Doxycycline (monohydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Doxycycline (monohydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Doxycycline (monohydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.115733
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0483936
IARS1 isoleucyl-tRNA synthetase 1 0.0418097
NUP58 nucleoporin 58 0.0409595
GARS1 glycyl-tRNA synthetase 1 0.0378122
ERRFI1 ERBB receptor feedback inhibitor 1 0.0347864
FNDC3B fibronectin type III domain containing 3B 0.034008
ANKRD11 ankyrin repeat domain 11 0.0328396
SBF2 SET binding factor 2 0.0314838
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0303305
KMT2C lysine (K)-specific methyltransferase 2C 0.0300159
ZNF292 zinc finger protein 292 0.0271748
GOLGA4 golgin A4 0.0267045
RUNX1 runt-related transcription factor 1 0.0266844
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0263432
HELZ helicase with zinc finger 0.026175
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0250006
RNMT RNA (guanine-7-) methyltransferase 0.0245259
YEATS2 YEATS domain containing 2 0.0243106
UBA6 ubiquitin-like modifier activating enzyme 6 0.0234443
RAB6A RAB6A, member RAS oncogene family 0.0221674
WDR26 WD repeat domain 26 0.0215531
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0213744
RBM39 RNA binding motif protein 39 0.0212246
ESRP1 epithelial splicing regulatory protein 1 0.0209864
ZFC3H1 zinc finger, C3H1-type containing 0.0209596
KDM6A lysine (K)-specific demethylase 6A 0.0204281
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0203586
ZFAND3 zinc finger, AN1-type domain 3 0.02008
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0198174
MATR3 matrin 3 0.0197948
TMEM39A transmembrane protein 39A 0.0197338
PUM2 pumilio RNA-binding family member 2 0.0196441
WDR43 WD repeat domain 43 0.0188969
NBAS neuroblastoma amplified sequence 0.0186279
OLA1 Obg-like ATPase 1 0.018463
CAMTA1 calmodulin binding transcription activator 1 0.0183651
YME1L1 YME1-like 1 ATPase 0.017987
TXNRD1 thioredoxin reductase 1 0.0175995
ITCH itchy E3 ubiquitin protein ligase 0.0173604
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0171702
DSCAM Down syndrome cell adhesion molecule 0.0169842
TARS1 threonyl-tRNA synthetase 1 0.0169564
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0168614
VEGFA vascular endothelial growth factor A 0.0166251
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.016347
SEC24D SEC24 family member D 0.0163283
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0162904
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0161868
MON2 MON2 homolog (S. cerevisiae) 0.0160486
WAC WW domain containing adaptor with coiled-coil 0.0159672
CLTC clathrin, heavy chain (Hc) 0.0158961
FAR1 fatty acyl CoA reductase 1 0.0158746
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0158523
SCARB1 scavenger receptor class B, member 1 0.0157462
USP34 ubiquitin specific peptidase 34 0.0153559
ADAM17 ADAM metallopeptidase domain 17 0.0152896
RLF rearranged L-myc fusion 0.0152596
INSIG2 insulin induced gene 2 0.0151753
SMAD4 SMAD family member 4 0.0151638
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0149924
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0148932
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0148588
CARS1 cysteinyl-tRNA synthetase 1 0.014812
PGM3 phosphoglucomutase 3 0.0148085
CCNL1 cyclin L1 0.014571
POM121C POM121 transmembrane nucleoporin C 0.0145481
TFG TRK-fused gene 0.0143195
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0142123
BCLAF1 BCL2-associated transcription factor 1 0.0140094
CCNT2 cyclin T2 0.0139296
NOP58 NOP58 ribonucleoprotein 0.0139262
PTBP2 polypyrimidine tract binding protein 2 0.0139214
FTH1 ferritin, heavy polypeptide 1 0.0138668
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0138652
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.013856
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0138427
MED13 mediator complex subunit 13 0.0136941
NCKAP1 NCK-associated protein 1 0.0136736
TMEM87A transmembrane protein 87A 0.0135046
ESYT2 extended synaptotagmin-like protein 2 0.0134697
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0134276
CEP95 centrosomal protein 95kDa 0.0134256
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0134203
FAF1 Fas (TNFRSF6) associated factor 1 0.0133295
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0132979
RAB21 RAB21, member RAS oncogene family 0.0132064
MAP4 microtubule-associated protein 4 0.0131575
BRD4 bromodomain containing 4 0.0130004
THOC1 THO complex 1 0.0129768
PTEN phosphatase and tensin homolog 0.012871
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0127616
ZNF33A zinc finger protein 33A 0.0127574
TNRC6A trinucleotide repeat containing 6A 0.0127443
SETD5 SET domain containing 5 0.0127394
FAM117B family with sequence similarity 117, member B 0.0126114
RAB1A RAB1A, member RAS oncogene family 0.0125782
CLINT1 clathrin interactor 1 0.012578
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.012551
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0125422

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.36578
AHNAK AHNAK nucleoprotein -0.182749
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.166943
LOC112694756 uncharaterized LOC112694756 -0.0693484
TMSB10 thymosin beta 10 -0.0664025
ENO1 enolase 1, (alpha) -0.0648153
TPT1 tumor protein, translationally-controlled 1 -0.0645091
FTL ferritin, light polypeptide -0.0584887
CANX calnexin -0.0513077
UBC ubiquitin C -0.0507936
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.047439
RPS27A ribosomal protein S27a -0.0474149
RPS8 ribosomal protein S8 -0.0453235
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0438797
FAT1 FAT atypical cadherin 1 -0.0422527
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0398896
LDHA lactate dehydrogenase A -0.0389893
RPS3 ribosomal protein S3 -0.03814
RPL26 ribosomal protein L26 -0.0381222
RPL23 ribosomal protein L23 -0.0352583
PTMA prothymosin, alpha -0.0350528
S100A10 S100 calcium binding protein A10 -0.0335911
RPL35A ribosomal protein L35a -0.0334889
MT2A metallothionein 2A -0.0329711
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0324792
KRT18 keratin 18, type I -0.0321331
MKI67 marker of proliferation Ki-67 -0.0319051
EIF1 eukaryotic translation initiation factor 1 -0.031694
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0304324
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0294133
RPL11 ribosomal protein L11 -0.0290407
KRT19 keratin 19, type I -0.0286722
PKM pyruvate kinase, muscle -0.0280451
ZNF638 zinc finger protein 638 -0.0278612
RPLP1 ribosomal protein, large, P1 -0.0277208
RPLP0 ribosomal protein, large, P0 -0.0274299
EZR ezrin -0.0271897
RPL31 ribosomal protein L31 -0.0266259
PDIA4 protein disulfide isomerase family A, member 4 -0.0260675
RPS6 ribosomal protein S6 -0.025742
RPL34 ribosomal protein L34 -0.0255901
RRBP1 ribosome binding protein 1 -0.0249501
CENPF centromere protein F, 350/400kDa -0.0247371
PCBP2 poly(rC) binding protein 2 -0.0245179
EEF2 eukaryotic translation elongation factor 2 -0.0244149
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0242636
RPL7A ribosomal protein L7a -0.0238019
RPL8 ribosomal protein L8 -0.0236866
RPS19 ribosomal protein S19 -0.023596
JUN jun proto-oncogene -0.0235236
MYO9A myosin IXA -0.0233281
RACK1 receptor for activated C kinase 1 -0.0232919
PDIA3 protein disulfide isomerase family A, member 3 -0.0232656
RPL37A ribosomal protein L37a -0.023136
TPI1 triosephosphate isomerase 1 -0.0230611
ASPH aspartate beta-hydroxylase -0.0230057
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0227671
RPS12 ribosomal protein S12 -0.0227125
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0225616
RPS24 ribosomal protein S24 -0.0216961
SRRM2 serine/arginine repetitive matrix 2 -0.0213377
TXNIP thioredoxin interacting protein -0.0213114
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0210702
RPL18 ribosomal protein L18 -0.0210364
RPLP2 ribosomal protein, large, P2 -0.0205437
RPS13 ribosomal protein S13 -0.0205207
SPDYA speedy/RINGO cell cycle regulator family member A -0.0201084
RPL12 ribosomal protein L12 -0.0201076
ADD3 adducin 3 (gamma) -0.0198324
SQSTM1 sequestosome 1 -0.0198048
RPL19 ribosomal protein L19 -0.019702
AKAP9 A kinase (PRKA) anchor protein 9 -0.0195842
RPS25 ribosomal protein S25 -0.0195654
PERP PERP, TP53 apoptosis effector -0.0192386
RPS11 ribosomal protein S11 -0.0191289
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0190948
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0188016
TTC3 tetratricopeptide repeat domain 3 -0.0187709
RPL5 ribosomal protein L5 -0.0185619
HDLBP high density lipoprotein binding protein -0.0184633
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0183909
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0183814
EPCAM epithelial cell adhesion molecule -0.0179341
LMNA lamin A/C -0.0179065
RPS5 ribosomal protein S5 -0.0173608
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0173416
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0170383
BPTF bromodomain PHD finger transcription factor -0.0168733
RSL1D1 ribosomal L1 domain containing 1 -0.0168363
CCNI cyclin I -0.0166675
RPL7 ribosomal protein L7 -0.0166475
LMAN1 lectin, mannose-binding, 1 -0.0166379
TUBB4B tubulin, beta 4B class IVb -0.0166091
PCM1 pericentriolar material 1 -0.0162289
RPL36 ribosomal protein L36 -0.0160733
S100A9 S100 calcium binding protein A9 -0.0159231
RNF213 ring finger protein 213 -0.0159153
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0158432
RPL32 ribosomal protein L32 -0.0157868
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0156827