Doxycycline (monohydrate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MBNL2 muscleblind-like splicing regulator 2 0.0501562
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0500152
ZMYM2 zinc finger, MYM-type 2 0.0370046
FNDC3B fibronectin type III domain containing 3B 0.033321
FNIP1 folliculin interacting protein 1 0.0331754
BTBD9 BTB (POZ) domain containing 9 0.0296656
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0286657
MCTP2 multiple C2 domains, transmembrane 2 0.0280769
FNDC3A fibronectin type III domain containing 3A 0.0279493
SREBF2 sterol regulatory element binding transcription factor 2 0.0264661
GRK3 G protein-coupled receptor kinase 3 0.0251962
CANX calnexin 0.0250439
USP3 ubiquitin specific peptidase 3 0.0232625
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0231985
PCCA propionyl CoA carboxylase, alpha polypeptide 0.023126
YEATS2 YEATS domain containing 2 0.0230435
RNF149 ring finger protein 149 0.0229334
HELZ helicase with zinc finger 0.0222672
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0222213
KDM6A lysine (K)-specific demethylase 6A 0.0219954
SEC24D SEC24 family member D 0.0218506
PTEN phosphatase and tensin homolog 0.0215978
UBAC2 UBA domain containing 2 0.0213261
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0212981
TMEM39A transmembrane protein 39A 0.0210709
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0210463
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0201261
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0200558
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0200414
USPL1 ubiquitin specific peptidase like 1 0.0189607
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.018826
PUM2 pumilio RNA-binding family member 2 0.0184096
METTL15 methyltransferase like 15 0.0182859
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0181652
PHF3 PHD finger protein 3 0.0180844
KMT2C lysine (K)-specific methyltransferase 2C 0.0174864
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0174368
KDM3A lysine (K)-specific demethylase 3A 0.0172808
CAMTA1 calmodulin binding transcription activator 1 0.0168048
KAZN kazrin, periplakin interacting protein 0.0168036
RBM26 RNA binding motif protein 26 0.0166977
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0164994
GOLGA4 golgin A4 0.0164942
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0164398
KIF16B kinesin family member 16B 0.0161465
BIRC6 baculoviral IAP repeat containing 6 0.0159369
OGA O-GlcNAcase 0.01592
RBM39 RNA binding motif protein 39 0.0158612
TM9SF2 transmembrane 9 superfamily member 2 0.0158248
CLTC clathrin, heavy chain (Hc) 0.0157978
TAS2R14 taste receptor, type 2, member 14 0.0157723
SBF2 SET binding factor 2 0.0149568
LCORL ligand dependent nuclear receptor corepressor-like 0.0148284
ZFC3H1 zinc finger, C3H1-type containing 0.0148203
BRWD3 bromodomain and WD repeat domain containing 3 0.0148087
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0147386
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0147352
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0146519
UBA6 ubiquitin-like modifier activating enzyme 6 0.0145821
COG3 component of oligomeric golgi complex 3 0.014537
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0145223
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0144378
PMM2 phosphomannomutase 2 0.0143672
PDS5B PDS5 cohesin associated factor B 0.0142499
RAB6A RAB6A, member RAS oncogene family 0.0142131
HDLBP high density lipoprotein binding protein 0.0140652
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0139542
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0139458
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0139211
TUBGCP3 tubulin, gamma complex associated protein 3 0.0137742
ITCH itchy E3 ubiquitin protein ligase 0.0136979
RAB1A RAB1A, member RAS oncogene family 0.0136863
STK39 serine threonine kinase 39 0.0136307
ZNF638 zinc finger protein 638 0.0136291
PRELID2 PRELI domain containing 2 0.0136219
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0134574
GOLGA3 golgin A3 0.0134174
COG6 component of oligomeric golgi complex 6 0.0133554
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0131645
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0131613
ZDHHC20 zinc finger, DHHC-type containing 20 0.0130258
ERP44 endoplasmic reticulum protein 44 0.0130202
MATR3 matrin 3 0.0129712
AHI1 Abelson helper integration site 1 0.0129247
RBM33 RNA binding motif protein 33 0.0128727
LRRC1 leucine rich repeat containing 1 0.0128638
SAMD4A sterile alpha motif domain containing 4A 0.0128483
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0128043
FDPS farnesyl diphosphate synthase 0.012741
RNF43 ring finger protein 43 0.0127282
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0126103
SCFD1 sec1 family domain containing 1 0.0125702
SUCO SUN domain containing ossification factor 0.0125327
ZNRF3 zinc and ring finger 3 0.0125176
DSCAM Down syndrome cell adhesion molecule 0.0124638
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0124092
MSI2 musashi RNA-binding protein 2 0.0123735
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0121217
HBS1L HBS1-like translational GTPase 0.0119674
MON2 MON2 homolog (S. cerevisiae) 0.0119282

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.262236
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.166114
LMO7 LIM domain 7 -0.127118
TPT1 tumor protein, translationally-controlled 1 -0.117064
LCN2 lipocalin 2 -0.116838
EGR1 early growth response 1 -0.114405
C6ORF132 chromosome 6 open reading frame 132 -0.10711
IFI6 interferon, alpha-inducible protein 6 -0.0977659
HLA-B major histocompatibility complex, class I, B -0.0963135
ANXA2 annexin A2 -0.0860209
RNF213 ring finger protein 213 -0.0814553
MYO1E myosin IE -0.0779531
FTL ferritin, light polypeptide -0.0749938
LOC102724023 ES1 protein homolog, mitochondrial -0.0718711
IFI27 interferon, alpha-inducible protein 27 -0.0694015
PERP PERP, TP53 apoptosis effector -0.0674836
EPSTI1 epithelial stromal interaction 1 (breast) -0.0637993
AREG amphiregulin -0.0630111
PTMA prothymosin, alpha -0.0623237
EZR ezrin -0.0608848
STAT1 signal transducer and activator of transcription 1, 91kDa -0.060341
MX2 MX dynamin-like GTPase 2 -0.0583007
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0572518
TMSB10 thymosin beta 10 -0.0566241
RPS6 ribosomal protein S6 -0.0560197
PKM pyruvate kinase, muscle -0.0545323
SP100 SP100 nuclear antigen -0.0540061
RAB7A RAB7A, member RAS oncogene family -0.0529348
ITGA6 integrin, alpha 6 -0.0525081
MT2A metallothionein 2A -0.0524281
RPL23 ribosomal protein L23 -0.0518942
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0506013
RPL35A ribosomal protein L35a -0.0499995
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0499968
TJP1 tight junction protein 1 -0.0495949
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0494792
MX1 MX dynamin-like GTPase 1 -0.04878
EIF1 eukaryotic translation initiation factor 1 -0.0482246
RIGI RNA sensor RIG-I -0.0475147
TMC5 transmembrane channel-like 5 -0.0470013
GCLC glutamate-cysteine ligase, catalytic subunit -0.0455204
RPLP1 ribosomal protein, large, P1 -0.0450498
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0450244
IRF1 interferon regulatory factor 1 -0.0435465
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0432108
SLC38A1 solute carrier family 38, member 1 -0.0428346
JUN jun proto-oncogene -0.0410926
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0408916
ACTG1 actin gamma 1 -0.0404248
EFNB2 ephrin-B2 -0.0401779
CST3 cystatin C -0.0396909
NCKAP5 NCK-associated protein 5 -0.039423
S100A10 S100 calcium binding protein A10 -0.0392899
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0390297
INTS6 integrator complex subunit 6 -0.0387338
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0383528
HLA-C major histocompatibility complex, class I, C -0.0375051
VCL vinculin -0.0367227
RPL19 ribosomal protein L19 -0.0363724
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0361491
SQSTM1 sequestosome 1 -0.036012
IFITM3 interferon induced transmembrane protein 3 -0.0358423
CLDN4 claudin 4 -0.0352934
RPS19 ribosomal protein S19 -0.0349612
HLA-A major histocompatibility complex, class I, A -0.034768
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0340193
ZMYND8 zinc finger, MYND-type containing 8 -0.0333783
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0331875
CCNL1 cyclin L1 -0.0327478
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0327033
LOC112694756 uncharaterized LOC112694756 -0.0325432
TSC22D1 TSC22 domain family, member 1 -0.0321518
ZSWIM6 zinc finger, SWIM-type containing 6 -0.032117
RPLP2 ribosomal protein, large, P2 -0.0320695
TPI1 triosephosphate isomerase 1 -0.0320664
POTEF POTE ankyrin domain family, member F -0.0319577
RPS27 ribosomal protein S27 -0.0319196
MACC1 metastasis associated in colon cancer 1 -0.0318606
STK24 serine/threonine kinase 24 -0.0318416
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0314145
EXT1 exostosin glycosyltransferase 1 -0.0313681
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0312837
DSTN destrin (actin depolymerizing factor) -0.0312278
BPTF bromodomain PHD finger transcription factor -0.0310713
RPS8 ribosomal protein S8 -0.0308877
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0306197
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0305424
IRS2 insulin receptor substrate 2 -0.0299328
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0296721
UBC ubiquitin C -0.0293286
XAF1 XIAP associated factor 1 -0.0293054
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0292415
HLA-E major histocompatibility complex, class I, E -0.0291619
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.029103
RPL31 ribosomal protein L31 -0.0290166
GCC2 GRIP and coiled-coil domain containing 2 -0.0289301
RPL34 ribosomal protein L34 -0.0286549
VMP1 vacuole membrane protein 1 -0.0285617
RRBP1 ribosome binding protein 1 -0.0283042
MCL1 myeloid cell leukemia 1 -0.0282773