Doxycycline (monohydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.111033
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0836587
FNDC3B fibronectin type III domain containing 3B 0.0571234
CD109 CD109 molecule 0.0522944
VGF VGF nerve growth factor inducible 0.0459884
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0414641
IGF1R insulin-like growth factor 1 receptor 0.0357782
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0351235
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0317605
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0314264
SMAD3 SMAD family member 3 0.0304825
INSIG1 insulin induced gene 1 0.0291098
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0286647
CALU calumenin 0.0280915
NAV2 neuron navigator 2 0.0276385
MYO10 myosin X 0.0266742
RYBP RING1 and YY1 binding protein 0.0263845
CDC73 cell division cycle 73 0.0257877
PNPLA8 patatin-like phospholipase domain containing 8 0.0257867
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0254402
ZNF292 zinc finger protein 292 0.0254078
RIPK4 receptor-interacting serine-threonine kinase 4 0.0246666
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0237012
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0233401
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0233268
FMNL2 formin-like 2 0.0231048
EXT1 exostosin glycosyltransferase 1 0.0225156
NUP58 nucleoporin 58 0.0222146
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0218951
ANXA5 annexin A5 0.0216025
MACROD2 MACRO domain containing 2 0.0212596
JARID2 jumonji, AT rich interactive domain 2 0.0209689
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0209203
C1ORF21 chromosome 1 open reading frame 21 0.0204293
MYOF myoferlin 0.0198607
MSMO1 methylsterol monooxygenase 1 0.0197836
LSAMP limbic system-associated membrane protein 0.0194327
PTK2 protein tyrosine kinase 2 0.0193719
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0192306
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0190253
EPS8 epidermal growth factor receptor pathway substrate 8 0.0187496
CORO1C coronin, actin binding protein, 1C 0.0185292
ZMIZ1 zinc finger, MIZ-type containing 1 0.0184673
RHEB Ras homolog enriched in brain 0.0183989
LRMDA leucine rich melanocyte differentiation associated 0.0180952
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0179376
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0178742
NLGN1 neuroligin 1 0.0178663
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0176586
MACF1 microtubule-actin crosslinking factor 1 0.0174015
NEK7 NIMA-related kinase 7 0.0168982
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0165871
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0165156
SEPTIN9 septin 9 0.0165077
SAMD4A sterile alpha motif domain containing 4A 0.0163922
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0159619
PTPRM protein tyrosine phosphatase, receptor type, M 0.0156492
GLS2 glutaminase 2 (liver, mitochondrial) 0.0156425
RAD23B RAD23 homolog B (S. cerevisiae) 0.0155389
BACE2 beta-site APP-cleaving enzyme 2 0.0154999
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0153092
NBAS neuroblastoma amplified sequence 0.015241
FBXO7 F-box protein 7 0.0152369
FRMD6 FERM domain containing 6 0.0152362
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0151849
NCAPG2 non-SMC condensin II complex, subunit G2 0.0149076
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0149046
FAT1 FAT atypical cadherin 1 0.0148618
BIRC2 baculoviral IAP repeat containing 2 0.014671
CADM1 cell adhesion molecule 1 0.0146426
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0143442
ZNF704 zinc finger protein 704 0.0140498
APP amyloid beta (A4) precursor protein 0.0139738
SND1 staphylococcal nuclease and tudor domain containing 1 0.0139652
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0136489
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0134298
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0133592
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0132055
NOTCH2 notch 2 0.0129221
UBASH3B ubiquitin associated and SH3 domain containing B 0.0128394
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0127945
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0127467
CPED1 cadherin-like and PC-esterase domain containing 1 0.0126977
RBM33 RNA binding motif protein 33 0.0126028
MED15 mediator complex subunit 15 0.0124734
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0124646
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0124246
CAPRIN1 cell cycle associated protein 1 0.0122577
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0121663
SSBP3 single stranded DNA binding protein 3 0.01205
ZBTB10 zinc finger and BTB domain containing 10 0.0120344
YAP1 Yes-associated protein 1 0.0119716
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0118976
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0117356
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0116958
MAML3 mastermind-like 3 (Drosophila) 0.0116829
STOM stomatin 0.0116514
TRA2B transformer 2 beta homolog (Drosophila) 0.0116264
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0115683
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0115477

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.309843
VIM vimentin -0.188619
FN1 fibronectin 1 -0.137691
MT2A metallothionein 2A -0.12796
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.127286
IFI16 interferon, gamma-inducible protein 16 -0.0708505
TMSB10 thymosin beta 10 -0.0680613
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0538052
S100A6 S100 calcium binding protein A6 -0.0522921
GDF15 growth differentiation factor 15 -0.0504413
HLA-B major histocompatibility complex, class I, B -0.0484133
IGFBP5 insulin-like growth factor binding protein 5 -0.0479083
LOC112694756 uncharaterized LOC112694756 -0.0448918
EGR1 early growth response 1 -0.0444299
RPLP1 ribosomal protein, large, P1 -0.0438589
ENO1 enolase 1, (alpha) -0.0435353
EHBP1 EH domain binding protein 1 -0.0421303
PTMA prothymosin, alpha -0.0418403
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0414555
OXR1 oxidation resistance 1 -0.0388785
NPAS2 neuronal PAS domain protein 2 -0.0361652
PTCHD4 patched domain containing 4 -0.0350286
MT1X metallothionein 1X -0.034677
RPS8 ribosomal protein S8 -0.0337165
RPS19 ribosomal protein S19 -0.0335871
IFITM3 interferon induced transmembrane protein 3 -0.0332307
ZBTB20 zinc finger and BTB domain containing 20 -0.0331081
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0330576
TPR translocated promoter region, nuclear basket protein -0.0328897
IGFBP3 insulin-like growth factor binding protein 3 -0.0326664
ACTG1 actin gamma 1 -0.0321208
IER3 immediate early response 3 -0.0312679
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0303407
FTL ferritin, light polypeptide -0.0296202
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0291059
COL19A1 collagen, type XIX, alpha 1 -0.0288056
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0287675
TPI1 triosephosphate isomerase 1 -0.0281586
RPL37A ribosomal protein L37a -0.0281424
A2M alpha-2-macroglobulin -0.0268901
RPLP2 ribosomal protein, large, P2 -0.0268466
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0261931
PKM pyruvate kinase, muscle -0.0258438
RPL35A ribosomal protein L35a -0.0257388
RPL34 ribosomal protein L34 -0.0246472
KDM3A lysine (K)-specific demethylase 3A -0.0244703
ARHGAP5 Rho GTPase activating protein 5 -0.0244654
RPL12 ribosomal protein L12 -0.0243643
LOC102724023 ES1 protein homolog, mitochondrial -0.0241527
RPL19 ribosomal protein L19 -0.0238612
TXNIP thioredoxin interacting protein -0.02386
S100A9 S100 calcium binding protein A9 -0.0233754
RPS12 ribosomal protein S12 -0.0232698
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0232208
EIF1 eukaryotic translation initiation factor 1 -0.0231975
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0225219
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0225028
RPL26 ribosomal protein L26 -0.02216
TNRC6B trinucleotide repeat containing 6B -0.0221295
PRRC2C proline-rich coiled-coil 2C -0.0216732
FAM162A family with sequence similarity 162, member A -0.021386
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0212146
IFITM1 interferon induced transmembrane protein 1 -0.021044
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0207872
HILPDA hypoxia inducible lipid droplet-associated -0.0205691
TAGLN2 transgelin 2 -0.0202656
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0202637
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0200899
CSNK1E casein kinase 1, epsilon -0.0199651
RCAN1 regulator of calcineurin 1 -0.0198203
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0198031
VDAC1 voltage-dependent anion channel 1 -0.0197628
PLIN2 perilipin 2 -0.0197107
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0196512
RPL23 ribosomal protein L23 -0.01958
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0195225
RPS3 ribosomal protein S3 -0.0194664
TPT1 tumor protein, translationally-controlled 1 -0.0192584
CDH19 cadherin 19, type 2 -0.0191581
RPS5 ribosomal protein S5 -0.0189299
RPS13 ribosomal protein S13 -0.018905
CALD1 caldesmon 1 -0.0188115
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.018718
KTN1 kinectin 1 (kinesin receptor) -0.0186758
ADM adrenomedullin -0.0186445
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0186098
RPS6 ribosomal protein S6 -0.0185629
ZC3H7A zinc finger CCCH-type containing 7A -0.0185575
GNAS GNAS complex locus -0.0185246
RPLP0 ribosomal protein, large, P0 -0.0184625
IFITM2 interferon induced transmembrane protein 2 -0.018385
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0183631
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0183171
NDRG1 N-myc downstream regulated 1 -0.0182975
MTPN myotrophin -0.01829
RPS27A ribosomal protein S27a -0.0181911
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0181242
ZMYND8 zinc finger, MYND-type containing 8 -0.0180336
TNNC1 troponin C type 1 (slow) -0.0180054
MRPS6 mitochondrial ribosomal protein S6 -0.0178769