Doxycycline (monohydrate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0499685
KMT2C lysine (K)-specific methyltransferase 2C 0.0329206
FMNL2 formin-like 2 0.0319481
NEBL nebulette 0.0314988
ARHGAP32 Rho GTPase activating protein 32 0.0309958
ATP11A ATPase, class VI, type 11A 0.0253881
SLIT2 slit homolog 2 (Drosophila) 0.0250436
COL5A2 collagen, type V, alpha 2 0.0238196
KDM6A lysine (K)-specific demethylase 6A 0.023231
NUP58 nucleoporin 58 0.0228944
TRIO trio Rho guanine nucleotide exchange factor 0.0225876
ZNF292 zinc finger protein 292 0.0207556
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0204938
YEATS2 YEATS domain containing 2 0.0200168
SREBF2 sterol regulatory element binding transcription factor 2 0.0198486
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0195888
ATRN attractin 0.0195347
PIAS2 protein inhibitor of activated STAT, 2 0.0184418
PUS7 pseudouridylate synthase 7 (putative) 0.0183998
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0182401
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0173346
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0172375
CASC3 cancer susceptibility candidate 3 0.0163773
FXR1 fragile X mental retardation, autosomal homolog 1 0.0163305
ZCCHC7 zinc finger, CCHC domain containing 7 0.0162291
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0161587
NGLY1 N-glycanase 1 0.0160288
BRWD1 bromodomain and WD repeat domain containing 1 0.0157725
USP9X ubiquitin specific peptidase 9, X-linked 0.0157327
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0155779
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0155236
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0154185
ZNF326 zinc finger protein 326 0.015172
PUM2 pumilio RNA-binding family member 2 0.0150085
PGAP1 post-GPI attachment to proteins 1 0.014924
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0148496
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0147504
KDM1A lysine (K)-specific demethylase 1A 0.0146938
FAT1 FAT atypical cadherin 1 0.014537
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0142599
CAMTA1 calmodulin binding transcription activator 1 0.0142416
TBCD tubulin folding cofactor D 0.0141292
MDN1 MDN1, midasin homolog (yeast) 0.0139361
YAP1 Yes-associated protein 1 0.0138635
HELZ helicase with zinc finger 0.0137472
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0136036
HSPA8 heat shock 70kDa protein 8 0.0135394
KIF1B kinesin family member 1B 0.0134346
ESYT2 extended synaptotagmin-like protein 2 0.013107
GYS1 glycogen synthase 1 (muscle) 0.0129162
ZNF608 zinc finger protein 608 0.0128433
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0127842
AHCTF1 AT hook containing transcription factor 1 0.012686
CCNY cyclin Y 0.0125764
MEF2A myocyte enhancer factor 2A 0.0125494
PYGL phosphorylase, glycogen, liver 0.0124783
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0124536
TOP2B topoisomerase (DNA) II beta 180kDa 0.0124107
CHD1 chromodomain helicase DNA binding protein 1 0.0124013
NCKAP1 NCK-associated protein 1 0.012397
WDFY3 WD repeat and FYVE domain containing 3 0.0122027
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0121225
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0119812
FAR1 fatty acyl CoA reductase 1 0.0118369
HELLS helicase, lymphoid-specific 0.011742
ANKRD36 ankyrin repeat domain 36 0.0116293
ADAM9 ADAM metallopeptidase domain 9 0.011608
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0115781
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0114366
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0114297
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0113092
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0112072
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0111528
KCMF1 potassium channel modulatory factor 1 0.0110023
SLK STE20-like kinase 0.0109493
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.010917
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0109118
NRG1 neuregulin 1 0.010851
JMY junction mediating and regulatory protein, p53 cofactor 0.0107691
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0103992
SCAF4 SR-related CTD-associated factor 4 0.0103479
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0102969
TENM3 teneurin transmembrane protein 3 0.0102576
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0101853
DENR density-regulated protein 0.010167
CCNT2 cyclin T2 0.0101582
WDR43 WD repeat domain 43 0.00997536
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00997129
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0099621
STRN3 striatin, calmodulin binding protein 3 0.00994282
UBE3A ubiquitin protein ligase E3A 0.0099123
RANBP17 RAN binding protein 17 0.00986126
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.00983994
EIF4B eukaryotic translation initiation factor 4B 0.00983506
VEGFC vascular endothelial growth factor C 0.00973986
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00969283
ZEB1 zinc finger E-box binding homeobox 1 0.00949331
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00942744
ZNF638 zinc finger protein 638 0.00938049
OSBPL10 oxysterol binding protein-like 10 0.00935824

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.261362
RPS8 ribosomal protein S8 -0.109615
PTMA prothymosin, alpha -0.108579
RPLP1 ribosomal protein, large, P1 -0.102942
RPS6 ribosomal protein S6 -0.102387
RPL11 ribosomal protein L11 -0.0953106
IFI6 interferon, alpha-inducible protein 6 -0.0939317
TMSB10 thymosin beta 10 -0.0877817
ACTG1 actin gamma 1 -0.081536
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0781694
RPLP2 ribosomal protein, large, P2 -0.0728484
RPS19 ribosomal protein S19 -0.0705717
RPL23 ribosomal protein L23 -0.0705606
RPS21 ribosomal protein S21 -0.0694288
RPL31 ribosomal protein L31 -0.0684134
TPT1 tumor protein, translationally-controlled 1 -0.066711
RPL37A ribosomal protein L37a -0.0646643
RPL28 ribosomal protein L28 -0.0632959
RPS29 ribosomal protein S29 -0.0620298
RPL12 ribosomal protein L12 -0.0599302
RPL34 ribosomal protein L34 -0.0596344
RPS11 ribosomal protein S11 -0.0594968
RPS3 ribosomal protein S3 -0.0584902
RPS24 ribosomal protein S24 -0.058197
RPL26 ribosomal protein L26 -0.0576641
SOX4 SRY (sex determining region Y)-box 4 -0.0571308
RPL9 ribosomal protein L9 -0.0557532
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0534984
GNAS GNAS complex locus -0.0519164
RPL19 ribosomal protein L19 -0.0508455
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0507751
RPL32 ribosomal protein L32 -0.0507254
RPL36 ribosomal protein L36 -0.0496601
VCL vinculin -0.0495984
B2M beta-2-microglobulin -0.0489345
RPS4X ribosomal protein S4, X-linked -0.0485433
RPS13 ribosomal protein S13 -0.0474275
RPS5 ribosomal protein S5 -0.0466669
RPS23 ribosomal protein S23 -0.0465631
RPL5 ribosomal protein L5 -0.0456102
RPL35A ribosomal protein L35a -0.0445697
RPS25 ribosomal protein S25 -0.0431825
PNISR PNN-interacting serine/arginine-rich protein -0.0431819
MYL12B myosin, light chain 12B, regulatory -0.0431717
FTL ferritin, light polypeptide -0.0430358
RPS15 ribosomal protein S15 -0.0429619
RPS27A ribosomal protein S27a -0.0422373
RPL7A ribosomal protein L7a -0.0413008
RPL13A ribosomal protein L13a -0.0411531
ISG15 ISG15 ubiquitin-like modifier -0.0406538
RPL37 ribosomal protein L37 -0.0406374
RPS16 ribosomal protein S16 -0.0398614
RPL8 ribosomal protein L8 -0.0398038
RPS12 ribosomal protein S12 -0.0397615
RPS17 ribosomal protein S17 -0.0396228
DEK DEK proto-oncogene -0.0390171
LOC112694756 uncharaterized LOC112694756 -0.0387762
HMGB1 high mobility group box 1 -0.0381364
RPL38 ribosomal protein L38 -0.0380234
ENO1 enolase 1, (alpha) -0.0379335
EGR1 early growth response 1 -0.0371937
CENPF centromere protein F, 350/400kDa -0.0366869
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0366417
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0365969
RPLP0 ribosomal protein, large, P0 -0.0365079
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0363398
RPL36A ribosomal protein L36a -0.0362083
MT2A metallothionein 2A -0.0358235
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0356835
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0349998
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0345928
EIF1 eukaryotic translation initiation factor 1 -0.0345152
TPI1 triosephosphate isomerase 1 -0.0345006
VIM vimentin -0.0343259
JMJD1C jumonji domain containing 1C -0.0341143
S100A9 S100 calcium binding protein A9 -0.0337203
HLA-B major histocompatibility complex, class I, B -0.0337121
RPS14 ribosomal protein S14 -0.0335332
RPL18 ribosomal protein L18 -0.0324156
NAP1L1 nucleosome assembly protein 1-like 1 -0.0324064
RPL27A ribosomal protein L27a -0.032159
RPS20 ribosomal protein S20 -0.0321178
SEPTIN7 septin 7 -0.0320786
ADGRG6 adhesion G protein-coupled receptor G6 -0.0317439
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0315042
PDE4D phosphodiesterase 4D, cAMP-specific -0.0314954
PABPN1 poly(A) binding protein, nuclear 1 -0.0313917
RPS27 ribosomal protein S27 -0.0308371
RIGI RNA sensor RIG-I -0.0302276
RACK1 receptor for activated C kinase 1 -0.0300489
RPS28 ribosomal protein S28 -0.0293505
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0291422
H1-0 H1.0 linker histone -0.0287422
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0285986
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0285247
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0284652
RPL30 ribosomal protein L30 -0.0280901
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0280399
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0279497
NFIA nuclear factor I/A -0.0279341