Doxycycline (monohydrate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 0.101668
PBX1 pre-B-cell leukemia homeobox 1 0.0648255
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0640661
TRPS1 trichorhinophalangeal syndrome I 0.0636988
ACACA acetyl-CoA carboxylase alpha 0.06367
CATSPERB catsper channel auxiliary subunit beta 0.0536115
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0491476
THSD4 thrombospondin, type I, domain containing 4 0.0481992
ELOVL5 ELOVL fatty acid elongase 5 0.0480183
PTPRK protein tyrosine phosphatase, receptor type, K 0.0468488
KAZN kazrin, periplakin interacting protein 0.0458891
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0434515
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0431531
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0395849
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0394301
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0361434
IGFBP5 insulin-like growth factor binding protein 5 0.0350116
BCAS1 breast carcinoma amplified sequence 1 0.0342315
TENM2 teneurin transmembrane protein 2 0.0332183
TRAPPC9 trafficking protein particle complex 9 0.031022
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0308859
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0308
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.0307331
SRCIN1 SRC kinase signaling inhibitor 1 0.0303431
LRP1B low density lipoprotein receptor-related protein 1B 0.0301733
NCAM2 neural cell adhesion molecule 2 0.029658
ALCAM activated leukocyte cell adhesion molecule 0.0286436
SHROOM3 shroom family member 3 0.0284917
LGALS12 lectin, galactoside-binding, soluble, 12 0.0278982
TRIO trio Rho guanine nucleotide exchange factor 0.027718
ITCH itchy E3 ubiquitin protein ligase 0.0272914
MLPH melanophilin 0.0270004
MYO5B myosin VB 0.0258645
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0258556
LPP LIM domain containing preferred translocation partner in lipoma 0.0258287
MED13L mediator complex subunit 13-like 0.0257211
PATJ PATJ crumbs cell polarity complex component 0.0254552
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0254515
SAMD12 sterile alpha motif domain containing 12 0.0253373
DNAH14 dynein, axonemal, heavy chain 14 0.0252506
NFIA nuclear factor I/A 0.0251922
MSI2 musashi RNA-binding protein 2 0.0251873
WWOX WW domain containing oxidoreductase 0.0250312
GSE1 Gse1 coiled-coil protein 0.0241154
KDM6A lysine (K)-specific demethylase 6A 0.0239374
CDK12 cyclin-dependent kinase 12 0.0237777
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0236941
PRLR prolactin receptor 0.0231175
AFF3 AF4/FMR2 family, member 3 0.0221287
TTC6 tetratricopeptide repeat domain 6 0.0221162
MACROD2 MACRO domain containing 2 0.0219308
ACSL3 acyl-CoA synthetase long-chain family member 3 0.021839
ANKRD36C ankyrin repeat domain 36C 0.0209942
TBL1X transducin (beta)-like 1X-linked 0.020203
BCAS3 breast carcinoma amplified sequence 3 0.0201402
FNDC3B fibronectin type III domain containing 3B 0.0200291
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0199158
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.019798
EFNA5 ephrin-A5 0.0196371
ESR1 estrogen receptor 1 0.0194141
EXOC4 exocyst complex component 4 0.0193984
ENAH enabled homolog (Drosophila) 0.0192876
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0191173
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.0191157
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.0190819
AUTS2 autism susceptibility candidate 2 0.018865
NRCAM neuronal cell adhesion molecule 0.0187711
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0187307
PTK2 protein tyrosine kinase 2 0.0182902
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0180129
MACF1 microtubule-actin crosslinking factor 1 0.0178588
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0178419
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0175903
IGF1R insulin-like growth factor 1 receptor 0.0174964
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0173614
UNC13B unc-13 homolog B (C. elegans) 0.0171895
FGF13 fibroblast growth factor 13 0.0170547
TC2N tandem C2 domains, nuclear 0.0169359
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0167599
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0167302
KIF16B kinesin family member 16B 0.0166606
TCF12 transcription factor 12 0.0166049
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0165691
RIMS2 regulating synaptic membrane exocytosis 2 0.0165386
PUM1 pumilio RNA-binding family member 1 0.0163344
PTPRG protein tyrosine phosphatase, receptor type, G 0.0162393
DENND1A DENN/MADD domain containing 1A 0.0160572
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0159756
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0158872
MYH9 myosin, heavy chain 9, non-muscle 0.0157905
OLA1 Obg-like ATPase 1 0.0156907
YAP1 Yes-associated protein 1 0.015634
CEP250 centrosomal protein 250kDa 0.0155693
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.015522
DUSP16 dual specificity phosphatase 16 0.0154225
CTNND2 catenin (cadherin-associated protein), delta 2 0.015413
ARHGAP10 Rho GTPase activating protein 10 0.0152942
ARHGAP32 Rho GTPase activating protein 32 0.0152388
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.014842
ANKRD11 ankyrin repeat domain 11 0.014796

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.357817
RPL19 ribosomal protein L19 -0.27599
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119121
MT2A metallothionein 2A -0.097799
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0855791
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0850209
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0817043
RPS3 ribosomal protein S3 -0.0762895
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0753611
ZMYND8 zinc finger, MYND-type containing 8 -0.0750323
FTH1 ferritin, heavy polypeptide 1 -0.0727072
ACTG1 actin gamma 1 -0.0677966
PTMA prothymosin, alpha -0.0664195
RPL35A ribosomal protein L35a -0.06579
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0596808
ANKRD12 ankyrin repeat domain 12 -0.0594097
NDRG1 N-myc downstream regulated 1 -0.0580697
TPT1 tumor protein, translationally-controlled 1 -0.0525368
TMSB10 thymosin beta 10 -0.0514743
RPS6 ribosomal protein S6 -0.0496493
RPL12 ribosomal protein L12 -0.0479768
SLC38A1 solute carrier family 38, member 1 -0.0472917
ASPH aspartate beta-hydroxylase -0.044578
CCNI cyclin I -0.0416967
FBXL20 F-box and leucine-rich repeat protein 20 -0.040977
UGCG UDP-glucose ceramide glucosyltransferase -0.0406712
WSB1 WD repeat and SOCS box containing 1 -0.0400676
PRRC2C proline-rich coiled-coil 2C -0.0396528
B2M beta-2-microglobulin -0.0381735
RPL35 ribosomal protein L35 -0.0375442
MCL1 myeloid cell leukemia 1 -0.0367696
RPS8 ribosomal protein S8 -0.03667
RPL7A ribosomal protein L7a -0.0365047
LDHA lactate dehydrogenase A -0.0364967
RPLP1 ribosomal protein, large, P1 -0.0359924
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0346245
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0345259
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0340964
ZNF292 zinc finger protein 292 -0.0339553
SMC4 structural maintenance of chromosomes 4 -0.0337211
PFDN4 prefoldin subunit 4 -0.0335782
KTN1 kinectin 1 (kinesin receptor) -0.033514
MYL12B myosin, light chain 12B, regulatory -0.0334473
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0332955
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0328148
GNAS GNAS complex locus -0.0327883
RAB22A RAB22A, member RAS oncogene family -0.0326269
FTL ferritin, light polypeptide -0.0325819
RPS19 ribosomal protein S19 -0.0325384
RPL37A ribosomal protein L37a -0.0311236
S100A9 S100 calcium binding protein A9 -0.0309309
PGK1 phosphoglycerate kinase 1 -0.0306805
RPL8 ribosomal protein L8 -0.0306169
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0304611
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0302656
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0302474
RPS12 ribosomal protein S12 -0.0299346
TSC22D2 TSC22 domain family, member 2 -0.0296309
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0295496
EGFR epidermal growth factor receptor -0.0291142
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0288537
RPLP0 ribosomal protein, large, P0 -0.0287702
EIF1 eukaryotic translation initiation factor 1 -0.028753
RPL9 ribosomal protein L9 -0.028736
TMEM165 transmembrane protein 165 -0.0285748
TUBA1B tubulin, alpha 1b -0.0283041
RAB6A RAB6A, member RAS oncogene family -0.0282285
ANXA2 annexin A2 -0.0278165
RAB7A RAB7A, member RAS oncogene family -0.0277931
LOC112694756 uncharaterized LOC112694756 -0.0275546
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0273536
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0272129
S100A14 S100 calcium binding protein A14 -0.0268744
ENO1 enolase 1, (alpha) -0.0268142
PRR11 proline rich 11 -0.0268089
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.026652
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.026295
RPL26 ribosomal protein L26 -0.026223
SERF2 small EDRK-rich factor 2 -0.0258893
RPL11 ribosomal protein L11 -0.0258374
PKM pyruvate kinase, muscle -0.0257214
RPS29 ribosomal protein S29 -0.025565
IFI6 interferon, alpha-inducible protein 6 -0.0255408
NAMPT nicotinamide phosphoribosyltransferase -0.0255199
RPL36 ribosomal protein L36 -0.0254945
RPS27 ribosomal protein S27 -0.0254185
HLA-B major histocompatibility complex, class I, B -0.0252001
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0250432
CBX3 chromobox homolog 3 -0.0248852
WASF2 WAS protein family, member 2 -0.0248718
PNISR PNN-interacting serine/arginine-rich protein -0.0245929
RPL31 ribosomal protein L31 -0.0245925
S100A8 S100 calcium binding protein A8 -0.0244778
RPS16 ribosomal protein S16 -0.0244171
POTEF POTE ankyrin domain family, member F -0.0242856
DSTN destrin (actin depolymerizing factor) -0.0242092
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0241451
RTN4 reticulon 4 -0.0239135
S100A6 S100 calcium binding protein A6 -0.0235637
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0234842