549
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0334438
RPLP0 ribosomal protein, large, P0 -0.0334058
MYOF myoferlin -0.0333513
KCMF1 potassium channel modulatory factor 1 -0.0331805
ARHGAP5 Rho GTPase activating protein 5 -0.0331144
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.033069
ENO1 enolase 1, (alpha) -0.0328021
VEZT vezatin, adherens junctions transmembrane protein -0.0325449
KRT19 keratin 19, type I -0.032415
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0322562
DSTN destrin (actin depolymerizing factor) -0.0321183
PKM pyruvate kinase, muscle -0.0321048
KTN1 kinectin 1 (kinesin receptor) -0.0313441
RPL31 ribosomal protein L31 -0.0306222
PFN1 profilin 1 -0.0306215
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0305358
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0302853
RPS23 ribosomal protein S23 -0.0302338
CAPN2 calpain 2, (m/II) large subunit -0.030156
RPL35A ribosomal protein L35a -0.0299384
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0299347
SEPTIN7 septin 7 -0.0290381
MYL12B myosin, light chain 12B, regulatory -0.0289127
VDAC1 voltage-dependent anion channel 1 -0.028903
FAM13A family with sequence similarity 13, member A -0.0288253
ADM adrenomedullin -0.0282825
B2M beta-2-microglobulin -0.0281143
RPL34 ribosomal protein L34 -0.0277701
ERBIN erbb2 interacting protein -0.0277463
PRRC2C proline-rich coiled-coil 2C -0.0277194