Doxycycline (monohydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HELZ helicase with zinc finger 0.0748568
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0564111
LPIN1 lipin 1 0.048114
FAM13A family with sequence similarity 13, member A 0.045667
SSBP2 single-stranded DNA binding protein 2 0.0453233
ZNF292 zinc finger protein 292 0.0435315
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.043522
KDM3A lysine (K)-specific demethylase 3A 0.0425126
KMT2C lysine (K)-specific methyltransferase 2C 0.0413854
AOPEP aminopeptidase O (putative) 0.0399953
NEK7 NIMA-related kinase 7 0.0392876
MEIS2 Meis homeobox 2 0.0384945
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0379051
NAMPT nicotinamide phosphoribosyltransferase 0.0355451
SOS1 son of sevenless homolog 1 (Drosophila) 0.0352379
SPAG9 sperm associated antigen 9 0.0352044
WAC WW domain containing adaptor with coiled-coil 0.0342423
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.033865
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.033593
NRG1 neuregulin 1 0.032641
PTK2 protein tyrosine kinase 2 0.0322134
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0316984
XPO1 exportin 1 0.0316888
TRIO trio Rho guanine nucleotide exchange factor 0.031069
MED13L mediator complex subunit 13-like 0.0309362
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0297407
KMT2E lysine (K)-specific methyltransferase 2E 0.0294101
DSCAM Down syndrome cell adhesion molecule 0.0289229
DST dystonin 0.0286727
MARCHF6 membrane associated ring-CH-type finger 6 0.0285563
QKI QKI, KH domain containing, RNA binding 0.0284206
ADGRG6 adhesion G protein-coupled receptor G6 0.0277496
ZFAND3 zinc finger, AN1-type domain 3 0.0275344
RNF145 ring finger protein 145 0.0270851
FNDC3B fibronectin type III domain containing 3B 0.0266519
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0265263
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0262405
OGA O-GlcNAcase 0.0261635
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0261584
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0259719
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0257607
WDR43 WD repeat domain 43 0.0255345
NPEPPS aminopeptidase puromycin sensitive 0.0253969
NUP58 nucleoporin 58 0.0253928
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0253342
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0252901
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0250164
PHIP pleckstrin homology domain interacting protein 0.0244033
USP3 ubiquitin specific peptidase 3 0.0243288
TLK2 tousled-like kinase 2 0.0241008
FCHSD2 FCH and double SH3 domains 2 0.0237046
CD46 CD46 molecule, complement regulatory protein 0.0228869
CADM1 cell adhesion molecule 1 0.0227417
NCKAP1 NCK-associated protein 1 0.022261
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0222119
LCORL ligand dependent nuclear receptor corepressor-like 0.0216306
UBA6 ubiquitin-like modifier activating enzyme 6 0.021479
NBAS neuroblastoma amplified sequence 0.0212734
APP amyloid beta (A4) precursor protein 0.0211951
MEF2A myocyte enhancer factor 2A 0.021126
NCAM2 neural cell adhesion molecule 2 0.0210204
BIRC6 baculoviral IAP repeat containing 6 0.0210052
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0208413
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0205638
ADAM9 ADAM metallopeptidase domain 9 0.0205393
KCTD3 potassium channel tetramerization domain containing 3 0.020394
PDS5B PDS5 cohesin associated factor B 0.0201096
EPS8 epidermal growth factor receptor pathway substrate 8 0.0197081
CHD1 chromodomain helicase DNA binding protein 1 0.0194632
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0191876
NUP153 nucleoporin 153kDa 0.0191725
FXR1 fragile X mental retardation, autosomal homolog 1 0.0190483
CDC73 cell division cycle 73 0.0189868
NRIP1 nuclear receptor interacting protein 1 0.0188257
CD36 CD36 molecule (thrombospondin receptor) 0.0186964
KDM6A lysine (K)-specific demethylase 6A 0.0185347
ZMYM2 zinc finger, MYM-type 2 0.0183847
KLHL13 kelch-like family member 13 0.0182543
BIRC2 baculoviral IAP repeat containing 2 0.0180802
MATR3 matrin 3 0.0180695
ANKRD28 ankyrin repeat domain 28 0.01791
USP34 ubiquitin specific peptidase 34 0.0176305
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0175961
MEMO1 mediator of cell motility 1 0.0175819
HSPA8 heat shock 70kDa protein 8 0.0175699
KAT6A K(lysine) acetyltransferase 6A 0.017382
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0173281
MSMO1 methylsterol monooxygenase 1 0.0172666
AFDN afadin, adherens junction formation factor 0.0171068
CASC3 cancer susceptibility candidate 3 0.0169116
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0167803
MYO6 myosin VI 0.0166173
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0164378
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0164365
AHCTF1 AT hook containing transcription factor 1 0.0163172
PCNX1 pecanex 1 0.0162837
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0161939
PICALM phosphatidylinositol binding clathrin assembly protein 0.0161347
BRWD1 bromodomain and WD repeat domain containing 1 0.0159692
ZNF148 zinc finger protein 148 0.0158831

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.15153
IGF2 insulin-like growth factor 2 -0.0942383
PTMA prothymosin, alpha -0.092329
VIM vimentin -0.0895389
VCL vinculin -0.0781139
RPS6 ribosomal protein S6 -0.0778896
LSAMP limbic system-associated membrane protein -0.0682038
RPL23 ribosomal protein L23 -0.0660791
RPL35A ribosomal protein L35a -0.0634617
AKAP12 A kinase (PRKA) anchor protein 12 -0.05978
RPL19 ribosomal protein L19 -0.0596619
RPLP1 ribosomal protein, large, P1 -0.0565107
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0524379
ACTG1 actin gamma 1 -0.0494919
RPS12 ribosomal protein S12 -0.0454345
RPL34 ribosomal protein L34 -0.0444871
NALF1 NALCN channel auxiliary factor 1 -0.0443047
CRH corticotropin releasing hormone -0.0439936
TMSB10 thymosin beta 10 -0.0438756
PRKCA protein kinase C, alpha -0.0425416
RPL31 ribosomal protein L31 -0.0414595
RPL37A ribosomal protein L37a -0.0401414
PTPRD protein tyrosine phosphatase, receptor type, D -0.039074
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0381769
IGFBP3 insulin-like growth factor binding protein 3 -0.0373744
RPS3 ribosomal protein S3 -0.0368303
TPT1 tumor protein, translationally-controlled 1 -0.0354623
EIF1 eukaryotic translation initiation factor 1 -0.0347856
EGR1 early growth response 1 -0.0347343
RPLP0 ribosomal protein, large, P0 -0.0341528
RPS19 ribosomal protein S19 -0.0331347
PLAT plasminogen activator, tissue -0.0328397
B2M beta-2-microglobulin -0.0322255
RPS17 ribosomal protein S17 -0.0318129
RPL12 ribosomal protein L12 -0.0306816
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0305284
RPS24 ribosomal protein S24 -0.0305183
RPS8 ribosomal protein S8 -0.0301886
RPL38 ribosomal protein L38 -0.0297857
RPL27 ribosomal protein L27 -0.0297467
FTL ferritin, light polypeptide -0.029642
RPL26 ribosomal protein L26 -0.0291617
RACK1 receptor for activated C kinase 1 -0.0283283
BPTF bromodomain PHD finger transcription factor -0.0282767
RPS25 ribosomal protein S25 -0.0276695
S100A9 S100 calcium binding protein A9 -0.0274742
RPL37 ribosomal protein L37 -0.0274297
CANX calnexin -0.027191
RPS27A ribosomal protein S27a -0.027024
RPS27 ribosomal protein S27 -0.0257322
MCL1 myeloid cell leukemia 1 -0.0257203
RPS23 ribosomal protein S23 -0.0254771
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0252039
RPS14 ribosomal protein S14 -0.0249194
RPL18 ribosomal protein L18 -0.0248886
RPS29 ribosomal protein S29 -0.0247937
RPL7A ribosomal protein L7a -0.0246651
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0246205
TPM4 tropomyosin 4 -0.0246171
RPL36 ribosomal protein L36 -0.0245451
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0237553
DPH6 diphthamine biosynthesis 6 -0.0235138
RPS13 ribosomal protein S13 -0.0234997
RPL7 ribosomal protein L7 -0.0224381
S100A6 S100 calcium binding protein A6 -0.0223531
RPLP2 ribosomal protein, large, P2 -0.0222875
RPS5 ribosomal protein S5 -0.0220387
SYT1 synaptotagmin I -0.0214512
ENO1 enolase 1, (alpha) -0.02141
ASPH aspartate beta-hydroxylase -0.0212867
RPL9 ribosomal protein L9 -0.021217
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0210496
PDIA3 protein disulfide isomerase family A, member 3 -0.0209842
RPS21 ribosomal protein S21 -0.0208845
CUX1 cut-like homeobox 1 -0.0207659
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0202662
SOX4 SRY (sex determining region Y)-box 4 -0.0200444
IER3 immediate early response 3 -0.0198852
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0197344
TPI1 triosephosphate isomerase 1 -0.0197206
BICD1 bicaudal D homolog 1 (Drosophila) -0.0191028
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0190576
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0189803
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0188365
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0187515
RPS20 ribosomal protein S20 -0.018581
RPL8 ribosomal protein L8 -0.018245
RSF1 remodeling and spacing factor 1 -0.0180746
RPL32 ribosomal protein L32 -0.0178478
RPL30 ribosomal protein L30 -0.0178436
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0178426
TPM1 tropomyosin 1 (alpha) -0.0178155
RPL10A ribosomal protein L10a -0.0177228
RPL11 ribosomal protein L11 -0.0173081
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0172884
RPS15 ribosomal protein S15 -0.017159
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.016982
IGFBP5 insulin-like growth factor binding protein 5 -0.0169333
MYO1E myosin IE -0.0168115
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0168109